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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ACAGUAU
Z-value: 0.67
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miRNA associated with seed ACAGUAU
| Name | miRBASE accession |
|---|---|
|
hsa-miR-144-3p
|
MIMAT0000436 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ACAGUAU
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 9.0 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
| 1.8 | 8.8 | GO:0002439 | chronic inflammatory response to antigenic stimulus(GO:0002439) |
| 0.4 | 8.5 | GO:0032780 | negative regulation of ATPase activity(GO:0032780) |
| 0.7 | 7.9 | GO:0032000 | positive regulation of fatty acid beta-oxidation(GO:0032000) |
| 1.1 | 7.6 | GO:0035583 | sequestering of TGFbeta in extracellular matrix(GO:0035583) |
| 2.4 | 7.3 | GO:0010752 | negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) regulation of cGMP-mediated signaling(GO:0010752) |
| 1.7 | 6.7 | GO:0003175 | tricuspid valve development(GO:0003175) tricuspid valve morphogenesis(GO:0003186) |
| 0.0 | 5.0 | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0006919) |
| 0.4 | 4.8 | GO:0001886 | endothelial cell morphogenesis(GO:0001886) |
| 0.1 | 4.8 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 16.9 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.1 | 11.2 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.6 | 9.0 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 2.0 | 7.9 | GO:0005899 | insulin receptor complex(GO:0005899) |
| 0.4 | 7.6 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.6 | 7.3 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 6.5 | GO:0005819 | spindle(GO:0005819) |
| 0.0 | 6.2 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 5.9 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 5.9 | GO:0031965 | nuclear membrane(GO:0031965) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 17.0 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.1 | 10.2 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 1.5 | 8.8 | GO:0004013 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.3 | 8.7 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.2 | 8.6 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.3 | 8.5 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 1.1 | 7.6 | GO:0030023 | extracellular matrix constituent conferring elasticity(GO:0030023) |
| 0.2 | 7.6 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.0 | 7.6 | GO:0050839 | cell adhesion molecule binding(GO:0050839) |
| 2.4 | 7.3 | GO:0070052 | collagen V binding(GO:0070052) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.6 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.1 | 10.9 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 9.2 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.2 | 8.3 | PID S1P S1P2 PATHWAY | S1P2 pathway |
| 0.1 | 7.3 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.2 | 7.1 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.2 | 6.4 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.1 | 5.9 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 5.6 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.1 | 5.2 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.2 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.3 | 8.8 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.2 | 8.7 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.2 | 8.2 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.4 | 7.9 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.1 | 6.2 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.2 | 5.6 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.2 | 5.3 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.2 | 4.8 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.1 | 4.8 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |