Motif ID: Zbtb33_Chd2

Z-value: 2.498

Transcription factors associated with Zbtb33_Chd2:

Gene SymbolEntrez IDGene Name
Chd2 ENSMUSG00000078671.4 Chd2
Zbtb33 ENSMUSG00000048047.3 Zbtb33

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb33mm10_v2_chrX_+_38189780_381898260.841.1e-10Click!
Chd2mm10_v2_chr7_-_73541738_735417580.794.9e-09Click!


Activity profile for motif Zbtb33_Chd2.

activity profile for motif Zbtb33_Chd2


Sorted Z-values histogram for motif Zbtb33_Chd2

Sorted Z-values for motif Zbtb33_Chd2



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb33_Chd2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_34833631 16.751 ENSMUST00000093191.2
 Spdl1
spindle apparatus coiled-coil protein 1
chr11_-_90638062 15.550 ENSMUST00000020858.7
ENSMUST00000107875.1
ENSMUST00000107872.1
ENSMUST00000143203.1
 Stxbp4



syntaxin binding protein 4



chr5_+_45669907 13.697 ENSMUST00000117396.1
 Ncapg
non-SMC condensin I complex, subunit G
chr4_-_118437331 9.916 ENSMUST00000006565.6
 Cdc20
cell division cycle 20
chr3_+_69004969 9.873 ENSMUST00000136502.1
ENSMUST00000107803.1
 Smc4

structural maintenance of chromosomes 4

chr3_+_69004711 9.706 ENSMUST00000042901.8
 Smc4
structural maintenance of chromosomes 4
chr9_-_72491939 9.637 ENSMUST00000185151.1
ENSMUST00000085358.5
ENSMUST00000184125.1
ENSMUST00000183574.1
ENSMUST00000184831.1
 Tex9




testis expressed gene 9




chr16_+_48994185 9.440 ENSMUST00000117994.1
ENSMUST00000048374.5
 C330027C09Rik

RIKEN cDNA C330027C09 gene

chr19_+_38931008 9.237 ENSMUST00000145051.1
 Hells
helicase, lymphoid specific
chr9_+_121719172 8.953 ENSMUST00000035112.6
ENSMUST00000182311.1
 Nktr

natural killer tumor recognition sequence

chr15_+_99074968 8.713 ENSMUST00000039665.6
 Troap
trophinin associated protein
chr11_+_29172890 8.603 ENSMUST00000102856.2
ENSMUST00000020755.5
 Smek2

SMEK homolog 2, suppressor of mek1 (Dictyostelium)

chr9_+_54863742 8.126 ENSMUST00000034843.7
 Ireb2
iron responsive element binding protein 2
chr19_+_38930909 8.087 ENSMUST00000025965.5
 Hells
helicase, lymphoid specific
chr4_+_24496434 8.049 ENSMUST00000108222.2
ENSMUST00000138567.2
ENSMUST00000050446.6
 Mms22l


MMS22-like, DNA repair protein


chr9_+_121719403 7.974 ENSMUST00000182225.1
 Nktr
natural killer tumor recognition sequence
chr11_+_98203059 7.898 ENSMUST00000107539.1
 Cdk12
cyclin-dependent kinase 12
chr2_-_156180135 7.306 ENSMUST00000126992.1
ENSMUST00000146288.1
ENSMUST00000029149.6
ENSMUST00000109587.2
ENSMUST00000109584.1
 Rbm39




RNA binding motif protein 39




chr14_-_57826128 7.097 ENSMUST00000022536.2
 Ska3
spindle and kinetochore associated complex subunit 3
chr17_+_45433823 6.926 ENSMUST00000181149.1
 B230354K17Rik
RIKEN cDNA B230354K17 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 188 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 20.9 GO:0071459 protein localization to chromosome, centromeric region(GO:0071459)
2.4 19.6 GO:0010032 meiotic chromosome condensation(GO:0010032)
2.5 17.3 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.6 16.9 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
1.5 16.3 GO:0031145 anaphase-promoting complex-dependent catabolic process(GO:0031145)
0.2 15.7 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
3.9 15.5 GO:0010838 positive regulation of keratinocyte proliferation(GO:0010838)
1.2 12.9 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
1.2 10.8 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.6 10.4 GO:0030953 astral microtubule organization(GO:0030953)
0.3 10.1 GO:0045005 DNA-dependent DNA replication maintenance of fidelity(GO:0045005)
0.1 9.1 GO:2000179 positive regulation of neural precursor cell proliferation(GO:2000179)
0.5 9.0 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
2.9 8.7 GO:0072554 arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) endothelial cell fate specification(GO:0060847) Notch signaling pathway involved in arterial endothelial cell fate commitment(GO:0060853) blood vessel lumenization(GO:0072554) blood vessel endothelial cell fate specification(GO:0097101) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) positive regulation of heart induction(GO:1901321) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066)
0.2 8.7 GO:0035329 hippo signaling(GO:0035329)
2.7 8.1 GO:0090649 response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)
0.1 7.1 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.0 7.1 GO:0006470 protein dephosphorylation(GO:0006470)
1.2 6.9 GO:0016584 nucleosome positioning(GO:0016584)
1.0 6.8 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 108 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.9 39.4 GO:0000796 condensin complex(GO:0000796)
1.8 23.8 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.7 19.1 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 13.3 GO:0005815 microtubule organizing center(GO:0005815)
0.4 12.8 GO:0030992 intraciliary transport particle B(GO:0030992)
0.5 11.4 GO:0005680 anaphase-promoting complex(GO:0005680)
1.7 8.7 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
2.7 8.0 GO:0035101 FACT complex(GO:0035101)
2.6 7.9 GO:0002944 cyclin K-CDK12 complex(GO:0002944)
0.0 6.7 GO:0030424 axon(GO:0030424)
0.6 6.4 GO:0016589 NURF complex(GO:0016589)
0.4 6.3 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 6.3 GO:0000786 nucleosome(GO:0000786)
0.0 6.1 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.2 5.9 GO:0034451 centriolar satellite(GO:0034451)
0.2 5.5 GO:0005685 U1 snRNP(GO:0005685)
0.1 5.2 GO:0005643 nuclear pore(GO:0005643)
0.7 4.9 GO:0005827 polar microtubule(GO:0005827)
0.1 4.8 GO:0031941 filamentous actin(GO:0031941)
1.1 4.5 GO:0000939 condensed chromosome inner kinetochore(GO:0000939)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 124 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 23.9 GO:0004386 helicase activity(GO:0004386)
0.2 21.0 GO:0003697 single-stranded DNA binding(GO:0003697)
0.4 16.9 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
3.4 16.8 GO:0043515 kinetochore binding(GO:0043515)
0.2 16.0 GO:0019905 syntaxin binding(GO:0019905)
0.2 15.1 GO:0031491 nucleosome binding(GO:0031491)
0.1 13.8 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 13.2 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
1.7 9.9 GO:0010997 anaphase-promoting complex binding(GO:0010997)
1.3 9.3 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.2 8.7 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
2.7 8.1 GO:0030350 iron-responsive element binding(GO:0030350)
0.4 7.9 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 7.4 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.2 7.3 GO:0043014 alpha-tubulin binding(GO:0043014)
0.8 6.5 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.1 6.4 GO:0008565 protein transporter activity(GO:0008565)
0.2 6.1 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.3 5.9 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 5.9 GO:0045296 cadherin binding(GO:0045296)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 40.2 PID_AURORA_B_PATHWAY Aurora B signaling
0.7 34.4 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.3 12.8 PID_PLK1_PATHWAY PLK1 signaling events
0.1 11.9 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.2 10.3 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.3 9.9 PID_AURORA_A_PATHWAY Aurora A signaling
0.3 8.8 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.1 8.2 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 4.4 PID_VEGFR1_PATHWAY VEGFR1 specific signals
0.2 3.6 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 3.0 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 3.0 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 2.7 PID_CXCR4_PATHWAY CXCR4-mediated signaling events
0.0 2.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 1.9 PID_BARD1_PATHWAY BARD1 signaling events
0.1 1.7 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 1.7 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.6 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.1 1.3 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 1.2 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 18.5 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.6 11.4 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 10.6 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.5 8.7 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.3 8.7 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 5.4 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.2 5.0 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 5.0 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 4.7 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 3.8 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.1 3.5 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1 3.5 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 3.4 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 3.2 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.1 3.1 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 3.1 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.3 3.0 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.2 2.9 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.1 2.7 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 2.7 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation