Motif ID: Zfp423

Z-value: 0.642


Transcription factors associated with Zfp423:

Gene SymbolEntrez IDGene Name
Zfp423 ENSMUSG00000045333.9 Zfp423

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zfp423mm10_v2_chr8_-_87959560_87959595-0.545.6e-04Click!


Activity profile for motif Zfp423.

activity profile for motif Zfp423


Sorted Z-values histogram for motif Zfp423

Sorted Z-values for motif Zfp423



Network of associatons between targets according to the STRING database.



First level regulatory network of Zfp423

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_180499893 6.104 ENSMUST00000029084.2
 Ntsr1
neurotensin receptor 1
chr14_+_119138415 5.254 ENSMUST00000065904.3
 Hs6st3
heparan sulfate 6-O-sulfotransferase 3
chr4_+_42917234 3.499 ENSMUST00000107976.2
ENSMUST00000069184.2
 N28178

expressed sequence N28178

chr19_+_6401675 2.538 ENSMUST00000113471.1
ENSMUST00000113469.2
 Rasgrp2

RAS, guanyl releasing protein 2

chr6_+_110645572 2.324 ENSMUST00000071076.6
ENSMUST00000172951.1
 Grm7

glutamate receptor, metabotropic 7

chr14_+_70553687 2.306 ENSMUST00000161069.1
 Hr
hairless
chr9_-_37552904 2.102 ENSMUST00000065668.5
 Nrgn
neurogranin
chrX_+_7822289 2.036 ENSMUST00000009875.4
 Kcnd1
potassium voltage-gated channel, Shal-related family, member 1
chr19_+_10041548 1.932 ENSMUST00000115995.2
 Fads3
fatty acid desaturase 3
chr10_+_13966268 1.874 ENSMUST00000015645.4
 Hivep2
human immunodeficiency virus type I enhancer binding protein 2
chr9_+_120492606 1.791 ENSMUST00000007139.4
 Eif1b
eukaryotic translation initiation factor 1B
chr7_+_29307924 1.750 ENSMUST00000108230.1
ENSMUST00000065181.5
 Dpf1

D4, zinc and double PHD fingers family 1

chr2_+_164785823 1.358 ENSMUST00000174070.1
ENSMUST00000172577.1
ENSMUST00000056181.6
 Snx21


sorting nexin family member 21


chr4_-_106464167 1.244 ENSMUST00000049507.5
 Pcsk9
proprotein convertase subtilisin/kexin type 9
chr15_-_78718113 1.222 ENSMUST00000088592.4
 Elfn2
leucine rich repeat and fibronectin type III, extracellular 2
chr2_+_164785994 1.202 ENSMUST00000152471.1
 Snx21
sorting nexin family member 21
chr11_+_82101836 1.152 ENSMUST00000000194.3
 Ccl12
chemokine (C-C motif) ligand 12
chr17_+_69156791 1.051 ENSMUST00000112680.1
ENSMUST00000080208.5
 Epb4.1l3

erythrocyte protein band 4.1-like 3

chr8_+_27260327 0.956 ENSMUST00000033880.5
 Eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
chr12_-_14152038 0.907 ENSMUST00000020926.6
 Fam84a
family with sequence similarity 84, member A
chr7_-_105633525 0.886 ENSMUST00000153371.1
ENSMUST00000106789.1
ENSMUST00000057525.7
 Trim3


tripartite motif-containing 3


chr5_-_135934590 0.862 ENSMUST00000055808.5
 Ywhag
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
chr10_-_62110945 0.847 ENSMUST00000142821.1
ENSMUST00000124615.1
ENSMUST00000064050.4
ENSMUST00000125704.1
ENSMUST00000142796.1
 2010107G23Rik




RIKEN cDNA 2010107G23 gene




chr11_+_102836296 0.837 ENSMUST00000021302.8
ENSMUST00000107072.1
 Higd1b

HIG1 domain family, member 1B

chr14_-_70520254 0.781 ENSMUST00000022693.7
 Bmp1
bone morphogenetic protein 1
chr1_+_167598450 0.748 ENSMUST00000111386.1
ENSMUST00000111384.1
 Rxrg

retinoid X receptor gamma

chr7_-_105633479 0.721 ENSMUST00000147044.1
ENSMUST00000106791.1
 Trim3

tripartite motif-containing 3

chr6_+_86628174 0.658 ENSMUST00000043400.6
 Asprv1
aspartic peptidase, retroviral-like 1
chr7_-_25754701 0.598 ENSMUST00000108401.1
ENSMUST00000043765.7
 Hnrnpul1

heterogeneous nuclear ribonucleoprotein U-like 1

chr11_+_11115784 0.592 ENSMUST00000056344.4
 Vwc2
von Willebrand factor C domain containing 2
chr4_+_129513581 0.589 ENSMUST00000062356.6
 Marcksl1
MARCKS-like 1
chr6_-_128200598 0.567 ENSMUST00000071101.6
 Gm10010
predicted gene 10010
chr8_+_58912257 0.558 ENSMUST00000160055.1
 BC030500
cDNA sequence BC030500
chr19_-_10869757 0.534 ENSMUST00000120524.1
ENSMUST00000025645.7
 Tmem132a

transmembrane protein 132A

chr5_-_136565432 0.496 ENSMUST00000176172.1
 Cux1
cut-like homeobox 1
chr11_-_33203588 0.486 ENSMUST00000037746.6
 Tlx3
T cell leukemia, homeobox 3
chr19_-_10101501 0.476 ENSMUST00000025567.7
 Fads2
fatty acid desaturase 2
chr10_+_3973086 0.437 ENSMUST00000117291.1
ENSMUST00000120585.1
ENSMUST00000043735.7
 Mthfd1l


methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like


chr2_-_30359278 0.429 ENSMUST00000163668.2
ENSMUST00000028214.8
ENSMUST00000113621.3
 Sh3glb2


SH3-domain GRB2-like endophilin B2


chr12_-_69183986 0.406 ENSMUST00000110620.1
ENSMUST00000110619.1
 Rpl36al

ribosomal protein L36A-like

chr17_-_29347902 0.397 ENSMUST00000095427.4
ENSMUST00000118366.1
 Mtch1

mitochondrial carrier homolog 1 (C. elegans)

chr2_-_30359190 0.388 ENSMUST00000100215.4
ENSMUST00000113620.3
 Sh3glb2

SH3-domain GRB2-like endophilin B2

chr9_+_57130690 0.365 ENSMUST00000160147.1
ENSMUST00000161663.1
ENSMUST00000034836.9
ENSMUST00000161182.1
 Man2c1



mannosidase, alpha, class 2C, member 1



chr18_-_80151467 0.358 ENSMUST00000066743.9
 Adnp2
ADNP homeobox 2
chr17_+_55986494 0.353 ENSMUST00000011733.8
 Fsd1
fibronectin type 3 and SPRY domain-containing protein
chr12_+_69184158 0.349 ENSMUST00000060579.8
 Mgat2
mannoside acetylglucosaminyltransferase 2
chr2_-_29253001 0.339 ENSMUST00000071201.4
 Ntng2
netrin G2
chr12_-_69184056 0.338 ENSMUST00000054544.6
 Rpl36al
ribosomal protein L36A-like
chr1_+_167598384 0.330 ENSMUST00000015987.3
 Rxrg
retinoid X receptor gamma
chr11_+_54902743 0.326 ENSMUST00000082430.3
 Gpx3
glutathione peroxidase 3
chr6_-_124756478 0.313 ENSMUST00000088357.5
 Atn1
atrophin 1
chr6_+_6863769 0.310 ENSMUST00000031768.6
 Dlx6
distal-less homeobox 6
chr19_+_4231899 0.301 ENSMUST00000025773.3
 Pold4
polymerase (DNA-directed), delta 4
chr13_+_3538075 0.292 ENSMUST00000059515.6
 Gdi2
guanosine diphosphate (GDP) dissociation inhibitor 2
chr15_-_66286224 0.271 ENSMUST00000070256.7
 Kcnq3
potassium voltage-gated channel, subfamily Q, member 3
chr5_+_24423805 0.270 ENSMUST00000153274.1
 Slc4a2
solute carrier family 4 (anion exchanger), member 2
chr7_-_120670256 0.247 ENSMUST00000033178.2
 Pdzd9
PDZ domain containing 9
chr8_-_94012558 0.236 ENSMUST00000053766.6
 Amfr
autocrine motility factor receptor
chr5_-_22344690 0.206 ENSMUST00000062372.7
ENSMUST00000161356.1
 Reln

reelin

chr7_-_19458494 0.200 ENSMUST00000085715.5
 Mark4
MAP/microtubule affinity-regulating kinase 4
chr8_-_83699095 0.187 ENSMUST00000005616.8
 Pkn1
protein kinase N1
chr11_-_76846968 0.177 ENSMUST00000021201.5
 Cpd
carboxypeptidase D
chr6_-_124415037 0.136 ENSMUST00000035861.5
ENSMUST00000112532.1
ENSMUST00000080557.5
 Pex5


peroxisomal biogenesis factor 5


chr4_+_31964081 0.130 ENSMUST00000037607.4
ENSMUST00000080933.6
ENSMUST00000108183.1
ENSMUST00000108184.2
 Map3k7



mitogen-activated protein kinase kinase kinase 7



chr17_-_10840285 0.129 ENSMUST00000041463.6
 Pacrg
PARK2 co-regulated
chr12_+_102948843 0.121 ENSMUST00000101099.5
 Unc79
unc-79 homolog (C. elegans)
chr17_-_35074485 0.116 ENSMUST00000007259.3
 Ly6g6d
lymphocyte antigen 6 complex, locus G6D
chr2_-_147085445 0.113 ENSMUST00000067020.2
 Nkx2-4
NK2 homeobox 4
chr10_-_127620960 0.103 ENSMUST00000121829.1
 Lrp1
low density lipoprotein receptor-related protein 1
chr11_-_106160101 0.092 ENSMUST00000045923.3
 Limd2
LIM domain containing 2
chr17_-_32166879 0.077 ENSMUST00000087723.3
 Notch3
notch 3
chr4_-_117125618 0.074 ENSMUST00000183310.1
 Btbd19
BTB (POZ) domain containing 19
chr1_-_51941261 0.073 ENSMUST00000097103.3
 Gm8420
predicted gene 8420
chr11_+_54902917 0.066 ENSMUST00000149324.1
 Gpx3
glutathione peroxidase 3
chr5_+_24423851 0.043 ENSMUST00000141966.1
 Slc4a2
solute carrier family 4 (anion exchanger), member 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 6.1 GO:0090238 positive regulation of arachidonic acid secretion(GO:0090238)
0.9 5.3 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.5 2.3 GO:0001661 conditioned taste aversion(GO:0001661)
0.4 1.2 GO:2000501 natural killer cell chemotaxis(GO:0035747) negative regulation of lymphocyte migration(GO:2000402) regulation of natural killer cell chemotaxis(GO:2000501)
0.3 1.2 GO:0001920 negative regulation of receptor recycling(GO:0001920) negative regulation of low-density lipoprotein particle clearance(GO:0010989) positive regulation of low-density lipoprotein particle receptor catabolic process(GO:0032805)
0.2 1.0 GO:1990928 response to amino acid starvation(GO:1990928)
0.1 2.3 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.1 0.4 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.1 2.3 GO:1900273 positive regulation of long-term synaptic potentiation(GO:1900273)
0.1 0.3 GO:0009405 pathogenesis(GO:0009405)
0.0 0.1 GO:0016561 protein import into peroxisome matrix, translocation(GO:0016561)
0.0 0.4 GO:0006013 mannose metabolic process(GO:0006013)
0.0 0.2 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.0 2.3 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 0.5 GO:0002087 regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.0 0.1 GO:0097343 ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026)
0.0 0.1 GO:1905167 astrocyte activation involved in immune response(GO:0002265) positive regulation of lysosomal protein catabolic process(GO:1905167)
0.0 0.3 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.0 0.4 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.0 0.3 GO:0060081 membrane hyperpolarization(GO:0060081)
0.0 2.4 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.0 0.1 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 1.8 GO:0006413 translational initiation(GO:0006413)
0.0 1.2 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 1.1 GO:0031641 regulation of myelination(GO:0031641) protein homotetramerization(GO:0051289)
0.0 1.1 GO:0032526 response to retinoic acid(GO:0032526)
0.0 0.3 GO:0000731 DNA synthesis involved in DNA repair(GO:0000731)
0.0 0.1 GO:0072103 glomerulus vasculature morphogenesis(GO:0072103) glomerular capillary formation(GO:0072104)
0.0 0.5 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 2.0 GO:0071805 potassium ion transmembrane transport(GO:0071805)
0.0 0.6 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 6.1 GO:0032280 symmetric synapse(GO:0032280)
0.4 1.2 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.2 2.3 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.2 2.1 GO:0044327 dendritic spine head(GO:0044327)
0.1 0.3 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 1.7 GO:0071565 nBAF complex(GO:0071565)
0.0 2.6 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.6 GO:0005614 interstitial matrix(GO:0005614)
0.0 2.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 2.3 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.2 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.0 0.5 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.3 GO:0046658 anchored component of plasma membrane(GO:0046658)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.3 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.8 2.3 GO:0070905 serine binding(GO:0070905)
0.4 1.2 GO:0034190 very-low-density lipoprotein particle binding(GO:0034189) apolipoprotein receptor binding(GO:0034190)
0.4 2.0 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.4 1.1 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.3 6.1 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.3 1.2 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 2.3 GO:0042809 vitamin D receptor binding(GO:0042809)
0.1 0.4 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.1 2.1 GO:0070300 phosphatidic acid binding(GO:0070300)
0.1 0.5 GO:0004768 stearoyl-CoA 9-desaturase activity(GO:0004768)
0.1 1.0 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.1 0.3 GO:0005093 Rab GDP-dissociation inhibitor activity(GO:0005093)
0.1 0.2 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.1 2.6 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.2 GO:1904288 BAT3 complex binding(GO:1904288)
0.0 0.2 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.0 0.7 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.4 GO:0008430 selenium binding(GO:0008430)
0.0 0.1 GO:0016964 alpha-2 macroglobulin receptor activity(GO:0016964)
0.0 1.8 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.9 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 1.2 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.1 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.0 0.4 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.0 0.2 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.3 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.1 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 0.3 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.3 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.2 GO:0050321 tau-protein kinase activity(GO:0050321)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 1.9 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 0.7 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.3 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.1 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 1.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.3 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 5.3 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 2.5 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 6.1 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 0.8 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 1.0 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 2.3 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.3 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.5 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 1.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.3 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 0.1 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.9 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes