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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ARID3A
Z-value: 0.99
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Transcription factors associated with ARID3A
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ARID3A | hg38_v1_chr19_+_926001_926047 | 0.19 | 5.3e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ARID3A
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_121660892 Show fit | 14.87 |
ENST00000428394.6
ENST00000314583.8 |
hematopoietic cell-specific Lyn substrate 1 |
|
| chr12_-_53207271 Show fit | 13.33 |
ENST00000552972.5
ENST00000422257.7 |
integrin subunit beta 7 |
|
| chr12_-_53207241 Show fit | 13.09 |
ENST00000267082.10
ENST00000549086.2 |
integrin subunit beta 7 |
|
| chr1_-_145996567 Show fit | 12.06 |
ENST00000582401.6
|
thioredoxin interacting protein |
|
| chr2_-_89040745 Show fit | 11.43 |
ENST00000480492.1
|
immunoglobulin kappa variable 1-12 |
|
| chr2_+_90082635 Show fit | 11.35 |
ENST00000483379.1
|
immunoglobulin kappa variable 1D-17 |
|
| chr2_-_89100352 Show fit | 11.11 |
ENST00000479981.1
|
immunoglobulin kappa variable 1-16 |
|
| chr11_+_67583742 Show fit | 11.09 |
ENST00000398603.6
|
glutathione S-transferase pi 1 |
|
| chr2_+_90100235 Show fit | 10.67 |
ENST00000492446.1
|
immunoglobulin kappa variable 1D-16 |
|
| chr14_-_106269133 Show fit | 10.34 |
ENST00000390609.3
|
immunoglobulin heavy variable 3-23 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 65.7 | GO:0030449 | regulation of complement activation(GO:0030449) |
| 0.2 | 32.3 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 6.6 | 26.4 | GO:0003366 | cell-matrix adhesion involved in ameboidal cell migration(GO:0003366) |
| 0.8 | 23.6 | GO:0035590 | purinergic nucleotide receptor signaling pathway(GO:0035590) |
| 7.1 | 21.4 | GO:0035732 | nitric oxide storage(GO:0035732) |
| 0.9 | 14.9 | GO:0045651 | positive regulation of granulocyte differentiation(GO:0030854) positive regulation of macrophage differentiation(GO:0045651) |
| 0.5 | 13.4 | GO:0002347 | response to tumor cell(GO:0002347) |
| 4.1 | 12.3 | GO:0044278 | cell wall disruption in other organism(GO:0044278) |
| 1.2 | 9.7 | GO:0034316 | negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) |
| 1.0 | 9.4 | GO:0043382 | positive regulation of memory T cell differentiation(GO:0043382) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 31.6 | GO:0005615 | extracellular space(GO:0005615) |
| 6.6 | 26.4 | GO:0034669 | integrin alpha4-beta7 complex(GO:0034669) |
| 1.1 | 23.6 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453) |
| 0.1 | 22.4 | GO:0072562 | blood microparticle(GO:0072562) |
| 5.4 | 21.4 | GO:0097057 | TRAF2-GSTP1 complex(GO:0097057) |
| 0.0 | 12.7 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 12.6 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.2 | 10.3 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 9.7 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 3.1 | 9.4 | GO:0002079 | inner acrosomal membrane(GO:0002079) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 100.4 | GO:0003823 | antigen binding(GO:0003823) |
| 2.1 | 23.6 | GO:0035381 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 7.1 | 21.4 | GO:0035730 | S-nitrosoglutathione binding(GO:0035730) dinitrosyl-iron complex binding(GO:0035731) |
| 0.2 | 19.6 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.1 | 15.0 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 1.2 | 12.3 | GO:0070492 | oligosaccharide binding(GO:0070492) |
| 0.0 | 11.4 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 0.7 | 9.9 | GO:0032393 | MHC class I receptor activity(GO:0032393) |
| 1.2 | 9.7 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.0 | 9.5 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 26.4 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.2 | 21.4 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.1 | 13.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 5.9 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.2 | 5.7 | PID AR NONGENOMIC PATHWAY | Nongenotropic Androgen signaling |
| 0.0 | 5.7 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.2 | 5.4 | PID AVB3 OPN PATHWAY | Osteopontin-mediated events |
| 0.2 | 4.7 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 4.5 | PID GMCSF PATHWAY | GMCSF-mediated signaling events |
| 0.1 | 4.1 | PID IGF1 PATHWAY | IGF1 pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 38.6 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.5 | 17.7 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.9 | 16.7 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.4 | 9.0 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.5 | 8.8 | REACTOME ACYL CHAIN REMODELLING OF PI | Genes involved in Acyl chain remodelling of PI |
| 0.1 | 8.4 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 7.5 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 7.3 | REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS | Genes involved in Post NMDA receptor activation events |
| 0.0 | 6.8 | REACTOME MRNA PROCESSING | Genes involved in mRNA Processing |
| 0.1 | 5.8 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |