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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for AAGGCAC
Z-value: 1.33
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miRNA associated with seed AAGGCAC
| Name | miRBASE accession |
|---|---|
|
hsa-miR-124-3p.1
|
MIMAT0000422 |
Network of associatons between targets according to the STRING database.
First level regulatory network of AAGGCAC
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_+_17229267 Show fit | 21.29 |
ENST00000224237.9
|
vimentin |
|
| chr2_-_160493799 Show fit | 17.50 |
ENST00000348849.8
|
RNA binding motif single stranded interacting protein 1 |
|
| chr10_-_32957865 Show fit | 16.83 |
ENST00000437302.6
ENST00000396033.6 |
integrin subunit beta 1 |
|
| chr22_-_50307598 Show fit | 15.30 |
ENST00000425954.1
ENST00000449103.5 ENST00000359337.9 |
plexin B2 |
|
| chr1_+_223712491 Show fit | 15.13 |
ENST00000295006.6
|
calpain 2 |
|
| chr21_-_43427131 Show fit | 15.11 |
ENST00000270162.8
|
salt inducible kinase 1 |
|
| chr6_+_138404206 Show fit | 14.56 |
ENST00000607197.6
ENST00000367697.7 |
heme binding protein 2 |
|
| chr9_-_107489754 Show fit | 13.84 |
ENST00000610832.1
ENST00000374672.5 |
Kruppel like factor 4 |
|
| chr10_-_3785225 Show fit | 13.58 |
ENST00000542957.1
|
Kruppel like factor 6 |
|
| chr1_+_183023409 Show fit | 12.84 |
ENST00000258341.5
|
laminin subunit gamma 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 24.2 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 1.7 | 23.6 | GO:0070307 | lens fiber cell development(GO:0070307) |
| 2.4 | 19.1 | GO:1904627 | response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628) |
| 0.5 | 19.0 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
| 0.5 | 17.2 | GO:0071526 | semaphorin-plexin signaling pathway(GO:0071526) |
| 2.4 | 16.8 | GO:0007161 | calcium-independent cell-matrix adhesion(GO:0007161) regulation of collagen catabolic process(GO:0010710) |
| 3.0 | 15.1 | GO:0032792 | negative regulation of triglyceride biosynthetic process(GO:0010868) negative regulation of CREB transcription factor activity(GO:0032792) |
| 0.8 | 15.1 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 1.5 | 14.6 | GO:0010940 | positive regulation of necrotic cell death(GO:0010940) |
| 4.6 | 13.8 | GO:0014740 | negative regulation of muscle hyperplasia(GO:0014740) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 49.9 | GO:0042582 | primary lysosome(GO:0005766) azurophil granule(GO:0042582) |
| 0.3 | 47.3 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.1 | 34.5 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.2 | 28.8 | GO:1904813 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.0 | 26.6 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.2 | 26.3 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.2 | 24.6 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 22.2 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.2 | 21.0 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.1 | 20.4 | GO:0001650 | fibrillar center(GO:0001650) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 28.9 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.1 | 27.8 | GO:0003713 | transcription coactivator activity(GO:0003713) |
| 0.1 | 25.2 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.2 | 23.7 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 4.6 | 23.0 | GO:1990254 | keratin filament binding(GO:1990254) |
| 0.2 | 21.6 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 1.4 | 21.2 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.8 | 20.4 | GO:0004859 | phospholipase inhibitor activity(GO:0004859) |
| 0.5 | 19.9 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 1.2 | 19.8 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 47.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.4 | 41.6 | PID E2F PATHWAY | E2F transcription factor network |
| 0.8 | 37.7 | PID LYMPH ANGIOGENESIS PATHWAY | VEGFR3 signaling in lymphatic endothelium |
| 0.4 | 25.9 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.6 | 25.1 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.1 | 24.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.4 | 24.6 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.7 | 24.3 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.5 | 24.3 | PID ERBB1 RECEPTOR PROXIMAL PATHWAY | EGF receptor (ErbB1) signaling pathway |
| 0.4 | 22.3 | PID AURORA B PATHWAY | Aurora B signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 31.1 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.6 | 25.1 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.6 | 19.7 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 1.1 | 18.6 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.3 | 18.6 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.5 | 17.9 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 1.0 | 16.8 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.5 | 15.9 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.1 | 15.8 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.2 | 14.7 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |