Motif ID: Zscan4c

Z-value: 0.787


Transcription factors associated with Zscan4c:

Gene SymbolEntrez IDGene Name
Zscan4c ENSMUSG00000054272.5 Zscan4c



Activity profile for motif Zscan4c.

activity profile for motif Zscan4c


Sorted Z-values histogram for motif Zscan4c

Sorted Z-values for motif Zscan4c



Network of associatons between targets according to the STRING database.



First level regulatory network of Zscan4c

PNG image of the network

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Top targets:


Showing 1 to 20 of 86 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_118283719 5.939 ENSMUST00000117160.1
 Cdh13
cadherin 13
chr13_+_58807884 5.662 ENSMUST00000079828.5
 Ntrk2
neurotrophic tyrosine kinase, receptor, type 2
chr7_-_119184374 5.155 ENSMUST00000084650.4
 Gpr139
G protein-coupled receptor 139
chr4_-_46991842 5.117 ENSMUST00000107749.2
 Gabbr2
gamma-aminobutyric acid (GABA) B receptor, 2
chr5_-_44799643 4.805 ENSMUST00000070748.5
 Ldb2
LIM domain binding 2
chr8_-_48555846 3.878 ENSMUST00000110345.1
ENSMUST00000110343.1
 Tenm3

teneurin transmembrane protein 3

chr15_-_37458523 3.617 ENSMUST00000116445.2
 Ncald
neurocalcin delta
chr4_+_123183722 3.587 ENSMUST00000152194.1
 Hpcal4
hippocalcin-like 4
chr9_-_49798905 3.383 ENSMUST00000114476.2
 Ncam1
neural cell adhesion molecule 1
chr9_-_49798729 3.228 ENSMUST00000166811.2
 Ncam1
neural cell adhesion molecule 1
chr5_-_128953303 3.195 ENSMUST00000111346.1
 Rimbp2
RIMS binding protein 2
chr9_+_26733728 3.187 ENSMUST00000160899.1
ENSMUST00000161431.1
ENSMUST00000159799.1
 B3gat1


beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)


chr15_-_78718113 2.891 ENSMUST00000088592.4
 Elfn2
leucine rich repeat and fibronectin type III, extracellular 2
chr9_+_89909775 2.642 ENSMUST00000034912.4
ENSMUST00000034909.4
 Rasgrf1

RAS protein-specific guanine nucleotide-releasing factor 1

chr19_+_8664005 2.627 ENSMUST00000035444.3
ENSMUST00000163785.1
 Chrm1

cholinergic receptor, muscarinic 1, CNS

chr9_+_26733845 2.556 ENSMUST00000115269.2
 B3gat1
beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)
chr3_-_158562199 2.381 ENSMUST00000106044.1
 Lrrc7
leucine rich repeat containing 7
chr7_-_98178254 2.336 ENSMUST00000040971.7
 Capn5
calpain 5
chr7_-_47132698 2.143 ENSMUST00000033142.5
 Ptpn5
protein tyrosine phosphatase, non-receptor type 5
chr2_+_57238297 2.089 ENSMUST00000112618.2
ENSMUST00000028167.2
 Gpd2

glycerol phosphate dehydrogenase 2, mitochondrial


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 6.6 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.1 6.1 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
1.2 5.9 GO:0055095 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096)
0.7 5.7 GO:0099550 trans-synaptic signalling, modulating synaptic transmission(GO:0099550)
0.3 5.7 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.1 5.4 GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200)
0.2 5.1 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.5 3.9 GO:0097264 self proteolysis(GO:0097264)
0.0 3.6 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.5 2.6 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.1 2.6 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.4 2.1 GO:2001025 positive regulation of response to drug(GO:2001025)
0.3 2.1 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.3 2.1 GO:0061092 involuntary skeletal muscle contraction(GO:0003011) regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.7 2.0 GO:0035585 calcium-mediated signaling using extracellular calcium source(GO:0035585)
0.1 2.0 GO:0010669 epithelial structure maintenance(GO:0010669)
0.6 1.9 GO:2000501 natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501)
0.3 1.9 GO:0045218 zonula adherens maintenance(GO:0045218)
0.1 1.8 GO:0042178 xenobiotic catabolic process(GO:0042178)
0.4 1.7 GO:0014846 esophagus smooth muscle contraction(GO:0014846)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.6 GO:0031225 anchored component of membrane(GO:0031225)
0.1 5.7 GO:0048786 presynaptic active zone(GO:0048786)
0.0 5.7 GO:0000139 Golgi membrane(GO:0000139)
1.0 5.1 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 2.6 GO:0032279 asymmetric synapse(GO:0032279)
0.1 2.6 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 2.4 GO:0043194 axon initial segment(GO:0043194)
0.4 2.1 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 2.1 GO:1990635 proximal dendrite(GO:1990635)
0.5 2.0 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.2 1.9 GO:0005915 zonula adherens(GO:0005915)
0.1 1.6 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 1.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 1.4 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 1.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 0.7 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 0.7 GO:0097440 apical dendrite(GO:0097440)
0.0 0.5 GO:0016589 NURF complex(GO:0016589)
0.0 0.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.6 GO:0030275 LRR domain binding(GO:0030275)
1.2 5.9 GO:0055100 adiponectin binding(GO:0055100)
1.1 5.7 GO:0005030 neurotrophin receptor activity(GO:0005030)
1.0 5.7 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.3 5.2 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 5.2 GO:0005246 calcium channel regulator activity(GO:0005246)
0.9 5.1 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 4.8 GO:0035254 glutamate receptor binding(GO:0035254)
0.1 3.6 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 2.9 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.5 2.6 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.1 2.3 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.7 2.1 GO:0016901 glycerol-3-phosphate dehydrogenase activity(GO:0004368) oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.1 2.1 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.2 2.0 GO:0030274 LIM domain binding(GO:0030274)
0.0 2.0 GO:0030507 spectrin binding(GO:0030507)
0.1 1.9 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.1 1.9 GO:0008009 chemokine activity(GO:0008009)
0.2 1.8 GO:0016151 nickel cation binding(GO:0016151)
0.3 1.7 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.3 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 6.6 PID_FGF_PATHWAY FGF signaling pathway
0.0 3.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.8 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 3.3 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.7 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.4 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 1.4 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.0 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 0.8 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.1 0.7 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.5 PID_TNF_PATHWAY TNF receptor signaling pathway
0.0 0.4 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.6 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.2 5.9 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.2 5.7 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.4 5.1 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2 4.0 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.2 3.6 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.2 2.6 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 2.1 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 2.1 REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.0 1.9 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 1.8 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 1.4 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.1 1.1 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 1.1 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 1.0 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.1 1.0 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.9 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.9 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.8 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION_IN_THE_MEDIAL_TRANS_GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 0.8 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation