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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for AUGUGCC
Z-value: 0.42
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miRNA associated with seed AUGUGCC
| Name | miRBASE accession |
|---|---|
|
hsa-miR-455-5p
|
MIMAT0003150 |
Network of associatons between targets according to the STRING database.
First level regulatory network of AUGUGCC
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 7.7 | GO:0016578 | histone deubiquitination(GO:0016578) |
| 0.2 | 7.6 | GO:0048025 | negative regulation of mRNA splicing, via spliceosome(GO:0048025) |
| 0.2 | 5.7 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.3 | 5.2 | GO:0070935 | 3'-UTR-mediated mRNA stabilization(GO:0070935) |
| 0.1 | 4.8 | GO:0003016 | respiratory system process(GO:0003016) |
| 1.1 | 4.5 | GO:1901165 | positive regulation of trophoblast cell migration(GO:1901165) |
| 0.6 | 4.3 | GO:0060770 | negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770) |
| 1.0 | 4.2 | GO:0035964 | COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205) |
| 0.5 | 4.0 | GO:0042256 | mature ribosome assembly(GO:0042256) positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651) |
| 0.3 | 4.0 | GO:0071550 | death-inducing signaling complex assembly(GO:0071550) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 7.7 | GO:0070938 | contractile ring(GO:0070938) |
| 0.0 | 5.9 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.1 | 5.2 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
| 0.0 | 5.1 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 4.5 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 0.4 | 4.3 | GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex(GO:0031464) |
| 0.0 | 4.3 | GO:1904813 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.3 | 4.2 | GO:0030663 | COPI-coated vesicle membrane(GO:0030663) |
| 0.1 | 4.0 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.1 | 4.0 | GO:0031143 | pseudopodium(GO:0031143) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 15.9 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.1 | 7.7 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.3 | 5.7 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.0 | 5.4 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.4 | 5.2 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 0.1 | 4.5 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
| 0.3 | 4.3 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 1.0 | 4.0 | GO:0043273 | CTPase activity(GO:0043273) |
| 0.1 | 4.0 | GO:0031434 | mitogen-activated protein kinase kinase binding(GO:0031434) |
| 0.3 | 3.8 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.6 | PID FOXO PATHWAY | FoxO family signaling |
| 0.1 | 5.2 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 4.5 | PID BMP PATHWAY | BMP receptor signaling |
| 0.2 | 4.3 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.2 | 4.0 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.1 | 2.4 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.1 | 2.3 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.0 | 2.3 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 2.2 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 1.5 | PID IGF1 PATHWAY | IGF1 pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.6 | REACTOME MRNA 3 END PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.1 | 5.6 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.2 | 4.3 | REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.0 | 4.3 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.2 | 4.2 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 4.1 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.3 | 4.0 | REACTOME RAF MAP KINASE CASCADE | Genes involved in RAF/MAP kinase cascade |
| 0.1 | 3.9 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.1 | 3.8 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.1 | 3.0 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |