Motif ID: Xbp1_Creb3l1
Z-value: 0.872
Transcription factors associated with Xbp1_Creb3l1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Creb3l1 | ENSMUSG00000027230.9 | Creb3l1 |
| Xbp1 | ENSMUSG00000020484.12 | Xbp1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Creb3l1 | mm10_v2_chr2_-_92024502_92024529 | 0.59 | 1.1e-04 | Click! |
| Xbp1 | mm10_v2_chr11_+_5520652_5520659 | -0.42 | 9.4e-03 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.2 | GO:1990523 | bone regeneration(GO:1990523) |
| 0.4 | 2.9 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
| 0.4 | 1.9 | GO:2000680 | regulation of rubidium ion transport(GO:2000680) |
| 0.4 | 2.3 | GO:0060075 | regulation of resting membrane potential(GO:0060075) |
| 0.4 | 2.5 | GO:0032596 | protein transport into membrane raft(GO:0032596) dsRNA transport(GO:0033227) |
| 0.2 | 0.7 | GO:0006154 | adenosine catabolic process(GO:0006154) |
| 0.2 | 3.6 | GO:0033234 | negative regulation of protein sumoylation(GO:0033234) |
| 0.2 | 1.6 | GO:0090166 | Golgi disassembly(GO:0090166) |
| 0.2 | 0.5 | GO:0035359 | negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) regulation of oxidative phosphorylation uncoupler activity(GO:2000275) cell proliferation involved in heart valve development(GO:2000793) |
| 0.2 | 1.2 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.1 | 1.8 | GO:0048664 | neuron fate determination(GO:0048664) |
| 0.1 | 1.4 | GO:0019243 | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727) |
| 0.1 | 0.8 | GO:0016255 | attachment of GPI anchor to protein(GO:0016255) |
| 0.1 | 1.9 | GO:0060707 | trophoblast giant cell differentiation(GO:0060707) |
| 0.1 | 0.9 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.1 | 0.7 | GO:0016093 | polyprenol metabolic process(GO:0016093) |
| 0.1 | 2.1 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.1 | 0.6 | GO:0007016 | cytoskeletal anchoring at plasma membrane(GO:0007016) |
| 0.1 | 0.2 | GO:0036233 | glycine import(GO:0036233) |
| 0.1 | 0.4 | GO:2000623 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 0.1 | 0.8 | GO:0044387 | negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387) |
| 0.1 | 0.7 | GO:0001682 | tRNA 5'-leader removal(GO:0001682) |
| 0.1 | 1.0 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.1 | 0.9 | GO:0060628 | regulation of ER to Golgi vesicle-mediated transport(GO:0060628) |
| 0.1 | 0.4 | GO:0072697 | protein localization to cell cortex(GO:0072697) |
| 0.1 | 1.3 | GO:0034315 | regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315) |
| 0.1 | 1.0 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 0.1 | 0.6 | GO:2000653 | regulation of genetic imprinting(GO:2000653) |
| 0.1 | 0.8 | GO:0044144 | regulation of growth of symbiont in host(GO:0044126) modulation of growth of symbiont involved in interaction with host(GO:0044144) |
| 0.1 | 0.2 | GO:0070476 | rRNA (guanine-N7)-methylation(GO:0070476) |
| 0.0 | 0.3 | GO:0042045 | epithelial fluid transport(GO:0042045) |
| 0.0 | 0.4 | GO:0060770 | negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770) |
| 0.0 | 0.7 | GO:0044872 | lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872) |
| 0.0 | 0.7 | GO:0071712 | ER-associated misfolded protein catabolic process(GO:0071712) |
| 0.0 | 0.3 | GO:0044791 | modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791) |
| 0.0 | 0.3 | GO:0048793 | pronephros development(GO:0048793) |
| 0.0 | 3.4 | GO:0061077 | chaperone-mediated protein folding(GO:0061077) |
| 0.0 | 0.4 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
| 0.0 | 2.0 | GO:0045670 | regulation of osteoclast differentiation(GO:0045670) |
| 0.0 | 0.8 | GO:0044381 | glucose import in response to insulin stimulus(GO:0044381) |
| 0.0 | 0.1 | GO:2000048 | negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048) |
| 0.0 | 0.8 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 0.0 | 0.2 | GO:0018401 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) |
| 0.0 | 0.1 | GO:0030200 | heparan sulfate proteoglycan catabolic process(GO:0030200) |
| 0.0 | 0.2 | GO:0006824 | cobalt ion transport(GO:0006824) |
| 0.0 | 0.5 | GO:0097201 | negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201) |
| 0.0 | 0.5 | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539) |
| 0.0 | 0.3 | GO:0097502 | mannosylation(GO:0097502) |
| 0.0 | 0.2 | GO:0006102 | isocitrate metabolic process(GO:0006102) |
| 0.0 | 1.4 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.0 | 0.6 | GO:0090129 | positive regulation of synapse maturation(GO:0090129) |
| 0.0 | 0.5 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
| 0.0 | 1.5 | GO:0007528 | neuromuscular junction development(GO:0007528) |
| 0.0 | 0.2 | GO:0072015 | purine nucleotide salvage(GO:0032261) IMP salvage(GO:0032264) glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310) |
| 0.0 | 0.3 | GO:0007220 | Notch receptor processing(GO:0007220) |
| 0.0 | 0.1 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
| 0.0 | 0.7 | GO:0010259 | multicellular organism aging(GO:0010259) |
| 0.0 | 0.1 | GO:0019695 | choline metabolic process(GO:0019695) neurotransmitter receptor metabolic process(GO:0045213) |
| 0.0 | 0.2 | GO:0048820 | hair follicle maturation(GO:0048820) |
| 0.0 | 0.1 | GO:1990928 | response to amino acid starvation(GO:1990928) |
| 0.0 | 0.3 | GO:0006491 | N-glycan processing(GO:0006491) |
| 0.0 | 1.1 | GO:0030148 | sphingolipid biosynthetic process(GO:0030148) |
| 0.0 | 0.1 | GO:0030157 | pancreatic juice secretion(GO:0030157) |
| 0.0 | 0.7 | GO:0030514 | negative regulation of BMP signaling pathway(GO:0030514) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 2.1 | GO:1902937 | inward rectifier potassium channel complex(GO:1902937) |
| 0.5 | 1.9 | GO:0097487 | multivesicular body, internal vesicle(GO:0097487) |
| 0.2 | 0.6 | GO:0055087 | Ski complex(GO:0055087) |
| 0.2 | 1.3 | GO:0005785 | signal recognition particle receptor complex(GO:0005785) |
| 0.1 | 2.1 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.1 | 0.8 | GO:0042765 | GPI-anchor transamidase complex(GO:0042765) |
| 0.1 | 0.2 | GO:0016222 | procollagen-proline 4-dioxygenase complex(GO:0016222) |
| 0.1 | 0.7 | GO:0000172 | ribonuclease MRP complex(GO:0000172) |
| 0.1 | 0.4 | GO:0070939 | Dsl1p complex(GO:0070939) |
| 0.1 | 2.0 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.1 | 1.0 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.1 | 2.4 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.0 | 0.7 | GO:0017119 | Golgi transport complex(GO:0017119) |
| 0.0 | 0.8 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.0 | 1.8 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 0.3 | GO:0070765 | gamma-secretase complex(GO:0070765) |
| 0.0 | 1.2 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.0 | 1.1 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
| 0.0 | 0.4 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 0.1 | GO:0030121 | AP-1 adaptor complex(GO:0030121) |
| 0.0 | 1.2 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.0 | 0.2 | GO:0072669 | tRNA-splicing ligase complex(GO:0072669) |
| 0.0 | 1.1 | GO:0005844 | polysome(GO:0005844) |
| 0.0 | 1.5 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 24.0 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.0 | 0.9 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 0.1 | GO:0072487 | MSL complex(GO:0072487) |
| 0.0 | 0.2 | GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex(GO:0031464) |
| 0.0 | 0.2 | GO:0065010 | extracellular membrane-bounded organelle(GO:0065010) |
| 0.0 | 1.0 | GO:0016605 | PML body(GO:0016605) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.9 | GO:0046923 | ER retention sequence binding(GO:0046923) |
| 0.4 | 1.1 | GO:0001729 | ceramide kinase activity(GO:0001729) |
| 0.3 | 2.1 | GO:0022851 | GABA-gated chloride ion channel activity(GO:0022851) |
| 0.2 | 0.7 | GO:0042954 | lipoprotein transporter activity(GO:0042954) |
| 0.2 | 0.9 | GO:0004720 | protein-lysine 6-oxidase activity(GO:0004720) |
| 0.2 | 0.9 | GO:0004096 | catalase activity(GO:0004096) |
| 0.2 | 2.3 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.2 | 0.8 | GO:0055056 | D-glucose transmembrane transporter activity(GO:0055056) |
| 0.2 | 0.5 | GO:0017099 | very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099) |
| 0.2 | 3.4 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.2 | 1.4 | GO:0004416 | hydroxyacylglutathione hydrolase activity(GO:0004416) |
| 0.1 | 0.6 | GO:0008184 | glycogen phosphorylase activity(GO:0008184) |
| 0.1 | 0.8 | GO:0003923 | GPI-anchor transamidase activity(GO:0003923) |
| 0.1 | 3.6 | GO:0019789 | SUMO transferase activity(GO:0019789) |
| 0.1 | 0.4 | GO:0050510 | N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510) |
| 0.1 | 0.3 | GO:0005047 | signal recognition particle binding(GO:0005047) |
| 0.1 | 2.2 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.1 | 1.2 | GO:0016671 | oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671) |
| 0.1 | 2.4 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.1 | 0.7 | GO:0004526 | ribonuclease P activity(GO:0004526) |
| 0.1 | 0.9 | GO:0008484 | sulfuric ester hydrolase activity(GO:0008484) |
| 0.1 | 0.2 | GO:0004449 | isocitrate dehydrogenase (NAD+) activity(GO:0004449) |
| 0.1 | 0.6 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.1 | 0.7 | GO:0004000 | adenosine deaminase activity(GO:0004000) |
| 0.1 | 2.0 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.1 | 1.0 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.1 | 0.5 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.1 | 1.8 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.1 | 0.7 | GO:0042288 | MHC class I protein binding(GO:0042288) |
| 0.0 | 0.2 | GO:0004656 | procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798) |
| 0.0 | 0.8 | GO:0004659 | prenyltransferase activity(GO:0004659) |
| 0.0 | 0.1 | GO:0034046 | poly(G) binding(GO:0034046) |
| 0.0 | 0.1 | GO:0000033 | alpha-1,3-mannosyltransferase activity(GO:0000033) |
| 0.0 | 0.3 | GO:0090599 | alpha-glucosidase activity(GO:0090599) |
| 0.0 | 0.3 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.0 | 0.2 | GO:0004035 | alkaline phosphatase activity(GO:0004035) |
| 0.0 | 1.6 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.0 | 0.7 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.0 | 16.8 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 0.1 | GO:0070052 | collagen V binding(GO:0070052) |
| 0.0 | 0.7 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 0.1 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.0 | 0.8 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.0 | 0.2 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.0 | 0.1 | GO:0004104 | cholinesterase activity(GO:0004104) choline binding(GO:0033265) |
| 0.0 | 0.2 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) |
| 0.0 | 0.4 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
| 0.0 | 0.5 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.0 | 0.9 | GO:0020037 | heme binding(GO:0020037) |
| 0.0 | 0.2 | GO:0000030 | mannosyltransferase activity(GO:0000030) |
| 0.0 | 0.4 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.0 | 0.2 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.0 | 0.2 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.0 | 0.9 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 0.2 | GO:0070566 | adenylyltransferase activity(GO:0070566) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.6 | ST_JAK_STAT_PATHWAY | Jak-STAT Pathway |
| 0.1 | 2.2 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
| 0.0 | 1.5 | PID_ARF6_TRAFFICKING_PATHWAY | Arf6 trafficking events |
| 0.0 | 0.6 | PID_NECTIN_PATHWAY | Nectin adhesion pathway |
| 0.0 | 0.3 | PID_SYNDECAN_3_PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 0.5 | PID_HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 0.7 | PID_THROMBIN_PAR1_PATHWAY | PAR1-mediated thrombin signaling events |
| 0.0 | 1.8 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 1.7 | NABA_ECM_GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.3 | REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS | Genes involved in Tandem pore domain potassium channels |
| 0.2 | 8.8 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 2.1 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 0.9 | REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
| 0.1 | 0.8 | REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.1 | 0.7 | REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.0 | 0.6 | REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.0 | 0.8 | REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.0 | 1.0 | REACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |
| 0.0 | 0.3 | REACTOME_CALNEXIN_CALRETICULIN_CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.0 | 2.2 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 2.2 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 1.0 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 0.2 | REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.0 | 0.3 | REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR | Genes involved in Regulated proteolysis of p75NTR |
| 0.0 | 1.0 | REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.0 | 0.4 | REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.0 | 0.4 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
| 0.0 | 0.2 | REACTOME_PURINE_SALVAGE | Genes involved in Purine salvage |
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