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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ACAGUAC
Z-value: 0.50
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miRNA associated with seed ACAGUAC
| Name | miRBASE accession |
|---|---|
|
hsa-miR-101-3p.1
|
MIMAT0000099 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ACAGUAC
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 14.3 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
| 0.5 | 8.1 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 1.4 | 6.8 | GO:0044111 | development involved in symbiotic interaction(GO:0044111) |
| 0.5 | 6.7 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 0.8 | 6.6 | GO:0046604 | positive regulation of mitotic centrosome separation(GO:0046604) |
| 0.1 | 6.5 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.0 | 6.4 | GO:0045445 | myoblast differentiation(GO:0045445) |
| 0.0 | 6.4 | GO:0016573 | histone acetylation(GO:0016573) |
| 2.0 | 6.1 | GO:0045645 | regulation of eosinophil differentiation(GO:0045643) positive regulation of eosinophil differentiation(GO:0045645) |
| 0.1 | 5.7 | GO:0071349 | interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.2 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 11.7 | GO:0005635 | nuclear envelope(GO:0005635) |
| 0.1 | 11.1 | GO:0000775 | chromosome, centromeric region(GO:0000775) |
| 0.1 | 10.0 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.1 | 7.9 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 1.0 | 6.8 | GO:0044354 | pinosome(GO:0044352) macropinosome(GO:0044354) |
| 0.1 | 6.8 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 0.0 | 6.5 | GO:0034399 | nuclear periphery(GO:0034399) |
| 0.1 | 5.7 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.6 | 5.2 | GO:0097452 | GAIT complex(GO:0097452) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 16.0 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.2 | 13.8 | GO:0019003 | GDP binding(GO:0019003) |
| 0.3 | 10.1 | GO:0017025 | TBP-class protein binding(GO:0017025) |
| 0.2 | 7.6 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 1.4 | 6.8 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
| 2.1 | 6.4 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 0.2 | 6.1 | GO:0031434 | mitogen-activated protein kinase kinase binding(GO:0031434) |
| 0.2 | 6.0 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.8 | 5.8 | GO:0050291 | sphingosine N-acyltransferase activity(GO:0050291) |
| 0.0 | 5.1 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.3 | PID E2F PATHWAY | E2F transcription factor network |
| 0.2 | 8.4 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.1 | 7.5 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 6.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 4.2 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.2 | 3.9 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.1 | 3.4 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.0 | 3.4 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 2.8 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.1 | 2.7 | PID BARD1 PATHWAY | BARD1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 9.3 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.1 | 8.8 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.2 | 7.7 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 6.6 | REACTOME HOST INTERACTIONS OF HIV FACTORS | Genes involved in Host Interactions of HIV factors |
| 0.2 | 5.8 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.2 | 5.4 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.0 | 5.2 | REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 0.2 | 5.0 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.1 | 4.6 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.0 | 4.0 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |