Motif ID: Zbtb3

Z-value: 0.396


Transcription factors associated with Zbtb3:

Gene SymbolEntrez IDGene Name
Zbtb3 ENSMUSG00000071661.6 Zbtb3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb3mm10_v2_chr19_+_8802486_8802530-0.029.0e-01Click!


Activity profile for motif Zbtb3.

activity profile for motif Zbtb3


Sorted Z-values histogram for motif Zbtb3

Sorted Z-values for motif Zbtb3



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb3

PNG image of the network

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Top targets:


Showing 1 to 20 of 130 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_97018823 1.515 ENSMUST00000055433.4
 Spsb4
splA/ryanodine receptor domain and SOCS box containing 4
chr2_-_172043466 1.336 ENSMUST00000087950.3
 Cbln4
cerebellin 4 precursor protein
chr15_+_98167806 0.931 ENSMUST00000031914.4
 AI836003
expressed sequence AI836003
chr15_-_66969616 0.819 ENSMUST00000170903.1
ENSMUST00000166420.1
ENSMUST00000005256.6
ENSMUST00000164070.1
 Ndrg1



N-myc downstream regulated gene 1



chr15_-_67113909 0.800 ENSMUST00000092640.5
 St3gal1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr19_-_58455903 0.762 ENSMUST00000131877.1
 Gfra1
glial cell line derived neurotrophic factor family receptor alpha 1
chr7_-_103843154 0.725 ENSMUST00000063957.4
 Hbb-bh1
hemoglobin Z, beta-like embryonic chain
chr5_+_115908644 0.614 ENSMUST00000141101.1
 Cit
citron
chr8_+_10272572 0.514 ENSMUST00000042103.8
 Myo16
myosin XVI
chr4_-_44167988 0.494 ENSMUST00000143337.1
 Rnf38
ring finger protein 38
chr15_+_76797628 0.475 ENSMUST00000165535.2
 Gm17271
predicted gene, 17271
chr11_+_6561133 0.437 ENSMUST00000160633.1
 Ccm2
cerebral cavernous malformation 2
chr14_-_19977040 0.433 ENSMUST00000159028.1
 Gng2
guanine nucleotide binding protein (G protein), gamma 2
chr14_-_19977151 0.416 ENSMUST00000055100.7
ENSMUST00000162425.1
 Gng2

guanine nucleotide binding protein (G protein), gamma 2

chr8_+_83715177 0.404 ENSMUST00000019576.8
 Ddx39
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39
chr10_+_82954344 0.387 ENSMUST00000095396.3
 Gm4799
predicted gene 4799
chr8_+_83715504 0.386 ENSMUST00000109810.1
 Ddx39
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39
chr2_+_80617045 0.379 ENSMUST00000028384.4
 Dusp19
dual specificity phosphatase 19
chr7_+_19024387 0.378 ENSMUST00000153976.1
 Sympk
symplekin
chr14_-_104467984 0.373 ENSMUST00000053016.8
 Pou4f1
POU domain, class 4, transcription factor 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.1 GO:0006406 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.1 0.8 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.0 0.8 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.1 0.7 GO:0015671 oxygen transport(GO:0015671)
0.1 0.7 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.1 0.7 GO:0060837 blood vessel endothelial cell differentiation(GO:0060837)
0.0 0.7 GO:0006378 mRNA polyadenylation(GO:0006378)
0.0 0.6 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.1 0.4 GO:0019230 proprioception(GO:0019230)
0.0 0.4 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.4 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.1 0.3 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.1 0.3 GO:0006106 fumarate metabolic process(GO:0006106) aspartate biosynthetic process(GO:0006532) aspartate catabolic process(GO:0006533)
0.1 0.3 GO:1904529 regulation of actin filament binding(GO:1904529) regulation of actin binding(GO:1904616)
0.0 0.3 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.0 0.3 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.3 GO:0030953 astral microtubule organization(GO:0030953)
0.1 0.2 GO:0090202 transcriptional activation by promoter-enhancer looping(GO:0071733) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
0.0 0.2 GO:0010636 positive regulation of mitochondrial fusion(GO:0010636)
0.0 0.2 GO:1901526 positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925)

Gene overrepresentation in cellular_component category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.8 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 0.7 GO:0005833 hemoglobin complex(GO:0005833)
0.1 0.7 GO:0097165 nuclear stress granule(GO:0097165)
0.0 0.7 GO:0030286 dynein complex(GO:0030286)
0.0 0.6 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.2 GO:0097255 R2TP complex(GO:0097255)
0.0 0.2 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.1 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 0.1 GO:0033503 HULC complex(GO:0033503)
0.0 0.1 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 0.1 GO:0030126 COPI vesicle coat(GO:0030126)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.0 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 1.0 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.2 0.8 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.8 GO:0043015 gamma-tubulin binding(GO:0043015)
0.2 0.7 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.0 0.7 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.1 0.5 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.1 0.4 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.4 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 0.3 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.1 0.3 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.3 GO:0031005 filamin binding(GO:0031005)
0.0 0.2 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0 0.2 GO:0043532 angiostatin binding(GO:0043532)
0.0 0.2 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.2 GO:0008556 sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556)
0.0 0.2 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 0.2 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.1 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.1 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.0 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 0.8 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.8 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.7 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 0.6 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 0.5 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.2 PID_S1P_S1P4_PATHWAY S1P4 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.1 0.8 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.8 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 0.4 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.4 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.4 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.3 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.2 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.0 0.2 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.1 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.1 REACTOME_ACETYLCHOLINE_BINDING_AND_DOWNSTREAM_EVENTS Genes involved in Acetylcholine Binding And Downstream Events