Motif ID: Zic2

Z-value: 0.548


Transcription factors associated with Zic2:

Gene SymbolEntrez IDGene Name
Zic2 ENSMUSG00000061524.8 Zic2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zic2mm10_v2_chr14_+_122475397_1224754350.038.4e-01Click!


Activity profile for motif Zic2.

activity profile for motif Zic2


Sorted Z-values histogram for motif Zic2

Sorted Z-values for motif Zic2



Network of associatons between targets according to the STRING database.



First level regulatory network of Zic2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_19699008 1.582 ENSMUST00000174355.1
ENSMUST00000172983.1
ENSMUST00000174710.1
ENSMUST00000167646.2
ENSMUST00000003066.9
ENSMUST00000174064.1
 Apoe





apolipoprotein E





chr6_+_65671590 1.220 ENSMUST00000054351.4
 Ndnf
neuron-derived neurotrophic factor
chr14_-_78725089 1.049 ENSMUST00000074729.5
 Dgkh
diacylglycerol kinase, eta
chr7_-_19698206 0.907 ENSMUST00000172808.1
ENSMUST00000174191.1
 Apoe

apolipoprotein E

chr10_-_18743691 0.905 ENSMUST00000019999.5
 D10Bwg1379e
DNA segment, Chr 10, Brigham & Women's Genetics 1379 expressed
chrY_+_90784738 0.889 ENSMUST00000179483.1
 Erdr1
erythroid differentiation regulator 1
chr2_-_25469742 0.872 ENSMUST00000114259.2
ENSMUST00000015234.6
 Ptgds

prostaglandin D2 synthase (brain)

chrX_+_170009892 0.860 ENSMUST00000180251.1
 Gm21887
predicted gene, 21887
chr8_+_104170513 0.833 ENSMUST00000171018.1
ENSMUST00000167633.1
ENSMUST00000093245.5
ENSMUST00000164076.1
 Bean1



brain expressed, associated with Nedd4, 1



chrX_+_170009659 0.832 ENSMUST00000179760.1
 Gm21887
predicted gene, 21887
chr4_+_42240639 0.815 ENSMUST00000117202.2
 Gm10600
predicted gene 10600
chr2_-_25470031 0.814 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr2_-_93452679 0.795 ENSMUST00000111257.1
ENSMUST00000145553.1
 Cd82

CD82 antigen

chr4_+_42091207 0.777 ENSMUST00000178882.1
 Gm3893
predicted gene 3893
chr8_-_105471481 0.774 ENSMUST00000014990.6
 Tppp3
tubulin polymerization-promoting protein family member 3
chr5_+_137288273 0.729 ENSMUST00000024099.4
ENSMUST00000085934.3
 Ache

acetylcholinesterase

chr6_-_35308110 0.690 ENSMUST00000031868.4
 Slc13a4
solute carrier family 13 (sodium/sulfate symporters), member 4
chr9_+_49518336 0.679 ENSMUST00000068730.3
 Gm11149
predicted gene 11149
chr18_-_24709348 0.646 ENSMUST00000067987.1
 Gm9955
predicted gene 9955
chr11_+_84525669 0.642 ENSMUST00000126072.1
ENSMUST00000128121.1
 1500016L03Rik

RIKEN cDNA 1500016L03 gene


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 115 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 3.1 GO:1903002 regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002)
0.2 2.0 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.3 1.7 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.1 1.0 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.1 0.8 GO:0061092 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.1 0.7 GO:0019695 choline metabolic process(GO:0019695)
0.0 0.7 GO:0008272 sulfate transport(GO:0008272)
0.2 0.6 GO:0061743 motor learning(GO:0061743)
0.1 0.6 GO:1901731 positive regulation of platelet aggregation(GO:1901731)
0.0 0.6 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.1 0.5 GO:0070305 response to cGMP(GO:0070305) cellular response to cGMP(GO:0071321)
0.1 0.5 GO:0097491 trigeminal nerve morphogenesis(GO:0021636) trigeminal nerve structural organization(GO:0021637) trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) sympathetic neuron projection extension(GO:0097490) sympathetic neuron projection guidance(GO:0097491) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.1 0.5 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1 0.5 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.5 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.0 0.5 GO:0005980 polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.0 0.5 GO:0006677 glycosylceramide metabolic process(GO:0006677)
0.1 0.4 GO:0006601 creatine biosynthetic process(GO:0006601)
0.1 0.4 GO:0032430 positive regulation of phospholipase A2 activity(GO:0032430)
0.1 0.4 GO:0043490 malate-aspartate shuttle(GO:0043490)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 3.1 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.0 1.1 GO:0005581 collagen trimer(GO:0005581)
0.0 0.9 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 0.8 GO:0097427 microtubule bundle(GO:0097427)
0.1 0.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.2 0.6 GO:0005940 septin ring(GO:0005940)
0.2 0.6 GO:0097233 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.1 0.6 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.1 0.6 GO:0044301 climbing fiber(GO:0044301)
0.1 0.6 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 0.6 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.6 GO:0043218 compact myelin(GO:0043218)
0.2 0.5 GO:0098855 HCN channel complex(GO:0098855)
0.1 0.4 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.0 0.4 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 0.3 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.1 0.3 GO:0097543 ciliary inversin compartment(GO:0097543)
0.1 0.3 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 0.3 GO:0033093 Weibel-Palade body(GO:0033093)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 3.1 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.4 1.7 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.0 1.5 GO:0008201 heparin binding(GO:0008201)
0.1 1.0 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 1.0 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.9 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 0.7 GO:0004104 cholinesterase activity(GO:0004104) choline binding(GO:0033265)
0.1 0.6 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.1 0.6 GO:0015250 water channel activity(GO:0015250)
0.0 0.6 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.2 0.5 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.1 0.5 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.1 0.5 GO:2001070 starch binding(GO:2001070)
0.1 0.5 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.1 0.5 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.5 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.5 GO:0015485 cholesterol binding(GO:0015485)
0.1 0.4 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.1 0.4 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.1 0.4 GO:0015501 glutamate:sodium symporter activity(GO:0015501)

Gene overrepresentation in C2:CP category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.3 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 1.2 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 1.2 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.8 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.6 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.6 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.1 0.5 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.5 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.5 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.2 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.2 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.2 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.2 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.1 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.1 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 1.2 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 1.1 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 1.1 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.0 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 1.0 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.8 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.0 0.7 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.6 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.6 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 0.4 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.4 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 0.3 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.0 0.3 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.3 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.3 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.2 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.2 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.2 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.2 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus