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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for AAGGUGC
Z-value: 0.43
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miRNA associated with seed AAGGUGC
Network of associatons between targets according to the STRING database.
First level regulatory network of AAGGUGC
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.8 | GO:0043090 | amino acid import(GO:0043090) |
| 1.2 | 7.2 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 0.9 | 5.4 | GO:0070101 | epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030) positive regulation of chemokine-mediated signaling pathway(GO:0070101) |
| 0.0 | 4.6 | GO:0060348 | bone development(GO:0060348) |
| 0.0 | 4.5 | GO:0002576 | platelet degranulation(GO:0002576) |
| 1.4 | 4.2 | GO:0010752 | negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) regulation of cGMP-mediated signaling(GO:0010752) |
| 0.1 | 4.2 | GO:0048009 | insulin-like growth factor receptor signaling pathway(GO:0048009) |
| 0.7 | 3.5 | GO:0034721 | histone H3-K4 demethylation, trimethyl-H3-K4-specific(GO:0034721) |
| 0.1 | 3.5 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.5 | 3.0 | GO:0009212 | dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.8 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.1 | 7.2 | GO:0032154 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.1 | 5.4 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.2 | 4.3 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.4 | 4.2 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 3.8 | GO:0005819 | spindle(GO:0005819) |
| 0.1 | 2.7 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.0 | 2.6 | GO:1904813 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.1 | 2.4 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 2.3 | GO:0005811 | lipid particle(GO:0005811) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 8.8 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
| 1.8 | 7.2 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.1 | 5.4 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 0.1 | 4.5 | GO:0004407 | histone deacetylase activity(GO:0004407) |
| 0.1 | 4.5 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 4.3 | GO:0005125 | cytokine activity(GO:0005125) |
| 1.4 | 4.2 | GO:0005010 | insulin-like growth factor-activated receptor activity(GO:0005010) |
| 1.4 | 4.2 | GO:0070052 | collagen V binding(GO:0070052) |
| 0.7 | 3.9 | GO:0038049 | transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) |
| 0.7 | 3.5 | GO:0034647 | histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.2 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.2 | 5.4 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.1 | 4.2 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 4.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 2.4 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 2.0 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 1.8 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 1.1 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 0.8 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 0.8 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.2 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.2 | 5.4 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.0 | 4.2 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 3.1 | REACTOME DIABETES PATHWAYS | Genes involved in Diabetes pathways |
| 0.0 | 3.0 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.2 | 2.6 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.0 | 2.4 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.0 | 2.3 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 2.2 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |
| 0.0 | 2.0 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |