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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for AGGUAGU
Z-value: 0.42
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miRNA associated with seed AGGUAGU
Network of associatons between targets according to the STRING database.
First level regulatory network of AGGUAGU
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 6.0 | GO:0090402 | oncogene-induced cell senescence(GO:0090402) |
| 0.4 | 6.0 | GO:0043589 | skin morphogenesis(GO:0043589) |
| 0.5 | 4.2 | GO:1903898 | negative regulation of PERK-mediated unfolded protein response(GO:1903898) negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912) |
| 0.4 | 3.8 | GO:0032790 | ribosome disassembly(GO:0032790) |
| 0.7 | 3.6 | GO:0002904 | positive regulation of B cell apoptotic process(GO:0002904) |
| 0.1 | 3.5 | GO:0045022 | early endosome to late endosome transport(GO:0045022) |
| 0.2 | 2.9 | GO:0090435 | protein localization to nuclear envelope(GO:0090435) |
| 0.0 | 2.7 | GO:0048704 | embryonic skeletal system morphogenesis(GO:0048704) |
| 0.4 | 2.6 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 0.0 | 2.6 | GO:0043966 | histone H3 acetylation(GO:0043966) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 8.6 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.9 | 6.0 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.2 | 4.2 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 1.0 | 2.9 | GO:0044611 | nuclear pore inner ring(GO:0044611) |
| 0.3 | 2.9 | GO:0005672 | transcription factor TFIIA complex(GO:0005672) |
| 0.2 | 2.6 | GO:0070775 | H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776) |
| 0.0 | 2.1 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.3 | 1.8 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
| 0.1 | 1.8 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.0 | 1.8 | GO:0031225 | anchored component of membrane(GO:0031225) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 8.6 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.0 | 5.5 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.6 | 3.8 | GO:0043023 | ribosomal large subunit binding(GO:0043023) |
| 0.9 | 3.6 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
| 0.7 | 3.4 | GO:0004677 | DNA-dependent protein kinase activity(GO:0004677) |
| 0.1 | 2.9 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.2 | 2.6 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.1 | 2.4 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.0 | 2.3 | GO:0042393 | histone binding(GO:0042393) |
| 0.0 | 2.2 | GO:0003707 | steroid hormone receptor activity(GO:0003707) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.8 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 4.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 2.0 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 1.9 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.1 | 1.4 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 1.3 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.0 | 1.1 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.0 | 1.1 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.0 | 0.9 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.1 | 0.8 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 6.0 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.1 | 4.2 | REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.0 | 2.8 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.2 | 2.6 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.1 | 2.0 | REACTOME RAF MAP KINASE CASCADE | Genes involved in RAF/MAP kinase cascade |
| 0.1 | 1.3 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.0 | 1.2 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.0 | 1.1 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.0 | 1.1 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 1.0 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |