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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for AAUCUCU

Z-value: 0.17

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miRNA associated with seed AAUCUCU

NamemiRBASE accession
hsa-miR-216b-5p
MIMAT0004959

Activity profile of AAUCUCU motif

Sorted Z-values of AAUCUCU motif

Network of associatons between targets according to the STRING database.

First level regulatory network of AAUCUCU

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr13_-_30464234 2.86 ENST00000399489.5
ENST00000339872.8
HMGB1
high mobility group box 1
chr4_+_98995709 2.17 ENST00000296411.11
ENST00000625963.1
METAP1
methionyl aminopeptidase 1
chr14_+_57268963 1.94 ENST00000261558.8
AP5M1
adaptor related protein complex 5 subunit mu 1
chr3_-_113746218 1.78 ENST00000497255.1
ENST00000240922.8
ENST00000478020.1
ENST00000493900.5
NAA50
N-alpha-acetyltransferase 50, NatE catalytic subunit
chr8_+_48008409 1.54 ENST00000523432.5
ENST00000521346.5
ENST00000523111.7
ENST00000517630.5
UBE2V2
ubiquitin conjugating enzyme E2 V2
chr16_-_46689145 1.11 ENST00000299138.12
VPS35
VPS35 retromer complex component
chr17_+_32350132 0.75 ENST00000321233.10
ENST00000394673.6
ENST00000394670.9
ENST00000579634.5
ENST00000580759.5
ENST00000342555.10
ENST00000577908.5
ENST00000394679.9
ENST00000582165.1
ZNF207
zinc finger protein 207
chr7_+_12211259 0.70 ENST00000396668.8
ENST00000444443.5
ENST00000396667.7
TMEM106B
transmembrane protein 106B
chr12_+_59689337 0.65 ENST00000261187.8
SLC16A7
solute carrier family 16 member 7
chr2_-_241272812 0.61 ENST00000427007.5
ENST00000458564.5
ENST00000452065.5
ENST00000427183.6
ENST00000426343.5
ENST00000422080.5
ENST00000449504.5
ENST00000449864.5
ENST00000391975.5
HDLBP
high density lipoprotein binding protein
chr6_+_42782020 0.57 ENST00000314073.9
BICRAL
BRD4 interacting chromatin remodeling complex associated protein like
chr4_-_104494882 0.45 ENST00000394767.3
CXXC4
CXXC finger protein 4
chr14_+_70641896 0.43 ENST00000256367.3
TTC9
tetratricopeptide repeat domain 9
chr8_+_75539862 0.27 ENST00000396423.4
HNF4G
hepatocyte nuclear factor 4 gamma
chr15_+_73052449 0.26 ENST00000261908.11
NEO1
neogenin 1
chr1_+_2391775 0.21 ENST00000378513.7
ENST00000378518.5
ENST00000605895.6
ENST00000306256.13
ENST00000378512.5
RER1
retention in endoplasmic reticulum sorting receptor 1
chr1_+_63322558 0.21 ENST00000371116.4
FOXD3
forkhead box D3
chr9_-_20622479 0.20 ENST00000380338.9
MLLT3
MLLT3 super elongation complex subunit
chr17_+_66302606 0.05 ENST00000413366.8
PRKCA
protein kinase C alpha

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.9 GO:0002270 plasmacytoid dendritic cell activation(GO:0002270) regulation of restriction endodeoxyribonuclease activity(GO:0032072) negative regulation of apoptotic cell clearance(GO:2000426)
0.4 1.1 GO:1902822 positive regulation of Wnt protein secretion(GO:0061357) regulation of late endosome to lysosome transport(GO:1902822) regulation of dopamine biosynthetic process(GO:1903179) positive regulation of dopamine biosynthetic process(GO:1903181) negative regulation of vacuolar transport(GO:1903336)
0.2 2.2 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.1 1.8 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.1 0.4 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.1 0.6 GO:1901475 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 1.5 GO:0000729 DNA double-strand break processing(GO:0000729)
0.0 0.6 GO:0034384 high-density lipoprotein particle clearance(GO:0034384)
0.0 0.8 GO:0007094 mitotic spindle assembly checkpoint(GO:0007094) spindle assembly checkpoint(GO:0071173)
0.0 0.2 GO:0007379 segment specification(GO:0007379)
0.0 0.2 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.0 0.0 GO:0002159 desmosome assembly(GO:0002159)
0.0 0.7 GO:0007040 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.3 1.8 GO:0031415 NatA complex(GO:0031415)
0.1 1.5 GO:0031371 ubiquitin conjugating enzyme complex(GO:0031371)
0.0 1.9 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.0 2.9 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.6 GO:0034364 high-density lipoprotein particle(GO:0034364)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.9 GO:0010858 calcium-dependent protein kinase regulator activity(GO:0010858)
0.2 0.6 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.1 1.8 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 1.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 1.1 GO:0031748 D1 dopamine receptor binding(GO:0031748)
0.0 2.2 GO:0008235 aminopeptidase activity(GO:0004177) metalloexopeptidase activity(GO:0008235)
0.0 0.3 GO:0039706 co-receptor binding(GO:0039706)
0.0 0.2 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 0.0 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.9 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.9 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.6 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters