Project
GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for ATF4
Z-value: 1.13
Motif logo
Transcription factors associated with ATF4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ATF4 | hg38_v1_chr22_+_39520553_39520604 | 0.60 | 1.1e-22 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ATF4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 15.4 | 92.2 | GO:0019264 | glycine biosynthetic process from serine(GO:0019264) |
| 8.3 | 66.4 | GO:0006561 | proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129) |
| 9.3 | 37.4 | GO:0036229 | glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803) |
| 3.6 | 28.7 | GO:2000825 | positive regulation of androgen receptor activity(GO:2000825) |
| 8.6 | 25.9 | GO:0008615 | pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 biosynthetic process(GO:0042819) |
| 0.7 | 21.7 | GO:0015804 | neutral amino acid transport(GO:0015804) |
| 2.1 | 20.8 | GO:0045078 | enucleate erythrocyte differentiation(GO:0043353) positive regulation of interferon-gamma biosynthetic process(GO:0045078) |
| 2.0 | 20.5 | GO:0006116 | NADH oxidation(GO:0006116) |
| 3.5 | 17.4 | GO:0006535 | cysteine biosynthetic process from serine(GO:0006535) |
| 0.8 | 15.6 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.2 | 92.2 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.1 | 79.4 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.2 | 36.7 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 33.5 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.1 | 28.7 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 0.1 | 24.2 | GO:0005840 | ribosome(GO:0005840) |
| 3.9 | 15.7 | GO:0005850 | eukaryotic translation initiation factor 2 complex(GO:0005850) |
| 1.0 | 15.6 | GO:0044233 | ER-mitochondrion membrane contact site(GO:0044233) |
| 0.0 | 9.2 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.1 | 7.8 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 15.4 | 92.2 | GO:0004793 | glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
| 9.8 | 58.9 | GO:0004735 | pyrroline-5-carboxylate reductase activity(GO:0004735) |
| 4.7 | 37.4 | GO:0015186 | L-glutamine transmembrane transporter activity(GO:0015186) |
| 1.0 | 30.9 | GO:0015175 | neutral amino acid transmembrane transporter activity(GO:0015175) |
| 1.3 | 30.5 | GO:0008483 | transaminase activity(GO:0008483) |
| 0.3 | 24.1 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.6 | 20.8 | GO:0008301 | DNA binding, bending(GO:0008301) |
| 0.3 | 20.7 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 6.8 | 20.5 | GO:0004611 | phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613) |
| 3.5 | 17.4 | GO:0004122 | cystathionine beta-synthase activity(GO:0004122) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 20.5 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 9.2 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 7.7 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 4.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 2.9 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 1.1 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 0.6 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 0.1 | PID IL5 PATHWAY | IL5-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.8 | 107.7 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 1.4 | 68.3 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.3 | 20.5 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.2 | 15.7 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 1.0 | 15.6 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.3 | 9.9 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.8 | 9.1 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.2 | 7.3 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.2 | 4.6 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.2 | 4.1 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |