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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for AGCUGCC

Z-value: 0.66

Motif logo

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miRNA associated with seed AGCUGCC

NamemiRBASE accession
hsa-miR-22-3p
MIMAT0000077

Activity profile of AGCUGCC motif

Sorted Z-values of AGCUGCC motif

Network of associatons between targets according to the STRING database.

First level regulatory network of AGCUGCC

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr1_-_204411804 19.34 ENST00000367188.5
PPP1R15B
protein phosphatase 1 regulatory subunit 15B
chr1_-_9943314 15.32 ENST00000377223.6
ENST00000377213.1
LZIC
leucine zipper and CTNNBIP1 domain containing
chr1_+_24556087 10.66 ENST00000374392.3
NCMAP
non-compact myelin associated protein
chr4_-_88284553 10.28 ENST00000608933.6
ENST00000295908.11
PPM1K
protein phosphatase, Mg2+/Mn2+ dependent 1K
chr1_-_34859717 8.81 ENST00000423898.1
ENST00000521580.3
ENST00000456842.1
SMIM12
small integral membrane protein 12
chr22_+_30635746 8.70 ENST00000343605.5
SLC35E4
solute carrier family 35 member E4
chr1_+_52404591 8.20 ENST00000257181.10
PRPF38A
pre-mRNA processing factor 38A
chr7_-_35695120 7.52 ENST00000311350.8
ENST00000396081.5
HERPUD2
HERPUD family member 2
chr2_-_71227055 7.00 ENST00000244221.9
PAIP2B
poly(A) binding protein interacting protein 2B
chr17_-_8152380 6.01 ENST00000317276.9
PER1
period circadian regulator 1
chr17_+_49788672 5.93 ENST00000454930.6
ENST00000259021.9
ENST00000509773.5
ENST00000510819.5
ENST00000424009.6
KAT7
lysine acetyltransferase 7
chr15_-_50686768 5.84 ENST00000560955.5
ENST00000646667.1
TRPM7
transient receptor potential cation channel subfamily M member 7
chr2_+_17541157 5.73 ENST00000406397.1
VSNL1
visinin like 1
chr6_+_41072939 5.64 ENST00000341376.11
ENST00000353205.5
NFYA
nuclear transcription factor Y subunit alpha
chr7_-_44885446 5.50 ENST00000395699.5
PURB
purine rich element binding protein B
chr16_-_4242068 5.34 ENST00000399609.7
SRL
sarcalumenin
chr16_+_30699155 5.32 ENST00000262518.9
SRCAP
Snf2 related CREBBP activator protein
chr6_-_152637351 5.26 ENST00000367255.10
SYNE1
spectrin repeat containing nuclear envelope protein 1
chr3_-_57165332 5.25 ENST00000296318.12
IL17RD
interleukin 17 receptor D
chr11_+_114059702 4.97 ENST00000335953.9
ENST00000684612.1
ENST00000682810.1
ENST00000544220.1
ZBTB16
zinc finger and BTB domain containing 16
chr4_+_40056790 4.92 ENST00000261435.11
ENST00000515550.1
N4BP2
NEDD4 binding protein 2
chr1_+_192809031 4.84 ENST00000235382.7
RGS2
regulator of G protein signaling 2
chr8_-_47738153 4.75 ENST00000408965.4
CEBPD
CCAAT enhancer binding protein delta
chr15_+_41559189 4.70 ENST00000263798.8
TYRO3
TYRO3 protein tyrosine kinase
chr10_-_118754956 4.59 ENST00000369151.8
CACUL1
CDK2 associated cullin domain 1
chr2_+_69915100 4.36 ENST00000264444.7
MXD1
MAX dimerization protein 1
chr1_+_184386978 4.31 ENST00000235307.7
C1orf21
chromosome 1 open reading frame 21
chr4_-_152536045 4.24 ENST00000603548.6
ENST00000281708.10
FBXW7
F-box and WD repeat domain containing 7
chr11_-_62727444 4.24 ENST00000301785.7
HNRNPUL2
heterogeneous nuclear ribonucleoprotein U like 2
chr11_+_119206298 4.13 ENST00000634586.1
ENST00000634840.1
ENST00000264033.6
ENST00000637974.1
CBL
Cbl proto-oncogene
chr22_+_39994926 4.12 ENST00000333407.11
FAM83F
family with sequence similarity 83 member F
chr5_-_160312524 4.11 ENST00000520748.1
ENST00000257536.13
ENST00000393977.7
CCNJL
cyclin J like
chr1_-_212699817 4.08 ENST00000243440.2
BATF3
basic leucine zipper ATF-like transcription factor 3
chr17_+_49575828 4.02 ENST00000328741.6
NXPH3
neurexophilin 3
chr7_-_6272575 3.98 ENST00000350796.8
CYTH3
cytohesin 3
chr1_+_52142044 3.88 ENST00000287727.8
ENST00000371591.2
ZFYVE9
zinc finger FYVE-type containing 9
chr6_-_99425269 3.87 ENST00000647811.1
ENST00000481229.2
ENST00000369239.10
ENST00000681611.1
ENST00000681615.1
ENST00000438806.5
PNISR
PNN interacting serine and arginine rich protein
chr10_-_3785225 3.74 ENST00000542957.1
KLF6
Kruppel like factor 6
chr1_-_11805294 3.71 ENST00000413656.5
ENST00000376592.6
ENST00000376585.6
MTHFR
methylenetetrahydrofolate reductase
chr3_-_136196305 3.70 ENST00000473093.1
ENST00000309993.3
MSL2
MSL complex subunit 2
chr5_+_178113519 3.69 ENST00000274605.6
N4BP3
NEDD4 binding protein 3
chr22_+_41381923 3.47 ENST00000266304.9
TEF
TEF transcription factor, PAR bZIP family member
chr21_-_31558977 3.43 ENST00000286827.7
ENST00000541036.5
TIAM1
TIAM Rac1 associated GEF 1
chr10_+_74826550 3.30 ENST00000649657.1
ENST00000372714.6
ENST00000649442.1
ENST00000648539.1
ENST00000647666.1
ENST00000648048.1
ENST00000287239.10
ENST00000649375.1
KAT6B
lysine acetyltransferase 6B
chr11_-_75351609 3.29 ENST00000420843.7
ARRB1
arrestin beta 1
chr5_-_150113344 3.25 ENST00000286301.7
ENST00000511344.1
CSF1R
colony stimulating factor 1 receptor
chr2_-_98936155 3.25 ENST00000428096.5
ENST00000397899.7
ENST00000420294.1
CRACDL
CRACD like
chr6_-_62286161 3.21 ENST00000281156.5
KHDRBS2
KH RNA binding domain containing, signal transduction associated 2
chr2_-_43226594 3.15 ENST00000282388.4
ZFP36L2
ZFP36 ring finger protein like 2
chr21_+_31873010 3.07 ENST00000270112.7
HUNK
hormonally up-regulated Neu-associated kinase
chr2_-_25252251 2.97 ENST00000380746.8
ENST00000402667.1
DNMT3A
DNA methyltransferase 3 alpha
chr16_+_1706163 2.97 ENST00000250894.8
ENST00000673691.1
ENST00000356010.9
ENST00000610761.2
MAPK8IP3
mitogen-activated protein kinase 8 interacting protein 3
chr1_+_12166978 2.91 ENST00000376259.7
ENST00000536782.2
TNFRSF1B
TNF receptor superfamily member 1B
chr2_-_239400949 2.88 ENST00000345617.7
HDAC4
histone deacetylase 4
chr11_+_76860859 2.86 ENST00000679754.1
ENST00000534206.5
ENST00000680583.1
ENST00000532485.6
ENST00000526597.5
ENST00000533873.1
ACER3
alkaline ceramidase 3
chr2_+_43838963 2.65 ENST00000272286.4
ABCG8
ATP binding cassette subfamily G member 8
chr1_+_226548747 2.61 ENST00000366788.8
ENST00000366789.5
STUM
stum, mechanosensory transduction mediator homolog
chr1_-_175192769 2.53 ENST00000423313.6
KIAA0040
KIAA0040
chr10_-_73874502 2.51 ENST00000372765.5
ENST00000351293.7
ENST00000441192.2
ENST00000423381.6
CAMK2G
calcium/calmodulin dependent protein kinase II gamma
chr1_-_169893876 2.50 ENST00000367771.11
ENST00000367772.8
SCYL3
SCY1 like pseudokinase 3
chrX_-_54043927 2.46 ENST00000415025.5
ENST00000338946.10
PHF8
PHD finger protein 8
chr2_+_27148997 2.43 ENST00000296096.6
TCF23
transcription factor 23
chr16_+_30658399 2.42 ENST00000356166.11
FBRS
fibrosin
chr15_-_45378519 2.36 ENST00000558163.1
ENST00000396659.8
ENST00000675323.1
ENST00000558336.5
GATM
glycine amidinotransferase
chr9_-_98708856 2.33 ENST00000259455.4
GABBR2
gamma-aminobutyric acid type B receptor subunit 2
chr17_-_76453142 2.28 ENST00000319380.12
UBE2O
ubiquitin conjugating enzyme E2 O
chr10_-_35642286 2.28 ENST00000374694.3
FZD8
frizzled class receptor 8
chr12_+_56007484 2.26 ENST00000262032.9
IKZF4
IKAROS family zinc finger 4
chr5_+_149730260 2.25 ENST00000360453.8
ENST00000394320.7
ENST00000309241.10
PPARGC1B
PPARG coactivator 1 beta
chr7_-_79453544 2.19 ENST00000419488.5
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr1_+_27234612 2.18 ENST00000319394.8
ENST00000361771.7
WDTC1
WD and tetratricopeptide repeats 1
chr5_-_176537361 2.18 ENST00000274811.9
RNF44
ring finger protein 44
chr19_-_344786 2.16 ENST00000264819.7
MIER2
MIER family member 2
chr16_+_27550127 2.11 ENST00000261588.9
KATNIP
katanin interacting protein
chr3_+_10992717 2.09 ENST00000642767.1
ENST00000425938.6
ENST00000642515.1
ENST00000643498.1
ENST00000646072.1
ENST00000646570.1
ENST00000287766.10
ENST00000645281.1
ENST00000642820.1
ENST00000645054.1
ENST00000642735.1
ENST00000646022.1
ENST00000645776.1
ENST00000645592.1
ENST00000646924.1
ENST00000645974.1
ENST00000644314.1
ENST00000642639.1
ENST00000646060.1
ENST00000642201.1
ENST00000646487.1
ENST00000647194.1
ENST00000646088.1
SLC6A1
solute carrier family 6 member 1
chr9_-_19786928 1.98 ENST00000341998.6
ENST00000286344.3
SLC24A2
solute carrier family 24 member 2
chr10_+_91220603 1.90 ENST00000336126.6
PCGF5
polycomb group ring finger 5
chr12_+_70366277 1.86 ENST00000258111.5
KCNMB4
potassium calcium-activated channel subfamily M regulatory beta subunit 4
chr14_-_22819721 1.85 ENST00000554517.5
ENST00000285850.11
ENST00000397529.6
ENST00000555702.5
SLC7A7
solute carrier family 7 member 7
chr1_+_159171607 1.84 ENST00000368124.8
ENST00000368125.9
ENST00000416746.1
CADM3
cell adhesion molecule 3
chr11_-_47767275 1.83 ENST00000263773.10
FNBP4
formin binding protein 4
chr10_+_67884646 1.79 ENST00000212015.11
SIRT1
sirtuin 1
chr7_+_128937917 1.78 ENST00000357234.10
ENST00000613821.4
ENST00000477535.5
ENST00000479582.5
ENST00000464557.5
ENST00000402030.6
IRF5
interferon regulatory factor 5
chr17_-_714709 1.75 ENST00000401468.7
ENST00000575100.2
ENST00000680069.1
ENST00000681902.1
ENST00000576019.6
ENST00000571456.2
ENST00000679361.1
ENST00000680241.1
ENST00000681917.1
ENST00000681133.1
ENST00000437048.7
ENST00000680128.1
ENST00000681154.1
ENST00000679961.1
ENST00000680970.1
ENST00000681295.1
ENST00000574029.6
ENST00000681317.1
ENST00000571805.6
ENST00000291074.10
VPS53
VPS53 subunit of GARP complex
chr14_+_32939243 1.70 ENST00000346562.6
ENST00000548645.5
ENST00000356141.8
ENST00000357798.9
NPAS3
neuronal PAS domain protein 3
chr11_+_65711991 1.62 ENST00000377046.7
ENST00000352980.8
KAT5
lysine acetyltransferase 5
chr1_+_203475798 1.62 ENST00000343110.3
PRELP
proline and arginine rich end leucine rich repeat protein
chr3_+_43286512 1.61 ENST00000454177.5
ENST00000429705.6
ENST00000296088.12
ENST00000437827.1
SNRK
SNF related kinase
chr2_-_212538766 1.59 ENST00000342788.9
ERBB4
erb-b2 receptor tyrosine kinase 4
chr10_-_97334698 1.56 ENST00000371019.4
FRAT2
FRAT regulator of WNT signaling pathway 2
chr1_-_149917826 1.54 ENST00000369145.1
ENST00000369146.8
SV2A
synaptic vesicle glycoprotein 2A
chr7_+_20330893 1.50 ENST00000222573.5
ITGB8
integrin subunit beta 8
chr15_-_72117712 1.48 ENST00000444904.5
ENST00000564571.5
MYO9A
myosin IXA
chr17_-_75779758 1.45 ENST00000592643.5
ENST00000591890.5
ENST00000587171.1
ENST00000254810.8
ENST00000589599.5
H3-3B
H3.3 histone B
chr12_+_8082260 1.43 ENST00000638237.1
ENST00000339754.11
ENST00000639811.1
ENST00000639167.1
ENST00000541948.2
NECAP1
NECAP endocytosis associated 1
chr17_+_56834081 1.41 ENST00000572810.1
ENST00000284061.8
DGKE
diacylglycerol kinase epsilon
chr2_+_24491860 1.39 ENST00000406961.5
ENST00000405141.5
NCOA1
nuclear receptor coactivator 1
chr12_+_51912329 1.36 ENST00000547400.5
ENST00000550683.5
ENST00000419526.6
ACVRL1
activin A receptor like type 1
chr15_-_73368951 1.36 ENST00000261917.4
HCN4
hyperpolarization activated cyclic nucleotide gated potassium channel 4
chr2_-_127106961 1.35 ENST00000376113.6
BIN1
bridging integrator 1
chr1_+_183472465 1.33 ENST00000367537.7
SMG7
SMG7 nonsense mediated mRNA decay factor
chr9_+_84668485 1.30 ENST00000359847.4
ENST00000395882.6
ENST00000376208.6
ENST00000376213.6
NTRK2
neurotrophic receptor tyrosine kinase 2
chr17_+_41966787 1.30 ENST00000393892.8
ENST00000587679.1
CNP
2',3'-cyclic nucleotide 3' phosphodiesterase
chr6_+_96015964 1.30 ENST00000302103.6
FUT9
fucosyltransferase 9
chr16_+_10877181 1.30 ENST00000618207.4
ENST00000618327.4
ENST00000324288.14
ENST00000381835.9
CIITA
class II major histocompatibility complex transactivator
chr1_+_28369705 1.30 ENST00000373839.8
PHACTR4
phosphatase and actin regulator 4
chr3_-_50611767 1.28 ENST00000443053.6
ENST00000348721.4
CISH
cytokine inducible SH2 containing protein
chr4_+_93828746 1.27 ENST00000306011.6
ATOH1
atonal bHLH transcription factor 1
chr19_+_54201122 1.25 ENST00000391753.6
ENST00000441429.1
RPS9
ribosomal protein S9
chr17_-_19867929 1.23 ENST00000361658.6
ENST00000395544.9
ULK2
unc-51 like autophagy activating kinase 2
chr11_+_118436464 1.22 ENST00000389506.10
ENST00000534358.8
ENST00000531904.6
ENST00000649699.1
KMT2A
lysine methyltransferase 2A
chr3_+_8733779 1.22 ENST00000343849.3
ENST00000397368.2
CAV3
caveolin 3
chr4_-_42657085 1.21 ENST00000264449.14
ENST00000510289.1
ENST00000381668.9
ATP8A1
ATPase phospholipid transporting 8A1
chr1_+_171841466 1.21 ENST00000367733.6
ENST00000627582.3
ENST00000355305.9
ENST00000367731.5
DNM3
dynamin 3
chr2_+_28392802 1.20 ENST00000379619.5
ENST00000264716.9
FOSL2
FOS like 2, AP-1 transcription factor subunit
chr7_-_11832190 1.19 ENST00000423059.9
ENST00000617773.1
THSD7A
thrombospondin type 1 domain containing 7A
chr22_-_30505650 1.16 ENST00000381982.3
ENST00000255858.12
SEC14L4
SEC14 like lipid binding 4
chr1_+_209583706 1.15 ENST00000361322.3
ENST00000651530.1
ENST00000009105.5
ENST00000423146.5
CAMK1G
calcium/calmodulin dependent protein kinase IG
chr2_-_73269483 1.14 ENST00000295133.9
FBXO41
F-box protein 41
chr1_-_35557378 1.14 ENST00000325722.8
ENST00000469892.5
KIAA0319L
KIAA0319 like
chr10_+_70404129 1.13 ENST00000373218.5
EIF4EBP2
eukaryotic translation initiation factor 4E binding protein 2
chr4_-_52659238 1.11 ENST00000451218.6
ENST00000441222.8
USP46
ubiquitin specific peptidase 46
chr2_-_47570905 1.10 ENST00000327876.5
KCNK12
potassium two pore domain channel subfamily K member 12
chr19_+_708903 1.09 ENST00000338448.10
ENST00000264560.11
PALM
paralemmin
chr17_+_44758958 1.08 ENST00000200557.11
ADAM11
ADAM metallopeptidase domain 11
chr4_-_119628791 1.08 ENST00000354960.8
PDE5A
phosphodiesterase 5A
chr16_+_24256313 1.06 ENST00000005284.4
CACNG3
calcium voltage-gated channel auxiliary subunit gamma 3
chr12_+_106774630 1.05 ENST00000392839.6
ENST00000548914.5
ENST00000355478.6
ENST00000552619.1
ENST00000549643.5
ENST00000392837.9
RIC8B
RIC8 guanine nucleotide exchange factor B
chr9_-_129642094 1.05 ENST00000277459.8
ENST00000277458.5
ENST00000450050.6
ASB6
ankyrin repeat and SOCS box containing 6
chr21_+_38805165 1.04 ENST00000360214.8
ETS2
ETS proto-oncogene 2, transcription factor
chr16_+_66844914 1.04 ENST00000394069.3
CA7
carbonic anhydrase 7
chr12_+_62466791 1.03 ENST00000641654.1
ENST00000546600.5
ENST00000393630.8
ENST00000552738.5
ENST00000393629.6
ENST00000552115.5
MON2
MON2 homolog, regulator of endosome-to-Golgi trafficking
chr2_+_26764232 1.03 ENST00000344420.10
SLC35F6
solute carrier family 35 member F6
chr6_-_29559724 1.01 ENST00000377050.5
UBD
ubiquitin D
chrX_+_21374357 1.00 ENST00000643841.1
ENST00000379510.5
ENST00000425654.7
ENST00000644798.1
ENST00000543067.6
CNKSR2
connector enhancer of kinase suppressor of Ras 2
chr8_-_42051978 0.99 ENST00000265713.8
ENST00000648335.1
ENST00000485568.5
ENST00000426524.6
ENST00000396930.4
ENST00000406337.6
KAT6A
lysine acetyltransferase 6A
chr14_+_76761453 0.98 ENST00000167106.9
VASH1
vasohibin 1
chr12_+_53380639 0.98 ENST00000426431.2
SP1
Sp1 transcription factor
chr9_-_92404559 0.97 ENST00000262551.8
ENST00000375561.10
OGN
osteoglycin
chr13_+_46553157 0.97 ENST00000311191.10
ENST00000389797.8
ENST00000389798.7
LRCH1
leucine rich repeats and calponin homology domain containing 1
chr1_-_17119435 0.96 ENST00000375481.1
ENST00000375486.9
PADI2
peptidyl arginine deiminase 2
chr12_+_102957666 0.96 ENST00000266744.4
ASCL1
achaete-scute family bHLH transcription factor 1
chr10_-_103855406 0.95 ENST00000355946.6
ENST00000369774.8
SH3PXD2A
SH3 and PX domains 2A
chr17_-_42745025 0.94 ENST00000592492.5
ENST00000585893.5
ENST00000593214.5
ENST00000590078.5
ENST00000428826.7
ENST00000586382.5
ENST00000415827.6
ENST00000592743.5
ENST00000586089.5
EZH1
enhancer of zeste 1 polycomb repressive complex 2 subunit
chr2_+_134918811 0.89 ENST00000264157.10
ENST00000295238.10
CCNT2
cyclin T2
chr12_+_93377883 0.89 ENST00000337179.9
ENST00000415493.7
NUDT4
nudix hydrolase 4
chr12_+_8914698 0.88 ENST00000433083.6
ENST00000544539.5
ENST00000539063.5
PHC1
polyhomeotic homolog 1
chr5_-_141878396 0.88 ENST00000503492.5
ENST00000287008.8
ENST00000394536.4
PCDH1
protocadherin 1
chr16_+_12901591 0.86 ENST00000558583.3
SHISA9
shisa family member 9
chr3_-_197749688 0.83 ENST00000273582.9
RUBCN
rubicon autophagy regulator
chrX_-_154097668 0.80 ENST00000407218.5
ENST00000303391.11
ENST00000453960.7
MECP2
methyl-CpG binding protein 2
chr1_-_20486197 0.79 ENST00000375078.4
CAMK2N1
calcium/calmodulin dependent protein kinase II inhibitor 1
chr1_-_28088564 0.79 ENST00000373863.3
ENST00000373871.8
ENST00000540618.5
ENST00000436342.6
EYA3
EYA transcriptional coactivator and phosphatase 3
chrX_-_112840815 0.78 ENST00000304758.5
ENST00000371959.9
AMOT
angiomotin
chr1_-_15585015 0.77 ENST00000375826.4
AGMAT
agmatinase
chr1_+_45500287 0.75 ENST00000401061.9
ENST00000616135.1
MMACHC
metabolism of cobalamin associated C
chr12_-_57006476 0.72 ENST00000300101.3
ZBTB39
zinc finger and BTB domain containing 39
chr1_+_154405193 0.72 ENST00000622330.4
ENST00000344086.8
IL6R
interleukin 6 receptor
chr11_+_117144277 0.71 ENST00000419197.6
ENST00000527958.6
ENST00000304808.10
ENST00000529887.6
ENST00000530272.1
PAFAH1B2
platelet activating factor acetylhydrolase 1b catalytic subunit 2
chr1_-_113812448 0.68 ENST00000612242.4
ENST00000261441.9
RSBN1
round spermatid basic protein 1
chr14_+_70641896 0.68 ENST00000256367.3
TTC9
tetratricopeptide repeat domain 9
chr21_-_34888683 0.66 ENST00000344691.8
ENST00000358356.9
RUNX1
RUNX family transcription factor 1
chr20_+_49982969 0.66 ENST00000244050.3
SNAI1
snail family transcriptional repressor 1
chr12_+_51951663 0.66 ENST00000257963.9
ENST00000541224.5
ENST00000426655.6
ENST00000536420.5
ENST00000415850.6
ACVR1B
activin A receptor type 1B
chr9_-_114806031 0.65 ENST00000374045.5
TNFSF15
TNF superfamily member 15
chr11_-_31811314 0.64 ENST00000640368.2
ENST00000379123.10
ENST00000379115.9
ENST00000419022.6
ENST00000643871.1
ENST00000640610.1
ENST00000639034.2
PAX6
paired box 6
chr10_+_94402486 0.62 ENST00000225235.5
TBC1D12
TBC1 domain family member 12
chr4_-_86360071 0.60 ENST00000641677.1
ENST00000639234.1
ENST00000641553.1
ENST00000641826.1
ENST00000641537.1
ENST00000395169.9
ENST00000641408.1
ENST00000638225.1
ENST00000641052.1
MAPK10
mitogen-activated protein kinase 10
chr9_+_99105098 0.59 ENST00000374990.6
ENST00000374994.9
ENST00000552516.5
TGFBR1
transforming growth factor beta receptor 1
chr5_+_177357834 0.59 ENST00000408923.8
RGS14
regulator of G protein signaling 14
chr21_-_44240840 0.57 ENST00000344330.8
ENST00000407780.7
ENST00000400379.7
ENST00000400377.3
ICOSLG
inducible T cell costimulator ligand
chr11_-_64878612 0.56 ENST00000320631.8
EHD1
EH domain containing 1
chr5_-_100903252 0.56 ENST00000231461.10
ST8SIA4
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
chr10_+_100535927 0.55 ENST00000299163.7
HIF1AN
hypoxia inducible factor 1 subunit alpha inhibitor
chr15_-_74695987 0.55 ENST00000563009.5
ENST00000568176.5
ENST00000566243.5
ENST00000566219.1
ENST00000426797.7
ENST00000315127.9
ENST00000566119.5
EDC3
enhancer of mRNA decapping 3
chr19_+_48965304 0.54 ENST00000331825.11
FTL
ferritin light chain
chr4_-_41214602 0.53 ENST00000508676.5
ENST00000506352.5
ENST00000295974.12
APBB2
amyloid beta precursor protein binding family B member 2
chr15_-_34210073 0.50 ENST00000559515.1
ENST00000560108.5
ENST00000256544.8
ENST00000559462.1
KATNBL1
katanin regulatory subunit B1 like 1
chr16_-_58629816 0.47 ENST00000564557.1
ENST00000317147.10
ENST00000569240.5
ENST00000441024.6
CNOT1
CCR4-NOT transcription complex subunit 1
chr12_-_53499615 0.45 ENST00000267079.6
MAP3K12
mitogen-activated protein kinase kinase kinase 12
chr20_-_32207708 0.42 ENST00000246229.5
PLAGL2
PLAG1 like zinc finger 2
chr1_-_213015826 0.41 ENST00000360506.6
ENST00000535388.2
ENST00000366962.8
ANGEL2
angel homolog 2
chr1_+_213987929 0.39 ENST00000498508.6
ENST00000366958.9
PROX1
prospero homeobox 1
chr9_+_113444725 0.36 ENST00000374140.6
RGS3
regulator of G protein signaling 3
chr18_+_48539017 0.35 ENST00000256413.8
CTIF
cap binding complex dependent translation initiation factor
chr20_+_50510321 0.34 ENST00000541713.5
ENST00000371621.5
PTPN1
protein tyrosine phosphatase non-receptor type 1
chr1_+_16367088 0.33 ENST00000471507.5
ENST00000401089.3
ENST00000401088.9
ENST00000492354.1
SZRD1
SUZ RNA binding domain containing 1
chr11_+_120336357 0.33 ENST00000397843.7
ARHGEF12
Rho guanine nucleotide exchange factor 12
chr22_+_40177917 0.32 ENST00000454349.7
ENST00000335727.13
TNRC6B
trinucleotide repeat containing adaptor 6B
chr5_+_140547632 0.32 ENST00000310331.3
EIF4EBP3
eukaryotic translation initiation factor 4E binding protein 3
chr1_-_42958836 0.31 ENST00000372500.4
ENST00000674765.1
ENST00000460369.3
ENST00000426263.10
SLC2A1
solute carrier family 2 member 1
chr9_+_122371014 0.30 ENST00000362012.7
PTGS1
prostaglandin-endoperoxide synthase 1
chr1_-_204359885 0.29 ENST00000414478.1
ENST00000272203.8
PLEKHA6
pleckstrin homology domain containing A6
chr1_+_3069160 0.28 ENST00000511072.5
PRDM16
PR/SET domain 16
chr12_+_48978313 0.26 ENST00000293549.4
WNT1
Wnt family member 1
chr11_+_46719193 0.24 ENST00000311907.10
ENST00000530231.5
ENST00000442468.1
F2
coagulation factor II, thrombin
chr4_-_103719980 0.24 ENST00000304883.3
TACR3
tachykinin receptor 3
chr16_+_15395745 0.22 ENST00000287594.7
ENST00000396385.4
ENST00000568766.1
MPV17L
ENSG00000261130.5
MPV17 mitochondrial inner membrane protein like
novel protein
chr13_-_27969295 0.20 ENST00000381020.8
CDX2
caudal type homeobox 2
chr7_+_74289397 0.20 ENST00000223398.11
ENST00000361545.9
CLIP2
CAP-Gly domain containing linker protein 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 10.7 GO:0032290 peripheral nervous system myelin formation(GO:0032290)
2.2 19.7 GO:1903898 negative regulation of PERK-mediated unfolded protein response(GO:1903898)
1.9 5.8 GO:0016340 calcium-dependent cell-matrix adhesion(GO:0016340)
1.2 6.0 GO:0097167 circadian regulation of translation(GO:0097167)
1.2 5.9 GO:0072708 response to sorbitol(GO:0072708)
1.1 4.2 GO:2000639 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.9 2.7 GO:1904479 negative regulation of intestinal absorption(GO:1904479)
0.9 3.4 GO:1900147 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.8 5.0 GO:0051138 positive regulation of NK T cell differentiation(GO:0051138)
0.8 2.5 GO:0035574 histone H4-K20 demethylation(GO:0035574)
0.7 2.1 GO:0051939 gamma-aminobutyric acid import(GO:0051939)
0.6 3.7 GO:0070829 response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
0.6 4.8 GO:0060087 relaxation of vascular smooth muscle(GO:0060087)
0.6 1.8 GO:0031393 negative regulation of prostaglandin biosynthetic process(GO:0031393) negative regulation of response to alcohol(GO:1901420)
0.5 1.6 GO:0061026 cardiac muscle tissue regeneration(GO:0061026)
0.5 5.3 GO:0090292 nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.5 2.6 GO:2001038 regulation of cellular response to drug(GO:2001038)
0.5 3.0 GO:0090116 C-5 methylation of cytosine(GO:0090116)
0.5 4.1 GO:0090650 response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)
0.4 1.3 GO:0060988 lipid tube assembly(GO:0060988)
0.4 1.3 GO:0061386 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.4 1.2 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.4 3.1 GO:1904628 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
0.4 4.8 GO:0060068 vagina development(GO:0060068)
0.4 3.3 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.4 3.3 GO:0045217 cell-cell junction maintenance(GO:0045217)
0.3 1.0 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
0.3 1.0 GO:0036166 phenotypic switching(GO:0036166) regulation of phenotypic switching(GO:1900239)
0.3 10.3 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.3 1.0 GO:1901624 negative regulation of lymphocyte chemotaxis(GO:1901624)
0.3 1.0 GO:0021779 noradrenergic neuron development(GO:0003358) neuroblast differentiation(GO:0014016) spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780) regulation of timing of neuron differentiation(GO:0060164) olfactory pit development(GO:0060166)
0.3 1.0 GO:0072674 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.3 1.3 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.3 0.6 GO:0003342 proepicardium development(GO:0003342) septum transversum development(GO:0003343)
0.3 2.9 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.3 8.5 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.3 0.8 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) negative regulation of autophagosome maturation(GO:1901097)
0.3 2.2 GO:0003402 planar cell polarity pathway involved in axis elongation(GO:0003402)
0.3 0.8 GO:1900114 positive regulation of histone H3-K9 trimethylation(GO:1900114)
0.3 1.8 GO:1990822 regulation of arginine metabolic process(GO:0000821) basic amino acid transmembrane transport(GO:1990822)
0.2 1.2 GO:0035995 detection of muscle stretch(GO:0035995)
0.2 2.3 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.2 0.9 GO:0019086 late viral transcription(GO:0019086)
0.2 1.0 GO:0032849 positive regulation of cellular pH reduction(GO:0032849)
0.2 1.2 GO:0075044 autophagy of host cells involved in interaction with symbiont(GO:0075044) autophagy involved in symbiotic interaction(GO:0075071)
0.2 1.2 GO:0061092 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.2 1.3 GO:0099550 trans-synaptic signalling, modulating synaptic transmission(GO:0099550)
0.2 0.6 GO:0061428 negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.2 0.9 GO:2000980 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.2 0.7 GO:0002384 hepatic immune response(GO:0002384)
0.2 1.1 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.2 1.3 GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
0.2 0.9 GO:1901910 diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.2 1.5 GO:0014052 regulation of gamma-aminobutyric acid secretion(GO:0014052)
0.2 1.4 GO:0035912 dorsal aorta morphogenesis(GO:0035912)
0.2 0.7 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.2 2.6 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.2 5.1 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.2 2.4 GO:0006600 creatine metabolic process(GO:0006600)
0.2 1.1 GO:0060160 negative regulation of dopamine receptor signaling pathway(GO:0060160)
0.2 0.8 GO:1901162 primary amino compound biosynthetic process(GO:1901162)
0.2 2.9 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.2 0.3 GO:1904016 response to Thyroglobulin triiodothyronine(GO:1904016)
0.2 1.4 GO:0071321 cellular response to cGMP(GO:0071321)
0.1 1.0 GO:0001712 ectoderm formation(GO:0001705) ectodermal cell fate commitment(GO:0001712)
0.1 1.3 GO:0045348 positive regulation of MHC class I biosynthetic process(GO:0045345) positive regulation of MHC class II biosynthetic process(GO:0045348)
0.1 4.0 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.1 1.8 GO:0032494 response to peptidoglycan(GO:0032494)
0.1 5.7 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.1 3.5 GO:0007184 SMAD protein import into nucleus(GO:0007184)
0.1 0.7 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800) Notch signaling involved in heart development(GO:0061314)
0.1 2.5 GO:1901897 regulation of relaxation of cardiac muscle(GO:1901897)
0.1 0.4 GO:0046619 optic placode formation involved in camera-type eye formation(GO:0046619) lens fiber cell morphogenesis(GO:0070309)
0.1 0.3 GO:0021551 central nervous system morphogenesis(GO:0021551)
0.1 1.1 GO:0060013 righting reflex(GO:0060013)
0.1 2.2 GO:0045717 negative regulation of fatty acid biosynthetic process(GO:0045717)
0.1 0.4 GO:2000671 regulation of motor neuron apoptotic process(GO:2000671) negative regulation of motor neuron apoptotic process(GO:2000672)
0.1 2.1 GO:0001573 ganglioside metabolic process(GO:0001573)
0.1 1.3 GO:0042355 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.1 2.9 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.1 0.2 GO:0002537 nitric oxide production involved in inflammatory response(GO:0002537)
0.1 1.1 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 1.9 GO:0005513 detection of calcium ion(GO:0005513)
0.1 0.6 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.1 1.9 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.1 0.5 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.1 2.7 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.1 0.1 GO:2000015 regulation of determination of dorsal identity(GO:2000015)
0.1 0.3 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.1 0.8 GO:0042074 cell migration involved in gastrulation(GO:0042074)
0.1 0.6 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
0.1 2.3 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.1 0.5 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.1 13.7 GO:0010212 response to ionizing radiation(GO:0010212)
0.1 1.2 GO:0003334 keratinocyte development(GO:0003334)
0.1 3.0 GO:0007257 activation of JUN kinase activity(GO:0007257)
0.1 0.8 GO:0042364 water-soluble vitamin biosynthetic process(GO:0042364)
0.1 0.6 GO:0031087 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.1 0.2 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.1 2.3 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.1 0.7 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 1.0 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 4.0 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 1.7 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.2 GO:0042538 hyperosmotic salinity response(GO:0042538)
0.0 0.1 GO:0086092 regulation of the force of heart contraction by cardiac conduction(GO:0086092)
0.0 0.6 GO:0006972 hyperosmotic response(GO:0006972)
0.0 2.8 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 0.4 GO:0034378 chylomicron assembly(GO:0034378)
0.0 0.2 GO:0014807 regulation of somitogenesis(GO:0014807)
0.0 0.6 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 3.8 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.0 3.6 GO:0016573 histone acetylation(GO:0016573)
0.0 0.6 GO:0003322 pancreatic A cell development(GO:0003322)
0.0 2.3 GO:0071594 T cell differentiation in thymus(GO:0033077) thymocyte aggregation(GO:0071594)
0.0 0.7 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 1.3 GO:0009214 cyclic nucleotide catabolic process(GO:0009214)
0.0 0.4 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0 0.6 GO:2000785 regulation of autophagosome assembly(GO:2000785)
0.0 0.3 GO:0060213 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.0 3.8 GO:0006986 response to unfolded protein(GO:0006986)
0.0 0.1 GO:0002254 kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353)
0.0 3.5 GO:0007601 visual perception(GO:0007601)
0.0 1.6 GO:0051291 protein heterooligomerization(GO:0051291)
0.0 0.3 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 1.5 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 19.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.6 4.2 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.6 2.3 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.6 2.3 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.5 3.3 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.5 5.3 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.5 10.7 GO:0033270 paranode region of axon(GO:0033270)
0.5 1.5 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
0.5 5.6 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.5 3.7 GO:0072487 MSL complex(GO:0072487)
0.4 1.3 GO:0060987 lipid tube(GO:0060987)
0.4 2.9 GO:0043196 varicosity(GO:0043196)
0.4 5.3 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.4 1.6 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.4 1.2 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.4 4.3 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.3 5.5 GO:0005662 DNA replication factor A complex(GO:0005662)
0.3 1.8 GO:0033553 rDNA heterochromatin(GO:0033553)
0.3 8.2 GO:0071011 precatalytic spliceosome(GO:0071011)
0.3 2.7 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.3 4.1 GO:0016600 flotillin complex(GO:0016600)
0.2 1.7 GO:1990745 EARP complex(GO:1990745)
0.2 3.0 GO:0001741 XY body(GO:0001741)
0.2 2.2 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.2 0.7 GO:0048179 activin receptor complex(GO:0048179)
0.1 0.7 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.1 4.3 GO:0031143 pseudopodium(GO:0031143)
0.1 3.4 GO:0044295 axonal growth cone(GO:0044295)
0.1 0.5 GO:0008043 intracellular ferritin complex(GO:0008043) ferritin complex(GO:0070288)
0.1 1.5 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 1.2 GO:0042584 chromaffin granule membrane(GO:0042584)
0.1 0.6 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.1 0.6 GO:0020018 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.1 2.0 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 1.5 GO:0016461 unconventional myosin complex(GO:0016461)
0.1 0.6 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.1 0.9 GO:0035102 PRC1 complex(GO:0035102)
0.1 2.0 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 1.2 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 6.8 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 2.5 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.3 GO:0001939 female pronucleus(GO:0001939)
0.0 3.4 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.0 1.1 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 1.1 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.5 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 1.2 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 9.5 GO:0001726 ruffle(GO:0001726)
0.0 0.8 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 1.2 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.3 GO:0098554 sorting endosome(GO:0097443) cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.0 1.0 GO:0002102 podosome(GO:0002102)
0.0 4.5 GO:0031461 cullin-RING ubiquitin ligase complex(GO:0031461)
0.0 3.1 GO:0005796 Golgi lumen(GO:0005796)
0.0 1.0 GO:0016235 aggresome(GO:0016235)
0.0 1.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.3 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 2.5 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 1.7 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.5 GO:0031519 PcG protein complex(GO:0031519)
0.0 0.2 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.9 GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
1.1 3.3 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
1.1 3.3 GO:0005011 macrophage colony-stimulating factor receptor activity(GO:0005011)
0.9 10.4 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.8 2.5 GO:0035575 histone demethylase activity (H4-K20 specific)(GO:0035575)
0.8 5.3 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.6 3.7 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.6 2.3 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.6 2.9 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.5 4.2 GO:0050816 phosphothreonine binding(GO:0050816)
0.5 3.0 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.5 2.9 GO:0017040 ceramidase activity(GO:0017040)
0.5 1.4 GO:0033142 progesterone receptor binding(GO:0033142)
0.5 4.1 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.4 5.0 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.4 1.2 GO:0045322 unmethylated CpG binding(GO:0045322)
0.4 1.5 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.4 6.3 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.4 1.8 GO:1990254 keratin filament binding(GO:1990254)
0.3 5.9 GO:0003688 DNA replication origin binding(GO:0003688)
0.3 2.0 GO:0016361 activin receptor activity, type I(GO:0016361)
0.3 7.0 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.3 2.0 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.3 1.3 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
0.3 2.2 GO:0070699 type II activin receptor binding(GO:0070699)
0.3 1.4 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.3 0.8 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.3 3.1 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.3 2.1 GO:0015185 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.3 2.3 GO:0050682 AF-2 domain binding(GO:0050682)
0.2 1.0 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.2 0.7 GO:0019981 interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981) ciliary neurotrophic factor binding(GO:0070119)
0.2 6.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.2 3.0 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.2 2.5 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.2 1.3 GO:1990932 5.8S rRNA binding(GO:1990932)
0.2 0.9 GO:0034432 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) inositol diphosphate tetrakisphosphate diphosphatase activity(GO:0052840) inositol bisdiphosphate tetrakisphosphate diphosphatase activity(GO:0052841) inositol diphosphate pentakisphosphate diphosphatase activity(GO:0052842) inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity(GO:0052843) inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity(GO:0052844) inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity(GO:0052845) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity(GO:0052846) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052847) inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052848)
0.2 5.3 GO:0005521 lamin binding(GO:0005521)
0.2 20.6 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.2 2.0 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.2 1.2 GO:0071253 connexin binding(GO:0071253)
0.1 3.9 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 1.3 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.1 0.7 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
0.1 9.6 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.1 4.0 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 1.5 GO:0030371 translation repressor activity(GO:0030371)
0.1 1.2 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1 1.0 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1 6.8 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 3.2 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.1 2.7 GO:0017127 cholesterol transporter activity(GO:0017127)
0.1 1.1 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 3.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 3.2 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 0.3 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.1 7.0 GO:0070888 E-box binding(GO:0070888)
0.1 0.9 GO:0097322 7SK snRNA binding(GO:0097322)
0.1 2.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 2.9 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 12.3 GO:0008013 beta-catenin binding(GO:0008013)
0.1 0.5 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 0.6 GO:0071532 ankyrin repeat binding(GO:0071532)
0.1 0.8 GO:0010385 double-stranded methylated DNA binding(GO:0010385)
0.1 0.6 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 1.4 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 0.6 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 2.4 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.1 0.1 GO:0098821 BMP receptor activity(GO:0098821)
0.1 0.8 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.1 1.0 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 1.3 GO:0048156 tau protein binding(GO:0048156)
0.1 0.8 GO:0016723 oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.1 5.8 GO:0017022 myosin binding(GO:0017022)
0.1 0.3 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.1 1.0 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 1.9 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 2.3 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 6.0 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 0.2 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 1.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.6 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 10.1 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.5 GO:0008199 ferric iron binding(GO:0008199)
0.0 0.4 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.9 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.0 1.0 GO:0070628 proteasome binding(GO:0070628)
0.0 3.3 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 4.3 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 2.4 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.0 5.5 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.1 GO:0017002 activin-activated receptor activity(GO:0017002)
0.0 1.1 GO:0050780 dopamine receptor binding(GO:0050780)
0.0 0.3 GO:0016015 morphogen activity(GO:0016015)
0.0 1.6 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 1.1 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.2 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.0 1.1 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.6 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.6 GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891)
0.0 7.1 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.7 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.4 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 1.1 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.1 GO:0001727 lipid kinase activity(GO:0001727)
0.0 0.1 GO:0030274 LIM domain binding(GO:0030274)
0.0 1.5 GO:0003774 motor activity(GO:0003774)
0.0 0.2 GO:0051010 microtubule plus-end binding(GO:0051010)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 6.0 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.2 7.4 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.1 2.9 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 10.9 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 2.0 ST STAT3 PATHWAY STAT3 Pathway
0.1 3.1 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.1 7.6 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.1 3.0 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1 2.1 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 2.9 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 2.0 PID CONE PATHWAY Visual signal transduction: Cones
0.1 5.3 PID FGF PATHWAY FGF signaling pathway
0.1 2.5 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 4.1 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 4.0 PID ARF6 PATHWAY Arf6 signaling events
0.1 2.6 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 1.2 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.1 3.6 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.1 1.2 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 3.9 PID TGFBR PATHWAY TGF-beta receptor signaling
0.1 1.5 PID ALK1 PATHWAY ALK1 signaling events
0.1 5.5 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 5.3 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 2.1 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.2 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 1.2 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.2 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.7 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 1.0 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.9 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.7 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.4 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.7 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 1.3 PID P73PATHWAY p73 transcription factor network
0.0 0.4 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 5.6 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.3 4.8 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.2 2.6 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 3.3 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 2.3 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 2.7 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 4.2 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 4.5 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 2.9 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 4.3 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 2.1 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 1.0 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 2.9 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 5.0 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 2.2 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.1 2.0 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 1.9 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.1 4.0 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 2.9 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 1.3 REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE Genes involved in NGF signalling via TRKA from the plasma membrane
0.0 0.8 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.6 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.6 REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.0 1.4 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.8 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 3.4 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 2.3 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.8 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 8.0 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 1.7 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 0.6 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 5.3 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.0 1.0 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.6 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 1.5 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 1.2 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.8 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 2.1 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 2.0 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.1 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 0.8 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.5 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport
0.0 1.2 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.0 0.6 REACTOME COSTIMULATION BY THE CD28 FAMILY Genes involved in Costimulation by the CD28 family
0.0 0.3 REACTOME REGULATORY RNA PATHWAYS Genes involved in Regulatory RNA pathways