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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for BARHL1
Z-value: 2.07
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Transcription factors associated with BARHL1
Network of associatons between targets according to the STRING database.
First level regulatory network of BARHL1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_108058361 Show fit | 59.27 |
ENST00000398258.7
|
CD47 molecule |
|
| chr3_-_185923893 Show fit | 45.69 |
ENST00000259043.11
|
transformer 2 beta homolog |
|
| chr8_-_63026179 Show fit | 44.67 |
ENST00000677919.1
|
gamma-glutamyl hydrolase |
|
| chr4_+_106315534 Show fit | 42.76 |
ENST00000510207.5
|
aminoacyl tRNA synthetase complex interacting multifunctional protein 1 |
|
| chr14_+_55661272 Show fit | 40.33 |
ENST00000555573.5
|
kinectin 1 |
|
| chr15_+_41286011 Show fit | 40.25 |
ENST00000661438.1
|
novel protein |
|
| chr18_-_36122110 Show fit | 39.75 |
ENST00000586829.1
|
solute carrier family 39 member 6 |
|
| chr5_-_69369257 Show fit | 38.74 |
ENST00000509462.5
|
TATA-box binding protein associated factor 9 |
|
| chr8_-_27838034 Show fit | 37.41 |
ENST00000522944.5
|
PDZ binding kinase |
|
| chr15_-_60398733 Show fit | 36.15 |
ENST00000559818.6
|
annexin A2 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 330.7 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 2.1 | 156.8 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 2.3 | 146.8 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 4.4 | 137.9 | GO:0006418 | tRNA aminoacylation for protein translation(GO:0006418) |
| 2.1 | 98.1 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.4 | 96.3 | GO:0000377 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 5.9 | 76.7 | GO:0006265 | DNA topological change(GO:0006265) |
| 18.6 | 74.5 | GO:0009224 | CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035) |
| 5.5 | 71.4 | GO:1900625 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 9.5 | 66.7 | GO:0046726 | positive regulation by virus of viral protein levels in host cell(GO:0046726) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 208.0 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.2 | 149.3 | GO:0005730 | nucleolus(GO:0005730) |
| 0.6 | 133.9 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 1.6 | 123.6 | GO:0015935 | small ribosomal subunit(GO:0015935) |
| 2.1 | 122.6 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.4 | 122.5 | GO:0031965 | nuclear membrane(GO:0031965) |
| 4.4 | 122.1 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 8.6 | 102.8 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.7 | 82.2 | GO:0031985 | Golgi cisterna(GO:0031985) |
| 26.9 | 80.8 | GO:0017102 | methionyl glutamyl tRNA synthetase complex(GO:0017102) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.3 | 148.3 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 1.8 | 138.6 | GO:0019003 | GDP binding(GO:0019003) |
| 0.7 | 130.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 3.0 | 123.4 | GO:0070717 | poly-purine tract binding(GO:0070717) |
| 1.7 | 114.7 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 2.4 | 113.3 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 2.7 | 106.7 | GO:0000049 | tRNA binding(GO:0000049) |
| 8.0 | 103.8 | GO:1990825 | sequence-specific mRNA binding(GO:1990825) |
| 0.3 | 103.3 | GO:0045296 | cadherin binding(GO:0045296) |
| 2.3 | 97.3 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 177.4 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.7 | 118.0 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 1.9 | 95.0 | PID BARD1 PATHWAY | BARD1 signaling events |
| 1.4 | 91.3 | PID PLK1 PATHWAY | PLK1 signaling events |
| 1.0 | 91.1 | PID E2F PATHWAY | E2F transcription factor network |
| 1.3 | 87.5 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.9 | 86.3 | PID CDC42 PATHWAY | CDC42 signaling events |
| 2.3 | 70.8 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 1.7 | 66.2 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.7 | 58.3 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.6 | 316.0 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 2.7 | 231.5 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 2.7 | 149.0 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 1.1 | 143.4 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 1.1 | 140.2 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 3.4 | 131.3 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 4.0 | 124.5 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 1.1 | 100.1 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 1.3 | 97.7 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 3.1 | 94.3 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |