Motif ID: Zbtb14

Z-value: 1.384


Transcription factors associated with Zbtb14:

Gene SymbolEntrez IDGene Name
Zbtb14 ENSMUSG00000049672.8 Zbtb14

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb14mm10_v2_chr17_+_69383768_69383840-0.124.9e-01Click!


Activity profile for motif Zbtb14.

activity profile for motif Zbtb14


Sorted Z-values histogram for motif Zbtb14

Sorted Z-values for motif Zbtb14



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb14

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_7213897 11.285 ENSMUST00000020702.4
ENSMUST00000135887.2
 Igfbp3

insulin-like growth factor binding protein 3

chr11_+_7063423 7.493 ENSMUST00000020706.4
 Adcy1
adenylate cyclase 1
chr8_+_36457548 6.554 ENSMUST00000135373.1
ENSMUST00000147525.1
 6430573F11Rik

RIKEN cDNA 6430573F11 gene

chr7_+_123982799 6.550 ENSMUST00000106437.1
 Hs3st4
heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chr7_-_27396542 6.099 ENSMUST00000108363.1
 Sptbn4
spectrin beta, non-erythrocytic 4
chr14_+_33923582 5.883 ENSMUST00000168727.1
 Gdf10
growth differentiation factor 10
chr11_-_67922136 5.468 ENSMUST00000021288.3
ENSMUST00000108677.1
 Usp43

ubiquitin specific peptidase 43

chr10_+_13966268 5.270 ENSMUST00000015645.4
 Hivep2
human immunodeficiency virus type I enhancer binding protein 2
chr4_+_42917234 5.250 ENSMUST00000107976.2
ENSMUST00000069184.2
 N28178

expressed sequence N28178

chr2_-_104410334 5.246 ENSMUST00000089726.3
 D430041D05Rik
RIKEN cDNA D430041D05 gene
chr11_+_104231573 5.160 ENSMUST00000132977.1
ENSMUST00000132245.1
ENSMUST00000100347.4
 Mapt


microtubule-associated protein tau


chr11_+_104231465 5.154 ENSMUST00000145227.1
 Mapt
microtubule-associated protein tau
chr11_-_6065737 5.098 ENSMUST00000002817.5
ENSMUST00000109813.2
ENSMUST00000090443.3
 Camk2b


calcium/calmodulin-dependent protein kinase II, beta


chr11_+_104231515 5.093 ENSMUST00000106993.3
 Mapt
microtubule-associated protein tau
chr15_+_83779975 4.974 ENSMUST00000163723.1
 Mpped1
metallophosphoesterase domain containing 1
chr11_+_104231390 4.868 ENSMUST00000106992.3
 Mapt
microtubule-associated protein tau
chr15_+_83779999 4.600 ENSMUST00000046168.5
 Mpped1
metallophosphoesterase domain containing 1
chr11_-_6065538 4.582 ENSMUST00000101585.3
ENSMUST00000066431.7
ENSMUST00000109815.2
ENSMUST00000109812.2
ENSMUST00000101586.2
ENSMUST00000093355.5
ENSMUST00000019133.4
 Camk2b






calcium/calmodulin-dependent protein kinase II, beta






chr1_+_182763961 4.362 ENSMUST00000153348.1
 Susd4
sushi domain containing 4
chr1_-_136260873 4.293 ENSMUST00000086395.5
 Gpr25
G protein-coupled receptor 25

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 418 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 20.4 GO:1900034 regulation of cellular response to heat(GO:1900034)
3.1 12.3 GO:2000832 negative regulation of steroid hormone secretion(GO:2000832)
0.5 9.9 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
3.2 9.7 GO:0032430 inhibitory G-protein coupled receptor phosphorylation(GO:0002030) positive regulation of phospholipase A2 activity(GO:0032430) activation of meiosis involved in egg activation(GO:0060466)
1.4 8.7 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.3 8.3 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.5 8.0 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.6 7.3 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.2 7.1 GO:0061098 positive regulation of protein tyrosine kinase activity(GO:0061098)
0.6 6.6 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.8 5.9 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
1.9 5.7 GO:0051892 negative regulation of cardioblast differentiation(GO:0051892)
0.5 5.6 GO:0032482 Rab protein signal transduction(GO:0032482)
0.1 5.5 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.4 5.3 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.4 4.7 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
0.3 4.6 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 4.5 GO:0016579 protein deubiquitination(GO:0016579)
1.1 4.4 GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002924)
0.1 4.4 GO:0060997 dendritic spine morphogenesis(GO:0060997)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 169 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 20.3 GO:0045298 tubulin complex(GO:0045298)
0.0 18.3 GO:0005615 extracellular space(GO:0005615)
0.1 16.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 15.4 GO:0099572 postsynaptic specialization(GO:0099572)
0.1 15.3 GO:0000139 Golgi membrane(GO:0000139)
2.8 11.3 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.6 11.1 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.2 10.2 GO:0031594 neuromuscular junction(GO:0031594)
1.6 9.6 GO:0008091 spectrin(GO:0008091)
0.4 9.0 GO:0032279 asymmetric synapse(GO:0032279)
0.3 8.9 GO:0051233 spindle midzone(GO:0051233)
0.1 7.8 GO:0005769 early endosome(GO:0005769)
0.0 7.6 GO:0031965 nuclear membrane(GO:0031965)
0.1 6.4 GO:0044295 axonal growth cone(GO:0044295)
0.1 6.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 5.8 GO:0033268 node of Ranvier(GO:0033268)
0.2 5.8 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.2 5.8 GO:0032839 dendrite cytoplasm(GO:0032839)
1.1 5.7 GO:0030314 junctional membrane complex(GO:0030314)
0.4 5.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 254 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.9 20.3 GO:0099609 microtubule lateral binding(GO:0099609)
0.1 15.3 GO:0005096 GTPase activator activity(GO:0005096)
0.5 11.4 GO:0030506 ankyrin binding(GO:0030506)
2.3 11.3 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.4 11.0 GO:0043274 phospholipase binding(GO:0043274)
1.5 9.3 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.9 8.3 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.1 7.6 GO:0046875 ephrin receptor binding(GO:0046875)
1.4 7.1 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
1.1 6.6 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.6 6.3 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.1 6.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.5 5.9 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 5.7 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.1 5.2 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 5.1 GO:0008013 beta-catenin binding(GO:0008013)
0.1 5.0 GO:0005246 calcium channel regulator activity(GO:0005246)
1.0 4.9 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.1 4.8 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 4.7 GO:0004930 G-protein coupled receptor activity(GO:0004930)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 20.3 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 18.1 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.8 14.4 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.4 9.6 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 9.5 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 8.4 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 6.7 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 5.4 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 4.7 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway
0.1 4.6 PID_INSULIN_PATHWAY Insulin Pathway
0.1 4.2 ST_GA12_PATHWAY G alpha 12 Pathway
0.1 4.0 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.2 3.2 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.1 3.2 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 2.8 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.1 2.6 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.1 2.2 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 2.1 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 2.1 PID_P73PATHWAY p73 transcription factor network
0.1 1.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 92 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 20.2 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.6 14.6 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.3 12.0 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.7 11.3 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.9 11.1 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.2 7.8 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.3 6.6 REACTOME_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.3 6.5 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.3 5.9 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.4 5.3 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 4.6 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.1 4.2 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.3 4.1 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.4 4.0 REACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS Genes involved in Acetylcholine Binding And Downstream Events
0.0 3.5 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.1 3.3 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.1 3.3 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.1 3.2 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 3.2 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 2.9 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)