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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for AACACUG
Z-value: 0.68
Motif logo
miRNA associated with seed AACACUG
Network of associatons between targets according to the STRING database.
First level regulatory network of AACACUG
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chrX_-_13938618 Show fit | 11.56 |
ENST00000454189.6
|
glycoprotein M6B |
|
| chr3_+_62319037 Show fit | 10.06 |
ENST00000494481.5
|
chromosome 3 open reading frame 14 |
|
| chr1_+_51236252 Show fit | 9.55 |
ENST00000242719.4
|
ring finger protein 11 |
|
| chr3_+_159839847 Show fit | 8.47 |
ENST00000445224.6
|
schwannomin interacting protein 1 |
|
| chr17_-_8630713 Show fit | 7.44 |
ENST00000411957.1
ENST00000360416.8 |
myosin heavy chain 10 |
|
| chr1_-_6393339 Show fit | 6.83 |
ENST00000608083.5
|
acyl-CoA thioesterase 7 |
|
| chr7_-_47582076 Show fit | 6.28 |
ENST00000311160.14
|
tensin 3 |
|
| chr7_-_112206380 Show fit | 5.70 |
ENST00000437633.6
ENST00000428084.6 |
dedicator of cytokinesis 4 |
|
| chr1_-_211579064 Show fit | 5.57 |
ENST00000367001.5
|
solute carrier family 30 member 1 |
|
| chr6_-_122471774 Show fit | 5.24 |
ENST00000339697.5
|
serine incorporator 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 11.6 | GO:0051581 | negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.1 | 9.1 | GO:0051865 | protein autoubiquitination(GO:0051865) |
| 0.2 | 7.6 | GO:0015991 | energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) |
| 2.4 | 7.1 | GO:0021592 | fourth ventricle development(GO:0021592) third ventricle development(GO:0021678) |
| 0.5 | 6.9 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 1.7 | 6.8 | GO:1900533 | medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535) |
| 0.0 | 6.1 | GO:0000226 | microtubule cytoskeleton organization(GO:0000226) |
| 0.2 | 6.0 | GO:0030208 | dermatan sulfate biosynthetic process(GO:0030208) |
| 0.3 | 5.9 | GO:0007084 | mitotic nuclear envelope reassembly(GO:0007084) |
| 1.1 | 5.7 | GO:0045906 | negative regulation of vasoconstriction(GO:0045906) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.6 | GO:0005819 | spindle(GO:0005819) |
| 0.1 | 10.4 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.2 | 9.5 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 8.0 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.7 | 7.6 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 1.5 | 7.4 | GO:0097513 | myosin II filament(GO:0097513) |
| 0.2 | 6.6 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.0 | 6.6 | GO:0045121 | membrane raft(GO:0045121) |
| 0.2 | 6.3 | GO:1990752 | microtubule end(GO:1990752) |
| 0.1 | 6.3 | GO:0030315 | T-tubule(GO:0030315) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.3 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.2 | 8.6 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.3 | 7.6 | GO:0044769 | ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 0.3 | 7.4 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.8 | 6.8 | GO:0036042 | long-chain fatty acyl-CoA binding(GO:0036042) |
| 0.2 | 6.8 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.3 | 6.5 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
| 0.1 | 6.1 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.2 | 6.0 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.3 | 5.6 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.3 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 4.7 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.2 | 4.2 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.1 | 4.2 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 3.8 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.1 | 2.9 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.1 | 2.9 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.0 | 2.9 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 2.8 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.1 | 2.7 | PID IL4 2PATHWAY | IL4-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 8.1 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
| 0.3 | 7.6 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.2 | 7.6 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.3 | 6.8 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.3 | 6.0 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.3 | 5.6 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.2 | 5.4 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.1 | 4.5 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 4.2 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.0 | 4.0 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |