Motif ID: Zbtb12

Z-value: 0.515


Transcription factors associated with Zbtb12:

Gene SymbolEntrez IDGene Name
Zbtb12 ENSMUSG00000049823.8 Zbtb12

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb12mm10_v2_chr17_+_34894515_34894573-0.546.0e-04Click!


Activity profile for motif Zbtb12.

activity profile for motif Zbtb12


Sorted Z-values histogram for motif Zbtb12

Sorted Z-values for motif Zbtb12



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb12

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_-_12027958 4.000 ENSMUST00000109654.1
Grb10
growth factor receptor bound protein 10
chr3_+_88081997 2.691 ENSMUST00000071812.5
Iqgap3
IQ motif containing GTPase activating protein 3
chr17_-_15375969 2.292 ENSMUST00000014917.7
Dll1
delta-like 1 (Drosophila)
chr3_+_5218546 2.048 ENSMUST00000026284.6
Zfhx4
zinc finger homeodomain 4
chr4_-_45489794 1.893 ENSMUST00000146236.1
Shb
src homology 2 domain-containing transforming protein B
chr3_+_5218516 1.891 ENSMUST00000175866.1
Zfhx4
zinc finger homeodomain 4
chr13_+_104229366 1.875 ENSMUST00000022227.6
Cenpk
centromere protein K
chr11_-_88718078 1.726 ENSMUST00000092794.5
Msi2
musashi RNA-binding protein 2
chr4_-_149909719 1.663 ENSMUST00000105685.1
Spsb1
splA/ryanodine receptor domain and SOCS box containing 1
chr3_+_5218589 1.421 ENSMUST00000177488.1
Zfhx4
zinc finger homeodomain 4
chr18_-_70472429 1.340 ENSMUST00000067556.3
4930503L19Rik
RIKEN cDNA 4930503L19 gene
chr8_-_45382198 1.302 ENSMUST00000093526.6
Fam149a
family with sequence similarity 149, member A
chr4_-_119173849 1.202 ENSMUST00000052715.4
ENSMUST00000179290.1
ENSMUST00000154226.1
Zfp691


zinc finger protein 691


chr7_-_25477607 1.181 ENSMUST00000098669.1
ENSMUST00000098668.1
ENSMUST00000098666.2
Ceacam1


carcinoembryonic antigen-related cell adhesion molecule 1


chr2_-_28916668 1.109 ENSMUST00000113847.1
Barhl1
BarH-like 1 (Drosophila)
chr14_+_79481164 1.066 ENSMUST00000040131.5
Elf1
E74-like factor 1
chr6_-_124814288 1.019 ENSMUST00000172132.2
Tpi1
triosephosphate isomerase 1
chr9_+_57827284 1.004 ENSMUST00000163186.1
Gm17231
predicted gene 17231
chr6_+_29398920 0.999 ENSMUST00000181464.1
ENSMUST00000180829.1
Ccdc136

coiled-coil domain containing 136

chr4_-_151057933 0.963 ENSMUST00000030797.3
Vamp3
vesicle-associated membrane protein 3
chr11_+_54902917 0.829 ENSMUST00000149324.1
Gpx3
glutathione peroxidase 3
chr14_-_79481268 0.813 ENSMUST00000022601.5
Wbp4
WW domain binding protein 4
chr15_+_82341179 0.772 ENSMUST00000050349.2
Fam109b
family with sequence similarity 109, member B
chr11_+_54902743 0.638 ENSMUST00000082430.3
Gpx3
glutathione peroxidase 3
chrX_-_140956675 0.607 ENSMUST00000033805.8
ENSMUST00000112978.1
Psmd10

proteasome (prosome, macropain) 26S subunit, non-ATPase, 10

chr2_+_31759932 0.550 ENSMUST00000028190.6
Abl1
c-abl oncogene 1, non-receptor tyrosine kinase
chr13_+_76098734 0.542 ENSMUST00000091466.3
Ttc37
tetratricopeptide repeat domain 37
chr17_+_27909337 0.526 ENSMUST00000114842.1
ENSMUST00000025058.7
ENSMUST00000088027.5
Anks1


ankyrin repeat and SAM domain containing 1


chr17_-_27909206 0.526 ENSMUST00000114848.1
Taf11
TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr2_+_31759993 0.526 ENSMUST00000124089.1
Abl1
c-abl oncogene 1, non-receptor tyrosine kinase
chr7_+_92875253 0.485 ENSMUST00000076052.6
Prcp
prolylcarboxypeptidase (angiotensinase C)
chr17_+_17831004 0.472 ENSMUST00000172097.2
4930546H06Rik
RIKEN cDNA 4930546H06 gene
chr6_+_37900477 0.465 ENSMUST00000120238.1
Trim24
tripartite motif-containing 24
chr1_+_37997975 0.424 ENSMUST00000027252.7
Eif5b
eukaryotic translation initiation factor 5B
chr3_-_131344892 0.404 ENSMUST00000090246.4
ENSMUST00000126569.1
Sgms2

sphingomyelin synthase 2

chr3_-_84155762 0.397 ENSMUST00000047368.6
Mnd1
meiotic nuclear divisions 1 homolog (S. cerevisiae)
chr12_+_105784694 0.397 ENSMUST00000109901.2
ENSMUST00000168186.1
ENSMUST00000163473.1
ENSMUST00000170540.1
ENSMUST00000166735.1
ENSMUST00000170002.1
Papola





poly (A) polymerase alpha





chr7_-_141918481 0.341 ENSMUST00000151890.1
Tollip
toll interacting protein
chr7_-_127993831 0.309 ENSMUST00000033056.3
Pycard
PYD and CARD domain containing
chr7_+_126976338 0.269 ENSMUST00000032920.3
Cdipt
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
chr8_-_69774884 0.254 ENSMUST00000137573.1
ENSMUST00000149782.1
Zfp866
Gm20422
zinc finger protein 866
predicted gene 20422
chr5_+_67260696 0.253 ENSMUST00000161233.1
ENSMUST00000160352.1
Tmem33

transmembrane protein 33

chr17_-_32189457 0.241 ENSMUST00000087721.3
ENSMUST00000162117.1
Ephx3

epoxide hydrolase 3

chr15_-_79546741 0.239 ENSMUST00000054014.7
Ddx17
DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
chr4_+_43669266 0.228 ENSMUST00000107864.1
Tmem8b
transmembrane protein 8B
chr12_-_101958148 0.227 ENSMUST00000159883.1
ENSMUST00000160251.1
ENSMUST00000161011.1
ENSMUST00000021606.5
Atxn3



ataxin 3



chr17_+_27029259 0.224 ENSMUST00000053683.6
Ggnbp1
gametogenetin binding protein 1
chr1_+_69826986 0.209 ENSMUST00000065425.5
ENSMUST00000113940.2
Spag16

sperm associated antigen 16

chr19_-_10240689 0.190 ENSMUST00000088013.5
Myrf
myelin regulatory factor
chr11_+_69991061 0.170 ENSMUST00000018711.8
Gabarap
gamma-aminobutyric acid receptor associated protein
chr10_-_86011833 0.160 ENSMUST00000105304.1
ENSMUST00000061699.5
Bpifc

BPI fold containing family C

chr19_-_6080311 0.127 ENSMUST00000159832.1
Vps51
vacuolar protein sorting 51 homolog (S. cerevisiae)
chr11_-_59228162 0.051 ENSMUST00000163300.1
ENSMUST00000061242.7
Arf1

ADP-ribosylation factor 1

chr14_+_34220028 0.050 ENSMUST00000119693.1
ENSMUST00000035351.5
Syt15

synaptotagmin XV

chr3_-_130061553 0.039 ENSMUST00000168675.1
Sec24b
Sec24 related gene family, member B (S. cerevisiae)
chr10_-_70592782 0.027 ENSMUST00000162251.1
Phyhipl
phytanoyl-CoA hydroxylase interacting protein-like
chr9_-_78481724 0.026 ENSMUST00000042235.8
Eef1a1
eukaryotic translation elongation factor 1 alpha 1
chr15_-_88954400 0.022 ENSMUST00000109371.1
Ttll8
tubulin tyrosine ligase-like family, member 8

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:0001757 somite specification(GO:0001757) arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) endothelial cell fate specification(GO:0060847) Notch signaling pathway involved in arterial endothelial cell fate commitment(GO:0060853) blood vessel endothelial cell fate specification(GO:0097101)
0.4 4.0 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.4 1.2 GO:2001187 natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.4 1.1 GO:1900275 negative regulation of phospholipase C activity(GO:1900275)
0.3 1.0 GO:0019405 alditol catabolic process(GO:0019405) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.3 2.7 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.2 1.9 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.2 0.6 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.2 0.5 GO:1901187 regulation of ephrin receptor signaling pathway(GO:1901187)
0.1 0.3 GO:0002586 positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002586) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588)
0.1 0.5 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.1 0.3 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.1 0.3 GO:1903896 positive regulation of IRE1-mediated unfolded protein response(GO:1903896)
0.1 1.0 GO:0001675 acrosome assembly(GO:0001675)
0.1 1.5 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.1 1.1 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1 0.5 GO:0002154 thyroid hormone mediated signaling pathway(GO:0002154) regulation of thyroid hormone mediated signaling pathway(GO:0002155)
0.1 1.0 GO:0035493 SNARE complex assembly(GO:0035493)
0.0 0.8 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.4 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.2 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.5 GO:0043923 positive regulation by host of viral transcription(GO:0043923)
0.0 0.2 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.0 0.2 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.0 0.2 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.0 1.1 GO:0030901 midbrain development(GO:0030901)
0.0 0.1 GO:0097212 cleavage furrow ingression(GO:0036090) lysosomal membrane organization(GO:0097212) positive regulation of ER to Golgi vesicle-mediated transport(GO:1902953)
0.0 0.3 GO:0036010 protein localization to endosome(GO:0036010)
0.0 0.8 GO:0007032 endosome organization(GO:0007032)
0.0 0.2 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 0.4 GO:0031440 regulation of mRNA 3'-end processing(GO:0031440)
0.0 0.4 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0055087 Ski complex(GO:0055087)
0.1 0.3 GO:0061702 inflammasome complex(GO:0061702)
0.1 1.2 GO:0042101 T cell receptor complex(GO:0042101)
0.1 0.5 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 1.0 GO:0002080 acrosomal membrane(GO:0002080)
0.0 0.6 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 2.7 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.1 GO:1990745 EARP complex(GO:1990745)
0.0 1.0 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.0 1.7 GO:0005844 polysome(GO:0005844)
0.0 1.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.2 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 0.5 GO:0045178 basal part of cell(GO:0045178)
0.0 0.5 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.8 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 0.2 GO:0044447 axoneme part(GO:0044447)
0.0 0.3 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.2 GO:0097225 sperm midpiece(GO:0097225)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.7 GO:0032027 myosin light chain binding(GO:0032027)
0.2 1.2 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.1 2.3 GO:0030957 Tat protein binding(GO:0030957)
0.1 5.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 1.5 GO:0008430 selenium binding(GO:0008430)
0.1 1.0 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 1.1 GO:0070097 delta-catenin binding(GO:0070097)
0.1 0.5 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 0.4 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.1 1.7 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 0.5 GO:0034056 estrogen response element binding(GO:0034056)
0.1 0.4 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.3 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.0 0.3 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 1.0 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.5 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.8 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.2 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.3 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.5 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.3 GO:0017056 structural constituent of nuclear pore(GO:0017056)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.1 4.0 PID_IGF1_PATHWAY IGF1 pathway
0.0 2.7 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 2.3 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.0 1.1 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 1.1 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.3 PID_IL1_PATHWAY IL1-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.0 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.2 2.3 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.5 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 0.3 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 1.9 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 1.1 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 1.0 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.4 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.5 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.6 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.5 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.4 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination