Motif ID: Yy1_Yy2

Z-value: 2.656

Transcription factors associated with Yy1_Yy2:

Gene SymbolEntrez IDGene Name
Yy1 ENSMUSG00000021264.11 Yy1
Yy2 ENSMUSG00000091736.2 Yy2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Yy2mm10_v2_chrX_-_157598642_157598655-0.572.7e-04Click!
Yy1mm10_v2_chr12_+_108792946_1087929880.076.9e-01Click!


Activity profile for motif Yy1_Yy2.

activity profile for motif Yy1_Yy2


Sorted Z-values histogram for motif Yy1_Yy2

Sorted Z-values for motif Yy1_Yy2



Network of associatons between targets according to the STRING database.



First level regulatory network of Yy1_Yy2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_-_22163299 9.944 ENSMUST00000100052.4
 Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr19_-_50030735 6.317 ENSMUST00000071866.1
 Rpl13a-ps1
ribosomal protein 13A, pseudogene 1
chr11_+_75732869 6.087 ENSMUST00000067664.3
 Ywhae
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
chr3_-_90213577 5.965 ENSMUST00000170122.2
 Rps27
ribosomal protein S27
chr17_-_23829095 5.929 ENSMUST00000069579.5
 Tceb2
transcription elongation factor B (SIII), polypeptide 2
chr11_-_63922257 5.596 ENSMUST00000094103.3
 Hs3st3b1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr19_+_25610533 5.271 ENSMUST00000048935.4
 Dmrt3
doublesex and mab-3 related transcription factor 3
chr11_+_94741782 5.199 ENSMUST00000021240.6
 Cdc34-ps
cell division cycle 34 homolog, pseudogene (S. cerevisiae)
chr9_-_97018823 5.113 ENSMUST00000055433.4
 Spsb4
splA/ryanodine receptor domain and SOCS box containing 4
chr14_-_37098211 4.905 ENSMUST00000022337.9
 Cdhr1
cadherin-related family member 1
chr5_-_53707532 4.592 ENSMUST00000031093.3
 Cckar
cholecystokinin A receptor
chr11_+_75733037 4.415 ENSMUST00000131398.1
 Ywhae
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
chr14_-_54617993 4.294 ENSMUST00000022803.4
 Psmb5
proteasome (prosome, macropain) subunit, beta type 5
chr12_+_16810940 4.236 ENSMUST00000020908.7
 E2f6
E2F transcription factor 6
chr18_+_56707725 4.168 ENSMUST00000025486.8
 Lmnb1
lamin B1
chr3_+_146121655 4.159 ENSMUST00000039450.4
 Mcoln3
mucolipin 3
chr1_-_186117251 4.113 ENSMUST00000045388.7
 Lyplal1
lysophospholipase-like 1
chr6_-_23248264 4.093 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr10_-_128549102 4.087 ENSMUST00000176906.1
 Rpl41
ribosomal protein L41
chr11_-_70654624 3.888 ENSMUST00000018437.2
 Pfn1
profilin 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 877 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 28.8 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.4 21.9 GO:0002181 cytoplasmic translation(GO:0002181)
0.5 20.3 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.9 20.0 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.3 19.9 GO:0032543 mitochondrial translation(GO:0032543)
0.2 12.6 GO:0006413 translational initiation(GO:0006413)
0.8 12.4 GO:0043248 proteasome assembly(GO:0043248)
0.1 11.9 GO:0042254 ribosome biogenesis(GO:0042254)
0.4 11.4 GO:0000027 ribosomal large subunit assembly(GO:0000027)
1.6 11.1 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
1.0 10.6 GO:0032825 positive regulation of natural killer cell differentiation(GO:0032825)
2.1 10.5 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.4 9.6 GO:0042775 mitochondrial ATP synthesis coupled electron transport(GO:0042775)
0.1 9.2 GO:0051028 mRNA transport(GO:0051028)
0.7 8.8 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.3 8.8 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.6 8.5 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.3 8.5 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 8.4 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.6 7.7 GO:0002227 innate immune response in mucosa(GO:0002227)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 355 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 54.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.7 39.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.6 28.3 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.5 27.6 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.8 27.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 25.3 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.6 19.0 GO:0015935 small ribosomal subunit(GO:0015935)
0.7 17.8 GO:0070069 cytochrome complex(GO:0070069)
0.7 16.6 GO:0005839 proteasome core complex(GO:0005839)
0.4 15.7 GO:0000786 nucleosome(GO:0000786)
0.0 14.6 GO:0005730 nucleolus(GO:0005730)
0.7 10.0 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
2.0 9.8 GO:0032133 chromosome passenger complex(GO:0032133)
0.8 9.2 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 8.8 GO:0016607 nuclear speck(GO:0016607)
0.2 8.7 GO:0008180 COP9 signalosome(GO:0008180)
0.1 8.7 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.2 8.3 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.3 8.1 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 7.7 GO:0005871 kinesin complex(GO:0005871)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 496 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 118.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.5 23.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.8 22.7 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.3 22.2 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.3 16.7 GO:0003743 translation initiation factor activity(GO:0003743)
0.7 15.9 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.4 12.7 GO:0003954 NADH dehydrogenase activity(GO:0003954)
0.5 11.8 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
1.0 11.0 GO:0050815 phosphoserine binding(GO:0050815)
0.4 10.5 GO:0003785 actin monomer binding(GO:0003785)
0.2 10.4 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.6 8.3 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.2 8.3 GO:0008536 Ran GTPase binding(GO:0008536)
0.2 8.0 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.7 7.8 GO:0019992 diacylglycerol binding(GO:0019992)
0.2 7.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.6 7.3 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.8 7.1 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.4 7.0 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.5 6.9 GO:0070513 death domain binding(GO:0070513)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 98 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 21.2 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.6 20.4 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.2 18.3 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.5 18.2 PID_AURORA_A_PATHWAY Aurora A signaling
0.3 18.2 PID_PLK1_PATHWAY PLK1 signaling events
0.2 10.9 PID_IFNG_PATHWAY IFN-gamma pathway
0.2 10.5 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 8.0 PID_E2F_PATHWAY E2F transcription factor network
0.1 7.4 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.2 7.1 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 7.1 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.2 6.9 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.2 6.8 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.3 6.6 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.2 6.6 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 6.6 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway
0.3 5.9 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.2 5.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.4 5.3 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 5.1 PID_CASPASE_PATHWAY Caspase cascade in apoptosis

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 165 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 99.5 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.9 44.8 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.6 41.0 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.7 38.5 REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.2 21.5 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 20.0 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.8 14.5 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 14.5 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.3 13.4 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.5 10.3 REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.1 10.0 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.3 9.8 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.4 9.7 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 9.6 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.2 9.3 REACTOME_S_PHASE Genes involved in S Phase
0.3 8.8 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.2 8.6 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.3 8.5 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.2 7.6 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.3 7.1 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol