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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ARNT
Z-value: 2.09
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Transcription factors associated with ARNT
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ARNT | hg38_v1_chr1_-_150876571_150876609 | -0.40 | 6.0e-10 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ARNT
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chrX_+_78104229 Show fit | 103.32 |
ENST00000373316.5
|
phosphoglycerate kinase 1 |
|
| chr2_-_10447771 Show fit | 72.73 |
ENST00000405333.5
ENST00000443218.1 |
ornithine decarboxylase 1 |
|
| chr1_-_8879170 Show fit | 71.40 |
ENST00000489867.2
|
enolase 1 |
|
| chr1_-_8878706 Show fit | 68.43 |
ENST00000646156.1
|
enolase 1 |
|
| chr11_-_64246907 Show fit | 66.06 |
ENST00000309318.8
|
protein phosphatase 1 regulatory inhibitor subunit 14B |
|
| chr19_+_49677228 Show fit | 65.42 |
ENST00000454376.7
ENST00000524771.5 |
protein arginine methyltransferase 1 |
|
| chr1_-_8878646 Show fit | 60.72 |
ENST00000643438.1
|
enolase 1 |
|
| chr19_+_49677055 Show fit | 56.99 |
ENST00000534465.6
ENST00000391851.8 ENST00000610806.4 |
protein arginine methyltransferase 1 |
|
| chrX_+_23667461 Show fit | 55.72 |
ENST00000379341.9
ENST00000379331.3 |
peroxiredoxin 4 |
|
| chr1_-_25906457 Show fit | 55.55 |
ENST00000426559.6
|
stathmin 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 23.1 | 253.9 | GO:0010756 | positive regulation of plasminogen activation(GO:0010756) |
| 11.2 | 134.9 | GO:1905098 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
| 1.4 | 127.0 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 17.5 | 122.4 | GO:0043985 | histone H4-R3 methylation(GO:0043985) negative regulation of megakaryocyte differentiation(GO:0045653) |
| 7.5 | 119.5 | GO:0006089 | lactate metabolic process(GO:0006089) |
| 6.0 | 119.3 | GO:1904816 | positive regulation of protein localization to chromosome, telomeric region(GO:1904816) |
| 6.0 | 113.5 | GO:0031639 | plasminogen activation(GO:0031639) |
| 21.6 | 107.9 | GO:0033387 | putrescine biosynthetic process from ornithine(GO:0033387) |
| 1.3 | 99.4 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 1.1 | 97.9 | GO:0048208 | vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 643.9 | GO:0070062 | extracellular exosome(GO:0070062) |
| 31.7 | 253.9 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.9 | 162.4 | GO:1904813 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 3.7 | 123.2 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 7.7 | 122.4 | GO:0034709 | methylosome(GO:0034709) |
| 0.2 | 102.0 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 2.0 | 101.7 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 2.5 | 99.4 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 3.1 | 89.9 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.1 | 89.8 | GO:0005730 | nucleolus(GO:0005730) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 31.7 | 253.9 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.1 | 165.5 | GO:0003723 | RNA binding(GO:0003723) |
| 0.8 | 164.7 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 20.4 | 122.4 | GO:0044020 | histone methyltransferase activity (H4-R3 specific)(GO:0044020) |
| 2.1 | 117.1 | GO:0019212 | phosphatase inhibitor activity(GO:0019212) |
| 34.4 | 103.3 | GO:0004618 | phosphoglycerate kinase activity(GO:0004618) |
| 14.2 | 99.5 | GO:0004457 | lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459) |
| 2.1 | 98.6 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 1.9 | 73.0 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 13.3 | 66.5 | GO:0031871 | proteinase activated receptor binding(GO:0031871) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.8 | 687.7 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 2.0 | 178.4 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 3.4 | 171.0 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 6.7 | 134.2 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.4 | 84.4 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.3 | 73.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.8 | 71.9 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 1.0 | 55.8 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.7 | 55.7 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.9 | 55.2 | PID PLK1 PATHWAY | PLK1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.0 | 401.8 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 5.7 | 113.7 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 7.0 | 105.2 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 1.4 | 102.8 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.6 | 98.5 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 2.5 | 98.2 | REACTOME FATTY ACYL COA BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |
| 2.6 | 93.5 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 2.1 | 87.4 | REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC | Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC |
| 1.2 | 87.2 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 1.5 | 87.1 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |