ISMARA results: ATF6

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for ATF6

Z-value: 1.60

Motif logo

Transcription factors associated with ATF6

Gene Symbol	Gene ID	Gene Info
ATF6 Ensembl NCBI GeneCards UniProt	ENSG00000118217.7	ATF6

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ATF6	hg38_v1_chr1_+_161766282_161766303	0.35	1.7e-07	Click!

Activity profile of ATF6 motif

Sorted Z-values of ATF6 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ATF6

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Top targets:

Promoter	Score	Transcript	Gene	Gene Info
chr12_+_71754834 Show fit	37.19	ENST00000261263.5	RAB21 Ensembl NCBI GeneCards UniProt Show fit	RAB21, member RAS oncogene family
chr2_-_10448318 Show fit	29.29	ENST00000234111.9	ODC1 Ensembl NCBI GeneCards UniProt Show fit	ornithine decarboxylase 1
chr19_-_48390847 Show fit	27.98	ENST00000597017.5	KDELR1 Ensembl NCBI GeneCards UniProt Show fit	KDEL endoplasmic reticulum protein retention receptor 1
chr11_-_14499833 Show fit	27.05	ENST00000249923.7 ENST00000529866.5	COPB1 Ensembl NCBI GeneCards UniProt Show fit	COPI coat complex subunit beta 1
chrX_+_48574938 Show fit	26.96	ENST00000376755.1	RBM3 Ensembl NCBI GeneCards UniProt Show fit	RNA binding motif protein 3
chr1_+_43974902 Show fit	26.72	ENST00000532642.5 ENST00000236067.8 ENST00000471859.6 ENST00000472174.7	ATP6V0B Ensembl NCBI GeneCards UniProt Show fit	ATPase H+ transporting V0 subunit b
chr2_+_161308407 Show fit	26.67	ENST00000409682.8	PSMD14 Ensembl NCBI GeneCards UniProt Show fit	proteasome 26S subunit, non-ATPase 14
chr11_-_78079773 Show fit	26.61	ENST00000612612.5 ENST00000614236.2	NDUFC2-KCTD14 Ensembl NCBI GeneCards UniProt Show fit	NDUFC2-KCTD14 readthrough
chr11_-_14499803 Show fit	26.38	ENST00000439561.7 ENST00000534234.5	COPB1 Ensembl NCBI GeneCards UniProt Show fit	COPI coat complex subunit beta 1
chr22_-_38700655 Show fit	25.60	ENST00000216039.9	JOSD1 Ensembl NCBI GeneCards UniProt Show fit	Josephin domain containing 1
chrX_-_103686687 Show fit	24.67	ENST00000441076.7 ENST00000422355.5 ENST00000442614.5 ENST00000451301.5	MORF4L2 Ensembl NCBI GeneCards UniProt Show fit	mortality factor 4 like 2
chr6_-_85642877 Show fit	24.40	ENST00000369622.8	SYNCRIP Ensembl NCBI GeneCards UniProt Show fit	synaptotagmin binding cytoplasmic RNA interacting protein
chr6_+_24775413 Show fit	24.22	ENST00000378054.6 ENST00000620958.4 ENST00000476555.5	GMNN Ensembl NCBI GeneCards UniProt Show fit	geminin DNA replication inhibitor
chr1_+_109984756 Show fit	24.15	ENST00000393614.8 ENST00000369799.10	AHCYL1 Ensembl NCBI GeneCards UniProt Show fit	adenosylhomocysteinase like 1
chr19_+_16076485 Show fit	22.92	ENST00000643579.2 ENST00000646575.1	TPM4 Ensembl NCBI GeneCards UniProt Show fit	tropomyosin 4
chr6_+_24774925 Show fit	22.91	ENST00000356509.7 ENST00000230056.8	GMNN Ensembl NCBI GeneCards UniProt Show fit	geminin DNA replication inhibitor
chr17_+_51260520 Show fit	22.77	ENST00000225298.12	UTP18 Ensembl NCBI GeneCards UniProt Show fit	UTP18 small subunit processome component
chr17_+_68515399 Show fit	22.65	ENST00000588188.6	PRKAR1A Ensembl NCBI GeneCards UniProt Show fit	protein kinase cAMP-dependent type I regulatory subunit alpha
chr3_+_158801926 Show fit	22.51	ENST00000622669.4 ENST00000392813.8 ENST00000415822.8 ENST00000651862.1 ENST00000264266.12	MFSD1 Ensembl NCBI GeneCards UniProt Show fit	major facilitator superfamily domain containing 1
chr8_+_97644164 Show fit	22.05	ENST00000336273.8	MTDH Ensembl NCBI GeneCards UniProt Show fit	metadherin
chr1_-_23799533 Show fit	21.22	ENST00000429356.5	GALE Ensembl NCBI GeneCards UniProt Show fit	UDP-galactose-4-epimerase
chr20_-_5126534 Show fit	20.74	ENST00000379160.3	PCNA Ensembl NCBI GeneCards UniProt Show fit	proliferating cell nuclear antigen
chr22_-_38700920 Show fit	20.74	ENST00000456626.1 ENST00000412832.1 ENST00000683374.1	JOSD1 Ensembl NCBI GeneCards UniProt Show fit	Josephin domain containing 1
chr2_-_241272812 Show fit	20.03	ENST00000427007.5 ENST00000458564.5 ENST00000452065.5 ENST00000427183.6 ENST00000426343.5 ENST00000422080.5 ENST00000449504.5 ENST00000449864.5 ENST00000391975.5	HDLBP Ensembl NCBI GeneCards UniProt Show fit	high density lipoprotein binding protein
chr9_+_111631354 Show fit	19.77	ENST00000374294.3	DNAJC25-GNG10 Ensembl NCBI GeneCards UniProt Show fit	DNAJC25-GNG10 readthrough
chr11_-_119057105 Show fit	19.40	ENST00000534233.5 ENST00000614711.4 ENST00000530467.5 ENST00000621959.4 ENST00000532519.6 ENST00000532421.5 ENST00000610597.1 ENST00000612687.4	HYOU1 Ensembl NCBI GeneCards UniProt Show fit	hypoxia up-regulated 1
chr8_+_60517169 Show fit	18.76	ENST00000529579.5	RAB2A Ensembl NCBI GeneCards UniProt Show fit	RAB2A, member RAS oncogene family
chr2_+_222861059 Show fit	18.69	ENST00000681697.1 ENST00000680921.1	ACSL3 Ensembl NCBI GeneCards UniProt Show fit	acyl-CoA synthetase long chain family member 3
chr1_+_228082660 Show fit	18.63	ENST00000540651.5 ENST00000272102.10	ARF1 Ensembl NCBI GeneCards UniProt Show fit	ADP ribosylation factor 1
chr12_-_56315890 Show fit	18.57	ENST00000551286.1 ENST00000549318.5	CNPY2 Ensembl NCBI GeneCards UniProt Show fit ENSG00000144785.8 Ensembl NCBI GeneCards UniProt Show fit	canopy FGF signaling regulator 2 novel protein
chr11_-_119057185 Show fit	18.32	ENST00000614668.4 ENST00000617285.5	HYOU1 Ensembl NCBI GeneCards UniProt Show fit	hypoxia up-regulated 1
chr10_-_119080794 Show fit	18.28	ENST00000369144.8 ENST00000541549.2	EIF3A Ensembl NCBI GeneCards UniProt Show fit	eukaryotic translation initiation factor 3 subunit A
chr11_-_119057218 Show fit	17.93	ENST00000652093.1	HYOU1 Ensembl NCBI GeneCards UniProt Show fit	hypoxia up-regulated 1
chr2_+_222861005 Show fit	17.93	ENST00000680147.1 ENST00000681009.1 ENST00000679514.1 ENST00000357430.8	ACSL3 Ensembl NCBI GeneCards UniProt Show fit	acyl-CoA synthetase long chain family member 3
chr2_+_215312028 Show fit	17.54	ENST00000236959.14 ENST00000435675.5	ATIC Ensembl NCBI GeneCards UniProt Show fit	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr17_-_59106801 Show fit	17.26	ENST00000393065.6 ENST00000262294.12 ENST00000393066.7	TRIM37 Ensembl NCBI GeneCards UniProt Show fit	tripartite motif containing 37
chr12_-_56316002 Show fit	17.18	ENST00000547423.5 ENST00000548360.1 ENST00000551475.5	ENSG00000144785.8 Ensembl NCBI GeneCards UniProt Show fit CNPY2 Ensembl NCBI GeneCards UniProt Show fit	novel protein canopy FGF signaling regulator 2
chr6_-_85642922 Show fit	17.04	ENST00000616122.5 ENST00000678618.1 ENST00000678816.1 ENST00000676630.1 ENST00000678589.1 ENST00000678878.1 ENST00000676542.1 ENST00000355238.11 ENST00000678899.1	SYNCRIP Ensembl NCBI GeneCards UniProt Show fit	synaptotagmin binding cytoplasmic RNA interacting protein
chr21_-_37072688 Show fit	16.69	ENST00000464265.5 ENST00000399102.5	PIGP Ensembl NCBI GeneCards UniProt Show fit	phosphatidylinositol glycan anchor biosynthesis class P
chrX_-_101617921 Show fit	16.66	ENST00000361910.9 ENST00000538627.5 ENST00000539247.5	ARMCX6 Ensembl NCBI GeneCards UniProt Show fit	armadillo repeat containing X-linked 6
chr7_-_87220567 Show fit	16.48	ENST00000433078.5	TMEM243 Ensembl NCBI GeneCards UniProt Show fit	transmembrane protein 243
chr17_+_18781250 Show fit	16.27	ENST00000476139.5	TVP23B Ensembl NCBI GeneCards UniProt Show fit	trans-golgi network vesicle protein 23 homolog B
chr2_+_241315092 Show fit	16.03	ENST00000391973.6	SEPTIN2 Ensembl NCBI GeneCards UniProt Show fit	septin 2
chr2_+_222861423 Show fit	15.96	ENST00000681383.1 ENST00000413316.1 ENST00000679558.1 ENST00000680684.1	ACSL3 Ensembl NCBI GeneCards UniProt Show fit	acyl-CoA synthetase long chain family member 3
chr3_+_127598400 Show fit	15.88	ENST00000265056.12	MCM2 Ensembl NCBI GeneCards UniProt Show fit	minichromosome maintenance complex component 2
chr1_-_67430412 Show fit	15.84	ENST00000370994.8	SERBP1 Ensembl NCBI GeneCards UniProt Show fit	SERPINE1 mRNA binding protein 1
chr1_+_228083061 Show fit	15.75	ENST00000541182.1	ARF1 Ensembl NCBI GeneCards UniProt Show fit	ADP ribosylation factor 1
chr1_-_1891056 Show fit	15.48	ENST00000378609.9 ENST00000610897.4 ENST00000615252.4	GNB1 Ensembl NCBI GeneCards UniProt Show fit	G protein subunit beta 1
chr6_+_32969345 Show fit	15.34	ENST00000678250.1	BRD2 Ensembl NCBI GeneCards UniProt Show fit	bromodomain containing 2
chr12_-_56315952 Show fit	15.33	ENST00000273308.9	CNPY2 Ensembl NCBI GeneCards UniProt Show fit	canopy FGF signaling regulator 2
chr8_-_101205455 Show fit	15.29	ENST00000520984.5	ZNF706 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 706
chr11_+_112226345 Show fit	15.24	ENST00000280362.8 ENST00000525803.1	PTS Ensembl NCBI GeneCards UniProt Show fit	6-pyruvoyltetrahydropterin synthase
chr9_+_98056694 Show fit	15.22	ENST00000210444.6	NANS Ensembl NCBI GeneCards UniProt Show fit	N-acetylneuraminate synthase
chr3_-_129439925 Show fit	15.15	ENST00000429544.7	MBD4 Ensembl NCBI GeneCards UniProt Show fit	methyl-CpG binding domain 4, DNA glycosylase
chr1_-_67430386 Show fit	15.12	ENST00000370995.6 ENST00000361219.11	SERBP1 Ensembl NCBI GeneCards UniProt Show fit	SERPINE1 mRNA binding protein 1
chr21_-_37073170 Show fit	15.11	ENST00000399098.5	PIGP Ensembl NCBI GeneCards UniProt Show fit	phosphatidylinositol glycan anchor biosynthesis class P
chr4_-_82429402 Show fit	15.10	ENST00000602300.5	HNRNPDL Ensembl NCBI GeneCards UniProt Show fit	heterogeneous nuclear ribonucleoprotein D like
chr7_+_16753731 Show fit	15.08	ENST00000262067.5	TSPAN13 Ensembl NCBI GeneCards UniProt Show fit	tetraspanin 13
chr3_-_57597443 Show fit	15.07	ENST00000463880.1	ARF4 Ensembl NCBI GeneCards UniProt Show fit	ADP ribosylation factor 4
chr19_+_2269520 Show fit	14.71	ENST00000602676.6 ENST00000582888.8	OAZ1 Ensembl NCBI GeneCards UniProt Show fit	ornithine decarboxylase antizyme 1
chr9_+_99222258 Show fit	14.67	ENST00000223641.5	SEC61B Ensembl NCBI GeneCards UniProt Show fit	SEC61 translocon subunit beta
chr8_-_101205240 Show fit	14.67	ENST00000520347.5 ENST00000523922.1	ZNF706 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 706
chr10_-_103193252 Show fit	14.52	ENST00000404739.8 ENST00000674860.1 ENST00000675645.1 ENST00000343289.9	NT5C2 Ensembl NCBI GeneCards UniProt Show fit	5'-nucleotidase, cytosolic II
chr3_-_57597325 Show fit	14.49	ENST00000496292.5 ENST00000489843.1 ENST00000303436.11	ARF4 Ensembl NCBI GeneCards UniProt Show fit	ADP ribosylation factor 4
chr14_+_55051639 Show fit	14.41	ENST00000395468.9 ENST00000622254.1	MAPK1IP1L Ensembl NCBI GeneCards UniProt Show fit	mitogen-activated protein kinase 1 interacting protein 1 like
chr2_-_55049184 Show fit	14.38	ENST00000357376.7	RTN4 Ensembl NCBI GeneCards UniProt Show fit	reticulon 4
chrX_+_101408198 Show fit	14.36	ENST00000316594.6	HNRNPH2 Ensembl NCBI GeneCards UniProt Show fit	heterogeneous nuclear ribonucleoprotein H2
chr1_-_152036984 Show fit	14.33	ENST00000271638.3	S100A11 Ensembl NCBI GeneCards UniProt Show fit	S100 calcium binding protein A11
chr3_+_169966764 Show fit	14.19	ENST00000337002.9 ENST00000480708.5	SEC62 Ensembl NCBI GeneCards UniProt Show fit	SEC62 homolog, preprotein translocation factor
chr3_-_129440007 Show fit	14.05	ENST00000503197.5 ENST00000249910.5 ENST00000507208.1 ENST00000393278.6	MBD4 Ensembl NCBI GeneCards UniProt Show fit	methyl-CpG binding domain 4, DNA glycosylase
chr8_+_30095400 Show fit	14.04	ENST00000321250.13 ENST00000518001.1 ENST00000520682.5 ENST00000442880.6 ENST00000523116.5	LEPROTL1 Ensembl NCBI GeneCards UniProt Show fit	leptin receptor overlapping transcript like 1
chr6_-_85643778 Show fit	14.03	ENST00000676637.1 ENST00000678528.1	SYNCRIP Ensembl NCBI GeneCards UniProt Show fit	synaptotagmin binding cytoplasmic RNA interacting protein
chr6_+_32969165 Show fit	14.00	ENST00000496118.2 ENST00000449085.4	BRD2 Ensembl NCBI GeneCards UniProt Show fit	bromodomain containing 2
chr8_-_108443409 Show fit	13.90	ENST00000678023.1 ENST00000679198.1 ENST00000678881.1 ENST00000677084.1 ENST00000676663.1 ENST00000677614.1 ENST00000677040.1 ENST00000676487.1 ENST00000677409.1 ENST00000678797.1 ENST00000678334.1	EIF3E Ensembl NCBI GeneCards UniProt Show fit	eukaryotic translation initiation factor 3 subunit E
chrX_+_154444121 Show fit	13.34	ENST00000393600.8	FAM50A Ensembl NCBI GeneCards UniProt Show fit	family with sequence similarity 50 member A
chr13_+_113584683 Show fit	13.16	ENST00000375370.10	TFDP1 Ensembl NCBI GeneCards UniProt Show fit	transcription factor Dp-1
chr2_-_149587602 Show fit	13.15	ENST00000428879.5 ENST00000303319.10 ENST00000422782.2	MMADHC Ensembl NCBI GeneCards UniProt Show fit	metabolism of cobalamin associated D
chr10_-_43407769 Show fit	13.00	ENST00000357065.8	HNRNPF Ensembl NCBI GeneCards UniProt Show fit	heterogeneous nuclear ribonucleoprotein F
chr6_-_128520358 Show fit	12.84	ENST00000368215.7 ENST00000532331.5 ENST00000368213.9 ENST00000368207.7 ENST00000525459.1 ENST00000368226.9 ENST00000368210.7	PTPRK Ensembl NCBI GeneCards UniProt Show fit	protein tyrosine phosphatase receptor type K
chr1_-_193059489 Show fit	12.80	ENST00000367455.8 ENST00000421683.1	UCHL5 Ensembl NCBI GeneCards UniProt Show fit	ubiquitin C-terminal hydrolase L5
chr14_-_49620594 Show fit	12.73	ENST00000298289.7	RPL36AL Ensembl NCBI GeneCards UniProt Show fit	ribosomal protein L36a like
chr21_-_37073019 Show fit	12.65	ENST00000360525.9	PIGP Ensembl NCBI GeneCards UniProt Show fit	phosphatidylinositol glycan anchor biosynthesis class P
chr16_-_69339493 Show fit	12.48	ENST00000562595.5 ENST00000615447.1 ENST00000306875.10 ENST00000562081.2	COG8 Ensembl NCBI GeneCards UniProt Show fit	component of oligomeric golgi complex 8
chr7_-_100101915 Show fit	12.47	ENST00000621318.4 ENST00000343023.10	MCM7 Ensembl NCBI GeneCards UniProt Show fit	minichromosome maintenance complex component 7
chr7_-_26201301 Show fit	12.42	ENST00000608362.2 ENST00000676749.1 ENST00000677839.1	HNRNPA2B1 Ensembl NCBI GeneCards UniProt Show fit	heterogeneous nuclear ribonucleoprotein A2/B1
chr8_+_30095649 Show fit	12.41	ENST00000518192.5	LEPROTL1 Ensembl NCBI GeneCards UniProt Show fit	leptin receptor overlapping transcript like 1
chr4_-_1248976 Show fit	12.36	ENST00000514210.5 ENST00000382952.8 ENST00000290921.10	CTBP1 Ensembl NCBI GeneCards UniProt Show fit	C-terminal binding protein 1
chr2_+_222860942 Show fit	12.26	ENST00000392066.7 ENST00000680251.1 ENST00000679541.1 ENST00000679545.1 ENST00000680395.1	ACSL3 Ensembl NCBI GeneCards UniProt Show fit	acyl-CoA synthetase long chain family member 3
chr1_+_26472405 Show fit	12.19	ENST00000361427.6	HMGN2 Ensembl NCBI GeneCards UniProt Show fit	high mobility group nucleosomal binding domain 2
chrX_+_103376389 Show fit	11.95	ENST00000372645.3 ENST00000372635.1	BEX3 Ensembl NCBI GeneCards UniProt Show fit	brain expressed X-linked 3
chr8_+_108443601 Show fit	11.93	ENST00000524143.5 ENST00000220853.8	EMC2 Ensembl NCBI GeneCards UniProt Show fit	ER membrane protein complex subunit 2
chrX_+_103376488 Show fit	11.91	ENST00000361298.9	BEX3 Ensembl NCBI GeneCards UniProt Show fit	brain expressed X-linked 3
chr10_-_73096974 Show fit	11.76	ENST00000440381.5 ENST00000263556.3	P4HA1 Ensembl NCBI GeneCards UniProt Show fit	prolyl 4-hydroxylase subunit alpha 1
chr11_+_18394586 Show fit	11.74	ENST00000227157.8 ENST00000478970.6 ENST00000495052.5	LDHA Ensembl NCBI GeneCards UniProt Show fit	lactate dehydrogenase A
chr16_+_53130921 Show fit	11.54	ENST00000564845.5	CHD9 Ensembl NCBI GeneCards UniProt Show fit	chromodomain helicase DNA binding protein 9
chr2_+_200889327 Show fit	11.49	ENST00000426253.5 ENST00000454952.1 ENST00000651500.1 ENST00000409020.6 ENST00000359683.8	NIF3L1 Ensembl NCBI GeneCards UniProt Show fit	NGG1 interacting factor 3 like 1
chr11_+_118359572 Show fit	11.43	ENST00000252108.8 ENST00000431736.6	UBE4A Ensembl NCBI GeneCards UniProt Show fit	ubiquitination factor E4A
chr11_+_102347312 Show fit	11.43	ENST00000621637.1 ENST00000613397.4	BIRC2 Ensembl NCBI GeneCards UniProt Show fit	baculoviral IAP repeat containing 2
chr2_-_97995916 Show fit	11.19	ENST00000186436.10	TMEM131 Ensembl NCBI GeneCards UniProt Show fit	transmembrane protein 131
chr5_+_66144288 Show fit	10.90	ENST00000334121.11	SREK1 Ensembl NCBI GeneCards UniProt Show fit	splicing regulatory glutamic acid and lysine rich protein 1
chr12_-_120469571 Show fit	10.89	ENST00000550458.1	SRSF9 Ensembl NCBI GeneCards UniProt Show fit	serine and arginine rich splicing factor 9
chr1_+_26472459 Show fit	10.88	ENST00000619352.4	HMGN2 Ensembl NCBI GeneCards UniProt Show fit	high mobility group nucleosomal binding domain 2
chr7_-_26200734 Show fit	10.71	ENST00000354667.8 ENST00000618183.5	HNRNPA2B1 Ensembl NCBI GeneCards UniProt Show fit	heterogeneous nuclear ribonucleoprotein A2/B1
chr2_+_241315223 Show fit	10.69	ENST00000428282.5 ENST00000360051.7	SEPTIN2 Ensembl NCBI GeneCards UniProt Show fit	septin 2
chr7_-_151520080 Show fit	10.68	ENST00000496004.5	RHEB Ensembl NCBI GeneCards UniProt Show fit	Ras homolog, mTORC1 binding
chr19_+_49851205 Show fit	10.62	ENST00000601675.5	PTOV1 Ensembl NCBI GeneCards UniProt Show fit	PTOV1 extended AT-hook containing adaptor protein
chr19_+_48872412 Show fit	10.57	ENST00000200453.6	PPP1R15A Ensembl NCBI GeneCards UniProt Show fit	protein phosphatase 1 regulatory subunit 15A
chr5_-_141320755 Show fit	10.54	ENST00000624761.1 ENST00000313368.8	TAF7 Ensembl NCBI GeneCards UniProt Show fit	TATA-box binding protein associated factor 7
chr9_-_72365198 Show fit	10.48	ENST00000376962.10 ENST00000376960.8	ZFAND5 Ensembl NCBI GeneCards UniProt Show fit	zinc finger AN1-type containing 5
chr19_-_4670331 Show fit	10.47	ENST00000262947.8 ENST00000599630.1	MYDGF Ensembl NCBI GeneCards UniProt Show fit	myeloid derived growth factor
chr1_-_77683356 Show fit	10.25	ENST00000414381.5 ENST00000370798.5	ZZZ3 Ensembl NCBI GeneCards UniProt Show fit	zinc finger ZZ-type containing 3
chr2_+_200889411 Show fit	10.19	ENST00000409357.5 ENST00000409129.2	NIF3L1 Ensembl NCBI GeneCards UniProt Show fit	NGG1 interacting factor 3 like 1
chr3_-_150546403 Show fit	10.18	ENST00000239944.7 ENST00000491660.1 ENST00000487153.1	SERP1 Ensembl NCBI GeneCards UniProt Show fit	stress associated endoplasmic reticulum protein 1
chr6_+_32968557 Show fit	10.08	ENST00000374825.9	BRD2 Ensembl NCBI GeneCards UniProt Show fit	bromodomain containing 2
chr2_+_131105296 Show fit	10.07	ENST00000628582.2	PLEKHB2 Ensembl NCBI GeneCards UniProt Show fit	pleckstrin homology domain containing B2
chr19_+_49851136 Show fit	10.06	ENST00000391842.5	PTOV1 Ensembl NCBI GeneCards UniProt Show fit	PTOV1 extended AT-hook containing adaptor protein
chr7_+_128739292 Show fit	10.04	ENST00000535011.6 ENST00000542996.6 ENST00000249364.9 ENST00000449187.6	CALU Ensembl NCBI GeneCards UniProt Show fit	calumenin
chr7_+_128739395 Show fit	10.03	ENST00000479257.5	CALU Ensembl NCBI GeneCards UniProt Show fit	calumenin
chr1_-_50960230 Show fit	10.02	ENST00000396153.7	FAF1 Ensembl NCBI GeneCards UniProt Show fit	Fas associated factor 1
chr19_+_49851173 Show fit	9.98	ENST00000599732.5	PTOV1 Ensembl NCBI GeneCards UniProt Show fit	PTOV1 extended AT-hook containing adaptor protein
chr12_-_106247950 Show fit	9.74	ENST00000378026.5	CKAP4 Ensembl NCBI GeneCards UniProt Show fit	cytoskeleton associated protein 4
chr8_-_53842899 Show fit	9.73	ENST00000524234.1 ENST00000521275.5 ENST00000396774.6	ATP6V1H Ensembl NCBI GeneCards UniProt Show fit	ATPase H+ transporting V1 subunit H
chr1_-_193059296 Show fit	9.71	ENST00000367450.7 ENST00000367451.8 ENST00000367454.6 ENST00000367448.5 ENST00000367449.5	UCHL5 Ensembl NCBI GeneCards UniProt Show fit	ubiquitin C-terminal hydrolase L5
chr10_-_96586975 Show fit	9.70	ENST00000371142.9	TM9SF3 Ensembl NCBI GeneCards UniProt Show fit	transmembrane 9 superfamily member 3
chr5_-_58460076 Show fit	9.61	ENST00000274289.8 ENST00000617412.1	PLK2 Ensembl NCBI GeneCards UniProt Show fit	polo like kinase 2
chrX_+_103376887 Show fit	9.60	ENST00000372634.1	BEX3 Ensembl NCBI GeneCards UniProt Show fit	brain expressed X-linked 3
chr2_-_152717966 Show fit	9.58	ENST00000410080.8	PRPF40A Ensembl NCBI GeneCards UniProt Show fit	pre-mRNA processing factor 40 homolog A
chr10_-_73096850 Show fit	9.44	ENST00000307116.6 ENST00000373008.6 ENST00000394890.7	P4HA1 Ensembl NCBI GeneCards UniProt Show fit	prolyl 4-hydroxylase subunit alpha 1
chr8_-_53843228 Show fit	9.39	ENST00000359530.7	ATP6V1H Ensembl NCBI GeneCards UniProt Show fit	ATPase H+ transporting V1 subunit H
chr10_+_119819244 Show fit	9.33	ENST00000637174.1	INPP5F Ensembl NCBI GeneCards UniProt Show fit	inositol polyphosphate-5-phosphatase F
chr12_-_107093509 Show fit	9.30	ENST00000008527.10	CRY1 Ensembl NCBI GeneCards UniProt Show fit	cryptochrome circadian regulator 1
chr1_-_43367956 Show fit	9.29	ENST00000372458.8	ELOVL1 Ensembl NCBI GeneCards UniProt Show fit	ELOVL fatty acid elongase 1
chr1_-_77682639 Show fit	9.26	ENST00000370801.8 ENST00000433749.5	ZZZ3 Ensembl NCBI GeneCards UniProt Show fit	zinc finger ZZ-type containing 3
chrX_+_41333905 Show fit	9.14	ENST00000457138.7 ENST00000643821.1	DDX3X Ensembl NCBI GeneCards UniProt Show fit	DEAD-box helicase 3 X-linked
chr5_+_69093943 Show fit	9.07	ENST00000621204.4	SLC30A5 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 30 member 5
chr11_+_102347205 Show fit	9.05	ENST00000532832.5 ENST00000530675.5 ENST00000227758.7 ENST00000533742.5 ENST00000532672.5 ENST00000531259.5 ENST00000527465.1	BIRC2 Ensembl NCBI GeneCards UniProt Show fit	baculoviral IAP repeat containing 2
chr6_+_151452447 Show fit	9.05	ENST00000367294.4	ARMT1 Ensembl NCBI GeneCards UniProt Show fit	acidic residue methyltransferase 1
chr11_+_32091065 Show fit	8.94	ENST00000054950.4	RCN1 Ensembl NCBI GeneCards UniProt Show fit	reticulocalbin 1
chr7_-_100101333 Show fit	8.90	ENST00000303887.10	MCM7 Ensembl NCBI GeneCards UniProt Show fit	minichromosome maintenance complex component 7
chr21_+_37073213 Show fit	8.84	ENST00000418766.5 ENST00000450533.5 ENST00000438055.5 ENST00000355666.5 ENST00000540756.5 ENST00000399010.5	TTC3 Ensembl NCBI GeneCards UniProt Show fit	tetratricopeptide repeat domain 3
chr1_+_40040219 Show fit	8.68	ENST00000372797.7 ENST00000372802.5 ENST00000449311.5	CAP1 Ensembl NCBI GeneCards UniProt Show fit	cyclase associated actin cytoskeleton regulatory protein 1
chr12_-_102062079 Show fit	8.61	ENST00000545679.5	WASHC3 Ensembl NCBI GeneCards UniProt Show fit	WASH complex subunit 3
chr6_-_100881281 Show fit	8.60	ENST00000369143.2 ENST00000369162.7 ENST00000324723.10 ENST00000522650.5	ASCC3 Ensembl NCBI GeneCards UniProt Show fit	activating signal cointegrator 1 complex subunit 3
chrX_-_101407893 Show fit	8.51	ENST00000676156.1 ENST00000675592.1 ENST00000674634.2 ENST00000649178.1 ENST00000218516.4	GLA Ensembl NCBI GeneCards UniProt Show fit	galactosidase alpha
chr16_-_67481079 Show fit	8.47	ENST00000565835.5 ENST00000602876.5 ENST00000540149.5	ATP6V0D1 Ensembl NCBI GeneCards UniProt Show fit	ATPase H+ transporting V0 subunit d1
chr1_-_43368039 Show fit	8.47	ENST00000413844.3	ELOVL1 Ensembl NCBI GeneCards UniProt Show fit	ELOVL fatty acid elongase 1
chr6_-_109381739 Show fit	8.39	ENST00000504373.2	CD164 Ensembl NCBI GeneCards UniProt Show fit	CD164 molecule
chr14_+_93185304 Show fit	8.38	ENST00000415050.3	TMEM251 Ensembl NCBI GeneCards UniProt Show fit	transmembrane protein 251
chr19_+_14440254 Show fit	8.36	ENST00000342216.8	PKN1 Ensembl NCBI GeneCards UniProt Show fit	protein kinase N1
chr7_+_12686849 Show fit	8.36	ENST00000396662.5 ENST00000356797.7 ENST00000396664.2	ARL4A Ensembl NCBI GeneCards UniProt Show fit	ADP ribosylation factor like GTPase 4A
chr10_+_119651372 Show fit	8.31	ENST00000369085.8	BAG3 Ensembl NCBI GeneCards UniProt Show fit	BAG cochaperone 3
chr8_+_143018479 Show fit	8.28	ENST00000429120.6 ENST00000521699.5 ENST00000520531.5 ENST00000520466.5 ENST00000521003.5 ENST00000522528.5 ENST00000292494.11 ENST00000522971.5 ENST00000519611.5 ENST00000521182.5 ENST00000519546.5 ENST00000523847.5 ENST00000522024.1	LY6E Ensembl NCBI GeneCards UniProt Show fit	lymphocyte antigen 6 family member E
chr1_+_32179665 Show fit	8.21	ENST00000373610.8	TXLNA Ensembl NCBI GeneCards UniProt Show fit	taxilin alpha
chr19_+_49850687 Show fit	8.19	ENST00000594151.5 ENST00000600603.5 ENST00000601638.5	PTOV1 Ensembl NCBI GeneCards UniProt Show fit	PTOV1 extended AT-hook containing adaptor protein
chr16_-_46973634 Show fit	8.15	ENST00000317089.10	DNAJA2 Ensembl NCBI GeneCards UniProt Show fit	DnaJ heat shock protein family (Hsp40) member A2
chr12_-_102061946 Show fit	8.00	ENST00000240079.11	WASHC3 Ensembl NCBI GeneCards UniProt Show fit	WASH complex subunit 3
chr17_-_15563428 Show fit	7.98	ENST00000584811.5 ENST00000419890.3 ENST00000518321.6 ENST00000438826.7 ENST00000225576.7 ENST00000428082.6 ENST00000522212.6	TVP23C Ensembl NCBI GeneCards UniProt Show fit TVP23C-CDRT4 Ensembl NCBI GeneCards UniProt Show fit	trans-golgi network vesicle protein 23 homolog C TVP23C-CDRT4 readthrough
chr13_-_110706079 Show fit	7.87	ENST00000257347.9	CARS2 Ensembl NCBI GeneCards UniProt Show fit	cysteinyl-tRNA synthetase 2, mitochondrial
chr11_-_8964927 Show fit	7.81	ENST00000525069.5	TMEM9B Ensembl NCBI GeneCards UniProt Show fit	TMEM9 domain family member B
chr21_-_37072997 Show fit	7.73	ENST00000430792.1 ENST00000399103.5	PIGP Ensembl NCBI GeneCards UniProt Show fit	phosphatidylinositol glycan anchor biosynthesis class P
chr5_-_142012973 Show fit	7.72	ENST00000503794.5 ENST00000510194.5 ENST00000504424.1 ENST00000513454.5 ENST00000311337.11 ENST00000503229.5 ENST00000500692.6 ENST00000504139.5 ENST00000505689.5	GNPDA1 Ensembl NCBI GeneCards UniProt Show fit	glucosamine-6-phosphate deaminase 1
chr12_-_49018737 Show fit	7.63	ENST00000551121.5 ENST00000552212.5 ENST00000548605.5 ENST00000548950.5 ENST00000547125.1 ENST00000547306.5 ENST00000548857.5 ENST00000548065.7 ENST00000551696.5 ENST00000316299.9 ENST00000547082.1	PRKAG1 Ensembl NCBI GeneCards UniProt Show fit	protein kinase AMP-activated non-catalytic subunit gamma 1
chr17_-_41811930 Show fit	7.58	ENST00000393928.6	P3H4 Ensembl NCBI GeneCards UniProt Show fit	prolyl 3-hydroxylase family member 4 (inactive)
chr1_-_68497030 Show fit	7.45	ENST00000456315.7 ENST00000525124.1 ENST00000370966.9	DEPDC1 Ensembl NCBI GeneCards UniProt Show fit	DEP domain containing 1
chr14_+_64503943 Show fit	7.43	ENST00000556965.1 ENST00000554015.5	ZBTB1 Ensembl NCBI GeneCards UniProt Show fit	zinc finger and BTB domain containing 1
chr4_+_17614630 Show fit	7.39	ENST00000237380.12	MED28 Ensembl NCBI GeneCards UniProt Show fit	mediator complex subunit 28
chr5_-_73448769 Show fit	7.39	ENST00000615637.3	FOXD1 Ensembl NCBI GeneCards UniProt Show fit	forkhead box D1
chr10_-_109923428 Show fit	7.36	ENST00000403138.6 ENST00000369683.5 ENST00000502935.6 ENST00000322238.12	XPNPEP1 Ensembl NCBI GeneCards UniProt Show fit	X-prolyl aminopeptidase 1
chr17_+_35587478 Show fit	7.31	ENST00000618940.4	AP2B1 Ensembl NCBI GeneCards UniProt Show fit	adaptor related protein complex 2 subunit beta 1
chr1_-_93879198 Show fit	7.30	ENST00000436063.7	DNTTIP2 Ensembl NCBI GeneCards UniProt Show fit	deoxynucleotidyltransferase terminal interacting protein 2
chr17_+_59565598 Show fit	7.29	ENST00000251241.9 ENST00000425628.7 ENST00000584385.5 ENST00000580030.1	DHX40 Ensembl NCBI GeneCards UniProt Show fit	DEAH-box helicase 40
chr7_+_5592805 Show fit	7.21	ENST00000382361.8	FSCN1 Ensembl NCBI GeneCards UniProt Show fit	fascin actin-bundling protein 1
chr1_+_19644284 Show fit	7.17	ENST00000375136.8	NBL1 Ensembl NCBI GeneCards UniProt Show fit	NBL1, DAN family BMP antagonist
chr20_-_63568074 Show fit	7.14	ENST00000427522.6	HELZ2 Ensembl NCBI GeneCards UniProt Show fit	helicase with zinc finger 2
chr4_-_82429386 Show fit	7.06	ENST00000507721.5	HNRNPDL Ensembl NCBI GeneCards UniProt Show fit	heterogeneous nuclear ribonucleoprotein D like
chr3_+_37861926 Show fit	7.03	ENST00000443503.6	CTDSPL Ensembl NCBI GeneCards UniProt Show fit	CTD small phosphatase like
chr7_+_92057602 Show fit	6.96	ENST00000491695.2	AKAP9 Ensembl NCBI GeneCards UniProt Show fit	A-kinase anchoring protein 9
chr17_+_35587239 Show fit	6.78	ENST00000621914.4 ENST00000621668.4 ENST00000616681.4 ENST00000612035.4 ENST00000610402.5 ENST00000614600.4 ENST00000590432.5 ENST00000612116.5	AP2B1 Ensembl NCBI GeneCards UniProt Show fit	adaptor related protein complex 2 subunit beta 1
chr15_+_96325935 Show fit	6.65	ENST00000421109.6	NR2F2 Ensembl NCBI GeneCards UniProt Show fit	nuclear receptor subfamily 2 group F member 2
chr10_+_132537778 Show fit	6.55	ENST00000368594.8	INPP5A Ensembl NCBI GeneCards UniProt Show fit	inositol polyphosphate-5-phosphatase A
chr4_-_107720189 Show fit	6.32	ENST00000265174.5	PAPSS1 Ensembl NCBI GeneCards UniProt Show fit	3'-phosphoadenosine 5'-phosphosulfate synthase 1
chr17_+_28744034 Show fit	6.32	ENST00000444415.7 ENST00000262396.10	TRAF4 Ensembl NCBI GeneCards UniProt Show fit	TNF receptor associated factor 4
chr16_+_69339758 Show fit	6.31	ENST00000254940.10 ENST00000254941.6	NIP7 Ensembl NCBI GeneCards UniProt Show fit	nucleolar pre-rRNA processing protein NIP7
chr5_+_151771943 Show fit	6.31	ENST00000520177.6 ENST00000678854.1 ENST00000520006.2 ENST00000677105.1 ENST00000678101.1 ENST00000678910.1 ENST00000356245.8 ENST00000678646.1 ENST00000677433.1 ENST00000677369.1 ENST00000677284.1 ENST00000678564.1	G3BP1 Ensembl NCBI GeneCards UniProt Show fit	G3BP stress granule assembly factor 1
chr3_+_37861849 Show fit	6.28	ENST00000273179.10	CTDSPL Ensembl NCBI GeneCards UniProt Show fit	CTD small phosphatase like
chr3_+_183697770 Show fit	6.23	ENST00000305135.10	YEATS2 Ensembl NCBI GeneCards UniProt Show fit	YEATS domain containing 2
chr1_-_17054015 Show fit	6.22	ENST00000375499.8	SDHB Ensembl NCBI GeneCards UniProt Show fit	succinate dehydrogenase complex iron sulfur subunit B
chr4_-_118836067 Show fit	6.13	ENST00000280551.11	SEC24D Ensembl NCBI GeneCards UniProt Show fit	SEC24 homolog D, COPII coat complex component
chr7_+_155297776 Show fit	6.11	ENST00000344756.8 ENST00000425172.1 ENST00000340368.9 ENST00000342407.5	INSIG1 Ensembl NCBI GeneCards UniProt Show fit	insulin induced gene 1
chr17_+_67825664 Show fit	5.98	ENST00000321892.8	BPTF Ensembl NCBI GeneCards UniProt Show fit	bromodomain PHD finger transcription factor
chr6_-_89352706 Show fit	5.87	ENST00000435041.3	UBE2J1 Ensembl NCBI GeneCards UniProt Show fit	ubiquitin conjugating enzyme E2 J1
chr19_-_6502301 Show fit	5.86	ENST00000264071.7 ENST00000594276.5 ENST00000594075.5 ENST00000600216.5 ENST00000596926.5	TUBB4A Ensembl NCBI GeneCards UniProt Show fit	tubulin beta 4A class IVa
chr5_+_151771884 Show fit	5.78	ENST00000627077.2 ENST00000678976.1 ENST00000677408.1 ENST00000678070.1 ENST00000678964.1 ENST00000678925.1 ENST00000394123.7 ENST00000522761.6 ENST00000676827.1	G3BP1 Ensembl NCBI GeneCards UniProt Show fit	G3BP stress granule assembly factor 1
chr14_-_49586325 Show fit	5.77	ENST00000557519.1 ENST00000396020.7 ENST00000554075.2 ENST00000245458.11	RPS29 Ensembl NCBI GeneCards UniProt Show fit	ribosomal protein S29
chr1_+_32180044 Show fit	5.70	ENST00000373609.1	TXLNA Ensembl NCBI GeneCards UniProt Show fit	taxilin alpha
chr16_+_14632906 Show fit	5.63	ENST00000563971.5 ENST00000562442.5 ENST00000261658.7	BFAR Ensembl NCBI GeneCards UniProt Show fit	bifunctional apoptosis regulator
chr12_+_70242984 Show fit	5.56	ENST00000547780.5 ENST00000418359.7	CNOT2 Ensembl NCBI GeneCards UniProt Show fit	CCR4-NOT transcription complex subunit 2
chr22_+_46674593 Show fit	5.54	ENST00000408031.1	GRAMD4 Ensembl NCBI GeneCards UniProt Show fit	GRAM domain containing 4
chr19_-_42255119 Show fit	5.52	ENST00000222329.9 ENST00000594664.1	ERF Ensembl NCBI GeneCards UniProt Show fit ENSG00000268643.2 Ensembl NCBI GeneCards UniProt Show fit	ETS2 repressor factor novel protein
chr11_+_59142811 Show fit	5.45	ENST00000676459.1 ENST00000675163.1 ENST00000684135.1 ENST00000682018.1 ENST00000675806.2 ENST00000529985.3 ENST00000676340.1 ENST00000674617.1	FAM111A Ensembl NCBI GeneCards UniProt Show fit	FAM111 trypsin like peptidase A

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
16.2	64.8	GO:2001247	positive regulation of phosphatidylcholine biosynthetic process(GO:2001247)
13.9	55.6	GO:1903382	neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(GO:0036483) regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903381) negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903382)
11.5	34.4	GO:1902822	cleavage furrow ingression(GO:0036090) lysosomal membrane organization(GO:0097212) regulation of late endosome to lysosome transport(GO:1902822)
9.4	47.1	GO:0071163	DNA replication preinitiation complex assembly(GO:0071163)
6.8	20.5	GO:1902524	positive regulation of protein K48-linked ubiquitination(GO:1902524)
6.1	18.3	GO:0001732	formation of cytoplasmic translation initiation complex(GO:0001732)
5.9	29.3	GO:0033387	putrescine biosynthetic process from ornithine(GO:0033387)
5.8	17.5	GO:0046452	dihydrofolate metabolic process(GO:0046452)
5.8	28.9	GO:0006620	posttranslational protein targeting to membrane(GO:0006620)
5.2	20.7	GO:0006272	leading strand elongation(GO:0006272)
5.1	51.1	GO:0045716	positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716)
4.0	55.5	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
3.8	26.5	GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
3.7	7.4	GO:0072076	nephrogenic mesenchyme development(GO:0072076)
3.6	25.3	GO:0015846	polyamine transport(GO:0015846)
3.5	10.6	GO:1902310	positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
3.4	24.1	GO:0033353	S-adenosylmethionine cycle(GO:0033353)
3.4	13.4	GO:0035407	histone H3-T11 phosphorylation(GO:0035407)
3.3	23.1	GO:0044806	G-quadruplex DNA unwinding(GO:0044806)
3.1	9.3	GO:2000832	negative regulation of steroid hormone secretion(GO:2000832) negative regulation of corticosteroid hormone secretion(GO:2000847) negative regulation of glucocorticoid secretion(GO:2000850)
3.1	37.2	GO:2000643	positive regulation of early endosome to late endosome transport(GO:2000643)
3.1	12.4	GO:1903756	regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
3.1	30.8	GO:0045176	apical protein localization(GO:0045176)
3.0	30.2	GO:0006621	protein retention in ER lumen(GO:0006621)
3.0	38.6	GO:0006268	DNA unwinding involved in DNA replication(GO:0006268)
2.8	14.1	GO:0099590	neurotransmitter receptor internalization(GO:0099590)
2.6	52.2	GO:0016254	preassembly of GPI anchor in ER membrane(GO:0016254)
2.5	15.2	GO:0006729	tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
2.5	7.4	GO:2000176	regulation of pro-T cell differentiation(GO:2000174) positive regulation of pro-T cell differentiation(GO:2000176)
2.5	17.3	GO:0070842	aggresome assembly(GO:0070842)
2.4	21.2	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
2.3	9.3	GO:0031161	phosphatidylinositol catabolic process(GO:0031161)
2.2	29.2	GO:0045008	depyrimidination(GO:0045008)
2.2	17.8	GO:0019367	fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
2.1	6.3	GO:0000103	sulfate assimilation(GO:0000103)
2.0	6.1	GO:1901301	regulation of cargo loading into COPII-coated vesicle(GO:1901301)
2.0	13.9	GO:1902416	positive regulation of mRNA binding(GO:1902416)
1.9	3.8	GO:0019264	glycine biosynthetic process from serine(GO:0019264)
1.8	7.2	GO:0038098	sequestering of BMP from receptor via BMP binding(GO:0038098)
1.8	30.0	GO:1902455	negative regulation of stem cell population maintenance(GO:1902455)
1.8	54.3	GO:0015988	energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991)
1.7	13.8	GO:0006307	DNA dealkylation involved in DNA repair(GO:0006307)
1.7	6.7	GO:0009956	radial pattern formation(GO:0009956)
1.6	13.2	GO:0070345	negative regulation of fat cell proliferation(GO:0070345)
1.6	21.2	GO:0019388	galactose catabolic process(GO:0019388)
1.6	4.8	GO:0090611	ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611)
1.5	7.7	GO:0006041	glucosamine metabolic process(GO:0006041)
1.5	3.1	GO:0090158	endoplasmic reticulum membrane organization(GO:0090158)
1.5	22.7	GO:0046007	negative regulation of meiotic nuclear division(GO:0045835) negative regulation of activated T cell proliferation(GO:0046007)
1.4	7.2	GO:0030035	microspike assembly(GO:0030035)
1.4	14.4	GO:0071787	endoplasmic reticulum tubular network assembly(GO:0071787)
1.4	10.1	GO:0010606	positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
1.3	5.1	GO:0007206	phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
1.3	3.8	GO:1903094	regulation of protein K48-linked deubiquitination(GO:1903093) negative regulation of protein K48-linked deubiquitination(GO:1903094) negative regulation of ubiquitin-specific protease activity(GO:2000157)
1.3	20.0	GO:0021670	lateral ventricle development(GO:0021670)
1.1	9.1	GO:0071651	positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651)
1.1	60.9	GO:0006891	intra-Golgi vesicle-mediated transport(GO:0006891)
1.1	8.5	GO:0016139	glycoside catabolic process(GO:0016139)
1.0	4.2	GO:0046946	hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
1.0	20.8	GO:0007213	G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
1.0	19.0	GO:0034384	high-density lipoprotein particle clearance(GO:0034384)
1.0	4.9	GO:0033133	positive regulation of glucokinase activity(GO:0033133)
1.0	9.6	GO:2000074	regulation of type B pancreatic cell development(GO:2000074)
0.9	4.6	GO:1901350	cell-cell signaling involved in cell-cell junction organization(GO:1901350)
0.9	24.7	GO:0043968	histone H2A acetylation(GO:0043968)
0.9	14.5	GO:0046085	adenosine metabolic process(GO:0046085)
0.9	11.7	GO:0006089	lactate metabolic process(GO:0006089)
0.8	5.9	GO:0070862	negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.8	5.6	GO:1903895	negative regulation of IRE1-mediated unfolded protein response(GO:1903895)
0.8	26.7	GO:0070536	protein K63-linked deubiquitination(GO:0070536)
0.8	10.2	GO:0060124	positive regulation of growth hormone secretion(GO:0060124)
0.8	12.1	GO:0034975	protein folding in endoplasmic reticulum(GO:0034975)
0.7	9.6	GO:0061000	negative regulation of dendritic spine development(GO:0061000)
0.7	2.9	GO:0061187	regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
0.7	12.0	GO:0007130	synaptonemal complex assembly(GO:0007130)
0.7	3.4	GO:1903690	negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.6	8.1	GO:0010815	bradykinin catabolic process(GO:0010815)
0.6	7.4	GO:0051151	negative regulation of smooth muscle cell differentiation(GO:0051151)
0.6	7.9	GO:0040016	embryonic cleavage(GO:0040016)
0.6	1.8	GO:0006097	glyoxylate cycle(GO:0006097)
0.6	10.0	GO:0007253	cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.6	2.3	GO:0042450	arginine biosynthetic process via ornithine(GO:0042450)
0.5	13.0	GO:0009235	cobalamin metabolic process(GO:0009235)
0.5	20.8	GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.5	7.0	GO:0051661	maintenance of centrosome location(GO:0051661) regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909)
0.5	3.5	GO:0031339	negative regulation of vesicle fusion(GO:0031339)
0.5	7.5	GO:0090073	positive regulation of protein homodimerization activity(GO:0090073)
0.5	2.3	GO:0015688	iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
0.5	1.4	GO:0070625	zymogen granule exocytosis(GO:0070625)
0.5	8.3	GO:0097201	negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.5	30.7	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.4	6.6	GO:0046838	phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855)
0.4	3.5	GO:0036444	calcium ion transmembrane import into mitochondrion(GO:0036444)
0.4	35.0	GO:0071349	interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.4	10.7	GO:0009226	nucleotide-sugar biosynthetic process(GO:0009226)
0.4	0.8	GO:2000793	cell proliferation involved in heart valve development(GO:2000793)
0.4	1.5	GO:0032600	B cell receptor transport within lipid bilayer(GO:0032595) B cell receptor transport into membrane raft(GO:0032597) protein transport out of membrane raft(GO:0032599) chemokine receptor transport out of membrane raft(GO:0032600) negative regulation of transforming growth factor beta3 production(GO:0032913) chemokine receptor transport within lipid bilayer(GO:0033606)
0.4	1.5	GO:0036229	glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803)
0.4	23.1	GO:0031640	killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364)
0.3	5.9	GO:0031115	negative regulation of microtubule polymerization(GO:0031115)
0.3	1.0	GO:0051464	cortisol secretion(GO:0043400) regulation of cortisol secretion(GO:0051462) positive regulation of cortisol secretion(GO:0051464)
0.3	29.7	GO:0070830	bicellular tight junction assembly(GO:0070830)
0.3	5.1	GO:0006516	glycoprotein catabolic process(GO:0006516)
0.3	10.5	GO:0048745	smooth muscle tissue development(GO:0048745)
0.3	35.8	GO:0006334	nucleosome assembly(GO:0006334)
0.3	6.7	GO:0002021	response to dietary excess(GO:0002021)
0.3	6.2	GO:0006105	succinate metabolic process(GO:0006105)
0.3	22.9	GO:0030049	muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.3	34.1	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.3	7.9	GO:0006418	tRNA aminoacylation for protein translation(GO:0006418)
0.3	2.8	GO:0010917	negative regulation of mitochondrial membrane potential(GO:0010917)
0.3	1.3	GO:0050779	RNA destabilization(GO:0050779)
0.3	3.5	GO:0016024	CDP-diacylglycerol biosynthetic process(GO:0016024)
0.2	10.9	GO:0006376	mRNA splice site selection(GO:0006376)
0.2	8.4	GO:0050873	brown fat cell differentiation(GO:0050873)
0.2	3.1	GO:2000628	regulation of miRNA metabolic process(GO:2000628)
0.2	1.9	GO:2000042	negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.2	4.4	GO:0070914	UV-damage excision repair(GO:0070914)
0.2	3.4	GO:2000052	positive regulation of non-canonical Wnt signaling pathway(GO:2000052)
0.2	8.2	GO:0042026	protein refolding(GO:0042026)
0.2	11.1	GO:0032508	DNA duplex unwinding(GO:0032508)
0.2	3.4	GO:0050855	regulation of B cell receptor signaling pathway(GO:0050855)
0.2	5.2	GO:0002089	lens morphogenesis in camera-type eye(GO:0002089)
0.2	13.3	GO:0036498	IRE1-mediated unfolded protein response(GO:0036498)
0.2	0.5	GO:0021764	amygdala development(GO:0021764)
0.2	2.5	GO:0038003	opioid receptor signaling pathway(GO:0038003)
0.1	8.8	GO:0070936	protein K48-linked ubiquitination(GO:0070936)
0.1	8.4	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1	9.8	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1	3.3	GO:0031581	hemidesmosome assembly(GO:0031581)
0.1	3.4	GO:0001937	negative regulation of endothelial cell proliferation(GO:0001937)
0.1	12.8	GO:0034394	protein localization to cell surface(GO:0034394)
0.1	3.2	GO:0032897	negative regulation of viral transcription(GO:0032897)
0.1	19.6	GO:0045727	positive regulation of translation(GO:0045727)
0.1	9.0	GO:0006501	C-terminal protein lipidation(GO:0006501)
0.1	9.6	GO:0032465	regulation of cytokinesis(GO:0032465)
0.1	22.4	GO:0043488	regulation of mRNA stability(GO:0043488)
0.1	1.6	GO:0071257	cellular response to electrical stimulus(GO:0071257)
0.1	13.3	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.1	4.1	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.1	0.7	GO:0045627	positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.1	2.3	GO:0006379	mRNA cleavage(GO:0006379)
0.1	9.5	GO:0007030	Golgi organization(GO:0007030)
0.1	6.2	GO:0043966	histone H3 acetylation(GO:0043966)
0.1	2.0	GO:0030208	dermatan sulfate biosynthetic process(GO:0030208)
0.1	21.9	GO:0000398	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.1	6.3	GO:0042273	ribosomal large subunit biogenesis(GO:0042273)
0.1	4.2	GO:0008156	negative regulation of DNA replication(GO:0008156)
0.1	0.4	GO:0044351	macropinocytosis(GO:0044351)
0.1	2.8	GO:0050919	negative chemotaxis(GO:0050919)
0.1	5.4	GO:0045071	negative regulation of viral genome replication(GO:0045071)
0.1	4.3	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.1	4.8	GO:0007492	endoderm development(GO:0007492)
0.1	5.7	GO:0006614	SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.1	6.1	GO:0006414	translational elongation(GO:0006414)
0.1	2.2	GO:0006298	mismatch repair(GO:0006298)
0.0	5.6	GO:1901796	regulation of signal transduction by p53 class mediator(GO:1901796)
0.0	6.6	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.0	0.3	GO:0030490	maturation of SSU-rRNA(GO:0030490)
0.0	3.8	GO:0046718	viral entry into host cell(GO:0046718)
0.0	2.0	GO:0042632	cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.0	6.2	GO:0008154	actin polymerization or depolymerization(GO:0008154)
0.0	0.1	GO:0033211	adiponectin-activated signaling pathway(GO:0033211)
0.0	1.3	GO:0061615	NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.0	2.3	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0	0.1	GO:0045954	positive regulation of natural killer cell mediated immunity(GO:0002717) positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
7.1	21.2	GO:0016222	procollagen-proline 4-dioxygenase complex(GO:0016222)
6.2	55.5	GO:0097452	GAIT complex(GO:0097452)
5.2	52.2	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
5.1	81.2	GO:0030663	COPI-coated vesicle membrane(GO:0030663)
4.8	19.1	GO:0000221	vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
4.6	37.2	GO:0098559	cytoplasmic side of early endosome membrane(GO:0098559)
4.6	22.8	GO:0034388	Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
4.1	20.7	GO:0070557	PCNA-p21 complex(GO:0070557)
4.0	55.8	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
3.7	21.9	GO:0071256	Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
2.9	37.3	GO:0042555	MCM complex(GO:0042555)
2.8	49.9	GO:0031597	cytosolic proteasome complex(GO:0031597)
2.7	26.7	GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
2.6	34.4	GO:0030137	COPI-coated vesicle(GO:0030137)
2.4	7.2	GO:0044393	microspike(GO:0044393)
2.2	22.0	GO:0046581	intercellular canaliculus(GO:0046581)
2.0	20.1	GO:0033018	sarcoplasmic reticulum lumen(GO:0033018)
1.8	18.3	GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
1.7	7.0	GO:0044307	dendritic branch(GO:0044307)
1.6	22.9	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
1.6	4.9	GO:1990723	cytoplasmic periphery of the nuclear pore complex(GO:1990723)
1.5	30.3	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
1.4	4.2	GO:0055087	Ski complex(GO:0055087)
1.4	8.5	GO:0033179	proton-transporting two-sector ATPase complex, proton-transporting domain(GO:0033177) proton-transporting V-type ATPase, V0 domain(GO:0033179)
1.4	16.6	GO:0071203	WASH complex(GO:0071203)
1.4	25.7	GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
1.3	11.9	GO:0072546	ER membrane protein complex(GO:0072546)
1.3	23.0	GO:0005852	eukaryotic translation initiation factor 3 complex(GO:0005852)
1.3	20.5	GO:0001741	XY body(GO:0001741)
1.2	6.2	GO:0005749	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
1.2	3.5	GO:0005745	m-AAA complex(GO:0005745)
1.0	5.9	GO:0033269	internode region of axon(GO:0033269)
1.0	12.5	GO:0017119	Golgi transport complex(GO:0017119)
1.0	10.5	GO:0008024	cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.9	15.5	GO:0042622	photoreceptor outer segment membrane(GO:0042622)
0.9	6.0	GO:0016589	NURF complex(GO:0016589)
0.8	10.1	GO:0030015	CCR4-NOT core complex(GO:0030015)
0.8	17.3	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.8	13.8	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.8	24.7	GO:0035267	NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.7	64.9	GO:0031903	peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.6	14.1	GO:0036020	endolysosome membrane(GO:0036020)
0.6	10.6	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.6	5.3	GO:0031298	replication fork protection complex(GO:0031298)
0.6	14.4	GO:0071782	endoplasmic reticulum tubular network(GO:0071782)
0.6	6.2	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.5	20.5	GO:0034364	high-density lipoprotein particle(GO:0034364)
0.5	9.6	GO:0071004	U2-type prespliceosome(GO:0071004)
0.4	9.7	GO:0042599	lamellar body(GO:0042599)
0.4	14.9	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.4	4.4	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.4	2.2	GO:0032389	MutLalpha complex(GO:0032389)
0.3	4.8	GO:0090543	Flemming body(GO:0090543)
0.3	3.4	GO:0045180	basal cortex(GO:0045180)
0.3	1.2	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.3	36.1	GO:0071013	catalytic step 2 spliceosome(GO:0071013)
0.3	30.7	GO:0070469	respiratory chain(GO:0070469)
0.3	42.7	GO:0015934	large ribosomal subunit(GO:0015934)
0.3	25.0	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.3	4.3	GO:0030127	COPII vesicle coat(GO:0030127)
0.3	14.9	GO:0005793	endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.3	12.0	GO:0000795	synaptonemal complex(GO:0000795)
0.2	22.1	GO:0005681	spliceosomal complex(GO:0005681)
0.2	13.8	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.2	18.4	GO:0005791	rough endoplasmic reticulum(GO:0005791)
0.2	4.2	GO:0097025	MPP7-DLG1-LIN7 complex(GO:0097025)
0.2	0.2	GO:0005682	U5 snRNP(GO:0005682)
0.2	13.4	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.2	6.3	GO:0030687	preribosome, large subunit precursor(GO:0030687)
0.2	16.1	GO:0030864	cortical actin cytoskeleton(GO:0030864)
0.2	12.8	GO:0001750	photoreceptor outer segment(GO:0001750)
0.2	3.3	GO:0030056	hemidesmosome(GO:0030056)
0.2	25.6	GO:0032587	ruffle membrane(GO:0032587)
0.2	8.5	GO:0055038	recycling endosome membrane(GO:0055038)
0.2	22.3	GO:0005913	cell-cell adherens junction(GO:0005913)
0.1	10.2	GO:0005881	cytoplasmic microtubule(GO:0005881)
0.1	1.4	GO:0032059	bleb(GO:0032059)
0.1	9.2	GO:0045334	clathrin-coated endocytic vesicle(GO:0045334)
0.1	1.9	GO:0097225	sperm midpiece(GO:0097225)
0.1	1.5	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.1	1.3	GO:0005662	DNA replication factor A complex(GO:0005662)
0.1	1.6	GO:0097440	apical dendrite(GO:0097440)
0.1	4.2	GO:0009295	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1	1.9	GO:0035861	site of double-strand break(GO:0035861)
0.1	8.3	GO:0035578	azurophil granule lumen(GO:0035578)
0.1	10.1	GO:0005667	transcription factor complex(GO:0005667)
0.1	7.1	GO:0005923	bicellular tight junction(GO:0005923)
0.0	9.1	GO:0030018	Z disc(GO:0030018)
0.0	8.7	GO:0090575	RNA polymerase II transcription factor complex(GO:0090575)
0.0	5.8	GO:1904813	ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0	3.4	GO:0005758	mitochondrial intermembrane space(GO:0005758)
0.0	0.6	GO:0010369	chromocenter(GO:0010369)
0.0	5.0	GO:0030496	midbody(GO:0030496)
0.0	2.6	GO:0000777	condensed chromosome kinetochore(GO:0000777)
0.0	7.7	GO:0000785	chromatin(GO:0000785)
0.0	6.3	GO:0031965	nuclear membrane(GO:0031965)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
9.3	28.0	GO:0005046	KDEL sequence binding(GO:0005046)
8.4	33.5	GO:0005163	nerve growth factor receptor binding(GO:0005163)
7.1	21.2	GO:0003974	UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978)
6.9	20.7	GO:0030337	DNA polymerase processivity factor activity(GO:0030337)
5.8	29.2	GO:0008263	pyrimidine-specific mismatch base pair DNA N-glycosylase activity(GO:0008263)
5.8	52.2	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
5.1	20.5	GO:0098770	FBXO family protein binding(GO:0098770)
5.1	15.2	GO:0016838	carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
4.8	14.5	GO:0050146	nucleoside phosphotransferase activity(GO:0050146)
4.2	21.2	GO:0004656	procollagen-proline 4-dioxygenase activity(GO:0004656)
4.0	24.1	GO:0004013	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
3.9	15.5	GO:0047391	alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
3.8	26.7	GO:0061133	endopeptidase activator activity(GO:0061133)
3.4	13.4	GO:0035402	histone kinase activity (H3-T11 specific)(GO:0035402)
3.4	10.1	GO:0001226	RNA polymerase II transcription corepressor binding(GO:0001226)
2.9	14.7	GO:0008073	ornithine decarboxylase inhibitor activity(GO:0008073)
2.9	17.5	GO:0019238	cyclohydrolase activity(GO:0019238)
2.6	10.5	GO:0061628	H3K27me3 modified histone binding(GO:0061628)
2.6	64.9	GO:0102391	decanoate--CoA ligase activity(GO:0102391)
2.3	9.1	GO:0043273	CTPase activity(GO:0043273)
2.2	17.8	GO:0009922	fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
2.1	14.7	GO:0048408	epidermal growth factor binding(GO:0048408)
2.1	54.3	GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
2.0	34.4	GO:0016004	phospholipase activator activity(GO:0016004)
1.9	23.1	GO:1990247	pre-mRNA intronic binding(GO:0097157) N6-methyladenosine-containing RNA binding(GO:1990247)
1.8	9.1	GO:0010340	carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998)
1.8	12.4	GO:0030267	hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
1.8	5.3	GO:0003917	DNA topoisomerase type I activity(GO:0003917)
1.7	8.5	GO:0016936	galactoside binding(GO:0016936)
1.7	11.7	GO:0004459	lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459)
1.6	55.5	GO:0008143	poly(A) binding(GO:0008143)
1.6	6.2	GO:0008177	succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538)
1.5	30.3	GO:0008603	cAMP-dependent protein kinase regulator activity(GO:0008603)
1.3	3.8	GO:0070905	serine binding(GO:0070905)
1.2	9.3	GO:0052832	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
1.1	8.6	GO:0043140	ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
1.0	4.2	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823) procollagen galactosyltransferase activity(GO:0050211)
1.0	39.4	GO:0070577	lysine-acetylated histone binding(GO:0070577)
1.0	22.5	GO:0070628	proteasome binding(GO:0070628)
1.0	4.8	GO:0031871	proteinase activated receptor binding(GO:0031871)
1.0	10.6	GO:0072542	protein phosphatase activator activity(GO:0072542)
0.9	78.6	GO:0019003	GDP binding(GO:0019003)
0.8	33.5	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
0.8	11.4	GO:0034450	ubiquitin-ubiquitin ligase activity(GO:0034450)
0.8	2.3	GO:0004056	argininosuccinate lyase activity(GO:0004056)
0.7	23.1	GO:0031492	nucleosomal DNA binding(GO:0031492)
0.7	9.6	GO:0070567	cytidylyltransferase activity(GO:0070567)
0.7	30.0	GO:0051059	NF-kappaB binding(GO:0051059)
0.7	7.7	GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.7	2.0	GO:0047757	chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.7	6.6	GO:0042731	inositol-polyphosphate 5-phosphatase activity(GO:0004445) PH domain binding(GO:0042731)
0.6	8.3	GO:0000774	adenyl-nucleotide exchange factor activity(GO:0000774)
0.6	5.6	GO:0089720	caspase binding(GO:0089720)
0.6	14.9	GO:0003678	DNA helicase activity(GO:0003678)
0.6	14.1	GO:0098748	clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.6	1.8	GO:0004450	isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.6	64.0	GO:0051087	chaperone binding(GO:0051087)
0.6	9.3	GO:0009881	photoreceptor activity(GO:0009881)
0.6	30.7	GO:0050136	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.6	7.2	GO:0036122	BMP binding(GO:0036122)
0.6	14.3	GO:0044548	S100 protein binding(GO:0044548)
0.5	29.3	GO:0016831	carboxy-lyase activity(GO:0016831)
0.5	19.2	GO:0017025	TBP-class protein binding(GO:0017025)
0.5	24.8	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.5	16.2	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.5	8.7	GO:0008179	adenylate cyclase binding(GO:0008179)
0.5	27.8	GO:0005154	epidermal growth factor receptor binding(GO:0005154)
0.5	42.6	GO:0070491	repressing transcription factor binding(GO:0070491)
0.5	3.8	GO:0036435	K48-linked polyubiquitin binding(GO:0036435)
0.5	2.8	GO:0008420	CTD phosphatase activity(GO:0008420)
0.4	7.4	GO:0070530	K63-linked polyubiquitin binding(GO:0070530)
0.4	1.9	GO:0061649	ubiquitinated histone binding(GO:0061649)
0.4	2.3	GO:0046923	ER retention sequence binding(GO:0046923)
0.3	7.9	GO:0016875	aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.3	1.3	GO:0032422	purine-rich negative regulatory element binding(GO:0032422)
0.3	5.2	GO:0019104	DNA N-glycosylase activity(GO:0019104)
0.3	34.1	GO:0003730	mRNA 3'-UTR binding(GO:0003730)
0.3	1.3	GO:0034353	RNA pyrophosphohydrolase activity(GO:0034353)
0.3	5.1	GO:0035256	G-protein coupled glutamate receptor binding(GO:0035256)
0.3	21.3	GO:0003743	translation initiation factor activity(GO:0003743)
0.3	7.4	GO:0070006	metalloaminopeptidase activity(GO:0070006)
0.3	7.4	GO:0008301	DNA binding, bending(GO:0008301)
0.3	7.0	GO:0034237	protein kinase A regulatory subunit binding(GO:0034237)
0.3	8.2	GO:0070064	proline-rich region binding(GO:0070064)
0.3	26.0	GO:0004386	helicase activity(GO:0004386)
0.3	15.1	GO:0005246	calcium channel regulator activity(GO:0005246)
0.3	2.1	GO:0004467	long-chain fatty acid-CoA ligase activity(GO:0004467)
0.3	26.2	GO:0008307	structural constituent of muscle(GO:0008307)
0.2	3.4	GO:0002162	dystroglycan binding(GO:0002162)
0.2	4.2	GO:0097016	L27 domain binding(GO:0097016)
0.2	0.7	GO:0031626	beta-endorphin binding(GO:0031626)
0.2	6.2	GO:0003746	translation elongation factor activity(GO:0003746)
0.2	4.9	GO:0019789	SUMO transferase activity(GO:0019789)
0.2	6.3	GO:0070566	adenylyltransferase activity(GO:0070566)
0.2	7.8	GO:0005184	neuropeptide hormone activity(GO:0005184)
0.2	3.1	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2	12.1	GO:0004843	thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.2	2.2	GO:0030983	mismatched DNA binding(GO:0030983)
0.2	1.5	GO:0015186	L-glutamine transmembrane transporter activity(GO:0015186)
0.2	6.7	GO:0001972	retinoic acid binding(GO:0001972)
0.2	2.5	GO:0004985	opioid receptor activity(GO:0004985)
0.2	4.2	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.2	6.0	GO:0008094	DNA-dependent ATPase activity(GO:0008094)
0.1	2.8	GO:0038191	neuropilin binding(GO:0038191)
0.1	5.9	GO:0061650	ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
0.1	0.6	GO:0004392	heme oxygenase (decyclizing) activity(GO:0004392)
0.1	0.5	GO:0004839	ubiquitin activating enzyme activity(GO:0004839)
0.1	13.9	GO:0070851	growth factor receptor binding(GO:0070851)
0.1	1.8	GO:0015926	glucosidase activity(GO:0015926)
0.1	21.5	GO:0003735	structural constituent of ribosome(GO:0003735)
0.1	2.8	GO:0005521	lamin binding(GO:0005521)
0.1	4.1	GO:0050699	WW domain binding(GO:0050699)
0.1	5.1	GO:0003727	single-stranded RNA binding(GO:0003727)
0.1	123.5	GO:0003723	RNA binding(GO:0003723)
0.1	2.3	GO:0004190	aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1	43.4	GO:0005198	structural molecule activity(GO:0005198)
0.1	3.1	GO:0005484	SNAP receptor activity(GO:0005484)
0.1	2.9	GO:0035064	methylated histone binding(GO:0035064)
0.1	1.0	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.1	1.5	GO:0030296	protein tyrosine kinase activator activity(GO:0030296)
0.0	3.5	GO:0051082	unfolded protein binding(GO:0051082)
0.0	2.0	GO:0003684	damaged DNA binding(GO:0003684)
0.0	3.8	GO:0001618	virus receptor activity(GO:0001618)
0.0	2.9	GO:0008565	protein transporter activity(GO:0008565)
0.0	2.4	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.4	GO:0009931	calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0	0.8	GO:0043425	bHLH transcription factor binding(GO:0043425)
0.0	5.8	GO:0008134	transcription factor binding(GO:0008134)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.4	66.0	PID ARF 3PATHWAY	Arf1 pathway
0.7	12.7	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.6	37.3	PID ATR PATHWAY	ATR signaling pathway
0.6	20.8	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.5	68.3	PID RB 1PATHWAY	Regulation of retinoblastoma protein
0.5	10.2	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.5	20.7	PID BARD1 PATHWAY	BARD1 signaling events
0.5	65.2	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.5	16.1	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.4	10.0	ST FAS SIGNALING PATHWAY	Fas Signaling Pathway
0.4	10.6	PID BMP PATHWAY	BMP receptor signaling
0.3	20.5	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.3	22.7	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.3	4.9	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.3	14.7	PID AURORA A PATHWAY	Aurora A signaling
0.3	14.7	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.3	3.4	PID NECTIN PATHWAY	Nectin adhesion pathway
0.3	15.8	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.2	12.0	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.2	9.9	PID LKB1 PATHWAY	LKB1 signaling events
0.1	3.5	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.1	8.8	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.1	4.9	PID FOXO PATHWAY	FoxO family signaling
0.1	6.7	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.1	7.5	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.1	2.0	ST G ALPHA S PATHWAY	G alpha s Pathway
0.1	5.2	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.1	5.2	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.1	1.9	PID ATM PATHWAY	ATM pathway
0.1	3.5	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.1	18.3	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	5.2	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.0	1.3	PID MTOR 4PATHWAY	mTOR signaling pathway
0.0	0.4	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.0	0.1	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0	0.6	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
8.0	87.6	REACTOME COPI MEDIATED TRANSPORT	Genes involved in COPI Mediated Transport
2.7	82.7	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
2.5	37.3	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
2.3	52.2	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
2.1	39.9	REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX	Genes involved in Association of licensing factors with the pre-replicative complex
1.9	54.3	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
1.9	55.1	REACTOME RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY	Genes involved in Resolution of AP sites via the multiple-nucleotide patch replacement pathway
1.5	29.3	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
1.2	17.5	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
1.0	70.9	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
1.0	14.5	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.9	14.7	REACTOME ER PHAGOSOME PATHWAY	Genes involved in ER-Phagosome pathway
0.9	17.3	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.8	13.2	REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.8	20.8	REACTOME ADP SIGNALLING THROUGH P2RY12	Genes involved in ADP signalling through P2Y purinoceptor 12
0.8	14.4	REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	Genes involved in p75 NTR receptor-mediated signalling
0.8	31.9	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.7	15.2	REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.7	22.7	REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	Genes involved in PKA-mediated phosphorylation of CREB
0.6	41.4	REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC	Genes involved in Regulation of ornithine decarboxylase (ODC)
0.5	40.1	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.5	7.9	REACTOME MITOCHONDRIAL TRNA AMINOACYLATION	Genes involved in Mitochondrial tRNA aminoacylation
0.5	14.1	REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS	Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
0.5	6.1	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.4	17.5	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.4	6.3	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.3	55.7	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
0.3	28.3	REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	Genes involved in Apoptotic cleavage of cellular proteins
0.3	8.5	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.3	7.0	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII	Genes involved in CREB phosphorylation through the activation of CaMKII
0.3	9.6	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.2	5.9	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.2	24.9	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.2	1.8	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.2	1.8	REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE	Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.1	3.1	REACTOME DESTABILIZATION OF MRNA BY KSRP	Genes involved in Destabilization of mRNA by KSRP
0.1	10.3	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.1	13.4	REACTOME TRANSLATION	Genes involved in Translation
0.1	6.3	REACTOME CIRCADIAN CLOCK	Genes involved in Circadian Clock
0.1	1.9	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1	1.8	REACTOME PYRUVATE METABOLISM	Genes involved in Pyruvate metabolism
0.1	4.9	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.0	3.8	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.0	0.6	REACTOME MITOTIC M M G1 PHASES	Genes involved in Mitotic M-M/G1 phases
0.0	5.7	REACTOME L1CAM INTERACTIONS	Genes involved in L1CAM interactions
0.0	3.2	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.0	2.3	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
0.0	4.2	REACTOME INTEGRATION OF ENERGY METABOLISM	Genes involved in Integration of energy metabolism
0.0	0.6	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.0	0.4	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.0	3.6	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors

Results for ATF6

Z-value: 1.60

Motif logo

Transcription factors associated with ATF6

Activity-expression correlation:

Activity profile of ATF6 motif

Sorted Z-values of ATF6 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ATF6

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: