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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for BACH2
Z-value: 1.11
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Transcription factors associated with BACH2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BACH2 | hg38_v1_chr6_-_90296908_90296922, hg38_v1_chr6_-_90296824_90296851 | -0.40 | 7.6e-10 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of BACH2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 119.2 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 8.4 | 50.5 | GO:0035105 | sterol regulatory element binding protein import into nucleus(GO:0035105) |
| 0.7 | 38.2 | GO:0032467 | positive regulation of cytokinesis(GO:0032467) |
| 0.0 | 31.3 | GO:0045087 | innate immune response(GO:0045087) |
| 0.4 | 29.1 | GO:0042267 | natural killer cell mediated cytotoxicity(GO:0042267) |
| 0.2 | 27.3 | GO:0022617 | extracellular matrix disassembly(GO:0022617) |
| 1.3 | 23.9 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 3.9 | 23.6 | GO:0007296 | vitellogenesis(GO:0007296) |
| 0.2 | 23.3 | GO:0045669 | positive regulation of osteoblast differentiation(GO:0045669) |
| 1.2 | 21.9 | GO:0016540 | protein autoprocessing(GO:0016540) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.6 | 50.5 | GO:0005638 | lamin filament(GO:0005638) |
| 0.3 | 38.2 | GO:0031985 | Golgi cisterna(GO:0031985) |
| 0.1 | 38.2 | GO:0005819 | spindle(GO:0005819) |
| 11.3 | 34.0 | GO:0034515 | proteasome storage granule(GO:0034515) |
| 2.1 | 27.0 | GO:0031209 | SCAR complex(GO:0031209) |
| 2.4 | 26.3 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
| 0.9 | 26.1 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.4 | 23.9 | GO:0031430 | M band(GO:0031430) |
| 0.2 | 23.7 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 1.6 | 22.1 | GO:0019774 | proteasome core complex, beta-subunit complex(GO:0019774) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 53.9 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 1.2 | 49.3 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 39.2 | GO:0005198 | structural molecule activity(GO:0005198) |
| 1.3 | 37.6 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.4 | 37.6 | GO:0097110 | scaffold protein binding(GO:0097110) |
| 0.1 | 33.3 | GO:0003924 | GTPase activity(GO:0003924) |
| 1.0 | 30.6 | GO:0042288 | MHC class I protein binding(GO:0042288) |
| 0.2 | 29.4 | GO:0008201 | heparin binding(GO:0008201) |
| 2.2 | 23.9 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 1.2 | 19.6 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 52.5 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.6 | 47.1 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.3 | 37.1 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 1.2 | 32.1 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.4 | 28.7 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.4 | 23.6 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.2 | 22.0 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.4 | 21.9 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.3 | 20.9 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.2 | 18.6 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 118.2 | REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 | Genes involved in Autodegradation of the E3 ubiquitin ligase COP1 |
| 1.0 | 50.5 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 1.6 | 45.0 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 1.5 | 32.1 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.2 | 28.7 | REACTOME TRANSLATION | Genes involved in Translation |
| 0.4 | 23.7 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.2 | 19.1 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.5 | 16.9 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.4 | 15.6 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.2 | 14.9 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |