Motif ID: Zic4

Z-value: 0.914


Transcription factors associated with Zic4:

Gene SymbolEntrez IDGene Name
Zic4 ENSMUSG00000036972.8 Zic4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zic4mm10_v2_chr9_+_91368811_91368828-0.411.2e-02Click!


Activity profile for motif Zic4.

activity profile for motif Zic4


Sorted Z-values histogram for motif Zic4

Sorted Z-values for motif Zic4



Network of associatons between targets according to the STRING database.



First level regulatory network of Zic4

PNG image of the network

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Top targets:


Showing 1 to 20 of 191 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_180499893 5.938 ENSMUST00000029084.2
 Ntsr1
neurotensin receptor 1
chr4_+_141368116 3.514 ENSMUST00000006380.4
 Fam131c
family with sequence similarity 131, member C
chr19_-_12501996 3.436 ENSMUST00000045521.7
 Dtx4
deltex 4 homolog (Drosophila)
chr9_-_29412204 3.399 ENSMUST00000115237.1
 Ntm
neurotrimin
chr17_-_29237759 3.346 ENSMUST00000137727.1
ENSMUST00000024805.7
 Cpne5

copine V

chr4_-_72200833 2.938 ENSMUST00000102848.2
ENSMUST00000072695.6
ENSMUST00000107337.1
ENSMUST00000074216.7
 Tle1



transducin-like enhancer of split 1, homolog of Drosophila E(spl)



chr19_+_4099998 2.931 ENSMUST00000049658.7
 Pitpnm1
phosphatidylinositol transfer protein, membrane-associated 1
chr5_-_139325616 2.835 ENSMUST00000110865.1
 Adap1
ArfGAP with dual PH domains 1
chr4_+_104367549 2.734 ENSMUST00000106830.2
 Dab1
disabled 1
chr19_+_47178820 2.703 ENSMUST00000111808.3
 Neurl1a
neuralized homolog 1A (Drosophila)
chr4_+_152338619 2.696 ENSMUST00000030775.5
ENSMUST00000164662.1
 Chd5

chromodomain helicase DNA binding protein 5

chr5_+_139543889 2.689 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr4_+_152338887 2.529 ENSMUST00000005175.4
 Chd5
chromodomain helicase DNA binding protein 5
chr17_+_46297917 2.482 ENSMUST00000166617.1
ENSMUST00000170271.1
 Dlk2

delta-like 2 homolog (Drosophila)

chr7_-_47133684 2.151 ENSMUST00000102626.1
 Ptpn5
protein tyrosine phosphatase, non-receptor type 5
chr7_-_47133395 2.142 ENSMUST00000107617.1
 Ptpn5
protein tyrosine phosphatase, non-receptor type 5
chr12_+_112146187 2.077 ENSMUST00000128402.2
 Kif26a
kinesin family member 26A
chrY_+_897782 1.942 ENSMUST00000055032.7
 Kdm5d
lysine (K)-specific demethylase 5D
chr1_+_91179822 1.843 ENSMUST00000097648.4
ENSMUST00000165855.1
 Ramp1

receptor (calcitonin) activity modifying protein 1

chrX_-_107403295 1.806 ENSMUST00000033591.5
 Itm2a
integral membrane protein 2A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 89 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 5.9 GO:0090238 positive regulation of arachidonic acid secretion(GO:0090238)
0.7 5.2 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.1 4.9 GO:0048713 regulation of oligodendrocyte differentiation(GO:0048713)
0.9 4.3 GO:2001025 positive regulation of response to drug(GO:2001025)
0.0 3.4 GO:0010977 negative regulation of neuron projection development(GO:0010977)
1.1 3.2 GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055)
0.1 2.9 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.1 2.9 GO:2000811 negative regulation of anoikis(GO:2000811)
0.9 2.7 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.3 2.7 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.3 2.7 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0 2.2 GO:0015914 phospholipid transport(GO:0015914)
0.2 2.1 GO:0048484 enteric nervous system development(GO:0048484)
0.1 2.1 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 2.1 GO:0045598 regulation of fat cell differentiation(GO:0045598)
0.4 1.9 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.3 1.8 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.3 1.8 GO:0002317 plasma cell differentiation(GO:0002317) negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.3 1.8 GO:0097491 trigeminal nerve morphogenesis(GO:0021636) trigeminal nerve structural organization(GO:0021637) trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) sympathetic neuron projection extension(GO:0097490) sympathetic neuron projection guidance(GO:0097491) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.3 1.6 GO:0030644 cellular chloride ion homeostasis(GO:0030644)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 5.9 GO:0032280 symmetric synapse(GO:0032280)
0.2 5.8 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 5.0 GO:0031225 anchored component of membrane(GO:0031225)
0.3 4.3 GO:1990635 proximal dendrite(GO:1990635)
0.0 3.1 GO:0005871 kinesin complex(GO:0005871)
0.0 3.1 GO:0005811 lipid particle(GO:0005811)
0.1 2.7 GO:0097440 apical dendrite(GO:0097440)
0.4 1.8 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.0 1.8 GO:0005581 collagen trimer(GO:0005581)
0.0 1.7 GO:0005903 brush border(GO:0005903)
0.0 1.3 GO:0032590 dendrite membrane(GO:0032590)
0.1 1.2 GO:0005642 annulate lamellae(GO:0005642)
0.1 1.1 GO:0033391 chromatoid body(GO:0033391)
0.0 1.1 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 1.0 GO:0016461 unconventional myosin complex(GO:0016461)
0.2 0.9 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.0 0.9 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 0.7 GO:0035061 interchromatin granule(GO:0035061)
0.0 0.6 GO:0030131 clathrin adaptor complex(GO:0030131)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.9 GO:0008188 neuropeptide receptor activity(GO:0008188)
1.3 5.2 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
0.1 4.9 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 3.3 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
1.1 3.2 GO:0002153 steroid receptor RNA activator RNA binding(GO:0002153)
0.3 2.9 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.1 2.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 2.9 GO:0005096 GTPase activator activity(GO:0005096)
0.0 2.7 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.0 2.2 GO:0045182 translation regulator activity(GO:0045182)
0.1 2.1 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 2.1 GO:0003777 microtubule motor activity(GO:0003777)
0.3 1.9 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.4 1.8 GO:0097643 amylin receptor activity(GO:0097643)
0.1 1.8 GO:0038191 neuropilin binding(GO:0038191)
0.0 1.8 GO:0001540 beta-amyloid binding(GO:0001540)
0.1 1.5 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.1 1.5 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.2 1.4 GO:0034711 inhibin binding(GO:0034711)
0.0 1.4 GO:0008201 heparin binding(GO:0008201)

Gene overrepresentation in C2:CP category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.9 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 3.4 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 3.2 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 2.8 PID_ARF6_PATHWAY Arf6 signaling events
0.0 2.7 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.0 2.0 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.1 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.0 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.2 0.8 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.8 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.8 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 0.8 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.8 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 0.7 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.5 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.5 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.4 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.3 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.0 0.3 PID_ARF_3PATHWAY Arf1 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.0 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 3.2 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 2.9 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 2.4 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 2.1 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.1 2.1 REACTOME_KINESINS Genes involved in Kinesins
0.0 2.1 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 1.2 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 1.1 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 1.1 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 1.1 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.0 1.0 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.1 0.9 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.8 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.7 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.7 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.7 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.6 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.6 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 0.5 REACTOME_PLATELET_SENSITIZATION_BY_LDL Genes involved in Platelet sensitization by LDL