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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for BACH1_NFE2_NFE2L2
Z-value: 2.19
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Transcription factors associated with BACH1_NFE2_NFE2L2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFE2L2 | hg38_v1_chr2_-_177392673_177392704, hg38_v1_chr2_-_177263800_177263870, hg38_v1_chr2_-_177263522_177263572, hg38_v1_chr2_-_177264686_177264823 | 0.29 | 1.8e-05 | Click! |
| BACH1 | hg38_v1_chr21_+_29298890_29298932, hg38_v1_chr21_+_29299368_29299441 | -0.20 | 3.5e-03 | Click! |
| NFE2 | hg38_v1_chr12_-_54297884_54297941 | -0.02 | 7.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of BACH1_NFE2_NFE2L2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.4 | 773.0 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 3.6 | 122.6 | GO:0042744 | hydrogen peroxide catabolic process(GO:0042744) |
| 5.3 | 96.2 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 21.0 | 84.0 | GO:0071418 | cellular response to amine stimulus(GO:0071418) |
| 7.4 | 73.8 | GO:0035092 | sperm chromatin condensation(GO:0035092) |
| 24.1 | 72.2 | GO:0014810 | positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014810) |
| 1.2 | 58.4 | GO:0043486 | histone exchange(GO:0043486) |
| 14.0 | 56.0 | GO:1903070 | negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070) |
| 7.5 | 52.4 | GO:0006662 | glycerol ether metabolic process(GO:0006662) |
| 17.3 | 52.0 | GO:1904387 | response to human chorionic gonadotropin(GO:0044752) cellular response to thyroxine stimulus(GO:0097069) cellular response to L-phenylalanine derivative(GO:1904387) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 33.6 | 403.2 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 1.6 | 144.0 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.7 | 132.9 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 120.1 | GO:0070062 | extracellular exosome(GO:0070062) |
| 2.1 | 111.4 | GO:0000502 | proteasome complex(GO:0000502) |
| 10.0 | 110.1 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
| 0.6 | 86.8 | GO:0016363 | nuclear matrix(GO:0016363) |
| 9.0 | 81.4 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
| 3.7 | 71.0 | GO:0000812 | Swr1 complex(GO:0000812) |
| 0.2 | 61.1 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 15.0 | 421.0 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 15.7 | 125.3 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 11.6 | 115.8 | GO:0004784 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 8.7 | 96.2 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 14.7 | 88.4 | GO:0047134 | protein-disulfide reductase activity(GO:0047134) |
| 21.0 | 84.0 | GO:0004852 | uroporphyrinogen-III synthase activity(GO:0004852) |
| 0.3 | 82.8 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 9.0 | 81.4 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
| 8.4 | 75.6 | GO:0016668 | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668) |
| 1.3 | 74.5 | GO:0019212 | phosphatase inhibitor activity(GO:0019212) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 116.3 | PID AURORA B PATHWAY | Aurora B signaling |
| 1.6 | 114.5 | ST B CELL ANTIGEN RECEPTOR | B Cell Antigen Receptor |
| 0.9 | 108.6 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 1.2 | 101.3 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 1.4 | 63.4 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 1.3 | 57.6 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.5 | 47.6 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.6 | 45.9 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 1.2 | 45.5 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.6 | 40.6 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.6 | 773.0 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 4.4 | 148.5 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 3.9 | 116.9 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 3.5 | 112.3 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 5.5 | 98.4 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 1.7 | 95.8 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 3.1 | 90.0 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.4 | 50.7 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 1.2 | 47.5 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.2 | 46.1 | REACTOME TRANSLATION | Genes involved in Translation |