Motif ID: Zfp219_Zfp740

Z-value: 1.146

Transcription factors associated with Zfp219_Zfp740:

Gene SymbolEntrez IDGene Name
Zfp219 ENSMUSG00000049295.10 Zfp219
Zfp740 ENSMUSG00000046897.10 Zfp740

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zfp219mm10_v2_chr14_-_52020698_520207370.231.8e-01Click!
Zfp740mm10_v2_chr15_+_102203639_1022037090.212.1e-01Click!


Activity profile for motif Zfp219_Zfp740.

activity profile for motif Zfp219_Zfp740


Sorted Z-values histogram for motif Zfp219_Zfp740

Sorted Z-values for motif Zfp219_Zfp740



Network of associatons between targets according to the STRING database.



First level regulatory network of Zfp219_Zfp740

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_134747241 5.857 ENSMUST00000015138.9
 Eln
elastin
chr15_+_57694651 5.181 ENSMUST00000096430.4
 Zhx2
zinc fingers and homeoboxes 2
chr7_-_78578308 5.144 ENSMUST00000039431.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chr7_-_78577771 5.108 ENSMUST00000039438.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chr16_+_44173271 4.097 ENSMUST00000088356.4
ENSMUST00000169582.1
 Gm608

predicted gene 608

chr1_-_56972437 3.889 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr16_+_43503607 3.818 ENSMUST00000126100.1
ENSMUST00000123047.1
ENSMUST00000156981.1
 Zbtb20


zinc finger and BTB domain containing 20


chr2_-_180225812 3.707 ENSMUST00000015791.5
 Lama5
laminin, alpha 5
chr2_-_116065798 3.473 ENSMUST00000110907.1
ENSMUST00000110908.2
 Meis2

Meis homeobox 2

chr16_+_44173239 3.423 ENSMUST00000119746.1
 Gm608
predicted gene 608
chr4_-_88033328 3.332 ENSMUST00000078090.5
 Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr12_-_27342696 3.269 ENSMUST00000079063.5
 Sox11
SRY-box containing gene 11
chr4_+_144892813 2.896 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr10_-_127620922 2.844 ENSMUST00000118455.1
 Lrp1
low density lipoprotein receptor-related protein 1
chr17_+_75005523 2.735 ENSMUST00000001927.5
 Ltbp1
latent transforming growth factor beta binding protein 1
chr2_+_48949495 2.634 ENSMUST00000112745.1
 Mbd5
methyl-CpG binding domain protein 5
chr11_-_69369377 2.577 ENSMUST00000092971.6
ENSMUST00000108661.1
 Chd3

chromodomain helicase DNA binding protein 3

chr10_-_127341583 2.540 ENSMUST00000026474.3
 Gli1
GLI-Kruppel family member GLI1
chr6_+_4903350 2.493 ENSMUST00000175962.1
 Ppp1r9a
protein phosphatase 1, regulatory (inhibitor) subunit 9A
chr3_+_28263563 2.445 ENSMUST00000160307.2
ENSMUST00000159680.2
ENSMUST00000160518.1
ENSMUST00000162485.1
ENSMUST00000159308.1
ENSMUST00000162777.1
ENSMUST00000161964.1
 Tnik






TRAF2 and NCK interacting kinase







Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 223 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.4 10.3 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
0.4 5.9 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
1.4 5.8 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.5 5.2 GO:0042572 retinol metabolic process(GO:0042572)
0.0 5.1 GO:0006402 mRNA catabolic process(GO:0006402)
0.0 4.9 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.4 4.4 GO:0042118 endothelial cell activation(GO:0042118)
0.3 4.3 GO:1990403 embryonic brain development(GO:1990403)
1.4 4.1 GO:1904049 negative regulation of spontaneous neurotransmitter secretion(GO:1904049)
0.2 4.0 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971)
0.2 3.8 GO:0007379 segment specification(GO:0007379)
0.7 3.7 GO:0007256 activation of JNKK activity(GO:0007256)
0.6 3.4 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
1.1 3.3 GO:0060023 soft palate development(GO:0060023)
0.3 3.1 GO:0010745 negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.7 3.0 GO:2000525 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.4 3.0 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.1 3.0 GO:0048599 oocyte development(GO:0048599)
0.1 2.9 GO:0001755 neural crest cell migration(GO:0001755)
0.1 2.7 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 97 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.9 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 7.9 GO:0000118 histone deacetylase complex(GO:0000118)
2.0 5.9 GO:0071953 elastic fiber(GO:0071953)
0.0 5.5 GO:0032993 protein-DNA complex(GO:0032993)
0.0 4.7 GO:0055037 recycling endosome(GO:0055037)
0.0 4.6 GO:0016607 nuclear speck(GO:0016607)
0.1 4.4 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 4.3 GO:0035869 ciliary transition zone(GO:0035869)
0.8 4.1 GO:1990761 growth cone lamellipodium(GO:1990761)
0.9 3.7 GO:0043259 laminin-10 complex(GO:0043259)
0.0 3.7 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 3.4 GO:0016604 nuclear body(GO:0016604)
0.1 3.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 2.9 GO:0005844 polysome(GO:0005844)
0.0 2.8 GO:0009925 basal plasma membrane(GO:0009925)
0.9 2.7 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.1 2.7 GO:0010369 chromocenter(GO:0010369)
0.2 2.6 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 2.6 GO:0043235 receptor complex(GO:0043235)
0.2 2.5 GO:0097542 ciliary tip(GO:0097542)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 142 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 14.7 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
2.1 10.3 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.1 5.9 GO:0008013 beta-catenin binding(GO:0008013)
1.9 5.8 GO:0016964 alpha-2 macroglobulin receptor activity(GO:0016964)
0.2 5.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.7 5.2 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
1.1 4.4 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.2 3.8 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.3 3.7 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.2 3.6 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.1 3.4 GO:0070412 R-SMAD binding(GO:0070412)
0.1 3.4 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.1 3.2 GO:0008266 poly(U) RNA binding(GO:0008266)
0.2 3.0 GO:0005003 ephrin receptor activity(GO:0005003)
0.1 2.9 GO:0005158 insulin receptor binding(GO:0005158)
0.7 2.7 GO:0050436 microfibril binding(GO:0050436)
0.5 2.7 GO:0045322 unmethylated CpG binding(GO:0045322)
0.1 2.7 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.3 2.6 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.0 2.6 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.7 PID_SHP2_PATHWAY SHP2 signaling
0.2 9.4 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 9.1 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.2 5.6 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 4.4 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.5 4.0 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 3.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 3.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 3.0 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 2.9 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 2.5 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.1 2.3 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.2 2.1 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 2.1 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 2.0 PID_IGF1_PATHWAY IGF1 pathway
0.1 2.0 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 1.6 ST_JAK_STAT_PATHWAY Jak-STAT Pathway
0.0 1.6 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 1.5 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 1.5 PID_P53_REGULATION_PATHWAY p53 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.7 REACTOME_PI3K_AKT_ACTIVATION Genes involved in PI3K/AKT activation
0.1 4.2 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.2 3.9 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 3.5 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 3.3 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 2.6 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 2.5 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 2.1 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.5 1.8 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 1.6 REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION Genes involved in Nuclear Events (kinase and transcription factor activation)
0.0 1.6 REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.1 1.5 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.1 1.5 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 1.5 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.3 1.3 REACTOME_PI3K_EVENTS_IN_ERBB4_SIGNALING Genes involved in PI3K events in ERBB4 signaling
0.0 1.3 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.0 1.2 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 1.2 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 1.1 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 1.1 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions