Motif ID: Vsx1_Uncx_Prrx2_Shox2_Noto

Z-value: 1.443

Transcription factors associated with Vsx1_Uncx_Prrx2_Shox2_Noto:

Gene SymbolEntrez IDGene Name
Noto ENSMUSG00000068302.7 Noto
Prrx2 ENSMUSG00000039476.7 Prrx2
Shox2 ENSMUSG00000027833.10 Shox2
Uncx ENSMUSG00000029546.11 Uncx
Vsx1 ENSMUSG00000033080.8 Vsx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Uncxmm10_v2_chr5_+_139543889_1395439040.797.3e-09Click!
Shox2mm10_v2_chr3_-_66981279_669813180.511.2e-03Click!
Prrx2mm10_v2_chr2_+_30834972_308349720.134.3e-01Click!


Activity profile for motif Vsx1_Uncx_Prrx2_Shox2_Noto.

activity profile for motif Vsx1_Uncx_Prrx2_Shox2_Noto


Sorted Z-values histogram for motif Vsx1_Uncx_Prrx2_Shox2_Noto

Sorted Z-values for motif Vsx1_Uncx_Prrx2_Shox2_Noto



Network of associatons between targets according to the STRING database.



First level regulatory network of Vsx1_Uncx_Prrx2_Shox2_Noto

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_118478182 37.234 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr9_+_118478344 36.107 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr5_+_139543889 33.333 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr8_-_61902669 20.388 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr3_+_55782500 19.142 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr4_-_97778042 16.310 ENSMUST00000146447.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr5_-_62766153 15.846 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr7_-_49636847 12.860 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr12_+_38780284 12.000 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
 Etv1


ets variant gene 1


chr2_+_20737306 11.705 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr2_+_25372315 11.558 ENSMUST00000028329.6
ENSMUST00000114293.2
ENSMUST00000100323.2
 Sapcd2


suppressor APC domain containing 2


chr14_-_48665098 10.978 ENSMUST00000118578.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr8_+_45658666 10.651 ENSMUST00000134675.1
ENSMUST00000139869.1
ENSMUST00000126067.1
 Sorbs2


sorbin and SH3 domain containing 2


chr13_+_44121167 10.550 ENSMUST00000163056.1
ENSMUST00000159595.1
 Gm5083

predicted gene 5083

chr8_+_45658731 10.279 ENSMUST00000143820.1
ENSMUST00000132139.1
 Sorbs2

sorbin and SH3 domain containing 2

chr12_+_38780817 9.921 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr3_-_86548268 9.870 ENSMUST00000077524.3
 Mab21l2
mab-21-like 2 (C. elegans)
chr17_+_34592248 9.869 ENSMUST00000038149.6
 Pbx2
pre B cell leukemia homeobox 2
chr19_+_59458372 9.653 ENSMUST00000062216.3
 Emx2
empty spiracles homeobox 2
chr14_-_118052235 9.630 ENSMUST00000022725.2
 Dct
dopachrome tautomerase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 153 entries
Log-likelihood per target Total log-likelihoodTermDescription
24.4 73.3 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
4.0 43.5 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
4.2 33.3 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.6 27.5 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
1.3 20.4 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
1.1 20.4 GO:0071803 keratinocyte development(GO:0003334) positive regulation of podosome assembly(GO:0071803)
0.8 13.7 GO:0001833 inner cell mass cell proliferation(GO:0001833)
1.0 12.9 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
1.0 12.8 GO:0021796 cerebral cortex regionalization(GO:0021796)
3.1 12.2 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
4.0 12.0 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.1 9.9 GO:0030326 embryonic limb morphogenesis(GO:0030326) embryonic appendage morphogenesis(GO:0035113)
1.6 9.6 GO:0006570 tyrosine metabolic process(GO:0006570)
0.7 9.4 GO:0060013 righting reflex(GO:0060013)
0.5 9.4 GO:0007530 sex determination(GO:0007530)
0.4 9.1 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.1 9.1 GO:0043488 regulation of mRNA stability(GO:0043488)
0.0 8.9 GO:0022409 positive regulation of cell-cell adhesion(GO:0022409)
2.8 8.5 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.1 8.2 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 258.6 GO:0005634 nucleus(GO:0005634)
0.5 20.4 GO:0002102 podosome(GO:0002102)
0.1 17.0 GO:0005667 transcription factor complex(GO:0005667)
0.1 13.7 GO:0000792 heterochromatin(GO:0000792)
0.4 9.6 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.6 9.1 GO:0042788 polysomal ribosome(GO:0042788)
0.2 8.9 GO:0016459 myosin complex(GO:0016459)
0.1 8.6 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
2.1 8.5 GO:0060187 cell pole(GO:0060187)
1.3 8.0 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.0 6.5 GO:0005925 focal adhesion(GO:0005925)
0.1 6.2 GO:0070382 exocytic vesicle(GO:0070382)
0.0 6.1 GO:0005769 early endosome(GO:0005769)
0.2 6.0 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 5.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 5.8 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 4.5 GO:0032420 stereocilium(GO:0032420)
0.1 4.4 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 4.3 GO:0032590 dendrite membrane(GO:0032590)
0.1 4.2 GO:0097440 apical dendrite(GO:0097440)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 99 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 109.4 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.2 78.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
1.2 76.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
1.7 25.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 19.1 GO:0016779 nucleotidyltransferase activity(GO:0016779)
2.1 14.6 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.3 14.5 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 13.4 GO:0019904 protein domain specific binding(GO:0019904)
0.0 13.3 GO:0003779 actin binding(GO:0003779)
1.5 12.0 GO:0050693 LBD domain binding(GO:0050693)
0.3 10.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.7 9.6 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.3 9.1 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.3 9.1 GO:0017091 AU-rich element binding(GO:0017091)
0.3 8.1 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.7 8.0 GO:0043522 leucine zipper domain binding(GO:0043522)
0.7 7.2 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.9 6.8 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.8 6.8 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.3 6.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 73.3 PID_IL12_2PATHWAY IL12-mediated signaling events
1.3 44.7 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.3 14.5 PID_ARF6_PATHWAY Arf6 signaling events
0.1 13.4 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.3 11.7 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.3 10.2 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.3 9.1 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.3 7.2 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.3 6.7 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 6.1 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 5.5 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 4.9 NABA_COLLAGENS Genes encoding collagen proteins
0.2 4.0 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.1 2.9 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.2 2.4 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 2.1 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 1.8 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 1.1 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 1.1 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 1.0 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 18.0 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 14.7 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.4 14.6 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 9.1 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 8.8 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 4.9 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 4.9 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 3.4 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.1 3.3 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.2 2.9 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.3 2.6 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 2.4 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 2.1 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 2.1 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 1.9 REACTOME_G_ALPHA1213_SIGNALLING_EVENTS Genes involved in G alpha (12/13) signalling events
0.1 1.8 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 1.8 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 1.6 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 1.3 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 1.2 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones