Motif ID: Zfhx3

Z-value: 0.612


Transcription factors associated with Zfhx3:

Gene SymbolEntrez IDGene Name
Zfhx3 ENSMUSG00000038872.8 Zfhx3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zfhx3mm10_v2_chr8_+_108714644_108714644-0.163.3e-01Click!


Activity profile for motif Zfhx3.

activity profile for motif Zfhx3


Sorted Z-values histogram for motif Zfhx3

Sorted Z-values for motif Zfhx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Zfhx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 94 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_101377897 3.329 ENSMUST00000075994.6
Pdzrn3
PDZ domain containing RING finger 3
chr17_+_35076902 1.442 ENSMUST00000172494.1
ENSMUST00000172678.1
ENSMUST00000013910.4
Ly6g6e


lymphocyte antigen 6 complex, locus G6E


chr4_-_32923455 1.207 ENSMUST00000035719.4
ENSMUST00000084749.1
Ankrd6

ankyrin repeat domain 6

chr2_-_63184253 1.015 ENSMUST00000075052.3
ENSMUST00000112454.1
Kcnh7

potassium voltage-gated channel, subfamily H (eag-related), member 7

chr8_-_67818284 0.937 ENSMUST00000120071.1
Psd3
pleckstrin and Sec7 domain containing 3
chr13_-_110280103 0.927 ENSMUST00000167824.1
Rab3c
RAB3C, member RAS oncogene family
chr5_-_107875035 0.909 ENSMUST00000138111.1
ENSMUST00000112642.1
Evi5

ecotropic viral integration site 5

chr5_+_107497718 0.882 ENSMUST00000112671.2
A830010M20Rik
RIKEN cDNA A830010M20 gene
chr10_-_110000219 0.877 ENSMUST00000032719.7
Nav3
neuron navigator 3
chr2_+_82053222 0.852 ENSMUST00000047527.7
Zfp804a
zinc finger protein 804A
chr1_+_179961110 0.835 ENSMUST00000076687.5
ENSMUST00000097450.3
Cdc42bpa

CDC42 binding protein kinase alpha

chr9_+_95857597 0.808 ENSMUST00000034980.7
Atr
ataxia telangiectasia and Rad3 related
chr1_-_157256682 0.788 ENSMUST00000134543.1
Rasal2
RAS protein activator like 2
chr10_-_17947997 0.773 ENSMUST00000037879.6
Heca
headcase homolog (Drosophila)
chr2_-_63184170 0.761 ENSMUST00000112452.1
Kcnh7
potassium voltage-gated channel, subfamily H (eag-related), member 7
chr9_+_86485407 0.760 ENSMUST00000034987.8
Dopey1
dopey family member 1
chr10_-_56228636 0.743 ENSMUST00000099739.3
Tbc1d32
TBC1 domain family, member 32
chrM_-_14060 0.723 ENSMUST00000082419.1
mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr16_-_74411776 0.700 ENSMUST00000116586.2
Robo2
roundabout homolog 2 (Drosophila)
chr5_+_107497762 0.656 ENSMUST00000152474.1
ENSMUST00000060553.7
A830010M20Rik

RIKEN cDNA A830010M20 gene


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.3 GO:0007528 neuromuscular junction development(GO:0007528)
0.5 1.4 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
0.1 1.4 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 1.4 GO:0022401 desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401)
0.0 1.4 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 1.3 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.1 1.2 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.2 1.0 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
0.0 0.9 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.3 0.8 GO:1904884 telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.1 0.8 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.8 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.8 GO:0046677 response to antibiotic(GO:0046677)
0.0 0.8 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.2 0.7 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.1 0.7 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.2 0.5 GO:0003195 tricuspid valve formation(GO:0003195)
0.1 0.5 GO:0007256 activation of JNKK activity(GO:0007256)
0.1 0.5 GO:0033762 response to glucagon(GO:0033762)
0.0 0.5 GO:0080009 mRNA methylation(GO:0080009)

Gene overrepresentation in cellular_component category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.3 GO:0031594 neuromuscular junction(GO:0031594)
0.0 1.9 GO:0070469 respiratory chain(GO:0070469)
0.0 1.5 GO:0044295 axonal growth cone(GO:0044295)
0.0 1.4 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 1.3 GO:0042641 actomyosin(GO:0042641)
0.1 0.8 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.8 GO:0001741 XY body(GO:0001741)
0.0 0.7 GO:0030673 axolemma(GO:0030673)
0.1 0.5 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.0 0.5 GO:0045275 respiratory chain complex III(GO:0045275)
0.0 0.5 GO:0016580 Sin3 complex(GO:0016580)
0.1 0.4 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 0.4 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807)
0.0 0.3 GO:0071439 clathrin complex(GO:0071439)
0.0 0.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.2 GO:0000931 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.0 0.1 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.1 GO:0002177 manchette(GO:0002177)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.3 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 1.8 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 1.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.5 1.4 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
0.1 1.4 GO:0045499 chemorepellent activity(GO:0045499)
0.0 1.4 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 1.0 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 0.9 GO:0031489 myosin V binding(GO:0031489)
0.1 0.8 GO:0032405 MutLalpha complex binding(GO:0032405) MutSalpha complex binding(GO:0032407)
0.1 0.7 GO:0008046 axon guidance receptor activity(GO:0008046)
0.2 0.5 GO:0035939 microsatellite binding(GO:0035939)
0.1 0.5 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.1 0.5 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.5 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 0.4 GO:0050816 phosphothreonine binding(GO:0050816)
0.1 0.4 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.1 0.4 GO:0070739 protein-glutamic acid ligase activity(GO:0070739)
0.1 0.4 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.3 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.3 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)

Gene overrepresentation in C2:CP category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.3 PID_CDC42_PATHWAY CDC42 signaling events
0.0 1.2 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.9 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.8 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.4 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.4 PID_MYC_PATHWAY C-MYC pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.9 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 0.8 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.7 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.4 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus
0.0 0.3 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.2 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.1 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors