Motif ID: Zbtb6

Z-value: 0.815


Transcription factors associated with Zbtb6:

Gene SymbolEntrez IDGene Name
Zbtb6 ENSMUSG00000066798.3 Zbtb6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb6mm10_v2_chr2_-_37430835_374309190.221.9e-01Click!


Activity profile for motif Zbtb6.

activity profile for motif Zbtb6


Sorted Z-values histogram for motif Zbtb6

Sorted Z-values for motif Zbtb6



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb6

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_102897123 5.433 ENSMUST00000067444.3
 Gfap
glial fibrillary acidic protein
chr3_+_54156039 3.926 ENSMUST00000029311.6
 Trpc4
transient receptor potential cation channel, subfamily C, member 4
chr15_+_103503261 3.738 ENSMUST00000023132.3
 Pde1b
phosphodiesterase 1B, Ca2+-calmodulin dependent
chr6_+_114131229 3.643 ENSMUST00000032451.7
 Slc6a11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr11_-_102897146 3.205 ENSMUST00000077902.4
 Gfap
glial fibrillary acidic protein
chr6_+_124997062 2.324 ENSMUST00000159391.1
 Pianp
PILR alpha associated neural protein
chr8_+_25518783 2.274 ENSMUST00000084027.5
ENSMUST00000117179.2
 Fgfr1

fibroblast growth factor receptor 1

chr11_+_101246960 2.222 ENSMUST00000107282.3
 Ramp2
receptor (calcitonin) activity modifying protein 2
chr8_+_25518757 2.222 ENSMUST00000178276.1
ENSMUST00000179592.1
 Fgfr1

fibroblast growth factor receptor 1

chr7_-_4789541 2.165 ENSMUST00000168578.1
 Tmem238
transmembrane protein 238
chr11_+_101246405 1.987 ENSMUST00000122006.1
ENSMUST00000151830.1
 Ramp2

receptor (calcitonin) activity modifying protein 2

chr9_+_23223076 1.868 ENSMUST00000071982.5
 Bmper
BMP-binding endothelial regulator
chr6_+_124996681 1.847 ENSMUST00000032479.4
 Pianp
PILR alpha associated neural protein
chr1_+_75549581 1.725 ENSMUST00000154101.1
 Slc4a3
solute carrier family 4 (anion exchanger), member 3
chr19_+_46003468 1.698 ENSMUST00000099393.2
 Hps6
Hermansky-Pudlak syndrome 6
chr16_-_26371828 1.684 ENSMUST00000023154.2
 Cldn1
claudin 1
chr11_-_42182924 1.507 ENSMUST00000020707.5
ENSMUST00000132971.1
 Gabra1

gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1

chr4_+_107802277 1.398 ENSMUST00000106733.2
ENSMUST00000030356.3
ENSMUST00000106732.2
ENSMUST00000126573.1
 Lrp8



low density lipoprotein receptor-related protein 8, apolipoprotein e receptor



chr11_-_102946688 1.394 ENSMUST00000057849.5
 C1ql1
complement component 1, q subcomponent-like 1
chr8_-_70439557 1.317 ENSMUST00000076615.5
 Crtc1
CREB regulated transcription coactivator 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 8.6 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
1.5 4.5 GO:0021837 motogenic signaling involved in postnatal olfactory bulb interneuron migration(GO:0021837) positive regulation of mitotic cell cycle DNA replication(GO:1903465)
0.7 4.2 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.1 4.2 GO:0051453 regulation of intracellular pH(GO:0051453)
0.2 3.9 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.5 3.7 GO:0036006 response to macrophage colony-stimulating factor(GO:0036005) cellular response to macrophage colony-stimulating factor stimulus(GO:0036006)
0.0 3.6 GO:0006836 neurotransmitter transport(GO:0006836)
0.0 2.9 GO:0007416 synapse assembly(GO:0007416)
0.2 2.6 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.8 2.3 GO:0006601 creatine biosynthetic process(GO:0006601)
0.5 2.0 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.2 1.9 GO:0042118 endothelial cell activation(GO:0042118)
0.1 1.8 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.6 1.7 GO:1903348 positive regulation of bicellular tight junction assembly(GO:1903348)
0.1 1.7 GO:0030318 melanocyte differentiation(GO:0030318)
0.2 1.5 GO:0071420 cellular response to histamine(GO:0071420)
0.3 1.4 GO:0061743 motor learning(GO:0061743)
0.2 1.4 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.2 1.4 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
0.4 1.3 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 8.6 GO:0097450 astrocyte end-foot(GO:0097450)
0.0 7.9 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 6.9 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 6.0 GO:0043235 receptor complex(GO:0043235)
0.1 5.0 GO:0034704 calcium channel complex(GO:0034704)
0.8 4.2 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.2 2.7 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 2.7 GO:0043209 myelin sheath(GO:0043209)
0.0 2.0 GO:0045177 apical part of cell(GO:0045177)
0.1 1.9 GO:0030665 clathrin-coated vesicle membrane(GO:0030665)
0.4 1.7 GO:0031084 BLOC-2 complex(GO:0031084)
0.0 1.6 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 1.5 GO:1902711 GABA-A receptor complex(GO:1902711)
0.3 1.4 GO:0044301 climbing fiber(GO:0044301)
0.2 0.9 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.2 0.8 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.8 GO:0099738 cell cortex region(GO:0099738)
0.1 0.7 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.1 0.6 GO:1990393 3M complex(GO:1990393)
0.1 0.6 GO:0016272 prefoldin complex(GO:0016272)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.5 4.5 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.8 4.2 GO:0097643 amylin receptor activity(GO:0097643)
0.2 4.2 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.3 3.9 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.5 3.7 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
1.2 3.6 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.2 2.7 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 1.9 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.2 1.8 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 1.7 GO:0001618 virus receptor activity(GO:0001618)
0.1 1.7 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.3 1.5 GO:1904315 GABA-gated chloride ion channel activity(GO:0022851) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.3 1.4 GO:0038025 reelin receptor activity(GO:0038025)
0.1 1.4 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 1.3 GO:0008227 G-protein coupled amine receptor activity(GO:0008227)
0.0 1.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 1.2 GO:0015377 cation:chloride symporter activity(GO:0015377)
0.0 1.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.3 1.1 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)

Gene overrepresentation in C2:CP category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.2 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 1.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.7 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 1.4 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 1.4 PID_REELIN_PATHWAY Reelin signaling pathway
0.1 1.1 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 1.1 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 0.9 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.9 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.9 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.5 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.5 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.4 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.3 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.6 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.1 6.4 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.4 4.5 REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.2 4.2 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.4 4.1 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.4 3.9 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 3.8 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.0 1.9 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 1.7 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 1.5 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 1.4 REACTOME_PLATELET_SENSITIZATION_BY_LDL Genes involved in Platelet sensitization by LDL
0.1 1.3 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 1.1 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.0 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.1 0.9 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.9 REACTOME_AMYLOIDS Genes involved in Amyloids
0.1 0.8 REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.1 0.8 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.8 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 0.8 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling