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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ARID5B
Z-value: 0.54
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Transcription factors associated with ARID5B
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ARID5B | hg38_v1_chr10_+_61901678_61901706 | 0.19 | 5.1e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ARID5B
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 10.9 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 1.9 | 7.7 | GO:2001247 | positive regulation of phosphatidylcholine biosynthetic process(GO:2001247) |
| 0.4 | 6.8 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.1 | 6.5 | GO:0060216 | definitive hemopoiesis(GO:0060216) |
| 0.3 | 4.3 | GO:0001778 | plasma membrane repair(GO:0001778) |
| 1.3 | 3.8 | GO:2000863 | positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866) |
| 0.8 | 3.4 | GO:0021836 | cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) regulation of negative chemotaxis(GO:0050923) |
| 0.6 | 3.4 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.2 | 3.0 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.1 | 3.0 | GO:0006471 | protein ADP-ribosylation(GO:0006471) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 15.0 | GO:0009986 | cell surface(GO:0009986) |
| 2.2 | 10.9 | GO:0060201 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.1 | 7.7 | GO:0031903 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.0 | 6.9 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.4 | 6.8 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.3 | 6.5 | GO:0001527 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.9 | 4.3 | GO:0005826 | actomyosin contractile ring(GO:0005826) |
| 0.1 | 3.8 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.1 | 3.7 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.2 | 3.4 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 10.9 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.3 | 7.7 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 0.2 | 6.8 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.1 | 6.6 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 6.3 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.1 | 4.3 | GO:0000146 | microfilament motor activity(GO:0000146) |
| 0.4 | 3.4 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
| 0.2 | 3.4 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.6 | 3.1 | GO:0003956 | NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956) |
| 0.0 | 3.1 | GO:0051015 | actin filament binding(GO:0051015) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 13.2 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.1 | 11.6 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 5.9 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 4.3 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.1 | 3.4 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 3.0 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 2.5 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 2.2 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 1.6 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 1.5 | PID RHOA PATHWAY | RhoA signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 10.9 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.2 | 7.7 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.1 | 5.9 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 3.8 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 3.4 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.1 | 3.4 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.1 | 3.0 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.1 | 2.6 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 2.3 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.1 | 1.8 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |