Motif ID: Ybx1_Nfya_Nfyb_Nfyc_Cebpz

Z-value: 8.760

Transcription factors associated with Ybx1_Nfya_Nfyb_Nfyc_Cebpz:

Gene SymbolEntrez IDGene Name
Cebpz ENSMUSG00000024081.8 Cebpz
Nfya ENSMUSG00000023994.7 Nfya
Nfyb ENSMUSG00000020248.12 Nfyb
Nfyc ENSMUSG00000032897.11 Nfyc
Ybx1 ENSMUSG00000028639.8 Ybx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfycmm10_v2_chr4_-_120815703_1208157610.325.5e-02Click!
Cebpzmm10_v2_chr17_-_78937031_78937074-0.251.4e-01Click!
Ybx1mm10_v2_chr4_-_119294520_119294604-0.212.2e-01Click!
Nfybmm10_v2_chr10_-_82764088_82764144-0.182.9e-01Click!
Nfyamm10_v2_chr17_-_48409729_484099060.115.2e-01Click!


Activity profile for motif Ybx1_Nfya_Nfyb_Nfyc_Cebpz.

activity profile for motif Ybx1_Nfya_Nfyb_Nfyc_Cebpz


Sorted Z-values histogram for motif Ybx1_Nfya_Nfyb_Nfyc_Cebpz

Sorted Z-values for motif Ybx1_Nfya_Nfyb_Nfyc_Cebpz



Network of associatons between targets according to the STRING database.



First level regulatory network of Ybx1_Nfya_Nfyb_Nfyc_Cebpz

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_99024179 96.966 ENSMUST00000068031.7
 Top2a
topoisomerase (DNA) II alpha
chr6_+_124829582 81.705 ENSMUST00000024270.7
 Cdca3
cell division cycle associated 3
chr8_+_57511833 70.453 ENSMUST00000067925.6
 Hmgb2
high mobility group box 2
chr3_-_27153861 69.989 ENSMUST00000108300.1
ENSMUST00000108298.2
 Ect2

ect2 oncogene

chr14_-_67715585 69.293 ENSMUST00000163100.1
ENSMUST00000132705.1
ENSMUST00000124045.1
 Cdca2


cell division cycle associated 2


chr1_+_139454747 68.465 ENSMUST00000053364.8
ENSMUST00000097554.3
 Aspm

asp (abnormal spindle)-like, microcephaly associated (Drosophila)

chr8_+_83955507 68.021 ENSMUST00000005607.8
 Asf1b
ASF1 anti-silencing function 1 homolog B (S. cerevisiae)
chr3_-_27153844 67.449 ENSMUST00000176242.2
ENSMUST00000176780.1
 Ect2

ect2 oncogene

chr3_-_27153782 63.696 ENSMUST00000175857.1
ENSMUST00000177055.1
ENSMUST00000176535.1
 Ect2


ect2 oncogene


chr11_-_87108656 58.235 ENSMUST00000051395.8
 Prr11
proline rich 11
chr9_+_118478182 58.077 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr9_+_118478344 56.000 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr15_+_99074968 55.744 ENSMUST00000039665.6
 Troap
trophinin associated protein
chr6_+_124829540 55.250 ENSMUST00000150120.1
 Cdca3
cell division cycle associated 3
chr14_+_46760526 55.181 ENSMUST00000067426.4
 Cdkn3
cyclin-dependent kinase inhibitor 3
chr6_+_124830217 53.640 ENSMUST00000131847.1
ENSMUST00000151674.1
 Cdca3

cell division cycle associated 3

chr2_+_164769892 53.483 ENSMUST00000088248.6
ENSMUST00000001439.6
 Ube2c

ubiquitin-conjugating enzyme E2C

chr10_-_69352886 44.620 ENSMUST00000119827.1
ENSMUST00000020099.5
 Cdk1

cyclin-dependent kinase 1

chr3_-_8667033 43.891 ENSMUST00000042412.3
 Hey1
hairy/enhancer-of-split related with YRPW motif 1
chr13_+_51645232 43.467 ENSMUST00000075853.5
 Cks2
CDC28 protein kinase regulatory subunit 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 626 entries
Log-likelihood per target Total log-likelihoodTermDescription
15.6 281.6 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
1.4 237.6 GO:0007059 chromosome segregation(GO:0007059)
12.4 174.0 GO:0071459 protein localization to chromosome, centromeric region(GO:0071459)
5.1 158.5 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
1.5 128.8 GO:0006342 chromatin silencing(GO:0006342)
38.0 114.1 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
7.1 113.1 GO:0007100 mitotic centrosome separation(GO:0007100)
3.4 111.2 GO:0051310 metaphase plate congression(GO:0051310)
17.9 107.4 GO:0009786 regulation of asymmetric cell division(GO:0009786)
24.2 97.0 GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
6.7 93.4 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.9 92.2 GO:0007050 cell cycle arrest(GO:0007050)
3.7 89.5 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
8.1 72.7 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
1.4 71.1 GO:0008156 negative regulation of DNA replication(GO:0008156)
10.1 71.0 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
1.6 71.0 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
22.1 66.3 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
7.3 65.6 GO:0033504 floor plate development(GO:0033504)
1.1 63.9 GO:0006334 nucleosome assembly(GO:0006334)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 229 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 453.3 GO:0005634 nucleus(GO:0005634)
0.8 236.6 GO:0000790 nuclear chromatin(GO:0000790)
2.3 231.0 GO:0000793 condensed chromosome(GO:0000793)
3.2 222.7 GO:0000786 nucleosome(GO:0000786)
44.3 221.4 GO:0097149 centralspindlin complex(GO:0097149)
1.5 154.3 GO:0000776 kinetochore(GO:0000776)
3.4 134.3 GO:0005876 spindle microtubule(GO:0005876)
2.1 131.0 GO:0005657 replication fork(GO:0005657)
0.4 125.6 GO:0016607 nuclear speck(GO:0016607)
7.3 124.7 GO:0031616 spindle pole centrosome(GO:0031616)
1.7 120.4 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.5 118.8 GO:0005694 chromosome(GO:0005694)
22.0 110.1 GO:0032133 chromosome passenger complex(GO:0032133)
10.2 102.5 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
14.5 101.5 GO:0005818 aster(GO:0005818)
1.8 92.7 GO:0005871 kinesin complex(GO:0005871)
3.6 91.0 GO:0005680 anaphase-promoting complex(GO:0005680)
21.7 87.0 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.8 76.3 GO:0005913 cell-cell adherens junction(GO:0005913)
14.0 70.0 GO:0031262 Ndc80 complex(GO:0031262)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 358 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.4 215.2 GO:0031492 nucleosomal DNA binding(GO:0031492)
1.7 199.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.6 198.0 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
2.6 182.7 GO:0003777 microtubule motor activity(GO:0003777)
1.0 167.3 GO:0001047 core promoter binding(GO:0001047)
0.8 166.2 GO:0008017 microtubule binding(GO:0008017)
0.9 155.9 GO:0042393 histone binding(GO:0042393)
2.0 127.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
25.6 102.4 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
23.8 95.1 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
3.7 84.0 GO:0000400 four-way junction DNA binding(GO:0000400)
16.0 79.9 GO:0035174 histone serine kinase activity(GO:0035174)
1.7 78.0 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
12.7 76.3 GO:0010997 anaphase-promoting complex binding(GO:0010997)
11.8 70.9 GO:0050786 RAGE receptor binding(GO:0050786)
1.0 66.0 GO:0070491 repressing transcription factor binding(GO:0070491)
0.1 65.4 GO:0003677 DNA binding(GO:0003677)
1.7 60.3 GO:0050699 WW domain binding(GO:0050699)
7.5 60.1 GO:0061676 importin-alpha family protein binding(GO:0061676)
6.6 59.8 GO:0035173 histone kinase activity(GO:0035173)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
10.4 652.5 PID_PLK1_PATHWAY PLK1 signaling events
5.3 194.8 PID_AURORA_A_PATHWAY Aurora A signaling
2.7 158.0 PID_IL12_2PATHWAY IL12-mediated signaling events
2.7 120.7 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
6.5 90.6 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
1.1 80.5 PID_TELOMERASE_PATHWAY Regulation of Telomerase
1.7 73.1 PID_FANCONI_PATHWAY Fanconi anemia pathway
2.5 71.0 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
2.1 69.5 PID_AURORA_B_PATHWAY Aurora B signaling
1.0 54.5 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
1.1 51.0 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.8 42.2 PID_E2F_PATHWAY E2F transcription factor network
1.6 36.7 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.8 28.5 PID_RAS_PATHWAY Regulation of Ras family activation
0.5 28.2 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
1.7 27.9 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.5 27.1 PID_CDC42_PATHWAY CDC42 signaling events
0.6 24.8 PID_RHOA_PATHWAY RhoA signaling pathway
1.2 23.6 PID_MYC_PATHWAY C-MYC pathway
0.4 23.1 PID_AR_PATHWAY Coregulation of Androgen receptor activity

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 111 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.2 406.9 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
3.8 199.4 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
11.5 195.9 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
2.3 188.9 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
5.6 150.5 REACTOME_KINESINS Genes involved in Kinesins
7.9 126.6 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
5.5 120.1 REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A Genes involved in APC-Cdc20 mediated degradation of Nek2A
5.4 85.6 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.8 67.0 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
1.1 60.6 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
2.8 55.6 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
5.6 50.8 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
3.9 46.3 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
3.2 45.5 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.8 44.1 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.7 43.5 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.6 41.8 REACTOME_GLUCOSE_METABOLISM Genes involved in Glucose metabolism
0.6 41.5 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
3.3 39.2 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
2.4 38.9 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1