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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for AUUGCAC
Z-value: 0.65
Motif logo
miRNA associated with seed AUUGCAC
| Name | miRBASE accession |
|---|---|
|
hsa-miR-25-3p
|
MIMAT0000081 |
|
hsa-miR-32-5p
|
MIMAT0000090 |
|
hsa-miR-363-3p
|
MIMAT0000707 |
|
hsa-miR-367-3p
|
MIMAT0000719 |
|
hsa-miR-92a-3p
|
MIMAT0000092 |
|
hsa-miR-92b-3p
|
MIMAT0003218 |
Activity profile of AUUGCAC motif
Sorted Z-values of AUUGCAC motif
Network of associatons between targets according to the STRING database.
First level regulatory network of AUUGCAC
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 9.4 | GO:0033693 | neurofilament bundle assembly(GO:0033693) |
| 2.2 | 6.5 | GO:0045715 | negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715) |
| 2.0 | 6.1 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 2.0 | 9.9 | GO:1902613 | regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262) |
| 1.3 | 4.0 | GO:0072709 | cellular response to sorbitol(GO:0072709) |
| 1.3 | 4.0 | GO:2000687 | negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687) |
| 1.1 | 4.5 | GO:0045048 | protein insertion into ER membrane(GO:0045048) |
| 1.1 | 3.2 | GO:0051939 | gamma-aminobutyric acid import(GO:0051939) |
| 1.0 | 4.2 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
| 1.0 | 7.0 | GO:0048170 | positive regulation of long-term neuronal synaptic plasticity(GO:0048170) |
| 1.0 | 2.9 | GO:1901254 | modulation by host of viral RNA genome replication(GO:0044830) positive regulation of intracellular transport of viral material(GO:1901254) |
| 0.9 | 5.3 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) |
| 0.9 | 5.2 | GO:1903224 | regulation of endodermal cell differentiation(GO:1903224) |
| 0.9 | 3.4 | GO:0018231 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) |
| 0.8 | 3.2 | GO:0051182 | coenzyme transport(GO:0051182) |
| 0.8 | 4.6 | GO:0048549 | positive regulation of pinocytosis(GO:0048549) |
| 0.7 | 2.2 | GO:1902269 | positive regulation of polyamine transmembrane transport(GO:1902269) |
| 0.7 | 6.7 | GO:0016198 | axon choice point recognition(GO:0016198) |
| 0.7 | 5.2 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 0.7 | 2.2 | GO:0098928 | presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526) |
| 0.7 | 5.1 | GO:1902231 | positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231) |
| 0.7 | 4.4 | GO:0043456 | regulation of pentose-phosphate shunt(GO:0043456) |
| 0.7 | 4.4 | GO:0006065 | UDP-glucuronate biosynthetic process(GO:0006065) glucose 1-phosphate metabolic process(GO:0019255) |
| 0.7 | 2.1 | GO:1902955 | regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246) |
| 0.7 | 2.1 | GO:0003245 | cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245) |
| 0.7 | 2.7 | GO:0009138 | pyrimidine nucleoside diphosphate metabolic process(GO:0009138) |
| 0.7 | 3.3 | GO:0070425 | negative regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070425) negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070433) |
| 0.6 | 1.9 | GO:0090176 | microtubule cytoskeleton organization involved in establishment of planar polarity(GO:0090176) |
| 0.6 | 2.4 | GO:0099558 | maintenance of synapse structure(GO:0099558) |
| 0.6 | 4.2 | GO:0010724 | regulation of definitive erythrocyte differentiation(GO:0010724) |
| 0.6 | 1.8 | GO:1901899 | positive regulation of relaxation of cardiac muscle(GO:1901899) |
| 0.6 | 1.7 | GO:0090402 | oncogene-induced cell senescence(GO:0090402) |
| 0.6 | 1.7 | GO:0021718 | superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722) |
| 0.5 | 1.6 | GO:2000301 | negative regulation of synaptic vesicle exocytosis(GO:2000301) |
| 0.5 | 3.1 | GO:0010748 | regulation of plasma membrane long-chain fatty acid transport(GO:0010746) negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) |
| 0.5 | 1.5 | GO:1903281 | regulation of the force of heart contraction by cardiac conduction(GO:0086092) positive regulation of calcium:sodium antiporter activity(GO:1903281) |
| 0.5 | 4.6 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
| 0.5 | 1.5 | GO:0097212 | cleavage furrow ingression(GO:0036090) lysosomal membrane organization(GO:0097212) regulation of late endosome to lysosome transport(GO:1902822) |
| 0.5 | 8.4 | GO:0061339 | establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339) |
| 0.5 | 1.9 | GO:2000638 | regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639) |
| 0.5 | 1.4 | GO:0016344 | meiotic chromosome movement towards spindle pole(GO:0016344) |
| 0.5 | 1.4 | GO:0060382 | release from viral latency(GO:0019046) regulation of DNA strand elongation(GO:0060382) |
| 0.4 | 1.3 | GO:0032912 | negative regulation of transforming growth factor beta2 production(GO:0032912) |
| 0.4 | 1.3 | GO:0042704 | uterine wall breakdown(GO:0042704) |
| 0.4 | 3.3 | GO:0006013 | mannose metabolic process(GO:0006013) |
| 0.4 | 2.3 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 0.4 | 1.2 | GO:0051295 | establishment of meiotic spindle localization(GO:0051295) |
| 0.4 | 1.1 | GO:0006097 | glyoxylate cycle(GO:0006097) |
| 0.4 | 3.2 | GO:0072383 | plus-end-directed vesicle transport along microtubule(GO:0072383) |
| 0.4 | 1.4 | GO:1904980 | positive regulation of endosome organization(GO:1904980) |
| 0.3 | 1.7 | GO:0071896 | protein localization to adherens junction(GO:0071896) |
| 0.3 | 1.0 | GO:0044752 | response to human chorionic gonadotropin(GO:0044752) cellular response to thyroxine stimulus(GO:0097069) cellular response to L-phenylalanine derivative(GO:1904387) |
| 0.3 | 4.0 | GO:0045722 | positive regulation of gluconeogenesis(GO:0045722) |
| 0.3 | 2.0 | GO:0090269 | fibroblast growth factor production(GO:0090269) regulation of fibroblast growth factor production(GO:0090270) |
| 0.3 | 0.9 | GO:0071335 | submandibular salivary gland formation(GO:0060661) hair follicle cell proliferation(GO:0071335) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338) |
| 0.3 | 0.8 | GO:0060932 | mammary placode formation(GO:0060596) His-Purkinje system cell differentiation(GO:0060932) |
| 0.3 | 1.3 | GO:0042796 | snRNA transcription from RNA polymerase III promoter(GO:0042796) |
| 0.3 | 0.8 | GO:0098937 | dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937) |
| 0.2 | 3.0 | GO:0006451 | selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451) |
| 0.2 | 2.5 | GO:2000189 | positive regulation of cholesterol homeostasis(GO:2000189) |
| 0.2 | 1.7 | GO:0035583 | sequestering of TGFbeta in extracellular matrix(GO:0035583) |
| 0.2 | 1.2 | GO:2000320 | negative regulation of T-helper 17 type immune response(GO:2000317) negative regulation of T-helper 17 cell differentiation(GO:2000320) |
| 0.2 | 1.8 | GO:0034626 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
| 0.2 | 0.7 | GO:1903722 | regulation of centriole elongation(GO:1903722) |
| 0.2 | 3.3 | GO:0010839 | negative regulation of keratinocyte proliferation(GO:0010839) |
| 0.2 | 2.6 | GO:0090168 | Golgi reassembly(GO:0090168) |
| 0.2 | 0.6 | GO:0090234 | regulation of kinetochore assembly(GO:0090234) |
| 0.2 | 5.3 | GO:0089711 | L-glutamate transmembrane transport(GO:0089711) |
| 0.2 | 1.3 | GO:1902915 | negative regulation of histone ubiquitination(GO:0033183) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) negative regulation of protein polyubiquitination(GO:1902915) |
| 0.2 | 3.6 | GO:0034389 | lipid particle organization(GO:0034389) |
| 0.2 | 0.2 | GO:0032911 | negative regulation of transforming growth factor beta1 production(GO:0032911) |
| 0.2 | 2.0 | GO:0021740 | trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795) |
| 0.2 | 0.5 | GO:1902746 | regulation of lens fiber cell differentiation(GO:1902746) |
| 0.2 | 1.0 | GO:0008218 | bioluminescence(GO:0008218) |
| 0.2 | 3.2 | GO:0006012 | galactose metabolic process(GO:0006012) |
| 0.2 | 0.7 | GO:0003409 | optic cup structural organization(GO:0003409) |
| 0.2 | 5.9 | GO:0051491 | positive regulation of filopodium assembly(GO:0051491) |
| 0.2 | 0.8 | GO:0021590 | cerebellum maturation(GO:0021590) cerebellar cortex maturation(GO:0021699) |
| 0.2 | 0.9 | GO:0045876 | positive regulation of sister chromatid cohesion(GO:0045876) |
| 0.2 | 0.5 | GO:1904017 | cellular response to Thyroglobulin triiodothyronine(GO:1904017) |
| 0.2 | 2.6 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.1 | 2.1 | GO:0042340 | keratan sulfate catabolic process(GO:0042340) |
| 0.1 | 0.7 | GO:0042986 | positive regulation of amyloid precursor protein biosynthetic process(GO:0042986) |
| 0.1 | 0.4 | GO:0099404 | regulation of maintenance of sister chromatid cohesion(GO:0034091) negative regulation of maintenance of sister chromatid cohesion(GO:0034092) regulation of maintenance of mitotic sister chromatid cohesion(GO:0034182) negative regulation of maintenance of mitotic sister chromatid cohesion(GO:0034183) maintenance of mitotic sister chromatid cohesion, telomeric(GO:0099403) mitotic sister chromatid cohesion, telomeric(GO:0099404) regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904907) negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904908) |
| 0.1 | 2.2 | GO:0051386 | regulation of neurotrophin TRK receptor signaling pathway(GO:0051386) |
| 0.1 | 0.7 | GO:0097498 | endothelial tube lumen extension(GO:0097498) |
| 0.1 | 3.2 | GO:0015988 | energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) |
| 0.1 | 0.8 | GO:0006701 | progesterone biosynthetic process(GO:0006701) |
| 0.1 | 0.5 | GO:0090283 | regulation of protein glycosylation in Golgi(GO:0090283) |
| 0.1 | 1.1 | GO:0060613 | fat pad development(GO:0060613) |
| 0.1 | 1.8 | GO:0006048 | UDP-N-acetylglucosamine biosynthetic process(GO:0006048) |
| 0.1 | 1.8 | GO:0000338 | protein deneddylation(GO:0000338) |
| 0.1 | 1.9 | GO:0070070 | proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072) |
| 0.1 | 0.7 | GO:1902473 | regulation of protein localization to synapse(GO:1902473) positive regulation of protein localization to synapse(GO:1902474) |
| 0.1 | 1.8 | GO:0003334 | keratinocyte development(GO:0003334) |
| 0.1 | 1.0 | GO:2000786 | positive regulation of autophagosome assembly(GO:2000786) |
| 0.1 | 1.3 | GO:0000098 | sulfur amino acid catabolic process(GO:0000098) |
| 0.1 | 1.0 | GO:0099566 | regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566) |
| 0.1 | 0.7 | GO:0048619 | embryonic hindgut morphogenesis(GO:0048619) |
| 0.1 | 0.4 | GO:0034773 | histone H4-K20 trimethylation(GO:0034773) |
| 0.1 | 1.1 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
| 0.1 | 7.6 | GO:0051865 | protein autoubiquitination(GO:0051865) |
| 0.1 | 1.0 | GO:0061669 | spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814) |
| 0.1 | 0.4 | GO:1900827 | maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
| 0.1 | 0.3 | GO:0035359 | negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) negative regulation of oxidative phosphorylation uncoupler activity(GO:2000276) cell proliferation involved in heart valve development(GO:2000793) |
| 0.1 | 1.4 | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity(GO:0007175) |
| 0.1 | 1.5 | GO:0038166 | angiotensin-activated signaling pathway(GO:0038166) |
| 0.1 | 1.3 | GO:1902373 | negative regulation of mRNA catabolic process(GO:1902373) |
| 0.1 | 0.7 | GO:0071286 | cellular response to magnesium ion(GO:0071286) |
| 0.1 | 2.0 | GO:0010592 | positive regulation of lamellipodium assembly(GO:0010592) |
| 0.1 | 2.7 | GO:0000470 | maturation of LSU-rRNA(GO:0000470) |
| 0.1 | 0.3 | GO:1901301 | regulation of cargo loading into COPII-coated vesicle(GO:1901301) |
| 0.1 | 0.7 | GO:0007185 | transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185) |
| 0.1 | 0.8 | GO:0035331 | negative regulation of hippo signaling(GO:0035331) |
| 0.1 | 0.2 | GO:0006864 | pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519) |
| 0.1 | 1.9 | GO:2000785 | regulation of autophagosome assembly(GO:2000785) |
| 0.1 | 1.2 | GO:2000480 | negative regulation of cAMP-dependent protein kinase activity(GO:2000480) |
| 0.1 | 0.9 | GO:0006044 | N-acetylglucosamine metabolic process(GO:0006044) |
| 0.1 | 0.4 | GO:0051029 | rRNA transport(GO:0051029) |
| 0.1 | 1.3 | GO:0007253 | cytoplasmic sequestering of NF-kappaB(GO:0007253) |
| 0.1 | 0.8 | GO:0008354 | germ cell migration(GO:0008354) |
| 0.1 | 1.0 | GO:1904869 | regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) |
| 0.1 | 0.7 | GO:0061732 | mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732) |
| 0.1 | 0.3 | GO:0051088 | PMA-inducible membrane protein ectodomain proteolysis(GO:0051088) |
| 0.1 | 1.9 | GO:0070534 | protein K63-linked ubiquitination(GO:0070534) |
| 0.1 | 2.4 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.1 | 0.9 | GO:0021859 | pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860) |
| 0.1 | 0.7 | GO:0090154 | positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304) |
| 0.1 | 2.9 | GO:0016577 | histone demethylation(GO:0016577) |
| 0.1 | 0.4 | GO:0035063 | nuclear speck organization(GO:0035063) |
| 0.1 | 3.3 | GO:0006509 | membrane protein ectodomain proteolysis(GO:0006509) |
| 0.1 | 0.5 | GO:0016557 | peroxisome membrane biogenesis(GO:0016557) |
| 0.1 | 0.9 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.1 | 0.2 | GO:2000417 | negative regulation of eosinophil migration(GO:2000417) |
| 0.1 | 0.4 | GO:2000253 | positive regulation of feeding behavior(GO:2000253) |
| 0.1 | 0.6 | GO:0090136 | epithelial cell-cell adhesion(GO:0090136) |
| 0.1 | 0.5 | GO:0043589 | skin morphogenesis(GO:0043589) |
| 0.0 | 0.7 | GO:0050942 | positive regulation of pigment cell differentiation(GO:0050942) |
| 0.0 | 0.3 | GO:0032328 | alanine transport(GO:0032328) |
| 0.0 | 1.3 | GO:0022011 | myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292) |
| 0.0 | 0.3 | GO:0010606 | positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606) |
| 0.0 | 0.8 | GO:0061099 | negative regulation of protein tyrosine kinase activity(GO:0061099) |
| 0.0 | 1.1 | GO:1903206 | negative regulation of hydrogen peroxide-induced cell death(GO:1903206) |
| 0.0 | 3.3 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.0 | 0.4 | GO:1901223 | negative regulation of NIK/NF-kappaB signaling(GO:1901223) |
| 0.0 | 8.0 | GO:0090002 | establishment of protein localization to plasma membrane(GO:0090002) |
| 0.0 | 2.2 | GO:0090102 | cochlea development(GO:0090102) |
| 0.0 | 1.3 | GO:0002076 | osteoblast development(GO:0002076) |
| 0.0 | 0.7 | GO:0090382 | phagosome maturation(GO:0090382) |
| 0.0 | 0.5 | GO:0022417 | protein maturation by protein folding(GO:0022417) |
| 0.0 | 0.8 | GO:0070935 | 3'-UTR-mediated mRNA stabilization(GO:0070935) |
| 0.0 | 0.4 | GO:0034498 | early endosome to Golgi transport(GO:0034498) |
| 0.0 | 1.2 | GO:0048488 | synaptic vesicle endocytosis(GO:0048488) |
| 0.0 | 2.3 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.0 | 1.2 | GO:0007029 | endoplasmic reticulum organization(GO:0007029) |
| 0.0 | 0.4 | GO:0048262 | determination of dorsal/ventral asymmetry(GO:0048262) |
| 0.0 | 0.2 | GO:0007549 | dosage compensation(GO:0007549) dosage compensation by inactivation of X chromosome(GO:0009048) |
| 0.0 | 0.6 | GO:0030252 | growth hormone secretion(GO:0030252) |
| 0.0 | 0.1 | GO:0043988 | histone H3-S28 phosphorylation(GO:0043988) |
| 0.0 | 2.9 | GO:0061572 | actin filament bundle assembly(GO:0051017) actin filament bundle organization(GO:0061572) |
| 0.0 | 1.3 | GO:0019835 | cytolysis(GO:0019835) |
| 0.0 | 0.2 | GO:0007217 | tachykinin receptor signaling pathway(GO:0007217) |
| 0.0 | 0.3 | GO:0071044 | histone mRNA catabolic process(GO:0071044) |
| 0.0 | 0.3 | GO:0070601 | centromeric sister chromatid cohesion(GO:0070601) |
| 0.0 | 0.6 | GO:0007158 | neuron cell-cell adhesion(GO:0007158) |
| 0.0 | 1.6 | GO:0006901 | vesicle coating(GO:0006901) vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) |
| 0.0 | 0.5 | GO:0045671 | negative regulation of osteoclast differentiation(GO:0045671) |
| 0.0 | 5.3 | GO:0007266 | Rho protein signal transduction(GO:0007266) |
| 0.0 | 1.5 | GO:0071349 | interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349) |
| 0.0 | 3.1 | GO:0030509 | BMP signaling pathway(GO:0030509) |
| 0.0 | 0.5 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.0 | 1.3 | GO:0006303 | double-strand break repair via nonhomologous end joining(GO:0006303) |
| 0.0 | 0.5 | GO:0042276 | error-prone translesion synthesis(GO:0042276) |
| 0.0 | 0.5 | GO:0051457 | maintenance of protein location in nucleus(GO:0051457) |
| 0.0 | 0.2 | GO:0033631 | cell-cell adhesion mediated by integrin(GO:0033631) |
| 0.0 | 0.4 | GO:0007020 | microtubule nucleation(GO:0007020) |
| 0.0 | 0.1 | GO:0060235 | lens induction in camera-type eye(GO:0060235) |
| 0.0 | 3.9 | GO:0006457 | protein folding(GO:0006457) |
| 0.0 | 0.1 | GO:1903385 | regulation of homophilic cell adhesion(GO:1903385) |
| 0.0 | 0.1 | GO:0042759 | long-chain fatty acid biosynthetic process(GO:0042759) |
| 0.0 | 0.8 | GO:0006672 | ceramide metabolic process(GO:0006672) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 6.5 | GO:0034686 | integrin alphav-beta8 complex(GO:0034686) |
| 1.4 | 4.2 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 1.2 | 6.1 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 1.0 | 2.9 | GO:1902737 | dendritic filopodium(GO:1902737) |
| 0.9 | 2.7 | GO:0097637 | intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637) |
| 0.8 | 3.2 | GO:0042272 | nuclear RNA export factor complex(GO:0042272) |
| 0.7 | 2.2 | GO:0098831 | cytoskeleton of presynaptic active zone(GO:0048788) presynaptic active zone cytoplasmic component(GO:0098831) presynaptic cytoskeleton(GO:0099569) |
| 0.7 | 2.2 | GO:0036194 | muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195) |
| 0.7 | 3.3 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
| 0.6 | 9.4 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
| 0.6 | 3.4 | GO:0002178 | palmitoyltransferase complex(GO:0002178) |
| 0.5 | 1.5 | GO:0016939 | kinesin II complex(GO:0016939) |
| 0.5 | 6.1 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.5 | 2.7 | GO:0070545 | PeBoW complex(GO:0070545) |
| 0.4 | 1.9 | GO:0032584 | growth cone membrane(GO:0032584) |
| 0.4 | 1.9 | GO:0043291 | RAVE complex(GO:0043291) |
| 0.4 | 9.1 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.3 | 1.7 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
| 0.3 | 1.0 | GO:0017109 | glutamate-cysteine ligase complex(GO:0017109) |
| 0.3 | 4.6 | GO:0033643 | host cell part(GO:0033643) |
| 0.3 | 4.2 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.3 | 3.2 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.3 | 0.9 | GO:0097441 | basilar dendrite(GO:0097441) |
| 0.3 | 1.9 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.2 | 1.7 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.2 | 0.9 | GO:0000798 | nuclear cohesin complex(GO:0000798) |
| 0.2 | 1.2 | GO:0097513 | actomyosin contractile ring(GO:0005826) myosin II filament(GO:0097513) |
| 0.2 | 1.8 | GO:0042583 | chromaffin granule(GO:0042583) |
| 0.2 | 7.1 | GO:0090545 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.2 | 1.0 | GO:0044308 | axonal spine(GO:0044308) |
| 0.2 | 2.4 | GO:0043083 | synaptic cleft(GO:0043083) |
| 0.2 | 1.9 | GO:0000235 | astral microtubule(GO:0000235) aster(GO:0005818) |
| 0.2 | 2.0 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.1 | 3.3 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.1 | 0.4 | GO:0031933 | telomeric heterochromatin(GO:0031933) |
| 0.1 | 1.2 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.1 | 12.4 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.1 | 2.1 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.1 | 0.9 | GO:0000322 | storage vacuole(GO:0000322) |
| 0.1 | 5.9 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.1 | 0.5 | GO:1990425 | ryanodine receptor complex(GO:1990425) |
| 0.1 | 4.3 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.1 | 6.1 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.1 | 0.4 | GO:0033596 | TSC1-TSC2 complex(GO:0033596) |
| 0.1 | 0.9 | GO:0000125 | PCAF complex(GO:0000125) |
| 0.1 | 1.7 | GO:0001527 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.1 | 0.9 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 0.1 | 0.2 | GO:0071062 | alphav-beta3 integrin-vitronectin complex(GO:0071062) |
| 0.1 | 1.5 | GO:0030137 | COPI-coated vesicle(GO:0030137) |
| 0.1 | 1.4 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.1 | 3.8 | GO:0002102 | podosome(GO:0002102) |
| 0.1 | 1.2 | GO:0031254 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 0.1 | 4.8 | GO:0032154 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.1 | 0.8 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.1 | 0.3 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
| 0.1 | 1.2 | GO:0016342 | catenin complex(GO:0016342) |
| 0.1 | 2.4 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.1 | 3.2 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.1 | 1.5 | GO:0090533 | cation-transporting ATPase complex(GO:0090533) |
| 0.1 | 5.0 | GO:0030134 | ER to Golgi transport vesicle(GO:0030134) |
| 0.1 | 0.7 | GO:0045254 | pyruvate dehydrogenase complex(GO:0045254) |
| 0.1 | 1.7 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.1 | 6.3 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.1 | 0.4 | GO:0030905 | retromer, tubulation complex(GO:0030905) |
| 0.1 | 9.1 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.1 | 1.0 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
| 0.1 | 3.1 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.1 | 0.5 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.0 | 0.7 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.0 | 1.4 | GO:0030132 | clathrin coat of coated pit(GO:0030132) |
| 0.0 | 2.1 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 0.5 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 0.0 | 0.4 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
| 0.0 | 1.4 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.0 | 0.3 | GO:0031415 | NatA complex(GO:0031415) |
| 0.0 | 0.8 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.0 | 0.4 | GO:0017119 | Golgi transport complex(GO:0017119) |
| 0.0 | 1.8 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.0 | 0.3 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.0 | 2.8 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 0.4 | GO:0000780 | condensed nuclear chromosome, centromeric region(GO:0000780) |
| 0.0 | 0.5 | GO:0042575 | DNA polymerase complex(GO:0042575) |
| 0.0 | 5.8 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.0 | 2.9 | GO:0016459 | myosin complex(GO:0016459) |
| 0.0 | 2.0 | GO:0030662 | coated vesicle membrane(GO:0030662) |
| 0.0 | 0.7 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.0 | 4.5 | GO:0000922 | spindle pole(GO:0000922) |
| 0.0 | 0.3 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
| 0.0 | 1.9 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 7.2 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.0 | 1.2 | GO:0005776 | autophagosome(GO:0005776) |
| 0.0 | 1.5 | GO:0045335 | phagocytic vesicle(GO:0045335) |
| 0.0 | 0.9 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 2.1 | GO:0044306 | neuron projection terminus(GO:0044306) |
| 0.0 | 0.5 | GO:0005779 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.0 | 6.0 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 2.2 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 1.3 | GO:0036126 | sperm flagellum(GO:0036126) |
| 0.0 | 0.9 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.0 | 0.9 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.0 | 0.4 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.0 | 0.9 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.0 | 0.6 | GO:0030136 | clathrin-coated vesicle(GO:0030136) |
| 0.0 | 1.5 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 0.5 | GO:0031672 | A band(GO:0031672) |
| 0.0 | 0.9 | GO:0070821 | tertiary granule membrane(GO:0070821) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 6.5 | GO:1990430 | extracellular matrix protein binding(GO:1990430) |
| 1.4 | 7.0 | GO:0005105 | type 1 fibroblast growth factor receptor binding(GO:0005105) |
| 1.2 | 6.1 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 1.2 | 4.8 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 1.1 | 4.4 | GO:0051748 | UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748) |
| 1.1 | 4.3 | GO:0032184 | SUMO polymer binding(GO:0032184) |
| 1.0 | 6.2 | GO:0034046 | poly(G) binding(GO:0034046) |
| 0.9 | 4.4 | GO:0004619 | bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538) |
| 0.9 | 5.2 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.8 | 4.0 | GO:0005294 | neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294) |
| 0.7 | 1.4 | GO:0000285 | 1-phosphatidylinositol-3-phosphate 5-kinase activity(GO:0000285) |
| 0.6 | 4.1 | GO:0001517 | N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) |
| 0.6 | 1.7 | GO:0016534 | cyclin-dependent protein kinase 5 activator activity(GO:0016534) |
| 0.5 | 2.1 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.5 | 4.3 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) |
| 0.5 | 1.8 | GO:0004360 | glutamine-fructose-6-phosphate transaminase (isomerizing) activity(GO:0004360) |
| 0.4 | 1.7 | GO:0099609 | microtubule lateral binding(GO:0099609) |
| 0.4 | 3.2 | GO:0015185 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185) |
| 0.4 | 5.5 | GO:0022820 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.4 | 1.1 | GO:0004450 | isocitrate dehydrogenase (NADP+) activity(GO:0004450) |
| 0.4 | 4.8 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.3 | 1.0 | GO:0016309 | 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309) |
| 0.3 | 1.7 | GO:0004677 | DNA-dependent protein kinase activity(GO:0004677) |
| 0.3 | 1.7 | GO:0016308 | 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308) |
| 0.3 | 1.0 | GO:0004357 | glutamate-cysteine ligase activity(GO:0004357) |
| 0.3 | 2.2 | GO:0042978 | ornithine decarboxylase activator activity(GO:0042978) |
| 0.3 | 4.6 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.3 | 1.8 | GO:0045134 | uridine-diphosphatase activity(GO:0045134) |
| 0.3 | 2.4 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
| 0.3 | 0.9 | GO:0032427 | GBD domain binding(GO:0032427) |
| 0.3 | 1.7 | GO:0008273 | calcium, potassium:sodium antiporter activity(GO:0008273) |
| 0.3 | 1.7 | GO:0030023 | extracellular matrix constituent conferring elasticity(GO:0030023) |
| 0.3 | 3.0 | GO:0004791 | thioredoxin-disulfide reductase activity(GO:0004791) |
| 0.3 | 7.7 | GO:0043548 | phosphatidylinositol 3-kinase binding(GO:0043548) |
| 0.3 | 1.0 | GO:0071987 | WD40-repeat domain binding(GO:0071987) |
| 0.3 | 1.3 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
| 0.2 | 1.9 | GO:0050816 | phosphothreonine binding(GO:0050816) |
| 0.2 | 1.8 | GO:0102336 | fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338) |
| 0.2 | 5.2 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.2 | 0.9 | GO:0048763 | calcium-induced calcium release activity(GO:0048763) |
| 0.2 | 3.2 | GO:0008517 | folic acid transporter activity(GO:0008517) |
| 0.2 | 1.4 | GO:0043812 | phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812) |
| 0.2 | 0.7 | GO:0016230 | sphingomyelin phosphodiesterase activator activity(GO:0016230) |
| 0.2 | 3.3 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
| 0.2 | 0.7 | GO:0004739 | pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739) |
| 0.2 | 2.1 | GO:0046625 | sphingolipid binding(GO:0046625) |
| 0.2 | 4.1 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.2 | 2.7 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
| 0.2 | 3.6 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.2 | 1.5 | GO:0030346 | protein phosphatase 2B binding(GO:0030346) |
| 0.2 | 0.5 | GO:0033142 | progesterone receptor binding(GO:0033142) |
| 0.1 | 1.7 | GO:0016413 | O-acetyltransferase activity(GO:0016413) |
| 0.1 | 0.9 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.1 | 0.4 | GO:0015616 | DNA translocase activity(GO:0015616) |
| 0.1 | 1.9 | GO:0034452 | dynactin binding(GO:0034452) |
| 0.1 | 2.1 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.1 | 2.5 | GO:0019706 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 0.1 | 4.1 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.1 | 0.8 | GO:0042392 | sphingosine-1-phosphate phosphatase activity(GO:0042392) |
| 0.1 | 3.2 | GO:0044769 | ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 0.1 | 0.5 | GO:0042809 | vitamin D receptor binding(GO:0042809) |
| 0.1 | 1.0 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.1 | 0.4 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
| 0.1 | 1.5 | GO:0016004 | phospholipase activator activity(GO:0016004) |
| 0.1 | 2.6 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 1.2 | GO:0015924 | mannosyl-oligosaccharide mannosidase activity(GO:0015924) |
| 0.1 | 0.3 | GO:0004534 | 5'-3' exoribonuclease activity(GO:0004534) |
| 0.1 | 1.6 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.1 | 0.3 | GO:0001226 | RNA polymerase II transcription corepressor binding(GO:0001226) |
| 0.1 | 4.7 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.1 | 2.6 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 0.1 | 0.5 | GO:0070740 | tubulin-glutamic acid ligase activity(GO:0070740) |
| 0.1 | 1.5 | GO:0009931 | calcium-dependent protein serine/threonine kinase activity(GO:0009931) |
| 0.1 | 1.5 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 0.1 | 1.7 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.1 | 0.4 | GO:1990460 | leptin receptor binding(GO:1990460) |
| 0.1 | 0.2 | GO:0015218 | pyrimidine nucleotide transmembrane transporter activity(GO:0015218) |
| 0.1 | 0.8 | GO:0030292 | protein tyrosine kinase inhibitor activity(GO:0030292) |
| 0.1 | 0.7 | GO:0001727 | lipid kinase activity(GO:0001727) |
| 0.1 | 2.5 | GO:0015248 | sterol transporter activity(GO:0015248) |
| 0.1 | 4.3 | GO:0004407 | histone deacetylase activity(GO:0004407) |
| 0.1 | 1.3 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.1 | 2.9 | GO:0030159 | receptor signaling complex scaffold activity(GO:0030159) |
| 0.1 | 0.4 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.1 | 0.4 | GO:0042799 | histone methyltransferase activity (H4-K20 specific)(GO:0042799) |
| 0.1 | 1.2 | GO:0008603 | cAMP-dependent protein kinase regulator activity(GO:0008603) |
| 0.1 | 0.9 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.1 | 7.2 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 18.7 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.1 | 0.7 | GO:0019869 | chloride channel inhibitor activity(GO:0019869) |
| 0.1 | 5.5 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.1 | 1.3 | GO:0015172 | L-glutamate transmembrane transporter activity(GO:0005313) acidic amino acid transmembrane transporter activity(GO:0015172) |
| 0.0 | 0.9 | GO:0032183 | SUMO binding(GO:0032183) |
| 0.0 | 1.3 | GO:0031210 | phosphatidylcholine binding(GO:0031210) |
| 0.0 | 0.9 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.0 | 2.4 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.0 | 0.7 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 0.0 | 1.3 | GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) |
| 0.0 | 0.3 | GO:0004594 | pantothenate kinase activity(GO:0004594) |
| 0.0 | 1.6 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.0 | 0.3 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
| 0.0 | 0.6 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.0 | 1.7 | GO:0032452 | histone demethylase activity(GO:0032452) |
| 0.0 | 0.8 | GO:0048185 | activin binding(GO:0048185) |
| 0.0 | 1.3 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.0 | 0.2 | GO:0047696 | beta-adrenergic receptor kinase activity(GO:0047696) |
| 0.0 | 1.2 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.0 | 3.6 | GO:0004702 | receptor signaling protein serine/threonine kinase activity(GO:0004702) |
| 0.0 | 1.3 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
| 0.0 | 0.5 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.0 | 0.7 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.0 | 6.0 | GO:0008201 | heparin binding(GO:0008201) |
| 0.0 | 0.7 | GO:0008494 | translation activator activity(GO:0008494) |
| 0.0 | 4.3 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 8.6 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 0.9 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.0 | 0.3 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 0.0 | 4.0 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.0 | 0.5 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.0 | 0.4 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.0 | 0.7 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 0.0 | 0.2 | GO:0004957 | prostaglandin E receptor activity(GO:0004957) |
| 0.0 | 0.8 | GO:0032947 | protein complex scaffold(GO:0032947) |
| 0.0 | 0.3 | GO:0016881 | acid-amino acid ligase activity(GO:0016881) |
| 0.0 | 1.8 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.0 | 0.6 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 0.4 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 0.4 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 0.0 | 0.6 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.0 | 0.1 | GO:0005047 | signal recognition particle binding(GO:0005047) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 16.5 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.3 | 7.6 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.3 | 12.9 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.2 | 4.0 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.1 | 9.8 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 5.4 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.1 | 5.2 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.1 | 3.0 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.1 | 5.5 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.1 | 1.5 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.1 | 4.1 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.1 | 4.8 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 4.4 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 4.2 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 2.1 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.1 | 0.5 | PID LYMPH ANGIOGENESIS PATHWAY | VEGFR3 signaling in lymphatic endothelium |
| 0.1 | 1.3 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 1.1 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 2.7 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 2.3 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 1.7 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 0.4 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 3.0 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 0.7 | PID CXCR4 PATHWAY | CXCR4-mediated signaling events |
| 0.0 | 1.1 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 1.3 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.0 | 0.8 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.0 | 1.6 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 3.1 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.0 | 0.7 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.0 | 0.8 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 0.4 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 0.0 | 2.3 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 0.2 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.0 | 0.6 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 0.3 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 6.5 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.3 | 6.1 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.2 | 4.6 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.2 | 4.4 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.1 | 3.1 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.1 | 3.2 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.1 | 4.3 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.1 | 3.3 | REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI | Genes involved in N-glycan antennae elongation in the medial/trans-Golgi |
| 0.1 | 5.2 | REACTOME KERATAN SULFATE KERATIN METABOLISM | Genes involved in Keratan sulfate/keratin metabolism |
| 0.1 | 4.0 | REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| 0.1 | 1.5 | REACTOME COPI MEDIATED TRANSPORT | Genes involved in COPI Mediated Transport |
| 0.1 | 4.6 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 3.2 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.1 | 1.7 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.1 | 5.0 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.1 | 3.2 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 1.8 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.1 | 5.4 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 1.0 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
| 0.1 | 2.4 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.1 | 4.2 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.1 | 0.8 | REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING | Genes involved in Role of second messengers in netrin-1 signaling |
| 0.1 | 3.0 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.1 | 2.5 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.1 | 0.9 | REACTOME CD28 DEPENDENT VAV1 PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 0.1 | 5.1 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 4.3 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.1 | 1.5 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.1 | 2.4 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.1 | 3.3 | REACTOME RNA POL III TRANSCRIPTION | Genes involved in RNA Polymerase III Transcription |
| 0.1 | 1.3 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.1 | 1.2 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.1 | 1.8 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.1 | 4.0 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 1.0 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.0 | 1.3 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.0 | 7.7 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 0.6 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 1.2 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 0.3 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.0 | 2.7 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.0 | 0.8 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 0.6 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 1.0 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.0 | 0.6 | REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
| 0.0 | 0.5 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 0.7 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.0 | 0.7 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.0 | 0.9 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.0 | 0.5 | REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |
| 0.0 | 1.0 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 0.6 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.0 | 2.7 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.0 | 5.0 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.0 | 1.5 | REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE | Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle |
| 0.0 | 1.7 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 0.5 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.0 | 1.7 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 0.5 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 0.2 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.0 | 1.1 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.0 | 1.1 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 0.2 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.0 | 0.5 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 0.2 | REACTOME PROSTANOID LIGAND RECEPTORS | Genes involved in Prostanoid ligand receptors |
| 0.0 | 0.9 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |