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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for AAUACUG
Z-value: 1.07
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miRNA associated with seed AAUACUG
Network of associatons between targets according to the STRING database.
First level regulatory network of AAUACUG
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_150487658 Show fit | 18.24 |
ENST00000375734.6
ENST00000263895.9 ENST00000454202.5 |
Rho family GTPase 3 |
|
| chrX_+_65667645 Show fit | 17.25 |
ENST00000360270.7
|
moesin |
|
| chr12_-_108731505 Show fit | 16.24 |
ENST00000261401.8
ENST00000552871.5 |
coronin 1C |
|
| chr6_-_122471774 Show fit | 14.99 |
ENST00000339697.5
|
serine incorporator 1 |
|
| chr3_-_120450981 Show fit | 14.86 |
ENST00000424703.6
ENST00000469005.1 ENST00000295633.8 |
follistatin like 1 |
|
| chr9_+_110048598 Show fit | 13.61 |
ENST00000434623.6
ENST00000374525.5 |
PALM2 and AKAP2 fusion |
|
| chr9_+_109780292 Show fit | 13.23 |
ENST00000374530.7
|
PALM2 and AKAP2 fusion |
|
| chr5_+_17217617 Show fit | 12.77 |
ENST00000322611.4
|
brain abundant membrane attached signal protein 1 |
|
| chr2_-_36598140 Show fit | 12.29 |
ENST00000405912.8
ENST00000379245.8 |
fasciculation and elongation protein zeta 2 |
|
| chr9_-_136050502 Show fit | 12.15 |
ENST00000371753.5
|
NACC family member 2 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 29.6 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
| 0.5 | 20.5 | GO:0035329 | hippo signaling(GO:0035329) |
| 2.9 | 17.3 | GO:0022614 | membrane to membrane docking(GO:0022614) |
| 1.3 | 16.4 | GO:0044387 | negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387) |
| 0.9 | 16.3 | GO:0070831 | basement membrane assembly(GO:0070831) |
| 1.9 | 15.0 | GO:0015825 | L-serine transport(GO:0015825) |
| 0.0 | 15.0 | GO:0030036 | actin cytoskeleton organization(GO:0030036) |
| 0.9 | 13.9 | GO:0000338 | protein deneddylation(GO:0000338) |
| 2.6 | 12.8 | GO:2001074 | regulation of metanephric ureteric bud development(GO:2001074) positive regulation of metanephric ureteric bud development(GO:2001076) |
| 1.4 | 12.3 | GO:1902902 | negative regulation of autophagosome assembly(GO:1902902) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 36.3 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.1 | 30.4 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.2 | 26.4 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.1 | 24.4 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.5 | 23.2 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.5 | 21.6 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 21.1 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.9 | 17.3 | GO:0031254 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 0.7 | 13.7 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.3 | 12.1 | GO:0090545 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 40.9 | GO:0019003 | GDP binding(GO:0019003) |
| 0.1 | 29.8 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.1 | 26.4 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.3 | 25.3 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.1 | 24.5 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.1 | 17.8 | GO:0003924 | GTPase activity(GO:0003924) |
| 1.2 | 15.0 | GO:0015194 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
| 0.6 | 14.1 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
| 0.1 | 14.1 | GO:0008201 | heparin binding(GO:0008201) |
| 1.9 | 13.6 | GO:0050815 | phosphoserine binding(GO:0050815) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 30.4 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.5 | 28.7 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.4 | 22.7 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 15.8 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.2 | 13.6 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.3 | 13.5 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.3 | 12.4 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.2 | 11.4 | PID BMP PATHWAY | BMP receptor signaling |
| 0.4 | 10.5 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.5 | 10.3 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 26.8 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.5 | 23.9 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |
| 0.5 | 14.9 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.9 | 13.0 | REACTOME RAF MAP KINASE CASCADE | Genes involved in RAF/MAP kinase cascade |
| 0.2 | 11.7 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.7 | 11.6 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
| 0.5 | 11.4 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.1 | 11.4 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |
| 0.4 | 11.3 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.1 | 11.3 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |