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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for BARHL2
Z-value: 0.84
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Transcription factors associated with BARHL2
Network of associatons between targets according to the STRING database.
First level regulatory network of BARHL2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_-_137343752 Show fit | 15.05 |
ENST00000393083.2
|
pleiotrophin |
|
| chr12_-_91179355 Show fit | 14.89 |
ENST00000550563.5
ENST00000546370.5 |
decorin |
|
| chr2_-_237414157 Show fit | 13.24 |
ENST00000295550.9
ENST00000353578.9 ENST00000392004.7 ENST00000433762.1 ENST00000392003.6 |
collagen type VI alpha 3 chain |
|
| chr13_-_44474296 Show fit | 12.86 |
ENST00000611198.4
|
TSC22 domain family member 1 |
|
| chr12_-_91153149 Show fit | 12.67 |
ENST00000550758.1
|
decorin |
|
| chr7_-_137343688 Show fit | 12.27 |
ENST00000348225.7
|
pleiotrophin |
|
| chr19_+_44905785 Show fit | 11.50 |
ENST00000446996.5
ENST00000252486.9 ENST00000434152.5 |
apolipoprotein E |
|
| chr12_-_91182784 Show fit | 11.47 |
ENST00000547568.6
ENST00000052754.10 ENST00000552962.5 |
decorin |
|
| chr2_-_237414127 Show fit | 10.59 |
ENST00000472056.5
|
collagen type VI alpha 3 chain |
|
| chr14_-_59630806 Show fit | 10.16 |
ENST00000342503.8
|
reticulon 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.4 | 57.8 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 10.2 | 30.5 | GO:0060221 | retinal rod cell differentiation(GO:0060221) |
| 0.2 | 19.0 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.1 | 18.8 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 12.9 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 1.1 | 12.3 | GO:0010499 | proteasomal ubiquitin-independent protein catabolic process(GO:0010499) |
| 0.3 | 12.2 | GO:0070884 | regulation of calcineurin-NFAT signaling cascade(GO:0070884) |
| 3.8 | 11.5 | GO:1901628 | positive regulation of postsynaptic membrane organization(GO:1901628) |
| 0.8 | 11.4 | GO:0034372 | very-low-density lipoprotein particle remodeling(GO:0034372) |
| 0.3 | 10.7 | GO:0007628 | adult walking behavior(GO:0007628) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.3 | 81.6 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.3 | 33.4 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 23.1 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.2 | 16.1 | GO:0032432 | actin filament bundle(GO:0032432) |
| 0.3 | 13.3 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.2 | 12.1 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 11.8 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 2.9 | 11.5 | GO:0034365 | discoidal high-density lipoprotein particle(GO:0034365) |
| 0.5 | 11.3 | GO:0031045 | dense core granule(GO:0031045) |
| 0.0 | 10.6 | GO:0030424 | axon(GO:0030424) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 51.9 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.4 | 46.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 6.8 | 27.3 | GO:0035373 | chondroitin sulfate proteoglycan binding(GO:0035373) |
| 0.0 | 17.1 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.1 | 13.9 | GO:0008201 | heparin binding(GO:0008201) |
| 0.1 | 12.7 | GO:0044325 | ion channel binding(GO:0044325) |
| 2.9 | 11.5 | GO:0070326 | very-low-density lipoprotein particle receptor binding(GO:0070326) |
| 1.0 | 9.9 | GO:0004064 | arylesterase activity(GO:0004064) |
| 0.1 | 9.9 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 0.1 | 9.7 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 68.8 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.2 | 33.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 1.1 | 30.8 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.5 | 24.9 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 13.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 11.0 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 9.5 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 9.4 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 9.0 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.1 | 8.8 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 60.2 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.5 | 35.9 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.9 | 20.7 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.2 | 15.6 | REACTOME NUCLEAR SIGNALING BY ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.3 | 11.2 | REACTOME RNA POL I TRANSCRIPTION INITIATION | Genes involved in RNA Polymerase I Transcription Initiation |
| 0.6 | 9.9 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.3 | 9.7 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.2 | 9.0 | REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
| 0.1 | 8.8 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.3 | 7.9 | REACTOME KERATAN SULFATE BIOSYNTHESIS | Genes involved in Keratan sulfate biosynthesis |