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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ATF5
Z-value: 0.70
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Transcription factors associated with ATF5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ATF5 | hg38_v1_chr19_+_49929196_49929222 | 0.12 | 8.1e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ATF5
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chrX_-_19965142 Show fit | 23.22 |
ENST00000340625.3
|
BCLAF1 and THRAP3 family member 3 |
|
| chr11_+_92224801 Show fit | 15.68 |
ENST00000525166.6
|
FAT atypical cadherin 3 |
|
| chr12_-_12338674 Show fit | 11.78 |
ENST00000545735.1
|
MANSC domain containing 1 |
|
| chr14_+_92323154 Show fit | 11.56 |
ENST00000532405.6
ENST00000676001.1 ENST00000531433.5 |
solute carrier family 24 member 4 |
|
| chr21_-_26843063 Show fit | 7.34 |
ENST00000678221.1
|
ADAM metallopeptidase with thrombospondin type 1 motif 1 |
|
| chr21_-_26843012 Show fit | 7.29 |
ENST00000517777.6
|
ADAM metallopeptidase with thrombospondin type 1 motif 1 |
|
| chr19_+_41003946 Show fit | 6.10 |
ENST00000593831.1
|
cytochrome P450 family 2 subfamily B member 6 |
|
| chr1_-_145095528 Show fit | 6.09 |
ENST00000612199.4
ENST00000641863.1 |
SLIT-ROBO Rho GTPase activating protein 2B |
|
| chr12_+_53098846 Show fit | 5.64 |
ENST00000650247.1
ENST00000549628.1 |
insulin like growth factor binding protein 6 |
|
| chr1_+_121184964 Show fit | 5.33 |
ENST00000367123.8
|
SLIT-ROBO Rho GTPase activating protein 2C |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.4 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.6 | 14.6 | GO:0030208 | dermatan sulfate biosynthetic process(GO:0030208) |
| 0.8 | 14.0 | GO:0001542 | ovulation from ovarian follicle(GO:0001542) |
| 0.6 | 11.6 | GO:0097186 | amelogenesis(GO:0097186) |
| 0.7 | 8.9 | GO:1901978 | positive regulation of cell cycle checkpoint(GO:1901978) |
| 1.0 | 7.1 | GO:0010724 | regulation of definitive erythrocyte differentiation(GO:0010724) |
| 0.3 | 6.6 | GO:0097151 | positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828) |
| 0.4 | 6.1 | GO:0042738 | exogenous drug catabolic process(GO:0042738) |
| 0.2 | 5.6 | GO:0043567 | regulation of insulin-like growth factor receptor signaling pathway(GO:0043567) |
| 0.8 | 5.3 | GO:0051490 | negative regulation of filopodium assembly(GO:0051490) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.6 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 14.6 | GO:0005796 | Golgi lumen(GO:0005796) |
| 3.0 | 8.9 | GO:0044609 | DBIRD complex(GO:0044609) |
| 0.1 | 6.6 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.1 | 6.5 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.0 | 6.1 | GO:0098793 | presynapse(GO:0098793) |
| 0.0 | 5.7 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.5 | 5.6 | GO:0036454 | insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) |
| 0.1 | 5.1 | GO:0034361 | very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385) |
| 0.1 | 4.9 | GO:0045095 | keratin filament(GO:0045095) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 21.7 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.1 | 17.0 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.4 | 14.6 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 12.2 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 1.9 | 11.6 | GO:0008273 | calcium, potassium:sodium antiporter activity(GO:0008273) |
| 0.3 | 8.9 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.1 | 8.7 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.0 | 6.3 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.3 | 6.1 | GO:0008391 | arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392) |
| 0.0 | 5.8 | GO:0017137 | Rab GTPase binding(GO:0017137) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.4 | 14.6 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 5.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 5.1 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.1 | 4.8 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.0 | 4.4 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 4.1 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 3.9 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.1 | 3.9 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.1 | 3.8 | PID EPHA FWDPATHWAY | EPHA forward signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 14.6 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.1 | 11.5 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.3 | 6.6 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.3 | 6.1 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.1 | 5.7 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.2 | 5.6 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 4.8 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.1 | 3.9 | REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
| 0.2 | 3.8 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.0 | 3.4 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |