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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ARID5A
Z-value: 0.81
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Transcription factors associated with ARID5A
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ARID5A | hg38_v1_chr2_+_96537254_96537345 | 0.04 | 5.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ARID5A
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_91178520 Show fit | 9.87 |
ENST00000425043.5
ENST00000420120.6 ENST00000441303.6 ENST00000456569.2 |
decorin |
|
| chr4_+_105710809 Show fit | 9.34 |
ENST00000360505.9
ENST00000510865.5 ENST00000509336.5 |
glutathione S-transferase C-terminal domain containing |
|
| chr3_+_101827982 Show fit | 8.96 |
ENST00000461724.5
ENST00000483180.5 ENST00000394054.6 |
NFKB inhibitor zeta |
|
| chr12_-_91179355 Show fit | 8.81 |
ENST00000550563.5
ENST00000546370.5 |
decorin |
|
| chr11_-_114595777 Show fit | 8.80 |
ENST00000375478.4
|
neurexophilin and PC-esterase domain family member 4 |
|
| chr3_+_189789672 Show fit | 8.78 |
ENST00000434928.5
|
tumor protein p63 |
|
| chr11_-_114595750 Show fit | 8.61 |
ENST00000424261.6
|
neurexophilin and PC-esterase domain family member 4 |
|
| chr1_+_196819731 Show fit | 7.46 |
ENST00000320493.10
ENST00000367424.4 |
complement factor H related 1 |
|
| chr2_-_216860042 Show fit | 7.40 |
ENST00000236979.2
|
transition protein 1 |
|
| chr17_+_43780425 Show fit | 7.35 |
ENST00000449302.8
|
CFAP97 domain containing 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 27.2 | GO:0003322 | pancreatic A cell development(GO:0003322) |
| 2.0 | 25.5 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.1 | 13.8 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 1.0 | 12.4 | GO:0045919 | positive regulation of cytolysis(GO:0045919) |
| 0.1 | 11.1 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.7 | 10.5 | GO:0001778 | plasma membrane repair(GO:0001778) |
| 3.0 | 8.9 | GO:0045643 | regulation of eosinophil differentiation(GO:0045643) positive regulation of eosinophil differentiation(GO:0045645) |
| 0.5 | 8.9 | GO:0007342 | fusion of sperm to egg plasma membrane(GO:0007342) |
| 2.2 | 8.8 | GO:0007499 | ectoderm and mesoderm interaction(GO:0007499) |
| 1.3 | 7.9 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 74.9 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.0 | 64.3 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 33.7 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 2.0 | 25.5 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.1 | 12.3 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.1 | 11.5 | GO:0031227 | intrinsic component of endoplasmic reticulum membrane(GO:0031227) |
| 0.1 | 11.2 | GO:0072562 | blood microparticle(GO:0072562) |
| 2.1 | 10.5 | GO:0005826 | actomyosin contractile ring(GO:0005826) |
| 0.1 | 9.0 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 8.1 | GO:0016324 | apical plasma membrane(GO:0016324) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 27.2 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.3 | 25.5 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.1 | 14.7 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 13.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 11.9 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.3 | 10.5 | GO:0000146 | microfilament motor activity(GO:0000146) |
| 0.2 | 9.2 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.0 | 9.2 | GO:0005525 | GTP binding(GO:0005525) |
| 3.0 | 8.9 | GO:0005137 | interleukin-5 receptor binding(GO:0005137) |
| 1.3 | 7.8 | GO:0016807 | cysteine-type carboxypeptidase activity(GO:0016807) cysteine-type exopeptidase activity(GO:0070004) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 29.3 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 29.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 26.4 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.1 | 20.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 14.3 | NABA CORE MATRISOME | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans |
| 0.2 | 13.2 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.4 | 8.9 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.1 | 8.8 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.2 | 8.2 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.2 | 7.2 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 27.2 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.9 | 25.5 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.1 | 11.9 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.9 | 10.8 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.2 | 8.9 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.1 | 8.7 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.1 | 8.2 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 1.6 | 7.9 | REACTOME MRNA PROCESSING | Genes involved in mRNA Processing |
| 0.6 | 7.1 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.2 | 7.1 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |