Motif ID: Zbtb16

Z-value: 1.475


Transcription factors associated with Zbtb16:

Gene SymbolEntrez IDGene Name
Zbtb16 ENSMUSG00000066687.4 Zbtb16

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb16mm10_v2_chr9_-_48835932_48835962-0.271.0e-01Click!


Activity profile for motif Zbtb16.

activity profile for motif Zbtb16


Sorted Z-values histogram for motif Zbtb16

Sorted Z-values for motif Zbtb16



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb16

PNG image of the network

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Top targets:


Showing 1 to 20 of 186 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_44300876 14.325 ENSMUST00000045607.5
 Melk
maternal embryonic leucine zipper kinase
chr4_-_117178726 14.250 ENSMUST00000153953.1
ENSMUST00000106436.1
 Kif2c

kinesin family member 2C

chrY_+_90785442 10.879 ENSMUST00000177591.1
ENSMUST00000177671.1
ENSMUST00000179077.1
 Erdr1


erythroid differentiation regulator 1


chr11_+_69045640 10.291 ENSMUST00000108666.1
ENSMUST00000021277.5
 Aurkb

aurora kinase B

chrX_+_170010744 9.402 ENSMUST00000178789.1
 Gm21887
predicted gene, 21887
chr7_-_115846080 8.733 ENSMUST00000166207.1
 Sox6
SRY-box containing gene 6
chr19_-_30175414 8.646 ENSMUST00000025778.7
 Gldc
glycine decarboxylase
chr14_-_65833963 8.460 ENSMUST00000022613.9
 Esco2
establishment of cohesion 1 homolog 2 (S. cerevisiae)
chr6_+_137754529 6.940 ENSMUST00000087675.6
 Dera
2-deoxyribose-5-phosphate aldolase homolog (C. elegans)
chr4_-_19570073 5.832 ENSMUST00000029885.4
 Cpne3
copine III
chr4_+_80910646 5.782 ENSMUST00000055922.3
 Lurap1l
leucine rich adaptor protein 1-like
chr1_+_107511416 5.537 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr1_+_107511489 5.437 ENSMUST00000064916.2
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr11_+_23665615 5.300 ENSMUST00000109525.1
ENSMUST00000020520.4
 Pus10

pseudouridylate synthase 10

chr11_+_101627942 5.096 ENSMUST00000010506.3
 Rdm1
RAD52 motif 1
chr9_-_79977782 4.321 ENSMUST00000093811.4
 Filip1
filamin A interacting protein 1
chr5_+_92925400 4.175 ENSMUST00000172706.1
 Shroom3
shroom family member 3
chr1_+_74391479 3.903 ENSMUST00000027367.7
 Ctdsp1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chrX_-_7188713 3.845 ENSMUST00000004428.7
 Clcn5
chloride channel 5
chr2_-_170131156 3.616 ENSMUST00000063710.6
 Zfp217
zinc finger protein 217

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 98 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 14.9 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631)
2.8 14.2 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.2 12.6 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.1 11.0 GO:0010466 negative regulation of peptidase activity(GO:0010466)
3.4 10.3 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.8 8.7 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
2.9 8.6 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
1.7 8.5 GO:0034421 post-translational protein acetylation(GO:0034421)
0.3 8.2 GO:0010960 magnesium ion homeostasis(GO:0010960)
1.7 6.9 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
1.5 5.8 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.1 5.6 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.5 5.3 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.2 4.9 GO:0070207 protein homotrimerization(GO:0070207)
0.1 4.2 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
0.1 3.9 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.1 3.8 GO:1902476 chloride transmembrane transport(GO:1902476)
0.1 3.6 GO:0007569 cell aging(GO:0007569)
1.1 3.3 GO:0019343 cysteine biosynthetic process via cystathionine(GO:0019343) cysteine biosynthetic process(GO:0019344)
0.1 3.2 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 15.9 GO:0005938 cell cortex(GO:0005938)
0.4 14.2 GO:0035371 microtubule plus-end(GO:0035371)
0.0 12.1 GO:0005615 extracellular space(GO:0005615)
2.1 10.3 GO:0032133 chromosome passenger complex(GO:0032133)
0.1 8.8 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 8.7 GO:0015629 actin cytoskeleton(GO:0015629)
0.7 8.5 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.1 7.8 GO:1990204 oxidoreductase complex(GO:1990204)
0.0 6.9 GO:0005667 transcription factor complex(GO:0005667)
1.2 4.9 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 4.2 GO:0043296 apical junction complex(GO:0043296)
0.0 3.6 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 3.3 GO:0017119 Golgi transport complex(GO:0017119)
0.0 3.2 GO:0005643 nuclear pore(GO:0005643)
0.3 2.5 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.0 2.3 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.4 2.2 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.3 2.0 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0 2.0 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 2.0 GO:0016605 PML body(GO:0016605)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 14.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 14.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3 12.9 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.2 11.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 10.8 GO:1990782 protein tyrosine kinase binding(GO:1990782)
2.1 10.3 GO:0035174 histone serine kinase activity(GO:0035174)
0.7 8.8 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.5 8.6 GO:0016594 glycine binding(GO:0016594)
1.4 8.5 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
1.0 8.2 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.3 5.3 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.2 4.6 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 4.6 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.4 3.9 GO:0008420 CTD phosphatase activity(GO:0008420)
0.2 3.8 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.4 3.3 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.2 3.0 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1 2.6 GO:0017160 Ral GTPase binding(GO:0017160)
0.5 2.5 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.0 2.5 GO:0030551 cyclic nucleotide binding(GO:0030551)

Gene overrepresentation in C2:CP category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 24.5 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 11.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 7.1 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.2 4.9 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 4.6 PID_E2F_PATHWAY E2F transcription factor network
0.1 3.0 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 2.0 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 2.0 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 1.9 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.0 1.5 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.4 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 1.3 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 1.2 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.2 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.0 PID_BARD1_PATHWAY BARD1 signaling events
0.0 0.8 PID_FAS_PATHWAY FAS (CD95) signaling pathway
0.0 0.8 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.8 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.4 ST_P38_MAPK_PATHWAY p38 MAPK Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 14.2 REACTOME_KINESINS Genes involved in Kinesins
0.1 9.8 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0 9.6 REACTOME_HEMOSTASIS Genes involved in Hemostasis
0.8 4.9 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 4.0 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 3.3 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 2.4 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 2.2 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.2 2.0 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.1 2.0 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 1.9 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 1.8 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.6 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.3 1.5 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.1 1.5 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.1 1.5 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 1.4 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 1.3 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.2 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 1.2 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway