Motif ID: Zbtb7b

Z-value: 0.955


Transcription factors associated with Zbtb7b:

Gene SymbolEntrez IDGene Name
Zbtb7b ENSMUSG00000028042.9 Zbtb7b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb7bmm10_v2_chr3_-_89393294_893933780.343.9e-02Click!


Activity profile for motif Zbtb7b.

activity profile for motif Zbtb7b


Sorted Z-values histogram for motif Zbtb7b

Sorted Z-values for motif Zbtb7b



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb7b

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_32244632 5.797 ENSMUST00000181536.1
 0610007N19Rik
RIKEN cDNA 0610007N19
chr8_-_105471481 5.686 ENSMUST00000014990.6
 Tppp3
tubulin polymerization-promoting protein family member 3
chr7_+_51879041 5.484 ENSMUST00000107591.2
 Gas2
growth arrest specific 2
chr7_+_51878967 5.374 ENSMUST00000051912.6
 Gas2
growth arrest specific 2
chr1_-_119053339 5.042 ENSMUST00000161301.1
ENSMUST00000161451.1
ENSMUST00000162607.1
 Gli2


GLI-Kruppel family member GLI2


chr9_-_91365778 4.869 ENSMUST00000065360.3
 Zic1
zinc finger protein of the cerebellum 1
chr2_-_117342949 3.665 ENSMUST00000102534.4
 Rasgrp1
RAS guanyl releasing protein 1
chr2_-_117342709 3.546 ENSMUST00000173541.1
ENSMUST00000172901.1
ENSMUST00000173252.1
 Rasgrp1


RAS guanyl releasing protein 1


chr5_+_139543889 3.480 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr2_-_117342831 3.272 ENSMUST00000178884.1
 Rasgrp1
RAS guanyl releasing protein 1
chr3_+_90541146 3.082 ENSMUST00000107333.1
ENSMUST00000107331.1
ENSMUST00000098910.2
 S100a16


S100 calcium binding protein A16


chr19_+_55742242 3.038 ENSMUST00000111652.1
ENSMUST00000111649.1
ENSMUST00000111651.1
ENSMUST00000111653.1
ENSMUST00000111656.1
ENSMUST00000127233.1
ENSMUST00000153888.1
 Tcf7l2






transcription factor 7 like 2, T cell specific, HMG box






chr14_-_62456286 2.993 ENSMUST00000165651.1
ENSMUST00000022501.3
 Gucy1b2

guanylate cyclase 1, soluble, beta 2

chr7_-_4752972 2.966 ENSMUST00000183971.1
ENSMUST00000182173.1
ENSMUST00000182738.1
ENSMUST00000184143.1
ENSMUST00000182111.1
ENSMUST00000182048.1
ENSMUST00000063324.7
 Cox6b2






cytochrome c oxidase subunit VIb polypeptide 2






chr3_+_34649987 2.952 ENSMUST00000099151.2
 Sox2
SRY-box containing gene 2
chr2_+_102658640 2.816 ENSMUST00000080210.3
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr11_-_98053415 2.682 ENSMUST00000017544.2
 Stac2
SH3 and cysteine rich domain 2
chr7_-_101837776 2.530 ENSMUST00000165052.1
 Inppl1
inositol polyphosphate phosphatase-like 1
chr14_+_55854115 2.414 ENSMUST00000168479.1
 Nynrin
NYN domain and retroviral integrase containing
chr17_-_28350747 2.369 ENSMUST00000080572.7
ENSMUST00000156862.1
 Tead3

TEA domain family member 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 10.5 GO:1902715 positive regulation of interferon-gamma secretion(GO:1902715)
0.1 8.4 GO:0007050 cell cycle arrest(GO:0007050)
0.1 5.7 GO:0046785 microtubule polymerization(GO:0046785)
1.3 5.0 GO:0060032 notochord regression(GO:0060032)
0.1 4.9 GO:0007628 adult walking behavior(GO:0007628)
0.3 4.5 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.5 3.5 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 3.5 GO:0051592 response to calcium ion(GO:0051592)
0.9 3.4 GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.4 3.0 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.4 3.0 GO:0048625 myoblast fate commitment(GO:0048625)
0.1 3.0 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.4 2.8 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.4 2.5 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.3 2.4 GO:0015074 DNA integration(GO:0015074)
0.2 2.4 GO:0051451 myoblast migration(GO:0051451)
0.1 2.4 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.1 2.3 GO:0051973 positive regulation of telomerase activity(GO:0051973)
0.0 2.2 GO:0051028 mRNA transport(GO:0051028)
0.5 2.0 GO:0003357 noradrenergic neuron differentiation(GO:0003357)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.6 GO:0005667 transcription factor complex(GO:0005667)
0.6 5.7 GO:0097427 microtubule bundle(GO:0097427)
0.4 5.0 GO:0097542 ciliary tip(GO:0097542)
0.7 3.4 GO:0035189 Rb-E2F complex(GO:0035189)
0.3 3.0 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.2 3.0 GO:0030061 mitochondrial crista(GO:0030061)
0.2 3.0 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 2.8 GO:0030673 axolemma(GO:0030673)
0.3 2.4 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0 2.4 GO:0005871 kinesin complex(GO:0005871)
0.0 2.1 GO:0030027 lamellipodium(GO:0030027)
0.2 1.9 GO:0042587 glycogen granule(GO:0042587)
0.0 1.9 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 1.8 GO:0016235 aggresome(GO:0016235)
0.1 1.5 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 1.4 GO:0051233 spindle midzone(GO:0051233)
0.1 1.2 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 1.1 GO:0005901 caveola(GO:0005901)
0.0 1.0 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.2 0.9 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 12.8 GO:0008017 microtubule binding(GO:0008017)
1.0 10.5 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 6.2 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 5.0 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 4.7 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.0 4.3 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 4.1 GO:0015631 tubulin binding(GO:0015631)
0.0 3.2 GO:0001047 core promoter binding(GO:0001047)
0.2 3.0 GO:0004383 guanylate cyclase activity(GO:0004383)
0.2 3.0 GO:0035198 miRNA binding(GO:0035198)
0.1 3.0 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 3.0 GO:0003924 GTPase activity(GO:0003924)
0.5 2.8 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.3 2.5 GO:0004445 inositol-polyphosphate 5-phosphatase activity(GO:0004445) inositol trisphosphate phosphatase activity(GO:0046030)
0.2 2.4 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.0 2.4 GO:0019208 phosphatase regulator activity(GO:0019208)
0.0 2.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.5 2.0 GO:0008142 oxysterol binding(GO:0008142)
0.1 2.0 GO:0005109 frizzled binding(GO:0005109)
0.0 2.0 GO:0030332 cyclin binding(GO:0030332)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.7 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.2 10.5 PID_RAS_PATHWAY Regulation of Ras family activation
0.2 5.0 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.2 3.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 3.4 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 3.3 PID_PLK1_PATHWAY PLK1 signaling events
0.1 3.1 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.1 3.1 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 3.1 PID_E2F_PATHWAY E2F transcription factor network
0.0 3.1 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 2.9 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 2.5 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 2.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.6 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 1.4 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.9 NABA_COLLAGENS Genes encoding collagen proteins
0.0 0.7 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway
0.0 0.5 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.4 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.2 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 10.9 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.3 9.6 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.4 4.8 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.1 4.5 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2 3.1 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN Genes involved in Signalling to p38 via RIT and RIN
0.1 2.8 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.1 2.8 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 2.5 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.1 2.4 REACTOME_KINESINS Genes involved in Kinesins
0.2 2.0 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 2.0 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 1.5 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 0.9 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.9 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 0.7 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.6 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.6 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.5 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.3 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.3 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction