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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for AGUGCUU
Z-value: 0.60
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miRNA associated with seed AGUGCUU
Network of associatons between targets according to the STRING database.
First level regulatory network of AGUGCUU
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.0 | GO:0006469 | negative regulation of protein kinase activity(GO:0006469) |
| 1.1 | 10.3 | GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601) |
| 1.1 | 7.9 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 0.5 | 7.9 | GO:0060137 | maternal process involved in parturition(GO:0060137) |
| 0.1 | 7.9 | GO:1900449 | regulation of glutamate receptor signaling pathway(GO:1900449) |
| 0.7 | 6.9 | GO:0031580 | membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) |
| 1.6 | 6.3 | GO:1903294 | regulation of glutamate secretion, neurotransmission(GO:1903294) positive regulation of glutamate secretion, neurotransmission(GO:1903296) |
| 1.0 | 6.3 | GO:0071874 | microglia differentiation(GO:0014004) microglia development(GO:0014005) collateral sprouting in absence of injury(GO:0048669) smooth endoplasmic reticulum calcium ion homeostasis(GO:0051563) cellular response to norepinephrine stimulus(GO:0071874) |
| 0.2 | 6.3 | GO:0061003 | positive regulation of dendritic spine morphogenesis(GO:0061003) |
| 0.6 | 5.3 | GO:1902897 | regulation of postsynaptic density protein 95 clustering(GO:1902897) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.1 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.6 | 8.3 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.2 | 6.9 | GO:0043218 | compact myelin(GO:0043218) |
| 1.0 | 6.3 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
| 0.7 | 6.3 | GO:1990761 | growth cone lamellipodium(GO:1990761) |
| 0.3 | 5.3 | GO:0016342 | catenin complex(GO:0016342) |
| 0.0 | 4.9 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 4.1 | GO:0031519 | PcG protein complex(GO:0031519) |
| 0.1 | 4.0 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.5 | 3.7 | GO:0060203 | clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.8 | 14.4 | GO:0008427 | calcium-dependent protein kinase inhibitor activity(GO:0008427) |
| 0.1 | 9.2 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.4 | 7.2 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.6 | 6.9 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.2 | 6.8 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.6 | 6.3 | GO:0051425 | PTB domain binding(GO:0051425) |
| 0.2 | 6.3 | GO:0043274 | phospholipase binding(GO:0043274) |
| 0.8 | 4.6 | GO:0042392 | sphingosine-1-phosphate phosphatase activity(GO:0042392) |
| 0.0 | 4.4 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 4.4 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.3 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.1 | 7.8 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 5.7 | PID FGF PATHWAY | FGF signaling pathway |
| 0.1 | 5.4 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.1 | 4.2 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 4.1 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 3.9 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.1 | 3.9 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 3.6 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 3.3 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 6.3 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.3 | 6.3 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.1 | 5.5 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 5.3 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 4.2 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.1 | 4.0 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.1 | 3.3 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.0 | 3.2 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 3.1 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 2.9 | REACTOME KINESINS | Genes involved in Kinesins |