Motif ID: Zfhx3

Z-value: 0.612


Transcription factors associated with Zfhx3:

Gene SymbolEntrez IDGene Name
Zfhx3 ENSMUSG00000038872.8 Zfhx3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zfhx3mm10_v2_chr8_+_108714644_108714644-0.163.3e-01Click!


Activity profile for motif Zfhx3.

activity profile for motif Zfhx3


Sorted Z-values histogram for motif Zfhx3

Sorted Z-values for motif Zfhx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Zfhx3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_101377897 3.329 ENSMUST00000075994.6
Pdzrn3
PDZ domain containing RING finger 3
chr17_+_35076902 1.442 ENSMUST00000172494.1
ENSMUST00000172678.1
ENSMUST00000013910.4
Ly6g6e


lymphocyte antigen 6 complex, locus G6E


chr4_-_32923455 1.207 ENSMUST00000035719.4
ENSMUST00000084749.1
Ankrd6

ankyrin repeat domain 6

chr2_-_63184253 1.015 ENSMUST00000075052.3
ENSMUST00000112454.1
Kcnh7

potassium voltage-gated channel, subfamily H (eag-related), member 7

chr8_-_67818284 0.937 ENSMUST00000120071.1
Psd3
pleckstrin and Sec7 domain containing 3
chr13_-_110280103 0.927 ENSMUST00000167824.1
Rab3c
RAB3C, member RAS oncogene family
chr5_-_107875035 0.909 ENSMUST00000138111.1
ENSMUST00000112642.1
Evi5

ecotropic viral integration site 5

chr5_+_107497718 0.882 ENSMUST00000112671.2
A830010M20Rik
RIKEN cDNA A830010M20 gene
chr10_-_110000219 0.877 ENSMUST00000032719.7
Nav3
neuron navigator 3
chr2_+_82053222 0.852 ENSMUST00000047527.7
Zfp804a
zinc finger protein 804A
chr1_+_179961110 0.835 ENSMUST00000076687.5
ENSMUST00000097450.3
Cdc42bpa

CDC42 binding protein kinase alpha

chr9_+_95857597 0.808 ENSMUST00000034980.7
Atr
ataxia telangiectasia and Rad3 related
chr1_-_157256682 0.788 ENSMUST00000134543.1
Rasal2
RAS protein activator like 2
chr10_-_17947997 0.773 ENSMUST00000037879.6
Heca
headcase homolog (Drosophila)
chr2_-_63184170 0.761 ENSMUST00000112452.1
Kcnh7
potassium voltage-gated channel, subfamily H (eag-related), member 7
chr9_+_86485407 0.760 ENSMUST00000034987.8
Dopey1
dopey family member 1
chr10_-_56228636 0.743 ENSMUST00000099739.3
Tbc1d32
TBC1 domain family, member 32
chrM_-_14060 0.723 ENSMUST00000082419.1
mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr16_-_74411776 0.700 ENSMUST00000116586.2
Robo2
roundabout homolog 2 (Drosophila)
chr5_+_107497762 0.656 ENSMUST00000152474.1
ENSMUST00000060553.7
A830010M20Rik

RIKEN cDNA A830010M20 gene

chr10_+_115384951 0.646 ENSMUST00000036044.8
Zfc3h1
zinc finger, C3H1-type containing
chr1_-_24612700 0.646 ENSMUST00000088336.1
Gm10222
predicted gene 10222
chrM_+_9870 0.636 ENSMUST00000084013.1
mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L
chr3_+_66985680 0.616 ENSMUST00000065047.6
Rsrc1
arginine/serine-rich coiled-coil 1
chr6_-_86765807 0.580 ENSMUST00000123732.1
Anxa4
annexin A4
chrX_-_143933089 0.573 ENSMUST00000087313.3
Dcx
doublecortin
chr3_+_90537306 0.535 ENSMUST00000107335.1
S100a16
S100 calcium binding protein A16
chr2_+_177768044 0.523 ENSMUST00000108942.3
Gm14322
predicted gene 14322
chr2_-_140671440 0.511 ENSMUST00000099301.1
Flrt3
fibronectin leucine rich transmembrane protein 3
chr3_+_28263205 0.509 ENSMUST00000159236.2
Tnik
TRAF2 and NCK interacting kinase
chr10_-_30842765 0.499 ENSMUST00000019924.8
Hey2
hairy/enhancer-of-split related with YRPW motif 2
chr12_+_71170589 0.495 ENSMUST00000129376.1
2700049A03Rik
RIKEN cDNA 2700049A03 gene
chrM_+_14138 0.492 ENSMUST00000082421.1
mt-Cytb
mitochondrially encoded cytochrome b
chr2_+_3770673 0.490 ENSMUST00000177037.1
Fam107b
family with sequence similarity 107, member B
chr3_-_123385925 0.486 ENSMUST00000090371.7
ENSMUST00000174323.1
ENSMUST00000029759.9
Mettl14


methyltransferase like 14


chr8_-_67818218 0.477 ENSMUST00000059374.4
Psd3
pleckstrin and Sec7 domain containing 3
chr14_+_64588112 0.461 ENSMUST00000181808.1
A930011O12Rik
RIKEN cDNA A930011O12 gene
chr2_-_140671400 0.459 ENSMUST00000056760.3
Flrt3
fibronectin leucine rich transmembrane protein 3
chr13_-_75943812 0.457 ENSMUST00000022078.5
ENSMUST00000109606.1
Rhobtb3

Rho-related BTB domain containing 3

chr2_-_140671462 0.432 ENSMUST00000110057.2
Flrt3
fibronectin leucine rich transmembrane protein 3
chr1_+_74661794 0.432 ENSMUST00000129890.1
Ttll4
tubulin tyrosine ligase-like family, member 4
chr1_+_179960472 0.420 ENSMUST00000097453.2
ENSMUST00000111117.1
Cdc42bpa

CDC42 binding protein kinase alpha

chr19_+_10015016 0.414 ENSMUST00000137637.1
ENSMUST00000149967.1
Rab3il1

RAB3A interacting protein (rabin3)-like 1

chr6_-_86765866 0.409 ENSMUST00000113675.1
Anxa4
annexin A4
chrM_+_2743 0.409 ENSMUST00000082392.1
mt-Nd1
mitochondrially encoded NADH dehydrogenase 1
chr8_-_9976294 0.394 ENSMUST00000095476.4
Lig4
ligase IV, DNA, ATP-dependent
chr3_+_90537242 0.389 ENSMUST00000098911.3
S100a16
S100 calcium binding protein A16
chr3_+_84952146 0.384 ENSMUST00000029727.7
Fbxw7
F-box and WD-40 domain protein 7
chr13_+_83732438 0.375 ENSMUST00000182701.1
C130071C03Rik
RIKEN cDNA C130071C03 gene
chr2_+_110597298 0.371 ENSMUST00000045972.6
ENSMUST00000111026.2
Slc5a12

solute carrier family 5 (sodium/glucose cotransporter), member 12

chrX_-_111536325 0.359 ENSMUST00000156639.1
Rps6ka6
ribosomal protein S6 kinase polypeptide 6
chr9_-_22208546 0.354 ENSMUST00000167359.1
1810064F22Rik
RIKEN cDNA 1810064F22 gene
chrX_-_143933204 0.353 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
Dcx


doublecortin


chr3_-_39359128 0.329 ENSMUST00000056409.2
Gm9845
predicted pseudogene 9845
chr1_+_172698046 0.273 ENSMUST00000038495.3
Crp
C-reactive protein, pentraxin-related
chr7_-_99980431 0.269 ENSMUST00000080817.4
Rnf169
ring finger protein 169
chr18_+_37518341 0.266 ENSMUST00000097609.1
Pcdhb22
protocadherin beta 22
chrM_+_7759 0.261 ENSMUST00000082407.1
ENSMUST00000082408.1
mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr15_-_79285502 0.260 ENSMUST00000165408.1
Baiap2l2
BAI1-associated protein 2-like 2
chr15_+_31224371 0.237 ENSMUST00000044524.9
Dap
death-associated protein
chrX_-_139871637 0.236 ENSMUST00000033811.7
ENSMUST00000087401.5
Morc4

microrchidia 4

chrM_+_7005 0.216 ENSMUST00000082405.1
mt-Co2
mitochondrially encoded cytochrome c oxidase II
chr2_+_120977017 0.176 ENSMUST00000067582.7
Tmem62
transmembrane protein 62
chr2_-_37647199 0.175 ENSMUST00000028279.3
Strbp
spermatid perinuclear RNA binding protein
chr7_+_55794146 0.162 ENSMUST00000032627.3
Tubgcp5
tubulin, gamma complex associated protein 5
chr3_+_66985647 0.161 ENSMUST00000162362.1
ENSMUST00000065074.7
Rsrc1

arginine/serine-rich coiled-coil 1

chr3_+_136670076 0.148 ENSMUST00000070198.7
Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr18_+_55057557 0.148 ENSMUST00000181765.1
Gm4221
predicted gene 4221
chr11_+_24078173 0.128 ENSMUST00000109514.1
Bcl11a
B cell CLL/lymphoma 11A (zinc finger protein)
chr17_-_32886083 0.114 ENSMUST00000178401.1
Zfp870
zinc finger protein 870
chr5_+_24394388 0.109 ENSMUST00000115074.1
Abcb8
ATP-binding cassette, sub-family B (MDR/TAP), member 8
chr1_+_164275559 0.109 ENSMUST00000027867.6
Ccdc181
coiled-coil domain containing 181
chr5_+_25246775 0.091 ENSMUST00000144971.1
Galnt11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11
chr1_-_168432270 0.074 ENSMUST00000072863.4
Pbx1
pre B cell leukemia homeobox 1
chr8_+_83666827 0.071 ENSMUST00000019608.5
Ptger1
prostaglandin E receptor 1 (subtype EP1)
chr9_+_113812547 0.067 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
Clasp2


CLIP associating protein 2


chrX_+_163911401 0.066 ENSMUST00000140845.1
Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr8_+_47713266 0.062 ENSMUST00000180928.1
E030037K01Rik
RIKEN cDNA E030037K01 gene
chr10_+_23796946 0.049 ENSMUST00000119597.1
ENSMUST00000179321.1
Slc18b1

solute carrier family 18, subfamily B, member 1

chr3_+_76075583 0.043 ENSMUST00000160261.1
Fstl5
follistatin-like 5
chr1_-_126830786 0.043 ENSMUST00000162646.1
Nckap5
NCK-associated protein 5
chr9_+_54980880 0.040 ENSMUST00000093844.3
Chrna5
cholinergic receptor, nicotinic, alpha polypeptide 5
chr6_+_127453667 0.037 ENSMUST00000112193.1
Parp11
poly (ADP-ribose) polymerase family, member 11
chrX_+_107255878 0.036 ENSMUST00000101294.2
ENSMUST00000118820.1
ENSMUST00000120971.1
Gpr174


G protein-coupled receptor 174


chr8_-_66486494 0.031 ENSMUST00000026681.5
Tma16
translation machinery associated 16 homolog (S. cerevisiae)
chr18_-_66022580 0.026 ENSMUST00000143990.1
Lman1
lectin, mannose-binding, 1
chr12_-_12941827 0.025 ENSMUST00000043396.7
Mycn
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr9_+_55326913 0.022 ENSMUST00000085754.3
ENSMUST00000034862.4
AI118078

expressed sequence AI118078

chr2_-_120245157 0.016 ENSMUST00000090071.4
Pla2g4e
phospholipase A2, group IVE
chr10_+_79927039 0.015 ENSMUST00000019708.5
ENSMUST00000105377.1
Arid3a

AT rich interactive domain 3A (BRIGHT-like)

chr12_-_87443800 0.014 ENSMUST00000162961.1
Alkbh1
alkB, alkylation repair homolog 1 (E. coli)
chr10_+_79927330 0.013 ENSMUST00000105376.1
Arid3a
AT rich interactive domain 3A (BRIGHT-like)
chr13_-_18382041 0.004 ENSMUST00000139064.2
ENSMUST00000175703.2
Pou6f2

POU domain, class 6, transcription factor 2

chr17_+_36958571 0.000 ENSMUST00000040177.6
Znrd1as
Znrd1 antisense

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
0.3 0.8 GO:1904884 telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.2 0.7 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.2 0.5 GO:0003195 tricuspid valve formation(GO:0003195)
0.2 1.0 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
0.1 0.5 GO:0007256 activation of JNKK activity(GO:0007256)
0.1 0.7 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.1 0.5 GO:0033762 response to glucagon(GO:0033762)
0.1 0.4 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.1 1.2 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 0.4 GO:0097680 double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.1 3.3 GO:0007528 neuromuscular junction development(GO:0007528)
0.1 1.4 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 0.8 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 1.4 GO:0022401 desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401)
0.0 0.1 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) regulation of connective tissue replacement(GO:1905203)
0.0 0.5 GO:0080009 mRNA methylation(GO:0080009)
0.0 0.4 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.3 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.0 0.8 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 1.3 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.0 0.4 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.0 0.2 GO:0051418 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.0 0.8 GO:0046677 response to antibiotic(GO:0046677)
0.0 0.4 GO:0033194 response to hydroperoxide(GO:0033194)
0.0 1.4 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.9 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 0.3 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0 0.0 GO:0035095 behavioral response to nicotine(GO:0035095)
0.0 0.1 GO:0018243 protein O-linked glycosylation via threonine(GO:0018243)
0.0 0.8 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.1 0.4 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 0.4 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807)
0.1 0.8 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.5 GO:0045275 respiratory chain complex III(GO:0045275)
0.0 0.2 GO:0000931 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.0 3.3 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.8 GO:0001741 XY body(GO:0001741)
0.0 1.4 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.3 GO:0071439 clathrin complex(GO:0071439)
0.0 1.9 GO:0070469 respiratory chain(GO:0070469)
0.0 0.5 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.1 GO:0005955 calcineurin complex(GO:0005955)
0.0 1.5 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.7 GO:0030673 axolemma(GO:0030673)
0.0 0.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.1 GO:0002177 manchette(GO:0002177)
0.0 1.3 GO:0042641 actomyosin(GO:0042641)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
0.2 0.5 GO:0035939 microsatellite binding(GO:0035939)
0.1 0.8 GO:0032405 MutLalpha complex binding(GO:0032405) MutSalpha complex binding(GO:0032407)
0.1 0.5 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.1 0.7 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 1.8 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 1.4 GO:0045499 chemorepellent activity(GO:0045499)
0.1 0.4 GO:0050816 phosphothreonine binding(GO:0050816)
0.1 0.4 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.1 0.5 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 1.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.4 GO:0070739 protein-glutamic acid ligase activity(GO:0070739)
0.1 0.4 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 1.4 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.3 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.9 GO:0031489 myosin V binding(GO:0031489)
0.0 0.5 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.1 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 1.0 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 0.1 GO:0004954 icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955)
0.0 0.2 GO:0070513 death domain binding(GO:0070513)
0.0 0.2 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 3.3 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.3 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 1.2 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.9 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.4 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.4 PID_MYC_PATHWAY C-MYC pathway
0.0 1.3 PID_CDC42_PATHWAY CDC42 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.3 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 1.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.1 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.4 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus
0.0 0.2 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.7 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.9 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription