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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for AGCUGCC
Z-value: 0.66
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miRNA associated with seed AGCUGCC
| Name | miRBASE accession |
|---|---|
|
hsa-miR-22-3p
|
MIMAT0000077 |
Network of associatons between targets according to the STRING database.
First level regulatory network of AGCUGCC
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_204411804 Show fit | 19.34 |
ENST00000367188.5
|
protein phosphatase 1 regulatory subunit 15B |
|
| chr1_-_9943314 Show fit | 15.32 |
ENST00000377223.6
ENST00000377213.1 |
leucine zipper and CTNNBIP1 domain containing |
|
| chr1_+_24556087 Show fit | 10.66 |
ENST00000374392.3
|
non-compact myelin associated protein |
|
| chr4_-_88284553 Show fit | 10.28 |
ENST00000608933.6
ENST00000295908.11 |
protein phosphatase, Mg2+/Mn2+ dependent 1K |
|
| chr1_-_34859717 Show fit | 8.81 |
ENST00000423898.1
ENST00000521580.3 ENST00000456842.1 |
small integral membrane protein 12 |
|
| chr22_+_30635746 Show fit | 8.70 |
ENST00000343605.5
|
solute carrier family 35 member E4 |
|
| chr1_+_52404591 Show fit | 8.20 |
ENST00000257181.10
|
pre-mRNA processing factor 38A |
|
| chr7_-_35695120 Show fit | 7.52 |
ENST00000311350.8
ENST00000396081.5 |
HERPUD family member 2 |
|
| chr2_-_71227055 Show fit | 7.00 |
ENST00000244221.9
|
poly(A) binding protein interacting protein 2B |
|
| chr17_-_8152380 Show fit | 6.01 |
ENST00000317276.9
|
period circadian regulator 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 19.7 | GO:1903898 | negative regulation of PERK-mediated unfolded protein response(GO:1903898) |
| 0.1 | 13.7 | GO:0010212 | response to ionizing radiation(GO:0010212) |
| 2.7 | 10.7 | GO:0032290 | peripheral nervous system myelin formation(GO:0032290) |
| 0.3 | 10.3 | GO:0009083 | branched-chain amino acid catabolic process(GO:0009083) |
| 0.3 | 8.5 | GO:0045947 | negative regulation of translational initiation(GO:0045947) |
| 1.2 | 6.0 | GO:0097167 | circadian regulation of translation(GO:0097167) |
| 1.2 | 5.9 | GO:0072708 | response to sorbitol(GO:0072708) |
| 1.9 | 5.8 | GO:0016340 | calcium-dependent cell-matrix adhesion(GO:0016340) |
| 0.1 | 5.7 | GO:0046676 | negative regulation of insulin secretion(GO:0046676) |
| 0.5 | 5.3 | GO:0090292 | nuclear matrix anchoring at nuclear membrane(GO:0090292) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 19.3 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.5 | 10.7 | GO:0033270 | paranode region of axon(GO:0033270) |
| 0.0 | 9.5 | GO:0001726 | ruffle(GO:0001726) |
| 0.3 | 8.2 | GO:0071011 | precatalytic spliceosome(GO:0071011) |
| 0.1 | 6.8 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.5 | 5.6 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.3 | 5.5 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.5 | 5.3 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 0.4 | 5.3 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.0 | 4.5 | GO:0031461 | cullin-RING ubiquitin ligase complex(GO:0031461) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 20.6 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.1 | 12.3 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.9 | 10.4 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.0 | 10.1 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.1 | 9.6 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 0.0 | 7.1 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.3 | 7.0 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
| 0.1 | 7.0 | GO:0070888 | E-box binding(GO:0070888) |
| 0.1 | 6.8 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.2 | 6.5 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.9 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 7.6 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.2 | 7.4 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.3 | 6.0 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.1 | 5.5 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 5.3 | PID FGF PATHWAY | FGF signaling pathway |
| 0.1 | 5.3 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 4.1 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 4.0 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.1 | 3.9 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.0 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.4 | 5.6 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.0 | 5.3 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |
| 0.1 | 5.0 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.3 | 4.8 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.1 | 4.5 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.1 | 4.3 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.1 | 4.2 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.1 | 4.0 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 3.4 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |