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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for AR_NR3C2
Z-value: 1.11
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Transcription factors associated with AR_NR3C2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| AR | hg38_v1_chrX_+_67543973_67544054 | 0.45 | 2.6e-12 | Click! |
| NR3C2 | hg38_v1_chr4_-_148442508_148442526, hg38_v1_chr4_-_148444674_148444756, hg38_v1_chr4_-_148442342_148442431 | 0.39 | 2.6e-09 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of AR_NR3C2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_+_56625775 Show fit | 46.77 |
ENST00000330439.7
ENST00000568293.1 |
metallothionein 1E |
|
| chr16_+_56682461 Show fit | 29.28 |
ENST00000562939.1
ENST00000394485.5 ENST00000567563.1 |
metallothionein 1X novel transcript |
|
| chr1_+_22653189 Show fit | 28.11 |
ENST00000432749.6
|
complement C1q B chain |
|
| chr12_+_53050014 Show fit | 27.61 |
ENST00000314250.11
|
tensin 2 |
|
| chr3_-_58577367 Show fit | 26.76 |
ENST00000464064.5
ENST00000360997.7 |
family with sequence similarity 107 member A |
|
| chr1_+_22653228 Show fit | 26.11 |
ENST00000509305.6
|
complement C1q B chain |
|
| chr16_+_56608577 Show fit | 25.86 |
ENST00000245185.6
ENST00000561491.1 |
metallothionein 2A |
|
| chr12_+_53050179 Show fit | 25.47 |
ENST00000546602.5
ENST00000552570.5 ENST00000549700.5 |
tensin 2 |
|
| chr19_+_35140022 Show fit | 24.10 |
ENST00000588081.5
ENST00000589121.1 |
FXYD domain containing ion transport regulator 1 |
|
| chr3_-_58577648 Show fit | 23.50 |
ENST00000394481.5
|
family with sequence similarity 107 member A |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.7 | 80.6 | GO:0071294 | cellular response to zinc ion(GO:0071294) |
| 1.7 | 55.6 | GO:0014850 | response to muscle activity(GO:0014850) |
| 7.9 | 55.1 | GO:0036018 | cellular response to erythropoietin(GO:0036018) |
| 0.4 | 53.9 | GO:0030449 | regulation of complement activation(GO:0030449) |
| 8.3 | 49.8 | GO:0010734 | protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734) |
| 0.1 | 43.0 | GO:0007420 | brain development(GO:0007420) |
| 0.1 | 41.2 | GO:0001558 | regulation of cell growth(GO:0001558) |
| 0.1 | 38.8 | GO:0007160 | cell-matrix adhesion(GO:0007160) |
| 1.8 | 22.1 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.1 | 12.8 | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 143.2 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 13.6 | 54.2 | GO:0005602 | complement component C1 complex(GO:0005602) |
| 0.1 | 51.9 | GO:0005925 | focal adhesion(GO:0005925) |
| 2.8 | 49.8 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 5.1 | 41.0 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.1 | 38.1 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 27.4 | GO:0005730 | nucleolus(GO:0005730) |
| 2.5 | 22.1 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.1 | 5.1 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 5.0 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 123.3 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.2 | 55.4 | GO:0004721 | phosphoprotein phosphatase activity(GO:0004721) |
| 0.2 | 55.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.8 | 49.8 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 2.0 | 25.9 | GO:0046870 | cadmium ion binding(GO:0046870) |
| 0.1 | 9.5 | GO:0017022 | myosin binding(GO:0017022) |
| 0.1 | 9.4 | GO:0070888 | E-box binding(GO:0070888) |
| 0.1 | 7.5 | GO:0005179 | hormone activity(GO:0005179) |
| 0.0 | 5.7 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 1.7 | 5.0 | GO:0002113 | interleukin-33 binding(GO:0002113) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 56.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 25.9 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.1 | 22.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 12.8 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 10.6 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.5 | 9.4 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.1 | 6.9 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 6.3 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.5 | 4.7 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.1 | 4.0 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.9 | 54.2 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.2 | 23.6 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.2 | 9.4 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.3 | 8.0 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.1 | 6.3 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.1 | 4.8 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.2 | 4.0 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.2 | 4.0 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.1 | 3.3 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.1 | 3.2 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |