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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for AAUCUCA

Z-value: 0.20

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miRNA associated with seed AAUCUCA

NamemiRBASE accession
hsa-miR-216a-5p
MIMAT0000273

Activity profile of AAUCUCA motif

Sorted Z-values of AAUCUCA motif

Network of associatons between targets according to the STRING database.

First level regulatory network of AAUCUCA

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr13_-_30464234 2.53 ENST00000399489.5
ENST00000339872.8
HMGB1
high mobility group box 1
chr1_-_67430412 2.32 ENST00000370994.8
SERBP1
SERPINE1 mRNA binding protein 1
chr4_+_98995709 2.29 ENST00000296411.11
ENST00000625963.1
METAP1
methionyl aminopeptidase 1
chrX_-_20266834 1.99 ENST00000379565.9
RPS6KA3
ribosomal protein S6 kinase A3
chr2_+_231056845 1.69 ENST00000677230.1
ENST00000677259.1
ENST00000677180.1
ENST00000409643.6
ENST00000619128.5
ENST00000678679.1
ENST00000676740.1
ENST00000308696.11
ENST00000440838.5
ENST00000373635.9
PSMD1
proteasome 26S subunit, non-ATPase 1
chr2_-_241272812 1.27 ENST00000427007.5
ENST00000458564.5
ENST00000452065.5
ENST00000427183.6
ENST00000426343.5
ENST00000422080.5
ENST00000449504.5
ENST00000449864.5
ENST00000391975.5
HDLBP
high density lipoprotein binding protein
chr1_-_53328053 1.26 ENST00000371454.6
ENST00000667377.1
ENST00000306052.12
ENST00000668448.1
LRP8
LDL receptor related protein 8
chr4_-_112516176 1.04 ENST00000313341.4
NEUROG2
neurogenin 2
chr11_+_112074287 0.98 ENST00000532163.5
ENST00000280352.13
ENST00000393047.8
ENST00000526879.5
ENST00000525785.5
NKAPD1
NKAP domain containing 1
chr20_-_543770 0.97 ENST00000460062.7
ENST00000645187.1
ENST00000647348.1
ENST00000217244.9
ENST00000349736.10
CSNK2A1
casein kinase 2 alpha 1
chr7_+_12211259 0.92 ENST00000396668.8
ENST00000444443.5
ENST00000396667.7
TMEM106B
transmembrane protein 106B
chr1_-_67054100 0.87 ENST00000235345.6
SLC35D1
solute carrier family 35 member D1
chr7_-_140176970 0.82 ENST00000397560.7
KDM7A
lysine demethylase 7A
chr17_+_32350132 0.66 ENST00000321233.10
ENST00000394673.6
ENST00000394670.9
ENST00000579634.5
ENST00000580759.5
ENST00000342555.10
ENST00000577908.5
ENST00000394679.9
ENST00000582165.1
ZNF207
zinc finger protein 207
chr12_-_56636318 0.60 ENST00000549506.5
ENST00000379441.7
ENST00000551812.5
BAZ2A
bromodomain adjacent to zinc finger domain 2A
chr4_-_104494882 0.44 ENST00000394767.3
CXXC4
CXXC finger protein 4
chr12_+_49950733 0.43 ENST00000199280.4
ENST00000550862.1
AQP2
aquaporin 2
chr1_+_63322558 0.38 ENST00000371116.4
FOXD3
forkhead box D3
chr11_-_32430811 0.37 ENST00000379079.8
ENST00000530998.5
WT1
WT1 transcription factor
chr6_+_42782020 0.35 ENST00000314073.9
BICRAL
BRD4 interacting chromatin remodeling complex associated protein like
chr15_+_40440889 0.28 ENST00000416165.6
BAHD1
bromo adjacent homology domain containing 1
chr9_-_20622479 0.26 ENST00000380338.9
MLLT3
MLLT3 super elongation complex subunit
chr3_+_126983035 0.24 ENST00000393409.3
PLXNA1
plexin A1
chr17_+_66302606 0.08 ENST00000413366.8
PRKCA
protein kinase C alpha

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.5 GO:0002270 plasmacytoid dendritic cell activation(GO:0002270) regulation of restriction endodeoxyribonuclease activity(GO:0032072) negative regulation of apoptotic cell clearance(GO:2000426)
0.3 0.8 GO:0035574 histone H4-K20 demethylation(GO:0035574)
0.2 1.3 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
0.2 2.3 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.1 0.9 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065)
0.1 0.4 GO:0071288 cellular response to mercury ion(GO:0071288)
0.1 0.4 GO:0072299 posterior mesonephric tubule development(GO:0072166) negative regulation of metanephric glomerulus development(GO:0072299) negative regulation of metanephric glomerular mesangial cell proliferation(GO:0072302)
0.1 0.4 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.1 1.3 GO:0034384 high-density lipoprotein particle clearance(GO:0034384)
0.1 2.0 GO:0043555 regulation of translation in response to stress(GO:0043555)
0.1 0.6 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.0 1.6 GO:0071174 mitotic spindle checkpoint(GO:0071174)
0.0 0.2 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0 0.3 GO:0031507 heterochromatin assembly(GO:0031507)
0.0 0.3 GO:0007379 segment specification(GO:0007379)
0.0 0.1 GO:0002159 desmosome assembly(GO:0002159)
0.0 1.7 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.0 0.9 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0 2.3 GO:0043488 regulation of mRNA stability(GO:0043488)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0034515 proteasome storage granule(GO:0034515)
0.1 1.0 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.1 0.6 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.3 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 1.3 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.2 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 2.5 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 1.3 GO:0005901 caveola(GO:0005901)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.5 GO:0010858 calcium-dependent protein kinase regulator activity(GO:0010858)
0.3 0.8 GO:0035575 histone demethylase activity (H4-K20 specific)(GO:0035575)
0.3 1.3 GO:0038025 reelin receptor activity(GO:0038025)
0.1 0.9 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.1 0.4 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.1 0.4 GO:0015168 glycerol transmembrane transporter activity(GO:0015168)
0.0 1.6 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 2.3 GO:0004177 aminopeptidase activity(GO:0004177) metalloexopeptidase activity(GO:0008235)
0.0 0.6 GO:0001013 RNA polymerase I regulatory region DNA binding(GO:0001013) RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.0 0.1 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
0.0 2.3 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 1.0 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 1.0 GO:0070888 E-box binding(GO:0070888)
0.0 0.2 GO:0017154 semaphorin receptor activity(GO:0017154)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 2.2 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 2.0 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.5 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 1.3 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.0 2.0 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 0.9 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.4 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 1.7 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 1.0 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.0 0.2 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion