Motif ID: Zfp105

Z-value: 0.605


Transcription factors associated with Zfp105:

Gene SymbolEntrez IDGene Name
Zfp105 ENSMUSG00000057895.5 Zfp105

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zfp105mm10_v2_chr9_+_122923050_1229230990.676.3e-06Click!


Activity profile for motif Zfp105.

activity profile for motif Zfp105


Sorted Z-values histogram for motif Zfp105

Sorted Z-values for motif Zfp105



Network of associatons between targets according to the STRING database.



First level regulatory network of Zfp105

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_144892813 4.580 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr5_+_17574268 3.353 ENSMUST00000030568.7
 Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr1_-_190170671 3.154 ENSMUST00000175916.1
 Prox1
prospero-related homeobox 1
chr2_-_91931774 2.217 ENSMUST00000069423.6
 Mdk
midkine
chr5_-_111761697 2.075 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
 E130006D01Rik


RIKEN cDNA E130006D01 gene


chr4_+_11704439 2.000 ENSMUST00000108304.2
 Gem
GTP binding protein (gene overexpressed in skeletal muscle)
chr5_+_13399309 1.983 ENSMUST00000030714.7
ENSMUST00000141968.1
 Sema3a

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A

chr6_-_127151044 1.921 ENSMUST00000000188.8
 Ccnd2
cyclin D2
chr8_+_128359065 1.820 ENSMUST00000026917.8
 Nrp1
neuropilin 1
chr18_+_69344503 1.341 ENSMUST00000114985.3
 Tcf4
transcription factor 4
chr18_+_35829798 1.115 ENSMUST00000060722.6
 Cxxc5
CXXC finger 5
chr2_-_177267036 1.070 ENSMUST00000108963.1
 Gm14409
predicted gene 14409
chr9_-_78378725 0.997 ENSMUST00000034900.7
 Ooep
oocyte expressed protein
chr12_-_90738438 0.976 ENSMUST00000082432.3
 Dio2
deiodinase, iodothyronine, type II
chr8_-_11008458 0.936 ENSMUST00000040514.6
 Irs2
insulin receptor substrate 2
chr9_+_58134535 0.912 ENSMUST00000128378.1
ENSMUST00000150820.1
ENSMUST00000167479.1
ENSMUST00000134450.1
 Stra6



stimulated by retinoic acid gene 6



chr8_-_84773381 0.770 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr11_-_101466222 0.733 ENSMUST00000040430.7
 Vat1
vesicle amine transport protein 1 homolog (T californica)
chr13_-_67609667 0.682 ENSMUST00000012873.8
 AA987161
expressed sequence AA987161
chr13_-_67609617 0.681 ENSMUST00000138725.1
 AA987161
expressed sequence AA987161
chr11_-_100411874 0.611 ENSMUST00000141840.1
 Leprel4
leprecan-like 4
chr14_+_31019159 0.589 ENSMUST00000112094.1
ENSMUST00000144009.1
 Pbrm1

polybromo 1

chr8_-_64205970 0.549 ENSMUST00000066166.4
 Tll1
tolloid-like
chrM_+_3906 0.533 ENSMUST00000082396.1
 mt-Nd2
mitochondrially encoded NADH dehydrogenase 2
chr19_-_53464721 0.385 ENSMUST00000180489.1
 5830416P10Rik
RIKEN cDNA 5830416P10 gene
chr15_+_102460076 0.368 ENSMUST00000164688.1
 Prr13
proline rich 13
chr11_+_108920342 0.350 ENSMUST00000052915.7
 Axin2
axin2
chr1_-_13589717 0.300 ENSMUST00000027068.4
 Tram1
translocating chain-associating membrane protein 1
chr7_-_34313531 0.282 ENSMUST00000108074.1
 4931406P16Rik
RIKEN cDNA 4931406P16 gene
chr1_+_179960472 0.250 ENSMUST00000097453.2
ENSMUST00000111117.1
 Cdc42bpa

CDC42 binding protein kinase alpha

chr7_+_66109474 0.226 ENSMUST00000036372.6
 Chsy1
chondroitin sulfate synthase 1
chr4_+_105157339 0.216 ENSMUST00000064139.7
 Ppap2b
phosphatidic acid phosphatase type 2B
chr1_-_63114516 0.214 ENSMUST00000097718.2
 Ino80d
INO80 complex subunit D
chr1_+_171419027 0.178 ENSMUST00000171362.1
 Tstd1
thiosulfate sulfurtransferase (rhodanese)-like domain containing 1
chr11_-_102316691 0.150 ENSMUST00000107115.1
ENSMUST00000128016.1
 Ubtf

upstream binding transcription factor, RNA polymerase I

chr11_+_108920800 0.138 ENSMUST00000140821.1
 Axin2
axin2
chr6_-_99632376 0.093 ENSMUST00000176255.1
 Gm20696
predicted gene 20696
chr6_+_29859374 0.066 ENSMUST00000115238.3
 Ahcyl2
S-adenosylhomocysteine hydrolase-like 2
chr5_-_16731074 0.048 ENSMUST00000073014.5
 Gm8991
predicted pseudogene 8991
chr5_+_136953246 0.042 ENSMUST00000111094.1
ENSMUST00000111097.1
 Fis1

fission 1 (mitochondrial outer membrane) homolog (yeast)

chr10_+_128267997 0.032 ENSMUST00000050901.2
 Apof
apolipoprotein F

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.2 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
1.0 7.2 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.7 2.2 GO:0030421 defecation(GO:0030421)
0.4 4.6 GO:0042572 retinol metabolic process(GO:0042572)
0.2 2.0 GO:1901386 negative regulation of voltage-gated calcium channel activity(GO:1901386)
0.2 0.6 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
0.2 1.0 GO:0070460 thyroid-stimulating hormone secretion(GO:0070460)
0.2 0.9 GO:0046864 retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865) alveolar primary septum development(GO:0061143)
0.2 0.5 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.1 1.9 GO:0071481 cellular response to X-ray(GO:0071481)
0.1 0.7 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.1 1.3 GO:0042118 endothelial cell activation(GO:0042118)
0.1 0.9 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.1 0.8 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0 0.5 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.2 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.0 GO:1904578 response to thapsigargin(GO:1904578) cellular response to thapsigargin(GO:1904579)
0.0 1.0 GO:0007566 embryo implantation(GO:0007566)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.9 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.3 1.8 GO:0097443 sorting endosome(GO:0097443)
0.1 2.0 GO:0051233 spindle midzone(GO:0051233)
0.0 0.6 GO:0090544 BAF-type complex(GO:0090544)
0.0 0.2 GO:0032580 Golgi cisterna membrane(GO:0032580)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 4.6 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.4 5.3 GO:0038191 neuropilin binding(GO:0038191)
0.4 1.8 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.3 1.3 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.3 3.2 GO:0050693 LBD domain binding(GO:0050693)
0.1 0.2 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0 2.0 GO:0019003 GDP binding(GO:0019003)
0.0 0.1 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.0 0.9 GO:0051183 vitamin transporter activity(GO:0051183)
0.0 0.9 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 2.2 GO:0008083 growth factor activity(GO:0008083)
0.0 0.5 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.3 GO:0070411 I-SMAD binding(GO:0070411)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.8 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.1 4.6 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 2.2 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 5.3 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.9 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 0.9 PID_EPO_PATHWAY EPO signaling pathway
0.0 1.8 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.8 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 1.0 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.9 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.0 1.9 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 1.3 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.2 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis