Motif ID: Zbtb7c

Z-value: 0.613


Transcription factors associated with Zbtb7c:

Gene SymbolEntrez IDGene Name
Zbtb7c ENSMUSG00000044646.8 Zbtb7c

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb7cmm10_v2_chr18_+_75820174_75820210-0.212.1e-01Click!


Activity profile for motif Zbtb7c.

activity profile for motif Zbtb7c


Sorted Z-values histogram for motif Zbtb7c

Sorted Z-values for motif Zbtb7c



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb7c

PNG image of the network

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Top targets:


Showing 1 to 20 of 140 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_32938955 3.194 ENSMUST00000042868.4
 Camk4
calcium/calmodulin-dependent protein kinase IV
chr6_+_51432678 2.645 ENSMUST00000160133.1
 Nfe2l3
nuclear factor, erythroid derived 2, like 3
chr16_+_11984581 2.339 ENSMUST00000170672.2
ENSMUST00000023138.7
 Shisa9

shisa homolog 9 (Xenopus laevis)

chr11_-_26210553 2.041 ENSMUST00000101447.3
 5730522E02Rik
RIKEN cDNA 5730522E02 gene
chr8_+_40862379 1.927 ENSMUST00000098816.3
ENSMUST00000057784.8
ENSMUST00000141505.1
 Slc7a2


solute carrier family 7 (cationic amino acid transporter, y+ system), member 2


chr1_-_21961581 1.904 ENSMUST00000029667.6
ENSMUST00000173058.1
ENSMUST00000173404.1
 Kcnq5


potassium voltage-gated channel, subfamily Q, member 5


chr6_+_51432663 1.705 ENSMUST00000005103.5
 Nfe2l3
nuclear factor, erythroid derived 2, like 3
chr2_-_29253001 1.505 ENSMUST00000071201.4
 Ntng2
netrin G2
chr7_-_19310035 1.487 ENSMUST00000003640.2
 Fosb
FBJ osteosarcoma oncogene B
chr8_-_11312731 1.460 ENSMUST00000033898.9
 Col4a1
collagen, type IV, alpha 1
chr11_+_104231465 1.401 ENSMUST00000145227.1
 Mapt
microtubule-associated protein tau
chr12_+_81859964 1.336 ENSMUST00000021567.5
 Pcnx
pecanex homolog (Drosophila)
chr4_-_120287349 1.255 ENSMUST00000102656.3
 Foxo6
forkhead box O6
chr11_+_104231573 1.252 ENSMUST00000132977.1
ENSMUST00000132245.1
ENSMUST00000100347.4
 Mapt


microtubule-associated protein tau


chr9_+_100643755 1.222 ENSMUST00000133388.1
 Stag1
stromal antigen 1
chr11_+_104231515 1.216 ENSMUST00000106993.3
 Mapt
microtubule-associated protein tau
chr11_+_75531690 1.209 ENSMUST00000149727.1
ENSMUST00000042561.7
ENSMUST00000108433.1
ENSMUST00000143035.1
 Slc43a2



solute carrier family 43, member 2



chr7_+_5056706 1.187 ENSMUST00000144802.1
 Ccdc106
coiled-coil domain containing 106
chr6_+_135198034 1.178 ENSMUST00000130612.1
 8430419L09Rik
RIKEN cDNA 8430419L09 gene
chr9_+_67840386 1.173 ENSMUST00000077879.5
 Vps13c
vacuolar protein sorting 13C (yeast)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 3.9 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.0 3.3 GO:0071805 potassium ion transmembrane transport(GO:0071805)
0.2 3.2 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.0 2.6 GO:0015807 L-amino acid transport(GO:0015807)
0.1 2.3 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.6 1.9 GO:1902022 L-lysine transport(GO:1902022)
0.2 1.5 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
0.0 1.5 GO:0071277 cellular response to calcium ion(GO:0071277)
0.1 1.3 GO:0035646 endosome to melanosome transport(GO:0035646) endosome to pigment granule transport(GO:0043485) pigment granule maturation(GO:0048757)
0.0 1.3 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.2 1.2 GO:1901525 negative regulation of macromitophagy(GO:1901525) regulation of mitophagy in response to mitochondrial depolarization(GO:1904923)
0.1 1.2 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.1 1.1 GO:0099640 axo-dendritic protein transport(GO:0099640)
0.1 1.1 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.3 1.0 GO:0006566 threonine metabolic process(GO:0006566)
0.3 1.0 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 1.0 GO:0014898 muscle hypertrophy in response to stress(GO:0003299) cardiac muscle hypertrophy in response to stress(GO:0014898)
0.0 1.0 GO:0021702 cerebellar Purkinje cell differentiation(GO:0021702)
0.0 1.0 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.1 0.9 GO:0070050 neuron cellular homeostasis(GO:0070050)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 3.9 GO:0045298 tubulin complex(GO:0045298)
0.0 3.2 GO:0030118 clathrin coat(GO:0030118)
0.0 3.2 GO:0001650 fibrillar center(GO:0001650)
0.5 2.6 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.2 2.3 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 2.3 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.4 1.7 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
0.0 1.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 1.1 GO:0035253 ciliary rootlet(GO:0035253)
0.2 1.0 GO:0008091 spectrin(GO:0008091)
0.0 0.8 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.8 GO:0030137 COPI-coated vesicle(GO:0030137)
0.1 0.7 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.1 0.7 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.7 GO:0043034 costamere(GO:0043034)
0.2 0.6 GO:1990257 piccolo-bassoon transport vesicle(GO:1990257)
0.0 0.6 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 0.5 GO:0001533 cornified envelope(GO:0001533)
0.0 0.3 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.3 GO:0005605 basal lamina(GO:0005605)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 3.9 GO:0099609 microtubule lateral binding(GO:0099609)
0.0 3.5 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.3 3.2 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 2.6 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.5 1.9 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 1.9 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.2 1.7 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 1.7 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds(GO:0016810)
0.1 1.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 1.5 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 1.1 GO:0071837 HMG box domain binding(GO:0071837)
0.3 1.0 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.0 1.0 GO:0030506 ankyrin binding(GO:0030506)
0.1 0.9 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 0.8 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.8 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.8 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.8 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 0.7 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1 0.7 GO:0000182 rDNA binding(GO:0000182)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.1 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.2 3.9 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 3.2 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.2 1.7 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 1.4 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 1.3 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.7 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.0 0.5 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.5 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.2 3.9 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 3.2 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.1 2.6 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.6 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.2 2.1 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 1.7 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 1.7 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 1.1 REACTOME_KINESINS Genes involved in Kinesins
0.0 1.0 REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH Genes involved in NCAM signaling for neurite out-growth
0.0 0.9 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.1 0.8 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.0 0.7 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 0.5 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.4 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.3 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.3 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 0.2 REACTOME_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis