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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for AGCACCA
Z-value: 1.61
Motif logo
miRNA associated with seed AGCACCA
| Name | miRBASE accession |
|---|---|
|
hsa-miR-29a-3p
|
MIMAT0000086 |
|
hsa-miR-29b-3p
|
MIMAT0000100 |
|
hsa-miR-29c-3p
|
MIMAT0000681 |
Activity profile of AGCACCA motif
Sorted Z-values of AGCACCA motif
Network of associatons between targets according to the STRING database.
First level regulatory network of AGCACCA
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.8 | 49.1 | GO:0001957 | intramembranous ossification(GO:0001957) direct ossification(GO:0036072) |
| 8.1 | 24.3 | GO:2000591 | positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:0035793) regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:1900238) positive regulation of metanephric mesenchymal cell migration(GO:2000591) |
| 6.4 | 32.0 | GO:2000542 | negative regulation of gastrulation(GO:2000542) |
| 6.2 | 37.3 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 4.8 | 19.4 | GO:0032290 | peripheral nervous system myelin formation(GO:0032290) |
| 4.8 | 19.1 | GO:0061304 | retinal blood vessel morphogenesis(GO:0061304) |
| 4.7 | 14.1 | GO:0010847 | regulation of chromatin assembly(GO:0010847) |
| 4.4 | 4.4 | GO:0046619 | optic placode formation involved in camera-type eye formation(GO:0046619) |
| 3.6 | 21.7 | GO:0033591 | response to L-ascorbic acid(GO:0033591) |
| 3.6 | 32.4 | GO:1903912 | negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912) |
| 3.5 | 45.7 | GO:0043589 | skin morphogenesis(GO:0043589) |
| 3.2 | 12.7 | GO:0071409 | cellular response to cycloheximide(GO:0071409) |
| 2.6 | 29.1 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 2.6 | 12.9 | GO:0035582 | sequestering of BMP in extracellular matrix(GO:0035582) |
| 2.5 | 10.1 | GO:0086097 | phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097) |
| 2.4 | 12.1 | GO:1901906 | diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911) |
| 2.3 | 32.9 | GO:0038065 | collagen-activated signaling pathway(GO:0038065) |
| 2.2 | 13.0 | GO:0022027 | interkinetic nuclear migration(GO:0022027) |
| 2.0 | 12.0 | GO:1901673 | regulation of mitotic spindle assembly(GO:1901673) |
| 2.0 | 6.0 | GO:1903718 | carbamoyl phosphate metabolic process(GO:0070408) carbamoyl phosphate biosynthetic process(GO:0070409) cellular response to oleic acid(GO:0071400) response to ammonia(GO:1903717) cellular response to ammonia(GO:1903718) |
| 2.0 | 8.0 | GO:0060940 | epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940) |
| 2.0 | 9.8 | GO:0097167 | circadian regulation of translation(GO:0097167) |
| 1.8 | 5.5 | GO:0008065 | establishment of blood-nerve barrier(GO:0008065) cellular response to lead ion(GO:0071284) positive regulation of bicellular tight junction assembly(GO:1903348) |
| 1.7 | 3.4 | GO:0036166 | phenotypic switching(GO:0036166) regulation of phenotypic switching(GO:1900239) |
| 1.7 | 6.7 | GO:0021571 | rhombomere 5 development(GO:0021571) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284) |
| 1.7 | 16.8 | GO:1901538 | DNA methylation involved in embryo development(GO:0043045) changes to DNA methylation involved in embryo development(GO:1901538) |
| 1.6 | 4.8 | GO:0072675 | multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675) |
| 1.5 | 14.8 | GO:2000049 | positive regulation of cell-cell adhesion mediated by cadherin(GO:2000049) |
| 1.4 | 5.7 | GO:0072092 | ureteric bud invasion(GO:0072092) |
| 1.4 | 50.8 | GO:0030199 | collagen fibril organization(GO:0030199) |
| 1.3 | 4.0 | GO:2000053 | Wnt signaling pathway involved in somitogenesis(GO:0090244) regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000053) |
| 1.3 | 3.9 | GO:0045829 | negative regulation of isotype switching(GO:0045829) |
| 1.2 | 7.4 | GO:0006398 | mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) |
| 1.2 | 3.6 | GO:0100009 | circadian temperature homeostasis(GO:0060086) regulation of fever generation by regulation of prostaglandin secretion(GO:0071810) positive regulation of fever generation by positive regulation of prostaglandin secretion(GO:0071812) positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling(GO:0071848) regulation of fever generation by prostaglandin secretion(GO:0100009) |
| 1.2 | 8.1 | GO:0035879 | plasma membrane lactate transport(GO:0035879) |
| 1.2 | 13.9 | GO:1904896 | ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903) |
| 1.2 | 3.5 | GO:0050653 | chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653) |
| 1.1 | 2.3 | GO:1901491 | negative regulation of lymphangiogenesis(GO:1901491) |
| 1.1 | 11.2 | GO:0036066 | protein O-linked fucosylation(GO:0036066) |
| 1.1 | 13.2 | GO:0043587 | tongue morphogenesis(GO:0043587) |
| 1.1 | 17.4 | GO:0045116 | protein neddylation(GO:0045116) |
| 1.1 | 7.5 | GO:0038172 | interleukin-33-mediated signaling pathway(GO:0038172) |
| 1.1 | 7.5 | GO:1903378 | positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378) |
| 1.1 | 5.3 | GO:0009233 | menaquinone metabolic process(GO:0009233) |
| 1.0 | 8.2 | GO:0061088 | regulation of sequestering of zinc ion(GO:0061088) |
| 1.0 | 3.1 | GO:0097477 | spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477) |
| 1.0 | 3.1 | GO:0043321 | regulation of natural killer cell degranulation(GO:0043321) positive regulation of natural killer cell degranulation(GO:0043323) |
| 1.0 | 3.0 | GO:0072709 | cellular response to sorbitol(GO:0072709) |
| 1.0 | 9.6 | GO:0034088 | maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088) |
| 1.0 | 2.9 | GO:0097535 | lymphoid lineage cell migration(GO:0097534) lymphoid lineage cell migration into thymus(GO:0097535) |
| 0.9 | 16.7 | GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) |
| 0.9 | 2.7 | GO:0034148 | regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573) negative regulation of osteoclast proliferation(GO:0090291) |
| 0.9 | 2.7 | GO:0010808 | positive regulation of synaptic vesicle priming(GO:0010808) |
| 0.9 | 6.2 | GO:1902174 | positive regulation of keratinocyte apoptotic process(GO:1902174) positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231) |
| 0.9 | 6.0 | GO:0018095 | protein polyglutamylation(GO:0018095) |
| 0.9 | 6.0 | GO:2001137 | positive regulation of endocytic recycling(GO:2001137) |
| 0.8 | 1.7 | GO:1901859 | negative regulation of mitochondrial DNA replication(GO:0090298) negative regulation of mitochondrial DNA metabolic process(GO:1901859) |
| 0.8 | 2.5 | GO:1900275 | negative regulation of phospholipase C activity(GO:1900275) |
| 0.8 | 2.5 | GO:1904580 | regulation of intracellular mRNA localization(GO:1904580) positive regulation of intracellular mRNA localization(GO:1904582) |
| 0.8 | 2.4 | GO:0000019 | regulation of mitotic recombination(GO:0000019) |
| 0.8 | 4.0 | GO:1900425 | negative regulation of defense response to bacterium(GO:1900425) |
| 0.8 | 7.9 | GO:2000773 | negative regulation of cellular senescence(GO:2000773) |
| 0.8 | 3.1 | GO:0019086 | late viral transcription(GO:0019086) |
| 0.8 | 6.0 | GO:0006498 | N-terminal protein lipidation(GO:0006498) |
| 0.7 | 6.0 | GO:0034626 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 0.7 | 2.2 | GO:0044805 | late nucleophagy(GO:0044805) |
| 0.7 | 3.6 | GO:0061743 | motor learning(GO:0061743) |
| 0.7 | 3.5 | GO:1904075 | regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075) |
| 0.7 | 9.1 | GO:0034770 | histone H4-K20 methylation(GO:0034770) |
| 0.7 | 2.1 | GO:0001544 | initiation of primordial ovarian follicle growth(GO:0001544) |
| 0.7 | 4.1 | GO:0048549 | positive regulation of pinocytosis(GO:0048549) |
| 0.7 | 2.1 | GO:0098937 | dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) |
| 0.6 | 2.6 | GO:0006556 | S-adenosylmethionine biosynthetic process(GO:0006556) |
| 0.6 | 9.0 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
| 0.6 | 43.8 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.6 | 11.1 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.6 | 7.9 | GO:0032836 | glomerular basement membrane development(GO:0032836) |
| 0.6 | 3.0 | GO:0072014 | proximal tubule development(GO:0072014) |
| 0.6 | 4.2 | GO:0048263 | determination of dorsal identity(GO:0048263) |
| 0.6 | 4.6 | GO:0070166 | enamel mineralization(GO:0070166) |
| 0.6 | 4.6 | GO:0007256 | activation of JNKK activity(GO:0007256) |
| 0.6 | 6.3 | GO:0006685 | sphingomyelin catabolic process(GO:0006685) |
| 0.6 | 5.1 | GO:0031584 | activation of phospholipase D activity(GO:0031584) |
| 0.5 | 2.2 | GO:0031117 | positive regulation of microtubule depolymerization(GO:0031117) |
| 0.5 | 17.3 | GO:0042744 | hydrogen peroxide catabolic process(GO:0042744) |
| 0.5 | 4.2 | GO:0045176 | apical protein localization(GO:0045176) |
| 0.5 | 2.0 | GO:1900019 | regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020) |
| 0.5 | 5.1 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
| 0.5 | 11.1 | GO:1900151 | regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153) |
| 0.5 | 5.6 | GO:0070544 | histone H3-K36 demethylation(GO:0070544) |
| 0.5 | 1.5 | GO:0051230 | mitotic spindle disassembly(GO:0051228) spindle disassembly(GO:0051230) |
| 0.5 | 7.5 | GO:0033147 | negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147) |
| 0.5 | 6.4 | GO:0048227 | plasma membrane to endosome transport(GO:0048227) |
| 0.5 | 3.4 | GO:2000767 | positive regulation of cytoplasmic translation(GO:2000767) |
| 0.5 | 6.8 | GO:1903800 | positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800) |
| 0.5 | 4.6 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.5 | 4.1 | GO:0045078 | positive regulation of interferon-gamma biosynthetic process(GO:0045078) |
| 0.4 | 5.3 | GO:0034720 | histone H3-K4 demethylation(GO:0034720) |
| 0.4 | 4.3 | GO:0002371 | dendritic cell cytokine production(GO:0002371) |
| 0.4 | 1.3 | GO:0044332 | Wnt signaling pathway involved in dorsal/ventral axis specification(GO:0044332) |
| 0.4 | 5.1 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 0.4 | 3.7 | GO:0042074 | cell migration involved in gastrulation(GO:0042074) |
| 0.4 | 1.6 | GO:0035627 | ceramide transport(GO:0035627) |
| 0.4 | 3.1 | GO:0070236 | regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 0.4 | 6.7 | GO:0048304 | positive regulation of isotype switching to IgG isotypes(GO:0048304) |
| 0.4 | 3.9 | GO:0046886 | positive regulation of hormone biosynthetic process(GO:0046886) |
| 0.4 | 4.9 | GO:0090136 | epithelial cell-cell adhesion(GO:0090136) |
| 0.4 | 2.6 | GO:0009048 | dosage compensation(GO:0007549) dosage compensation by inactivation of X chromosome(GO:0009048) |
| 0.4 | 8.3 | GO:0044126 | regulation of growth of symbiont in host(GO:0044126) |
| 0.4 | 1.4 | GO:0032455 | nerve growth factor processing(GO:0032455) |
| 0.4 | 6.1 | GO:0007196 | adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196) |
| 0.4 | 2.5 | GO:2000698 | positive regulation of epithelial cell differentiation involved in kidney development(GO:2000698) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768) |
| 0.4 | 1.4 | GO:0010716 | negative regulation of extracellular matrix disassembly(GO:0010716) |
| 0.4 | 0.7 | GO:0090309 | positive regulation of methylation-dependent chromatin silencing(GO:0090309) |
| 0.3 | 11.9 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 0.3 | 5.9 | GO:0034356 | NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356) |
| 0.3 | 5.5 | GO:1903830 | magnesium ion transmembrane transport(GO:1903830) |
| 0.3 | 4.1 | GO:0043249 | erythrocyte maturation(GO:0043249) |
| 0.3 | 5.2 | GO:0035090 | maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199) |
| 0.3 | 3.5 | GO:0060633 | negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) |
| 0.3 | 1.2 | GO:1902725 | negative regulation of satellite cell differentiation(GO:1902725) |
| 0.3 | 1.2 | GO:1900169 | regulation of glucocorticoid mediated signaling pathway(GO:1900169) |
| 0.3 | 14.0 | GO:0015804 | neutral amino acid transport(GO:0015804) |
| 0.3 | 3.2 | GO:0021730 | trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.3 | 6.3 | GO:0006853 | carnitine shuttle(GO:0006853) |
| 0.3 | 1.7 | GO:0048050 | post-embryonic eye morphogenesis(GO:0048050) |
| 0.3 | 3.9 | GO:0015074 | DNA integration(GO:0015074) |
| 0.3 | 2.2 | GO:0031086 | nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087) |
| 0.3 | 3.5 | GO:0010991 | negative regulation of SMAD protein complex assembly(GO:0010991) |
| 0.3 | 2.4 | GO:0097084 | vascular smooth muscle cell development(GO:0097084) |
| 0.3 | 4.5 | GO:0070831 | basement membrane assembly(GO:0070831) |
| 0.3 | 2.4 | GO:0001661 | conditioned taste aversion(GO:0001661) |
| 0.3 | 1.6 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) |
| 0.3 | 2.1 | GO:0015886 | heme transport(GO:0015886) |
| 0.3 | 4.9 | GO:0032464 | positive regulation of protein homooligomerization(GO:0032464) |
| 0.3 | 1.3 | GO:0007198 | adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198) |
| 0.2 | 1.2 | GO:0044789 | modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791) |
| 0.2 | 8.0 | GO:0032008 | positive regulation of TOR signaling(GO:0032008) |
| 0.2 | 2.5 | GO:1902592 | viral budding(GO:0046755) multi-organism organelle organization(GO:1902590) multi-organism membrane budding(GO:1902592) |
| 0.2 | 1.0 | GO:0060282 | positive regulation of oocyte development(GO:0060282) |
| 0.2 | 5.8 | GO:0033622 | integrin activation(GO:0033622) |
| 0.2 | 4.5 | GO:0006829 | zinc II ion transport(GO:0006829) |
| 0.2 | 9.2 | GO:0009303 | rRNA transcription(GO:0009303) |
| 0.2 | 10.6 | GO:0006198 | cAMP catabolic process(GO:0006198) |
| 0.2 | 10.2 | GO:0016266 | O-glycan processing(GO:0016266) |
| 0.2 | 2.5 | GO:1902894 | negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894) |
| 0.2 | 1.8 | GO:0019375 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
| 0.2 | 0.7 | GO:0034729 | histone H3-K79 methylation(GO:0034729) |
| 0.2 | 4.1 | GO:1901897 | regulation of relaxation of cardiac muscle(GO:1901897) |
| 0.2 | 4.5 | GO:0035024 | negative regulation of Rho protein signal transduction(GO:0035024) |
| 0.2 | 7.5 | GO:0018146 | keratan sulfate biosynthetic process(GO:0018146) |
| 0.2 | 3.2 | GO:0034497 | protein localization to pre-autophagosomal structure(GO:0034497) |
| 0.2 | 4.7 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.2 | 2.2 | GO:0071372 | cellular response to follicle-stimulating hormone stimulus(GO:0071372) |
| 0.2 | 4.9 | GO:0051764 | actin crosslink formation(GO:0051764) |
| 0.2 | 3.5 | GO:0061418 | regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418) |
| 0.2 | 6.9 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.2 | 8.9 | GO:0032467 | positive regulation of cytokinesis(GO:0032467) |
| 0.2 | 2.7 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.2 | 2.9 | GO:0038092 | nodal signaling pathway(GO:0038092) |
| 0.2 | 4.4 | GO:0022011 | myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292) |
| 0.2 | 3.2 | GO:0034656 | nucleobase-containing small molecule catabolic process(GO:0034656) |
| 0.2 | 0.5 | GO:0070837 | dehydroascorbic acid transport(GO:0070837) |
| 0.2 | 10.0 | GO:0032922 | circadian regulation of gene expression(GO:0032922) |
| 0.2 | 2.6 | GO:0097264 | self proteolysis(GO:0097264) |
| 0.2 | 0.9 | GO:0070562 | regulation of vitamin D receptor signaling pathway(GO:0070562) |
| 0.2 | 0.8 | GO:0032000 | positive regulation of fatty acid beta-oxidation(GO:0032000) |
| 0.2 | 21.8 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.2 | 1.8 | GO:0001514 | selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451) |
| 0.1 | 6.6 | GO:0050435 | beta-amyloid metabolic process(GO:0050435) |
| 0.1 | 3.1 | GO:0090557 | establishment of endothelial intestinal barrier(GO:0090557) |
| 0.1 | 2.7 | GO:0022038 | corpus callosum development(GO:0022038) |
| 0.1 | 0.8 | GO:0044331 | cell-cell adhesion mediated by cadherin(GO:0044331) |
| 0.1 | 3.2 | GO:0060716 | labyrinthine layer blood vessel development(GO:0060716) |
| 0.1 | 2.9 | GO:0060732 | positive regulation of inositol phosphate biosynthetic process(GO:0060732) |
| 0.1 | 2.2 | GO:0035728 | response to hepatocyte growth factor(GO:0035728) |
| 0.1 | 1.7 | GO:2000394 | positive regulation of lamellipodium morphogenesis(GO:2000394) |
| 0.1 | 3.4 | GO:2001275 | positive regulation of glucose import in response to insulin stimulus(GO:2001275) |
| 0.1 | 8.8 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 0.1 | 1.4 | GO:0035585 | calcium-mediated signaling using extracellular calcium source(GO:0035585) |
| 0.1 | 1.6 | GO:0030208 | dermatan sulfate biosynthetic process(GO:0030208) |
| 0.1 | 10.6 | GO:0022617 | extracellular matrix disassembly(GO:0022617) |
| 0.1 | 4.0 | GO:0006099 | tricarboxylic acid cycle(GO:0006099) |
| 0.1 | 0.9 | GO:0060536 | cartilage morphogenesis(GO:0060536) |
| 0.1 | 1.4 | GO:0070327 | thyroid hormone transport(GO:0070327) |
| 0.1 | 6.9 | GO:0032755 | positive regulation of interleukin-6 production(GO:0032755) |
| 0.1 | 5.9 | GO:0021762 | substantia nigra development(GO:0021762) |
| 0.1 | 0.9 | GO:2000286 | receptor internalization involved in canonical Wnt signaling pathway(GO:2000286) |
| 0.1 | 5.6 | GO:0045824 | negative regulation of innate immune response(GO:0045824) |
| 0.1 | 4.6 | GO:0046473 | phosphatidic acid metabolic process(GO:0046473) |
| 0.1 | 3.0 | GO:0035635 | entry of bacterium into host cell(GO:0035635) |
| 0.1 | 0.8 | GO:0031936 | negative regulation of chromatin silencing(GO:0031936) |
| 0.1 | 4.7 | GO:0006904 | vesicle docking involved in exocytosis(GO:0006904) |
| 0.1 | 2.3 | GO:1904659 | hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659) |
| 0.1 | 0.7 | GO:0035331 | negative regulation of hippo signaling(GO:0035331) |
| 0.1 | 1.9 | GO:0015012 | heparan sulfate proteoglycan biosynthetic process(GO:0015012) |
| 0.1 | 1.0 | GO:0060252 | positive regulation of glial cell proliferation(GO:0060252) |
| 0.1 | 0.7 | GO:0061158 | 3'-UTR-mediated mRNA destabilization(GO:0061158) |
| 0.1 | 0.4 | GO:0003065 | positive regulation of heart rate by epinephrine(GO:0003065) |
| 0.1 | 1.2 | GO:0097094 | craniofacial suture morphogenesis(GO:0097094) |
| 0.1 | 12.1 | GO:0042594 | response to starvation(GO:0042594) |
| 0.1 | 4.8 | GO:0035914 | skeletal muscle cell differentiation(GO:0035914) |
| 0.1 | 0.7 | GO:0032958 | inositol phosphate biosynthetic process(GO:0032958) |
| 0.1 | 14.5 | GO:0006626 | protein targeting to mitochondrion(GO:0006626) |
| 0.1 | 20.3 | GO:0042787 | protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787) |
| 0.1 | 5.2 | GO:0006826 | iron ion transport(GO:0006826) |
| 0.1 | 0.2 | GO:1902723 | negative regulation of skeletal muscle cell proliferation(GO:0014859) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723) |
| 0.1 | 7.2 | GO:0030282 | bone mineralization(GO:0030282) |
| 0.1 | 5.1 | GO:0050868 | negative regulation of T cell activation(GO:0050868) |
| 0.1 | 0.3 | GO:0045048 | protein insertion into ER membrane(GO:0045048) |
| 0.1 | 2.6 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.1 | 3.2 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.1 | 4.6 | GO:0098869 | cellular oxidant detoxification(GO:0098869) |
| 0.1 | 2.5 | GO:1901998 | toxin transport(GO:1901998) |
| 0.1 | 0.6 | GO:0036152 | phosphatidylethanolamine acyl-chain remodeling(GO:0036152) |
| 0.1 | 3.1 | GO:0043631 | mRNA polyadenylation(GO:0006378) RNA polyadenylation(GO:0043631) |
| 0.1 | 6.8 | GO:0006368 | transcription elongation from RNA polymerase II promoter(GO:0006368) |
| 0.1 | 0.8 | GO:1904294 | positive regulation of ERAD pathway(GO:1904294) |
| 0.1 | 2.8 | GO:0070830 | bicellular tight junction assembly(GO:0070830) |
| 0.1 | 0.7 | GO:0006883 | cellular sodium ion homeostasis(GO:0006883) |
| 0.1 | 1.7 | GO:1903959 | regulation of anion transmembrane transport(GO:1903959) |
| 0.1 | 2.6 | GO:0002209 | behavioral fear response(GO:0001662) behavioral defense response(GO:0002209) |
| 0.1 | 3.2 | GO:0021549 | cerebellum development(GO:0021549) |
| 0.1 | 0.8 | GO:0046839 | phospholipid dephosphorylation(GO:0046839) |
| 0.0 | 0.6 | GO:0002517 | T cell tolerance induction(GO:0002517) |
| 0.0 | 2.4 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
| 0.0 | 0.4 | GO:0031507 | heterochromatin assembly(GO:0031507) |
| 0.0 | 2.6 | GO:0002028 | regulation of sodium ion transport(GO:0002028) |
| 0.0 | 5.9 | GO:0001508 | action potential(GO:0001508) |
| 0.0 | 0.2 | GO:0014877 | response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) |
| 0.0 | 2.0 | GO:0006891 | intra-Golgi vesicle-mediated transport(GO:0006891) |
| 0.0 | 1.1 | GO:0070884 | regulation of calcineurin-NFAT signaling cascade(GO:0070884) |
| 0.0 | 2.8 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.0 | 2.2 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 0.0 | 1.4 | GO:0050982 | detection of mechanical stimulus(GO:0050982) |
| 0.0 | 2.4 | GO:0035176 | social behavior(GO:0035176) intraspecies interaction between organisms(GO:0051703) |
| 0.0 | 1.8 | GO:0048477 | oogenesis(GO:0048477) |
| 0.0 | 5.0 | GO:0006661 | phosphatidylinositol biosynthetic process(GO:0006661) |
| 0.0 | 1.6 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 0.0 | 0.6 | GO:0001706 | endoderm formation(GO:0001706) |
| 0.0 | 1.1 | GO:0007520 | myoblast fusion(GO:0007520) |
| 0.0 | 0.2 | GO:0033227 | dsRNA transport(GO:0033227) |
| 0.0 | 0.2 | GO:0030238 | male sex determination(GO:0030238) |
| 0.0 | 0.2 | GO:0071481 | cellular response to X-ray(GO:0071481) |
| 0.0 | 2.3 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123) |
| 0.0 | 0.1 | GO:0032780 | negative regulation of ATPase activity(GO:0032780) |
| 0.0 | 0.7 | GO:0038083 | peptidyl-tyrosine autophosphorylation(GO:0038083) |
| 0.0 | 1.3 | GO:0060041 | retina development in camera-type eye(GO:0060041) |
| 0.0 | 0.5 | GO:0051031 | tRNA export from nucleus(GO:0006409) tRNA transport(GO:0051031) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431) |
| 0.0 | 0.9 | GO:0000910 | cytokinesis(GO:0000910) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 13.2 | 39.5 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 11.4 | 113.6 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 4.7 | 52.0 | GO:0098651 | basement membrane collagen trimer(GO:0098651) |
| 3.2 | 13.0 | GO:0070695 | FHF complex(GO:0070695) |
| 3.2 | 9.6 | GO:0032116 | SMC loading complex(GO:0032116) |
| 2.1 | 6.4 | GO:0070931 | Golgi-associated vesicle lumen(GO:0070931) |
| 1.9 | 32.4 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 1.9 | 7.4 | GO:0034681 | integrin alpha11-beta1 complex(GO:0034681) |
| 1.8 | 25.4 | GO:0098644 | complex of collagen trimers(GO:0098644) |
| 1.6 | 9.7 | GO:0001940 | male pronucleus(GO:0001940) |
| 1.5 | 4.5 | GO:0043259 | laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259) laminin-11 complex(GO:0043260) |
| 1.3 | 9.0 | GO:0036157 | outer dynein arm(GO:0036157) |
| 1.1 | 9.5 | GO:0036449 | microtubule minus-end(GO:0036449) |
| 1.1 | 7.4 | GO:0005683 | U7 snRNP(GO:0005683) |
| 1.0 | 5.1 | GO:0031905 | early endosome lumen(GO:0031905) |
| 1.0 | 4.0 | GO:1990851 | Wnt-Frizzled-LRP5/6 complex(GO:1990851) |
| 1.0 | 19.4 | GO:0033270 | paranode region of axon(GO:0033270) |
| 1.0 | 8.6 | GO:0030897 | HOPS complex(GO:0030897) |
| 0.9 | 7.4 | GO:0005593 | FACIT collagen trimer(GO:0005593) |
| 0.9 | 16.2 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.8 | 7.3 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.8 | 21.7 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.8 | 4.7 | GO:0034751 | aryl hydrocarbon receptor complex(GO:0034751) |
| 0.8 | 4.6 | GO:0032584 | growth cone membrane(GO:0032584) |
| 0.7 | 6.3 | GO:0000137 | Golgi cis cisterna(GO:0000137) |
| 0.7 | 2.1 | GO:0031251 | PAN complex(GO:0031251) |
| 0.6 | 5.1 | GO:0061700 | GATOR2 complex(GO:0061700) |
| 0.6 | 4.1 | GO:0044354 | pinosome(GO:0044352) macropinosome(GO:0044354) |
| 0.6 | 37.1 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.6 | 4.0 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.6 | 4.0 | GO:0045252 | oxoglutarate dehydrogenase complex(GO:0045252) |
| 0.5 | 2.7 | GO:0044305 | calyx of Held(GO:0044305) |
| 0.4 | 3.5 | GO:0035867 | alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867) |
| 0.4 | 3.9 | GO:0000347 | THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) |
| 0.4 | 2.5 | GO:0045298 | tubulin complex(GO:0045298) |
| 0.4 | 6.3 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.4 | 2.8 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.4 | 0.8 | GO:0005899 | insulin receptor complex(GO:0005899) |
| 0.4 | 16.3 | GO:0000791 | euchromatin(GO:0000791) |
| 0.4 | 4.3 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.3 | 3.1 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.3 | 2.4 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.3 | 16.5 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.3 | 16.4 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.3 | 6.3 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.3 | 5.6 | GO:0005922 | connexon complex(GO:0005922) |
| 0.3 | 4.0 | GO:0097431 | mitotic spindle pole(GO:0097431) |
| 0.3 | 3.1 | GO:0008024 | cyclin/CDK positive transcription elongation factor complex(GO:0008024) |
| 0.3 | 4.8 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.3 | 3.0 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.2 | 2.0 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.2 | 8.8 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.2 | 6.1 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
| 0.2 | 0.9 | GO:1990578 | perinuclear endoplasmic reticulum membrane(GO:1990578) |
| 0.2 | 24.5 | GO:0005901 | caveola(GO:0005901) |
| 0.2 | 4.1 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.2 | 7.9 | GO:0005605 | basal lamina(GO:0005605) |
| 0.2 | 2.4 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.2 | 2.1 | GO:0043190 | ATP-binding cassette (ABC) transporter complex(GO:0043190) |
| 0.2 | 63.6 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.2 | 2.5 | GO:0005845 | mRNA cap binding complex(GO:0005845) |
| 0.2 | 2.6 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.2 | 2.2 | GO:0036057 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.2 | 2.5 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.2 | 23.6 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.2 | 1.4 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.2 | 3.2 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.1 | 8.2 | GO:0031904 | endosome lumen(GO:0031904) |
| 0.1 | 33.9 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 2.6 | GO:0031045 | dense core granule(GO:0031045) |
| 0.1 | 1.8 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 0.1 | 7.1 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.1 | 12.3 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.1 | 4.8 | GO:0002102 | podosome(GO:0002102) |
| 0.1 | 1.5 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.1 | 2.4 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.1 | 9.4 | GO:0005884 | actin filament(GO:0005884) |
| 0.1 | 2.5 | GO:0031528 | microvillus membrane(GO:0031528) |
| 0.1 | 1.6 | GO:0044291 | cell-cell contact zone(GO:0044291) |
| 0.1 | 1.3 | GO:0033276 | transcription factor TFTC complex(GO:0033276) |
| 0.1 | 0.8 | GO:0036513 | Derlin-1 retrotranslocation complex(GO:0036513) |
| 0.1 | 1.2 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
| 0.1 | 2.6 | GO:0071339 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.1 | 4.1 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.1 | 5.1 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.1 | 1.4 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.1 | 9.3 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.1 | 0.9 | GO:0000815 | ESCRT III complex(GO:0000815) |
| 0.1 | 5.5 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.1 | 1.1 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.1 | 0.7 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
| 0.1 | 8.8 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 22.6 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.1 | 1.4 | GO:0030057 | desmosome(GO:0030057) |
| 0.1 | 1.7 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.1 | 0.2 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.1 | 1.8 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
| 0.1 | 6.9 | GO:0005814 | centriole(GO:0005814) |
| 0.1 | 2.9 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.0 | 3.1 | GO:0005903 | brush border(GO:0005903) |
| 0.0 | 6.2 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 5.1 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 0.4 | GO:0005677 | chromatin silencing complex(GO:0005677) |
| 0.0 | 5.0 | GO:0031461 | cullin-RING ubiquitin ligase complex(GO:0031461) |
| 0.0 | 3.2 | GO:0030666 | endocytic vesicle membrane(GO:0030666) |
| 0.0 | 73.8 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.0 | 3.8 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.0 | 5.4 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.0 | 1.4 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 4.1 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 0.5 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.0 | 3.3 | GO:0010008 | endosome membrane(GO:0010008) |
| 0.0 | 1.7 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 1.2 | GO:0016459 | myosin complex(GO:0016459) |
| 0.0 | 5.3 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.0 | 0.2 | GO:0031597 | cytosolic proteasome complex(GO:0031597) |
| 0.0 | 4.7 | GO:0005813 | centrosome(GO:0005813) |
| 0.0 | 10.5 | GO:0005615 | extracellular space(GO:0005615) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.7 | 164.8 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 5.6 | 16.9 | GO:0004720 | protein-lysine 6-oxidase activity(GO:0004720) |
| 3.7 | 14.8 | GO:0004741 | [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741) |
| 3.7 | 11.0 | GO:0030350 | iron-responsive element binding(GO:0030350) |
| 3.5 | 17.3 | GO:0005152 | interleukin-1 receptor antagonist activity(GO:0005152) |
| 2.9 | 11.7 | GO:0046404 | ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734) |
| 2.9 | 8.6 | GO:0004874 | aryl hydrocarbon receptor activity(GO:0004874) |
| 2.5 | 7.4 | GO:0008502 | melatonin receptor activity(GO:0008502) |
| 2.4 | 12.1 | GO:0052846 | endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) inositol diphosphate tetrakisphosphate diphosphatase activity(GO:0052840) inositol bisdiphosphate tetrakisphosphate diphosphatase activity(GO:0052841) inositol diphosphate pentakisphosphate diphosphatase activity(GO:0052842) inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity(GO:0052843) inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity(GO:0052844) inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity(GO:0052845) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity(GO:0052846) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052847) inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052848) |
| 2.3 | 9.2 | GO:0042134 | rRNA primary transcript binding(GO:0042134) |
| 2.1 | 12.9 | GO:0030023 | extracellular matrix constituent conferring elasticity(GO:0030023) |
| 2.0 | 10.1 | GO:0010861 | thyroid hormone receptor activator activity(GO:0010861) thyroid hormone receptor coactivator activity(GO:0030375) |
| 1.7 | 10.2 | GO:0042285 | UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285) |
| 1.7 | 8.3 | GO:0001010 | transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010) |
| 1.6 | 19.4 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 1.6 | 6.4 | GO:0008798 | beta-aspartyl-peptidase activity(GO:0008798) |
| 1.5 | 12.0 | GO:0038064 | collagen receptor activity(GO:0038064) |
| 1.5 | 6.0 | GO:0004088 | carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088) |
| 1.4 | 14.1 | GO:0001042 | RNA polymerase I core binding(GO:0001042) |
| 1.4 | 12.3 | GO:0004565 | beta-galactosidase activity(GO:0004565) |
| 1.3 | 4.0 | GO:1904928 | coreceptor activity involved in canonical Wnt signaling pathway(GO:1904928) |
| 1.3 | 7.9 | GO:0043237 | laminin-1 binding(GO:0043237) |
| 1.3 | 7.9 | GO:0008142 | oxysterol binding(GO:0008142) |
| 1.3 | 9.1 | GO:0042799 | histone methyltransferase activity (H4-K20 specific)(GO:0042799) |
| 1.2 | 7.1 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
| 1.1 | 7.5 | GO:0002114 | interleukin-33 receptor activity(GO:0002114) |
| 1.0 | 6.2 | GO:0061665 | SUMO ligase activity(GO:0061665) |
| 1.0 | 8.6 | GO:0004969 | histamine receptor activity(GO:0004969) |
| 0.9 | 78.0 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.9 | 5.1 | GO:0070728 | leucine binding(GO:0070728) |
| 0.8 | 2.5 | GO:0004534 | 5'-3' exoribonuclease activity(GO:0004534) |
| 0.8 | 4.0 | GO:0004591 | oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591) |
| 0.8 | 3.0 | GO:0035939 | microsatellite binding(GO:0035939) |
| 0.7 | 5.2 | GO:0030368 | interleukin-17 receptor activity(GO:0030368) |
| 0.7 | 6.0 | GO:0009922 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 0.7 | 14.0 | GO:0097602 | cullin family protein binding(GO:0097602) |
| 0.7 | 6.3 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.7 | 2.1 | GO:0050509 | N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509) |
| 0.7 | 4.8 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 0.6 | 9.0 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.6 | 1.8 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
| 0.6 | 2.9 | GO:0004999 | vasoactive intestinal polypeptide receptor activity(GO:0004999) |
| 0.6 | 3.5 | GO:0047237 | glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237) |
| 0.5 | 9.3 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.5 | 4.0 | GO:0050816 | phosphothreonine binding(GO:0050816) |
| 0.5 | 5.6 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.5 | 2.5 | GO:0046935 | phosphatidylinositol 3-kinase regulator activity(GO:0035014) 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935) |
| 0.5 | 4.9 | GO:0035374 | chondroitin sulfate binding(GO:0035374) |
| 0.5 | 2.5 | GO:0031871 | proteinase activated receptor binding(GO:0031871) |
| 0.5 | 5.9 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 0.5 | 10.3 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.5 | 1.9 | GO:0008467 | [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467) |
| 0.5 | 4.8 | GO:0030346 | protein phosphatase 2B binding(GO:0030346) |
| 0.5 | 5.5 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
| 0.4 | 3.1 | GO:0004652 | polynucleotide adenylyltransferase activity(GO:0004652) |
| 0.4 | 6.3 | GO:0004679 | AMP-activated protein kinase activity(GO:0004679) |
| 0.4 | 5.3 | GO:0032453 | histone demethylase activity (H3-K4 specific)(GO:0032453) |
| 0.4 | 1.7 | GO:0047391 | alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391) |
| 0.4 | 2.1 | GO:0015562 | efflux transmembrane transporter activity(GO:0015562) |
| 0.4 | 1.6 | GO:0017089 | glycolipid transporter activity(GO:0017089) ceramide binding(GO:0097001) |
| 0.4 | 11.4 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
| 0.4 | 8.9 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 0.4 | 5.1 | GO:0016018 | cyclosporin A binding(GO:0016018) |
| 0.4 | 3.1 | GO:0043426 | MRF binding(GO:0043426) |
| 0.4 | 50.3 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.4 | 8.2 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.4 | 4.6 | GO:0046790 | virion binding(GO:0046790) |
| 0.4 | 5.6 | GO:0005243 | gap junction channel activity(GO:0005243) |
| 0.4 | 1.8 | GO:0004800 | thyroxine 5'-deiodinase activity(GO:0004800) |
| 0.3 | 1.4 | GO:0005169 | neurotrophin TRKB receptor binding(GO:0005169) |
| 0.3 | 4.1 | GO:0004723 | calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) |
| 0.3 | 3.1 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
| 0.3 | 1.7 | GO:0001025 | RNA polymerase III transcription factor binding(GO:0001025) |
| 0.3 | 14.0 | GO:0015175 | neutral amino acid transmembrane transporter activity(GO:0015175) |
| 0.3 | 34.3 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.3 | 1.0 | GO:0004119 | cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) |
| 0.3 | 5.5 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.3 | 1.9 | GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740) |
| 0.3 | 5.1 | GO:0031702 | type 1 angiotensin receptor binding(GO:0031702) |
| 0.3 | 3.4 | GO:0015266 | protein channel activity(GO:0015266) BH3 domain binding(GO:0051434) |
| 0.3 | 2.5 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.3 | 0.8 | GO:0004421 | hydroxymethylglutaryl-CoA synthase activity(GO:0004421) |
| 0.3 | 2.4 | GO:0046923 | ER retention sequence binding(GO:0046923) |
| 0.3 | 6.3 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.3 | 2.6 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
| 0.3 | 17.6 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.3 | 4.8 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.2 | 10.6 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.2 | 4.3 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 0.2 | 9.7 | GO:0016706 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706) |
| 0.2 | 3.4 | GO:0015280 | ligand-gated sodium channel activity(GO:0015280) |
| 0.2 | 5.3 | GO:0004659 | prenyltransferase activity(GO:0004659) |
| 0.2 | 1.5 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
| 0.2 | 1.7 | GO:0003910 | DNA ligase (ATP) activity(GO:0003910) |
| 0.2 | 2.8 | GO:0055056 | D-glucose transmembrane transporter activity(GO:0055056) |
| 0.2 | 10.6 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.2 | 2.7 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.2 | 0.6 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 0.2 | 3.6 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.2 | 12.2 | GO:0070888 | E-box binding(GO:0070888) |
| 0.2 | 6.1 | GO:0008066 | glutamate receptor activity(GO:0008066) |
| 0.2 | 1.4 | GO:0015349 | thyroid hormone transmembrane transporter activity(GO:0015349) |
| 0.2 | 5.3 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.2 | 1.2 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.2 | 3.2 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.2 | 1.0 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.2 | 7.4 | GO:0017069 | snRNA binding(GO:0017069) |
| 0.2 | 3.4 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) |
| 0.2 | 7.2 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.2 | 2.8 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.2 | 3.1 | GO:0003756 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.2 | 5.8 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
| 0.2 | 2.4 | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity(GO:0000014) |
| 0.1 | 17.5 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.1 | 0.7 | GO:0033857 | diphosphoinositol-pentakisphosphate kinase activity(GO:0033857) |
| 0.1 | 3.1 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.1 | 4.6 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.1 | 5.9 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
