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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for AUUGCAC
Z-value: 0.65
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miRNA associated with seed AUUGCAC
Network of associatons between targets according to the STRING database.
First level regulatory network of AUUGCAC
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_12009082 Show fit | 9.93 |
ENST00000396505.7
|
dickkopf WNT signaling pathway inhibitor 3 |
|
| chr5_+_72107453 Show fit | 8.45 |
ENST00000296755.12
ENST00000511641.2 |
microtubule associated protein 1B |
|
| chr1_+_51236252 Show fit | 8.31 |
ENST00000242719.4
|
ring finger protein 11 |
|
| chr4_-_176002332 Show fit | 7.46 |
ENST00000280187.11
ENST00000512509.5 |
glycoprotein M6A |
|
| chr8_+_24914942 Show fit | 7.06 |
ENST00000433454.3
|
neurofilament medium |
|
| chr15_-_73633310 Show fit | 7.01 |
ENST00000345330.9
|
neuroplastin |
|
| chr8_+_131904071 Show fit | 6.97 |
ENST00000254624.10
ENST00000522709.5 |
EFR3 homolog A |
|
| chr3_-_120450981 Show fit | 6.50 |
ENST00000424703.6
ENST00000469005.1 ENST00000295633.8 |
follistatin like 1 |
|
| chr2_+_186590022 Show fit | 6.50 |
ENST00000261023.8
ENST00000374907.7 |
integrin subunit alpha V |
|
| chr9_-_136050502 Show fit | 6.40 |
ENST00000371753.5
|
NACC family member 2 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 9.9 | GO:1902613 | regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262) |
| 2.3 | 9.4 | GO:0033693 | neurofilament bundle assembly(GO:0033693) |
| 0.5 | 8.4 | GO:0061339 | establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339) |
| 0.0 | 8.0 | GO:0090002 | establishment of protein localization to plasma membrane(GO:0090002) |
| 0.1 | 7.6 | GO:0051865 | protein autoubiquitination(GO:0051865) |
| 1.0 | 7.0 | GO:0048170 | positive regulation of long-term neuronal synaptic plasticity(GO:0048170) |
| 0.7 | 6.7 | GO:0016198 | axon choice point recognition(GO:0016198) |
| 2.2 | 6.5 | GO:0045715 | negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715) |
| 2.0 | 6.1 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 0.2 | 5.9 | GO:0051491 | positive regulation of filopodium assembly(GO:0051491) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.4 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.6 | 9.4 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
| 0.4 | 9.1 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.1 | 9.1 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.0 | 7.2 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.2 | 7.1 | GO:0090545 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 2.2 | 6.5 | GO:0034686 | integrin alphav-beta8 complex(GO:0034686) |
| 0.1 | 6.3 | GO:0031902 | late endosome membrane(GO:0031902) |
| 1.2 | 6.1 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.5 | 6.1 | GO:0060077 | inhibitory synapse(GO:0060077) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.7 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.0 | 8.6 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.3 | 7.7 | GO:0043548 | phosphatidylinositol 3-kinase binding(GO:0043548) |
| 0.1 | 7.2 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 1.4 | 7.0 | GO:0005105 | type 1 fibroblast growth factor receptor binding(GO:0005105) |
| 1.6 | 6.5 | GO:1990430 | extracellular matrix protein binding(GO:1990430) |
| 1.0 | 6.2 | GO:0034046 | poly(G) binding(GO:0034046) |
| 1.2 | 6.1 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.0 | 6.0 | GO:0008201 | heparin binding(GO:0008201) |
| 0.4 | 5.5 | GO:0022820 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 16.5 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.3 | 12.9 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.1 | 9.8 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.3 | 7.6 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 5.5 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.1 | 5.4 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.1 | 5.2 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.1 | 4.8 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 4.4 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 4.2 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.7 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.4 | 6.5 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.3 | 6.1 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.1 | 5.4 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 5.2 | REACTOME KERATAN SULFATE KERATIN METABOLISM | Genes involved in Keratan sulfate/keratin metabolism |
| 0.1 | 5.1 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 5.0 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.0 | 5.0 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.2 | 4.6 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.1 | 4.6 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |