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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for AGUGCAA
Z-value: 1.02
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miRNA associated with seed AGUGCAA
Network of associatons between targets according to the STRING database.
First level regulatory network of AGUGCAA
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr20_+_10218808 Show fit | 34.09 |
ENST00000254976.7
ENST00000304886.6 |
synaptosome associated protein 25 |
|
| chr14_-_59630582 Show fit | 28.02 |
ENST00000395090.5
|
reticulon 1 |
|
| chr1_-_204411804 Show fit | 25.36 |
ENST00000367188.5
|
protein phosphatase 1 regulatory subunit 15B |
|
| chr19_+_47256518 Show fit | 16.70 |
ENST00000643617.1
ENST00000221922.11 |
coiled-coil domain containing 9 |
|
| chr1_+_77779618 Show fit | 16.22 |
ENST00000370791.7
ENST00000443751.3 ENST00000645756.1 ENST00000643390.1 ENST00000642959.1 |
mitoguardin 1 |
|
| chr5_+_72107453 Show fit | 16.08 |
ENST00000296755.12
ENST00000511641.2 |
microtubule associated protein 1B |
|
| chr1_-_9943314 Show fit | 15.67 |
ENST00000377223.6
ENST00000377213.1 |
leucine zipper and CTNNBIP1 domain containing |
|
| chr11_-_113875555 Show fit | 15.54 |
ENST00000003302.8
ENST00000545540.5 |
ubiquitin specific peptidase 28 |
|
| chr3_+_50674896 Show fit | 15.44 |
ENST00000266037.10
|
dedicator of cytokinesis 3 |
|
| chr17_-_80476597 Show fit | 15.03 |
ENST00000306773.5
|
neuronal pentraxin 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.8 | 34.1 | GO:0099590 | neurotransmitter receptor internalization(GO:0099590) |
| 2.8 | 25.4 | GO:1903898 | negative regulation of PERK-mediated unfolded protein response(GO:1903898) negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912) |
| 1.6 | 21.9 | GO:0016081 | synaptic vesicle docking(GO:0016081) |
| 0.3 | 21.6 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.9 | 18.7 | GO:0006012 | galactose metabolic process(GO:0006012) |
| 0.5 | 16.2 | GO:0008053 | mitochondrial fusion(GO:0008053) |
| 0.9 | 16.1 | GO:0061339 | establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339) |
| 0.5 | 16.1 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 0.1 | 15.1 | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332) |
| 0.1 | 13.3 | GO:0030516 | regulation of axon extension(GO:0030516) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.5 | 34.1 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) |
| 1.5 | 25.4 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.2 | 20.9 | GO:0000776 | kinetochore(GO:0000776) |
| 0.2 | 18.6 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.1 | 16.3 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.6 | 16.1 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) nuclear transcriptional repressor complex(GO:0090568) |
| 0.1 | 15.6 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 2.4 | 14.6 | GO:0032584 | growth cone membrane(GO:0032584) |
| 2.3 | 13.8 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
| 1.6 | 12.6 | GO:0043218 | compact myelin(GO:0043218) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 68.6 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.2 | 25.2 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.1 | 17.4 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 1.6 | 14.6 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) |
| 4.7 | 14.2 | GO:0004157 | dihydropyrimidinase activity(GO:0004157) |
| 0.3 | 14.0 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.6 | 13.0 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 1.8 | 12.8 | GO:0001517 | N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) |
| 1.1 | 12.8 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 1.1 | 12.6 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 21.6 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.4 | 20.5 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.3 | 14.8 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.2 | 12.7 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.2 | 10.4 | ST G ALPHA I PATHWAY | G alpha i Pathway |
| 0.2 | 10.0 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.2 | 8.5 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.1 | 8.2 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.5 | 7.1 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
| 0.2 | 6.1 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 34.1 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.1 | 13.7 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.3 | 12.9 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.5 | 12.4 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.1 | 11.7 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 10.8 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.4 | 10.0 | REACTOME REGULATION OF KIT SIGNALING | Genes involved in Regulation of KIT signaling |
| 0.3 | 9.8 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.4 | 9.2 | REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 0.3 | 8.6 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |