Motif ID: Vsx2_Dlx3
Z-value: 1.129
Transcription factors associated with Vsx2_Dlx3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Dlx3 | ENSMUSG00000001510.7 | Dlx3 |
| Vsx2 | ENSMUSG00000021239.6 | Vsx2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Vsx2 | mm10_v2_chr12_+_84569762_84569840 | 0.07 | 6.8e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.2 | 49.2 | GO:0035726 | common myeloid progenitor cell proliferation(GO:0035726) |
| 5.1 | 30.7 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
| 2.1 | 6.3 | GO:0003221 | right ventricular cardiac muscle tissue morphogenesis(GO:0003221) |
| 1.8 | 20.2 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 1.1 | 3.3 | GO:0061357 | Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357) |
| 1.1 | 8.8 | GO:0050957 | equilibrioception(GO:0050957) |
| 1.0 | 4.0 | GO:0061743 | motor learning(GO:0061743) |
| 0.8 | 2.4 | GO:0090526 | regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526) |
| 0.8 | 2.4 | GO:0060489 | orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490) |
| 0.7 | 11.8 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
| 0.6 | 7.0 | GO:2000741 | positive regulation of mesenchymal stem cell differentiation(GO:2000741) |
| 0.6 | 1.8 | GO:0060729 | intestinal epithelial structure maintenance(GO:0060729) |
| 0.6 | 2.3 | GO:0046552 | eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552) |
| 0.5 | 2.0 | GO:0021502 | neural fold elevation formation(GO:0021502) |
| 0.4 | 1.3 | GO:0002014 | vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure(GO:0002014) |
| 0.3 | 6.1 | GO:0021521 | ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573) |
| 0.3 | 5.4 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 0.3 | 1.3 | GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) |
| 0.3 | 1.5 | GO:0048245 | eosinophil chemotaxis(GO:0048245) |
| 0.3 | 0.8 | GO:1902915 | negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915) |
| 0.2 | 1.9 | GO:0043129 | surfactant homeostasis(GO:0043129) |
| 0.2 | 4.0 | GO:0007530 | sex determination(GO:0007530) |
| 0.2 | 0.6 | GO:0021759 | globus pallidus development(GO:0021759) |
| 0.2 | 3.4 | GO:0031987 | locomotion involved in locomotory behavior(GO:0031987) |
| 0.2 | 3.5 | GO:0071803 | keratinocyte development(GO:0003334) positive regulation of podosome assembly(GO:0071803) |
| 0.2 | 1.6 | GO:1900194 | negative regulation of oocyte maturation(GO:1900194) |
| 0.2 | 0.7 | GO:0035609 | C-terminal protein deglutamylation(GO:0035609) |
| 0.2 | 2.0 | GO:0034219 | carbohydrate transmembrane transport(GO:0034219) |
| 0.1 | 0.8 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
| 0.1 | 1.8 | GO:2000042 | negative regulation of double-strand break repair via homologous recombination(GO:2000042) |
| 0.1 | 0.4 | GO:0035553 | oxidative single-stranded RNA demethylation(GO:0035553) |
| 0.1 | 1.2 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.1 | 2.3 | GO:0008340 | determination of adult lifespan(GO:0008340) |
| 0.1 | 0.7 | GO:0006104 | succinyl-CoA metabolic process(GO:0006104) |
| 0.1 | 2.9 | GO:0050873 | brown fat cell differentiation(GO:0050873) |
| 0.1 | 1.0 | GO:0006107 | oxaloacetate metabolic process(GO:0006107) |
| 0.1 | 0.9 | GO:0045974 | miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974) |
| 0.1 | 2.7 | GO:0006493 | protein O-linked glycosylation(GO:0006493) |
| 0.1 | 0.3 | GO:0051697 | protein delipidation(GO:0051697) |
| 0.1 | 0.5 | GO:0016198 | axon choice point recognition(GO:0016198) |
| 0.0 | 4.2 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
| 0.0 | 0.1 | GO:1900149 | positive regulation of Schwann cell migration(GO:1900149) |
| 0.0 | 0.4 | GO:1990118 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
| 0.0 | 1.5 | GO:0051693 | actin filament capping(GO:0051693) |
| 0.0 | 1.2 | GO:0061028 | establishment of endothelial barrier(GO:0061028) |
| 0.0 | 0.2 | GO:0080009 | mRNA methylation(GO:0080009) |
| 0.0 | 1.5 | GO:0042773 | ATP synthesis coupled electron transport(GO:0042773) |
| 0.0 | 1.4 | GO:0051489 | regulation of filopodium assembly(GO:0051489) |
| 0.0 | 0.3 | GO:2000114 | regulation of establishment of cell polarity(GO:2000114) |
| 0.0 | 1.3 | GO:0032880 | regulation of protein localization(GO:0032880) |
| 0.0 | 0.9 | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184) |
| 0.0 | 0.9 | GO:0032007 | negative regulation of TOR signaling(GO:0032007) |
| 0.0 | 1.2 | GO:1903078 | positive regulation of protein localization to plasma membrane(GO:1903078) |
| 0.0 | 0.3 | GO:0060218 | hematopoietic stem cell differentiation(GO:0060218) |
| 0.0 | 1.0 | GO:0010633 | negative regulation of epithelial cell migration(GO:0010633) |
| 0.0 | 1.0 | GO:0008585 | female gonad development(GO:0008585) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 2.4 | GO:0060187 | cell pole(GO:0060187) |
| 0.4 | 2.6 | GO:0000444 | MIS12/MIND type complex(GO:0000444) |
| 0.3 | 2.4 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
| 0.2 | 3.3 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.2 | 1.2 | GO:0061689 | paranodal junction(GO:0033010) tricellular tight junction(GO:0061689) |
| 0.2 | 8.8 | GO:0032420 | stereocilium(GO:0032420) |
| 0.2 | 1.0 | GO:0001674 | female germ cell nucleus(GO:0001674) |
| 0.1 | 0.7 | GO:0030062 | mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062) |
| 0.1 | 1.5 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.1 | 0.9 | GO:0035068 | micro-ribonucleoprotein complex(GO:0035068) |
| 0.1 | 0.7 | GO:0042824 | MHC class I peptide loading complex(GO:0042824) |
| 0.1 | 1.5 | GO:0031045 | dense core granule(GO:0031045) |
| 0.1 | 11.8 | GO:0000792 | heterochromatin(GO:0000792) |
| 0.1 | 1.6 | GO:0033276 | transcription factor TFTC complex(GO:0033276) |
| 0.1 | 3.5 | GO:0002102 | podosome(GO:0002102) |
| 0.1 | 3.3 | GO:0032590 | dendrite membrane(GO:0032590) |
| 0.1 | 1.3 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.1 | 1.8 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.1 | 0.9 | GO:0044292 | dendrite terminus(GO:0044292) |
| 0.0 | 0.9 | GO:0016460 | myosin II complex(GO:0016460) |
| 0.0 | 0.3 | GO:0071437 | invadopodium(GO:0071437) |
| 0.0 | 1.4 | GO:0016459 | myosin complex(GO:0016459) |
| 0.0 | 0.5 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.0 | 0.3 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.0 | 0.1 | GO:0060091 | kinocilium(GO:0060091) |
| 0.0 | 7.3 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 121.3 | GO:0005634 | nucleus(GO:0005634) |
| 0.0 | 0.8 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 0.9 | GO:0005814 | centriole(GO:0005814) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 3.4 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 0.4 | 2.4 | GO:0070728 | leucine binding(GO:0070728) |
| 0.3 | 3.3 | GO:0031852 | mu-type opioid receptor binding(GO:0031852) |
| 0.3 | 1.8 | GO:0061649 | ubiquitinated histone binding(GO:0061649) |
| 0.2 | 0.7 | GO:0004774 | succinate-CoA ligase activity(GO:0004774) |
| 0.2 | 2.6 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 0.2 | 4.6 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.2 | 2.0 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 0.2 | 1.9 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
| 0.2 | 6.3 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.2 | 31.8 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.2 | 1.0 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
| 0.2 | 1.6 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.2 | 2.7 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.1 | 1.2 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.1 | 4.0 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.1 | 0.4 | GO:0035515 | oxidative RNA demethylase activity(GO:0035515) |
| 0.1 | 1.3 | GO:0043495 | protein anchor(GO:0043495) |
| 0.1 | 3.3 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.1 | 89.5 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
| 0.1 | 0.9 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 0.1 | 1.5 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.1 | 0.5 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) |
| 0.1 | 0.8 | GO:0005522 | profilin binding(GO:0005522) |
| 0.1 | 8.8 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 0.1 | 0.2 | GO:0042284 | sphingolipid delta-4 desaturase activity(GO:0042284) |
| 0.1 | 0.8 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
| 0.0 | 0.4 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
| 0.0 | 6.0 | GO:0016779 | nucleotidyltransferase activity(GO:0016779) |
| 0.0 | 2.0 | GO:0015144 | carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476) |
| 0.0 | 6.0 | GO:0003774 | motor activity(GO:0003774) |
| 0.0 | 1.3 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.0 | 0.4 | GO:0045125 | bioactive lipid receptor activity(GO:0045125) |
| 0.0 | 0.7 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.0 | 1.2 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
| 0.0 | 0.3 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.0 | 0.2 | GO:0008174 | mRNA methyltransferase activity(GO:0008174) |
| 0.0 | 3.0 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 0.6 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.0 | 0.9 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.0 | 1.5 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.0 | 0.4 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
| 0.0 | 0.9 | GO:0035254 | glutamate receptor binding(GO:0035254) |
| 0.0 | 0.9 | GO:0032947 | protein complex scaffold(GO:0032947) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 20.2 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 6.3 | PID_WNT_NONCANONICAL_PATHWAY | Noncanonical Wnt signaling pathway |
| 0.1 | 4.6 | SA_PTEN_PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.1 | 4.6 | PID_EPHRINB_REV_PATHWAY | Ephrin B reverse signaling |
| 0.1 | 3.4 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 9.8 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 1.9 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.1 | 1.6 | PID_PDGFRA_PATHWAY | PDGFR-alpha signaling pathway |
| 0.1 | 4.6 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.4 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
| 0.0 | 0.6 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.6 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.1 | 3.4 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 0.7 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.1 | 1.7 | REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.1 | 1.8 | REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.1 | 2.7 | REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 1.6 | REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.0 | 0.8 | REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.0 | 0.9 | REACTOME_REGULATORY_RNA_PATHWAYS | Genes involved in Regulatory RNA pathways |
| 0.0 | 1.4 | REACTOME_NETRIN1_SIGNALING | Genes involved in Netrin-1 signaling |
| 0.0 | 2.6 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 1.9 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 0.1 | REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
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