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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ATF6
Z-value: 1.60
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Transcription factors associated with ATF6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ATF6 | hg38_v1_chr1_+_161766282_161766303 | 0.35 | 1.7e-07 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ATF6
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_+_71754834 Show fit | 37.19 |
ENST00000261263.5
|
RAB21, member RAS oncogene family |
|
| chr2_-_10448318 Show fit | 29.29 |
ENST00000234111.9
|
ornithine decarboxylase 1 |
|
| chr19_-_48390847 Show fit | 27.98 |
ENST00000597017.5
|
KDEL endoplasmic reticulum protein retention receptor 1 |
|
| chr11_-_14499833 Show fit | 27.05 |
ENST00000249923.7
ENST00000529866.5 |
COPI coat complex subunit beta 1 |
|
| chrX_+_48574938 Show fit | 26.96 |
ENST00000376755.1
|
RNA binding motif protein 3 |
|
| chr1_+_43974902 Show fit | 26.72 |
ENST00000532642.5
ENST00000236067.8 ENST00000471859.6 ENST00000472174.7 |
ATPase H+ transporting V0 subunit b |
|
| chr2_+_161308407 Show fit | 26.67 |
ENST00000409682.8
|
proteasome 26S subunit, non-ATPase 14 |
|
| chr11_-_78079773 Show fit | 26.61 |
ENST00000612612.5
ENST00000614236.2 |
NDUFC2-KCTD14 readthrough |
|
| chr11_-_14499803 Show fit | 26.38 |
ENST00000439561.7
ENST00000534234.5 |
COPI coat complex subunit beta 1 |
|
| chr22_-_38700655 Show fit | 25.60 |
ENST00000216039.9
|
Josephin domain containing 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 16.2 | 64.8 | GO:2001247 | positive regulation of phosphatidylcholine biosynthetic process(GO:2001247) |
| 1.1 | 60.9 | GO:0006891 | intra-Golgi vesicle-mediated transport(GO:0006891) |
| 13.9 | 55.6 | GO:1903382 | neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(GO:0036483) regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903381) negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903382) |
| 4.0 | 55.5 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 1.8 | 54.3 | GO:0015988 | energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) |
| 2.6 | 52.2 | GO:0016254 | preassembly of GPI anchor in ER membrane(GO:0016254) |
| 5.1 | 51.1 | GO:0045716 | positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716) |
| 9.4 | 47.1 | GO:0071163 | DNA replication preinitiation complex assembly(GO:0071163) |
| 3.0 | 38.6 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 3.1 | 37.2 | GO:2000643 | positive regulation of early endosome to late endosome transport(GO:2000643) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.1 | 81.2 | GO:0030663 | COPI-coated vesicle membrane(GO:0030663) |
| 0.7 | 64.9 | GO:0031903 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 4.0 | 55.8 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 6.2 | 55.5 | GO:0097452 | GAIT complex(GO:0097452) |
| 5.2 | 52.2 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
| 2.8 | 49.9 | GO:0031597 | cytosolic proteasome complex(GO:0031597) |
| 0.3 | 42.7 | GO:0015934 | large ribosomal subunit(GO:0015934) |
| 2.9 | 37.3 | GO:0042555 | MCM complex(GO:0042555) |
| 4.6 | 37.2 | GO:0098559 | cytoplasmic side of early endosome membrane(GO:0098559) |
| 0.3 | 36.1 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 123.5 | GO:0003723 | RNA binding(GO:0003723) |
| 0.9 | 78.6 | GO:0019003 | GDP binding(GO:0019003) |
| 2.6 | 64.9 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 0.6 | 64.0 | GO:0051087 | chaperone binding(GO:0051087) |
| 1.6 | 55.5 | GO:0008143 | poly(A) binding(GO:0008143) |
| 2.1 | 54.3 | GO:0044769 | ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 5.8 | 52.2 | GO:0017176 | phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176) |
| 0.1 | 43.4 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.5 | 42.6 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
| 1.0 | 39.4 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 68.3 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 2.4 | 66.0 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.5 | 65.2 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.6 | 37.3 | PID ATR PATHWAY | ATR signaling pathway |
| 0.3 | 22.7 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.6 | 20.8 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.5 | 20.7 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.3 | 20.5 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.1 | 18.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.5 | 16.1 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.0 | 87.6 | REACTOME COPI MEDIATED TRANSPORT | Genes involved in COPI Mediated Transport |
| 2.7 | 82.7 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 1.0 | 70.9 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.3 | 55.7 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 1.9 | 55.1 | REACTOME RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY | Genes involved in Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| 1.9 | 54.3 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 2.3 | 52.2 | REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI | Genes involved in Synthesis of glycosylphosphatidylinositol (GPI) |
| 0.6 | 41.4 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.5 | 40.1 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 2.1 | 39.9 | REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX | Genes involved in Association of licensing factors with the pre-replicative complex |