Motif ID: Wrnip1_Mta3_Rcor1

Z-value: 3.234

Transcription factors associated with Wrnip1_Mta3_Rcor1:

Gene SymbolEntrez IDGene Name
Mta3 ENSMUSG00000055817.11 Mta3
Rcor1 ENSMUSG00000037896.11 Rcor1
Wrnip1 ENSMUSG00000021400.6 Wrnip1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rcor1mm10_v2_chr12_+_111039334_111039400-0.872.2e-12Click!
Mta3mm10_v2_chr17_+_83706170_837062000.437.6e-03Click!
Wrnip1mm10_v2_chr13_+_32802007_328021520.411.2e-02Click!


Activity profile for motif Wrnip1_Mta3_Rcor1.

activity profile for motif Wrnip1_Mta3_Rcor1


Sorted Z-values histogram for motif Wrnip1_Mta3_Rcor1

Sorted Z-values for motif Wrnip1_Mta3_Rcor1



Network of associatons between targets according to the STRING database.



First level regulatory network of Wrnip1_Mta3_Rcor1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_180499893 28.359 ENSMUST00000029084.2
 Ntsr1
neurotensin receptor 1
chr6_-_115994953 17.002 ENSMUST00000015511.8
 Plxnd1
plexin D1
chr15_-_66948419 16.672 ENSMUST00000167817.1
 Ndrg1
N-myc downstream regulated gene 1
chr5_+_30588078 13.878 ENSMUST00000066295.2
 Kcnk3
potassium channel, subfamily K, member 3
chr4_+_104367549 13.813 ENSMUST00000106830.2
 Dab1
disabled 1
chr7_+_36698002 13.626 ENSMUST00000021641.6
 Tshz3
teashirt zinc finger family member 3
chr4_-_68954351 12.835 ENSMUST00000030036.5
 Brinp1
bone morphogenic protein/retinoic acid inducible neural specific 1
chr18_-_66291770 12.683 ENSMUST00000130300.1
 Ccbe1
collagen and calcium binding EGF domains 1
chr7_+_43797567 12.406 ENSMUST00000085461.2
 Klk8
kallikrein related-peptidase 8
chr5_+_130448801 12.398 ENSMUST00000111288.2
 Caln1
calneuron 1
chr15_-_66969616 12.348 ENSMUST00000170903.1
ENSMUST00000166420.1
ENSMUST00000005256.6
ENSMUST00000164070.1
 Ndrg1



N-myc downstream regulated gene 1



chr11_+_104132841 12.229 ENSMUST00000093925.4
 Crhr1
corticotropin releasing hormone receptor 1
chr7_+_123982799 12.072 ENSMUST00000106437.1
 Hs3st4
heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chr3_-_54915867 11.489 ENSMUST00000070342.3
 Sertm1
serine rich and transmembrane domain containing 1
chr18_-_38211957 11.162 ENSMUST00000159405.1
ENSMUST00000160721.1
 Pcdh1

protocadherin 1

chr9_-_110742577 10.907 ENSMUST00000006005.7
 Pth1r
parathyroid hormone 1 receptor
chr4_-_138396438 10.741 ENSMUST00000105032.2
 Fam43b
family with sequence similarity 43, member B
chr7_-_31042078 10.612 ENSMUST00000162116.1
ENSMUST00000159924.1
ENSMUST00000159753.1
ENSMUST00000160689.1
ENSMUST00000162733.1
ENSMUST00000162087.1
ENSMUST00000009831.7
 Fxyd5






FXYD domain-containing ion transport regulator 5






chr5_-_108549934 10.563 ENSMUST00000129040.1
ENSMUST00000046892.9
 Cplx1

complexin 1

chr8_+_70501116 10.512 ENSMUST00000127983.1
 Crlf1
cytokine receptor-like factor 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,366 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 51.7 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
1.3 37.9 GO:0035640 exploration behavior(GO:0035640)
1.3 32.5 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.5 32.3 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.9 31.0 GO:0034605 cellular response to heat(GO:0034605)
5.1 30.4 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.6 28.2 GO:0006414 translational elongation(GO:0006414)
1.2 26.9 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
2.2 25.9 GO:1900121 negative regulation of receptor binding(GO:1900121)
0.6 25.9 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
6.4 25.8 GO:0090238 positive regulation of arachidonic acid secretion(GO:0090238)
2.7 24.0 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
1.3 24.0 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
4.7 23.4 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
1.2 22.8 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
1.1 22.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
1.8 22.1 GO:0031645 negative regulation of neurological system process(GO:0031645)
2.7 21.4 GO:0021894 cerebral cortex GABAergic interneuron development(GO:0021894)
2.4 21.4 GO:1900034 regulation of cellular response to heat(GO:1900034)
4.1 20.7 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 465 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 233.0 GO:0016021 integral component of membrane(GO:0016021)
0.5 138.5 GO:0097060 synaptic membrane(GO:0097060)
0.2 116.3 GO:0005615 extracellular space(GO:0005615)
0.2 86.7 GO:0005887 integral component of plasma membrane(GO:0005887)
1.4 65.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 63.1 GO:0031012 extracellular matrix(GO:0031012)
0.8 62.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.6 58.7 GO:0031225 anchored component of membrane(GO:0031225)
0.9 53.9 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.8 53.6 GO:0005581 collagen trimer(GO:0005581)
0.2 50.2 GO:0000139 Golgi membrane(GO:0000139)
1.1 49.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.6 47.7 GO:0043195 terminal bouton(GO:0043195)
0.9 44.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
1.1 39.4 GO:0055038 recycling endosome membrane(GO:0055038)
0.8 36.2 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
3.0 36.1 GO:0097418 neurofibrillary tangle(GO:0097418)
1.0 34.2 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
1.7 32.9 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
7.9 31.7 GO:0032280 symmetric synapse(GO:0032280)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 727 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 149.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.9 62.6 GO:0016247 channel regulator activity(GO:0016247)
0.9 55.4 GO:0035254 glutamate receptor binding(GO:0035254)
0.2 47.8 GO:0003924 GTPase activity(GO:0003924)
0.9 45.3 GO:0030276 clathrin binding(GO:0030276)
2.9 43.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)
1.0 41.9 GO:0043015 gamma-tubulin binding(GO:0043015)
1.1 41.8 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
3.0 36.1 GO:0004016 adenylate cyclase activity(GO:0004016)
0.9 33.5 GO:0005246 calcium channel regulator activity(GO:0005246)
1.6 32.7 GO:0008188 neuropeptide receptor activity(GO:0008188)
1.3 32.3 GO:0003746 translation elongation factor activity(GO:0003746)
0.5 31.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 30.5 GO:0005096 GTPase activator activity(GO:0005096)
5.9 29.6 GO:0097643 amylin receptor activity(GO:0097643)
1.2 29.2 GO:0017046 peptide hormone binding(GO:0017046)
0.9 25.2 GO:0017080 sodium channel regulator activity(GO:0017080)
0.4 24.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
2.6 23.1 GO:0070324 thyroid hormone binding(GO:0070324)
1.2 23.1 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 112 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 127.7 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.7 82.0 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.9 57.4 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
1.0 38.9 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.9 38.1 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
1.0 37.9 PID_ALK1_PATHWAY ALK1 signaling events
2.2 37.8 PID_LPA4_PATHWAY LPA4-mediated signaling events
1.2 36.5 PID_ARF_3PATHWAY Arf1 pathway
0.3 32.9 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.7 30.7 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway
1.0 29.5 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.9 29.0 PID_RAS_PATHWAY Regulation of Ras family activation
0.2 26.5 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.7 24.1 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.4 22.9 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.6 19.4 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.5 19.1 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.9 17.9 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.6 17.8 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.9 17.0 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 203 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 112.5 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.9 74.6 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.8 57.3 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.3 52.4 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.7 46.8 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.9 46.7 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
1.2 45.7 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
1.7 41.7 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
1.1 38.9 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
1.3 37.0 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
3.1 36.9 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
2.8 36.6 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
1.0 36.3 REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.7 35.6 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
2.1 32.9 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.9 32.4 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
1.8 29.3 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.6 28.6 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
1.2 28.1 REACTOME_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
1.0 27.1 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling