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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for AGCAGCA
Z-value: 0.96
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miRNA associated with seed AGCAGCA
Network of associatons between targets according to the STRING database.
First level regulatory network of AGCAGCA
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 66.7 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.5 | 18.5 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 3.5 | 17.5 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
| 1.5 | 16.7 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 0.7 | 16.7 | GO:0034162 | toll-like receptor 9 signaling pathway(GO:0034162) |
| 1.3 | 15.6 | GO:0016191 | synaptic vesicle uncoating(GO:0016191) |
| 1.6 | 12.7 | GO:0099525 | presynaptic dense core granule exocytosis(GO:0099525) |
| 1.7 | 12.0 | GO:0051013 | microtubule severing(GO:0051013) |
| 3.7 | 11.1 | GO:0097477 | spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477) |
| 1.8 | 10.9 | GO:0051138 | positive regulation of NK T cell differentiation(GO:0051138) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 146.9 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 0.2 | 27.7 | GO:0031461 | cullin-RING ubiquitin ligase complex(GO:0031461) |
| 0.2 | 21.8 | GO:0042641 | actomyosin(GO:0042641) |
| 1.4 | 19.1 | GO:0035253 | ciliary rootlet(GO:0035253) |
| 0.1 | 17.9 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 4.4 | 17.5 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 0.2 | 16.1 | GO:0030669 | clathrin-coated endocytic vesicle membrane(GO:0030669) |
| 0.3 | 14.3 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.1 | 13.2 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.6 | 11.8 | GO:0033270 | paranode region of axon(GO:0033270) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 42.7 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.9 | 30.3 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.9 | 25.5 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.0 | 21.0 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.3 | 16.8 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.1 | 12.9 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 1.0 | 12.1 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 1.7 | 12.0 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
| 0.1 | 11.5 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 1.8 | 10.8 | GO:0042392 | sphingosine-1-phosphate phosphatase activity(GO:0042392) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 19.5 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.5 | 16.7 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 14.7 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.3 | 11.6 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.1 | 9.7 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.3 | 7.9 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.2 | 6.7 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 6.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 6.1 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.2 | 4.0 | ST INTEGRIN SIGNALING PATHWAY | Integrin Signaling Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 27.6 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 1.0 | 21.0 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 1.5 | 16.7 | REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION | Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| 0.4 | 14.3 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.5 | 11.7 | REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.3 | 8.7 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.1 | 7.3 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.2 | 7.0 | REACTOME ELONGATION ARREST AND RECOVERY | Genes involved in Elongation arrest and recovery |
| 0.3 | 6.7 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.4 | 6.4 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |