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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for AGCUUAU
Z-value: 0.62
Motif logo
miRNA associated with seed AGCUUAU
Network of associatons between targets according to the STRING database.
First level regulatory network of AGCUUAU
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_+_110871903 Show fit | 7.07 |
ENST00000280154.12
|
programmed cell death 4 |
|
| chr7_-_140176970 Show fit | 6.98 |
ENST00000397560.7
|
lysine demethylase 7A |
|
| chr3_-_18425295 Show fit | 6.33 |
ENST00000338745.11
ENST00000450898.1 |
SATB homeobox 1 |
|
| chr2_-_43226594 Show fit | 5.84 |
ENST00000282388.4
|
ZFP36 ring finger protein like 2 |
|
| chr22_+_32801697 Show fit | 5.83 |
ENST00000266085.7
|
TIMP metallopeptidase inhibitor 3 |
|
| chr2_-_64144411 Show fit | 4.64 |
ENST00000358912.5
|
pellino E3 ubiquitin protein ligase 1 |
|
| chr10_-_3785225 Show fit | 4.57 |
ENST00000542957.1
|
Kruppel like factor 6 |
|
| chr4_+_123399488 Show fit | 4.20 |
ENST00000394339.2
|
sprouty RTK signaling antagonist 1 |
|
| chr9_+_36036899 Show fit | 3.98 |
ENST00000377966.4
|
reversion inducing cysteine rich protein with kazal motifs |
|
| chr7_-_44885446 Show fit | 3.82 |
ENST00000395699.5
|
purine rich element binding protein B |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 11.3 | GO:0060940 | epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940) |
| 0.5 | 7.5 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 2.3 | 7.0 | GO:0035574 | histone H4-K20 demethylation(GO:0035574) |
| 0.8 | 6.0 | GO:1904627 | response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628) |
| 1.5 | 5.8 | GO:1903984 | positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984) |
| 0.9 | 4.6 | GO:0008063 | Toll signaling pathway(GO:0008063) |
| 0.0 | 4.6 | GO:0050868 | negative regulation of T cell activation(GO:0050868) |
| 0.2 | 4.3 | GO:0060213 | regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213) |
| 0.0 | 4.2 | GO:0042787 | protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787) |
| 0.5 | 4.0 | GO:1904684 | negative regulation of metalloendopeptidase activity(GO:1904684) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.4 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 7.6 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 6.4 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 6.1 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.3 | 5.8 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.0 | 3.7 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.2 | 3.4 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.1 | 3.4 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.5 | 3.2 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.1 | 3.2 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 15.6 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 15.5 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.4 | 9.8 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.0 | 8.2 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.4 | 8.0 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 2.3 | 7.0 | GO:0035575 | histone demethylase activity (H4-K20 specific)(GO:0035575) |
| 0.3 | 5.6 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.3 | 4.6 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
| 0.0 | 4.3 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 1.1 | 3.2 | GO:0005026 | transforming growth factor beta receptor activity, type II(GO:0005026) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.8 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.1 | 6.3 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 6.1 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.0 | 5.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 4.3 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.1 | 4.0 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.1 | 4.0 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 3.0 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 2.7 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.1 | 2.2 | PID IL5 PATHWAY | IL5-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.3 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.5 | 4.6 | REACTOME IRAK1 RECRUITS IKK COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 0.1 | 4.2 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.2 | 3.2 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.1 | 3.2 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 3.1 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 2.9 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 2.9 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 2.8 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.1 | 2.7 | REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR | Genes involved in Signaling by constitutively active EGFR |