| 0.1 | 4.2 | GO:0005109 | frizzled binding(GO:0005109) |
| 0.1 | 3.3 | GO:0043548 | phosphatidylinositol 3-kinase binding(GO:0043548) |
| 0.1 | 4.6 | GO:0030296 | protein tyrosine kinase activator activity(GO:0030296) |
| 0.1 | 2.4 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.1 | 5.8 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.1 | 1.8 | GO:0008499 | UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499) |
| 0.1 | 0.8 | GO:1904288 | BAT3 complex binding(GO:1904288) |
| 0.1 | 3.4 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.1 | 3.4 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
| 0.1 | 1.7 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.1 | 1.4 | GO:0086056 | voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056) |
| 0.1 | 2.7 | GO:0005003 | ephrin receptor activity(GO:0005003) |
| 0.1 | 1.3 | GO:0043176 | amine binding(GO:0043176) serotonin binding(GO:0051378) |
| 0.1 | 2.4 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.1 | 25.2 | GO:0061659 | ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659) |
| 0.1 | 17.6 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 10.0 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.1 | 6.3 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.1 | 21.3 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.1 | 2.4 | GO:0030371 | translation repressor activity(GO:0030371) |
| 0.1 | 2.1 | GO:0001221 | transcription cofactor binding(GO:0001221) |
| 0.1 | 3.0 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.1 | 1.7 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.1 | 2.5 | GO:0036041 | long-chain fatty acid binding(GO:0036041) |
| 0.1 | 3.0 | GO:0030331 | estrogen receptor binding(GO:0030331) |
| 0.1 | 3.4 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 0.1 | 1.0 | GO:0004887 | thyroid hormone receptor activity(GO:0004887) |
| 0.1 | 2.3 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.1 | 2.4 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.1 | 26.5 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 10.7 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.1 | 2.2 | GO:0016891 | endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891) |
| 0.1 | 2.5 | GO:0042805 | actinin binding(GO:0042805) |
| 0.1 | 9.8 | GO:0008201 | heparin binding(GO:0008201) |
| 0.1 | 14.4 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.1 | 0.8 | GO:0008195 | phosphatidate phosphatase activity(GO:0008195) lipid phosphatase activity(GO:0042577) |
| 0.1 | 6.1 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.1 | 0.2 | GO:0086006 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006) |
| 0.0 | 4.7 | GO:0051117 | ATPase binding(GO:0051117) |
| 0.0 | 4.3 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 0.0 | 42.2 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.0 | 0.5 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.0 | 2.2 | GO:0008200 | ion channel inhibitor activity(GO:0008200) channel inhibitor activity(GO:0016248) |
| 0.0 | 0.2 | GO:0035033 | histone deacetylase regulator activity(GO:0035033) |
| 0.0 | 1.8 | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) |
| 0.0 | 0.7 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
| 0.0 | 1.4 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 0.2 | GO:0086083 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083) |
| 0.0 | 5.6 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 0.1 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
| 0.0 | 0.2 | GO:0051033 | nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033) |
| 0.0 | 0.8 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.0 | 0.7 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
| 0.0 | 1.4 | GO:0015297 | antiporter activity(GO:0015297) |
| 0.0 | 0.7 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
| 0.0 | 1.1 | GO:0097110 | scaffold protein binding(GO:0097110) |
| 0.0 | 0.4 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.0 | 0.7 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.0 | 10.8 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 0.5 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 0.0 | 0.7 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.0 | 242.2 | NABA COLLAGENS | Genes encoding collagen proteins |
| 1.4 | 5.5 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.9 | 2.8 | PID ER NONGENOMIC PATHWAY | Plasma membrane estrogen receptor signaling |
| 0.7 | 45.3 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.5 | 9.8 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.5 | 28.0 | PID AVB3 OPN PATHWAY | Osteopontin-mediated events |
| 0.4 | 22.9 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.4 | 14.3 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.4 | 8.7 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.4 | 5.1 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.3 | 7.9 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.3 | 51.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.3 | 7.4 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.3 | 5.1 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.2 | 6.4 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.2 | 10.5 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.2 | 5.0 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.2 | 9.0 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.2 | 9.1 | PID AVB3 INTEGRIN PATHWAY | Integrins in angiogenesis |
| 0.2 | 52.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 6.5 | PID IL27 PATHWAY | IL27-mediated signaling events |
| 0.2 | 11.8 | PID FGF PATHWAY | FGF signaling pathway |
| 0.1 | 9.1 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 5.6 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.1 | 2.7 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.1 | 3.0 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.1 | 20.6 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 5.8 | NABA CORE MATRISOME | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans |
| 0.1 | 3.2 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.1 | 1.5 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 0.1 | 14.4 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 1.7 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.1 | 2.2 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.1 | 2.7 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.1 | 3.1 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.1 | 4.9 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.1 | 3.8 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.1 | 2.5 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.1 | 3.9 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 6.5 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 4.7 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 0.1 | 3.4 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 3.2 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 5.5 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 1.4 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.1 | 1.4 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.1 | 1.2 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 0.7 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.0 | 3.0 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 1.6 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.0 | 0.8 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 1.6 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.0 | 0.8 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.9 | 259.6 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 1.0 | 25.4 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 1.0 | 16.7 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.9 | 5.2 | REACTOME SIGNALING BY FGFR | Genes involved in Signaling by FGFR |
| 0.7 | 9.9 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |
| 0.7 | 16.4 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.5 | 8.1 | REACTOME PYRUVATE METABOLISM | Genes involved in Pyruvate metabolism |
| 0.5 | 7.4 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 0.5 | 4.4 | REACTOME PROLONGED ERK ACTIVATION EVENTS | Genes involved in Prolonged ERK activation events |
| 0.5 | 13.3 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.5 | 5.1 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.4 | 8.3 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.4 | 12.7 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.4 | 4.3 | REACTOME DAG AND IP3 SIGNALING | Genes involved in DAG and IP3 signaling |
| 0.4 | 0.8 | REACTOME SOS MEDIATED SIGNALLING | Genes involved in SOS-mediated signalling |
| 0.4 | 2.2 | REACTOME GAB1 SIGNALOSOME | Genes involved in GAB1 signalosome |
| 0.3 | 6.3 | REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.3 | 8.8 | REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR | Genes involved in Thromboxane signalling through TP receptor |
| 0.3 | 5.6 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.3 | 6.8 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.3 | 15.4 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.3 | 6.1 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.3 | 5.4 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.3 | 8.2 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.3 | 6.4 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.3 | 7.5 | REACTOME KERATAN SULFATE BIOSYNTHESIS | Genes involved in Keratan sulfate biosynthesis |
| 0.2 | 4.9 | REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
| 0.2 | 8.3 | REACTOME SIGNALING BY EGFR IN CANCER | Genes involved in Signaling by EGFR in Cancer |
| 0.2 | 8.6 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.2 | 6.2 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.2 | 9.4 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.2 | 9.4 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.2 | 7.8 | REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN | Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen |
| 0.2 | 6.0 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.2 | 10.5 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.2 | 5.9 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.2 | 17.1 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.2 | 3.2 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.2 | 3.4 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.2 | 5.1 | REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 | Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1 |
| 0.2 | 2.4 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.1 | 2.2 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.1 | 9.4 | REACTOME DOWNSTREAM SIGNAL TRANSDUCTION | Genes involved in Downstream signal transduction |
| 0.1 | 6.5 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.1 | 11.6 | REACTOME G ALPHA S SIGNALLING EVENTS | Genes involved in G alpha (s) signalling events |
| 0.1 | 13.7 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 15.3 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 5.4 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.1 | 2.7 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.1 | 3.5 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.1 | 4.6 | REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX | Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex |
| 0.1 | 1.8 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.1 | 2.7 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.1 | 1.6 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.1 | 2.6 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.1 | 2.8 | REACTOME EXTRACELLULAR MATRIX ORGANIZATION | Genes involved in Extracellular matrix organization |
| 0.1 | 3.0 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 1.2 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.1 | 1.6 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.1 | 1.4 | REACTOME SIGNALLING BY NGF | Genes involved in Signalling by NGF |
| 0.1 | 1.4 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 | Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1) |
| 0.1 | 2.1 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.0 | 2.4 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 2.2 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 1.5 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 0.7 | REACTOME CD28 CO STIMULATION | Genes involved in CD28 co-stimulation |
| 0.0 | 0.8 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 0.7 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.0 | 8.1 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.0 | 0.5 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.0 | 1.5 | REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | Genes involved in Activation of NF-kappaB in B Cells |
| 0.0 | 1.2 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 0.2 | REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |
| 0.0 | 0.1 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |